P66Shc-induced redox changes drive endothelial insulin resistance

Atherosclerosis

Volumn 236, Issue 2, 2014, Pages 426-429

  Paneni, Francesco ^a,b   Costantino, Sarah ^a   Cosentino, Francesco ^a  

^a KAROLINSKA UNIVERSITY HOSPITAL   (Sweden)

^b SAPIENZA UNIVERSITY OF ROME   (Italy)

Author keywords

Cardiovascular disease; Endothelial insulin resistance; Inflammation; Obesity; Oxidative stress

Indexed keywords

ENDOTHELIAL NITRIC OXIDE SYNTHASE; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; INSULIN; INSULIN RECEPTOR SUBSTRATE 1; METHYLGLYOXAL; PROSTAGLANDIN I2 SYNTHASE; PROSTAGLANDIN SYNTHASE; PROTEIN KINASE B; PROTEIN P66; PROTEIN P66 SHC; PROTEIN SHC; REACTIVE OXYGEN METABOLITE; UNCLASSIFIED DRUG; CYTOCHROME P450; FATTY ACID; ISOMERASE; LEPTIN; NOS3 PROTEIN, MOUSE; PHENYLEPHRINE; PROSTACYCLIN SYNTHASE; SHC1 PROTEIN, MOUSE; SMALL INTERFERING RNA; SUPEROXIDE;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; BIOSYNTHESIS; CARDIOVASCULAR DISEASE; CONTROLLED STUDY; ENDOTHELIAL DYSFUNCTION; ENDOTHELIUM CELL; FATTY ACID OXIDATION; GENE SILENCING; INSULIN RESISTANCE; KNOCKOUT MOUSE; MALE; MOUSE; NONHUMAN; OBESITY; OXIDATION REDUCTION REACTION; OXIDATIVE STRESS; PROTEIN FUNCTION; SIGNAL TRANSDUCTION; VASCULAR ENDOTHELIUM; VASODILATATION; WILD TYPE; ANIMAL; ANTAGONISTS AND INHIBITORS; C57BL MOUSE; DEFICIENCY; DRUG EFFECTS; GENETICS; METABOLISM; MOLECULARLY TARGETED THERAPY; MOUSE MUTANT; PATHOPHYSIOLOGY; PHYSIOLOGY; RNA INTERFERENCE;

ANIMALS; CYTOCHROME P-450 ENZYME SYSTEM; ENDOTHELIUM, VASCULAR; FATTY ACIDS, NONESTERIFIED; INSULIN; INSULIN RESISTANCE; INTRAMOLECULAR OXIDOREDUCTASES; LEPTIN; MALE; MICE; MICE, INBRED C57BL; MICE, KNOCKOUT; MICE, OBESE; MOLECULAR TARGETED THERAPY; NF-KAPPA B; NITRIC OXIDE SYNTHASE TYPE III; OBESITY; OXIDATION-REDUCTION; PHENYLEPHRINE; PYRUVALDEHYDE; REACTIVE OXYGEN SPECIES; RNA INTERFERENCE; RNA, SMALL INTERFERING; SHC SIGNALING ADAPTOR PROTEINS; SUPEROXIDES; VASODILATION;

EID: 84907073942     PISSN: 00219150     EISSN: 18791484     Source Type: Journal    
DOI: 10.1016/j.atherosclerosis.2014.07.027     Document Type: Article

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