Histone H3 lysine 36 methyltransferase Whsc1 promotes the association of Runx2 and p300 in the activation of bone-related genes

PLoS ONE

Volumn 9, Issue 9, 2014, Pages

  Lee, Yu Fei ^a   Nimura, Keisuke ^a   Lo, Wan Ning ^a   Saga, Kotaro ^a   Kaneda, Yasufumi ^a  

^a OSAKA UNIVERSITY   (Japan)

Author keywords

[No Author keywords available]

Indexed keywords

COLLAGEN TYPE 1; E1A ASSOCIATED P300 PROTEIN; HISTONE LYSINE METHYLTRANSFERASE; HISTONE LYSINE METHYLTRANSFERASE WHSC1; OSTEOPONTIN; TRANSCRIPTION FACTOR RUNX2; UNCLASSIFIED DRUG; HISTONE; HISTONE ACETYLTRANSFERASE PCAF; HISTONE METHYLTRANSFERASE; LYSINE; P300-CBP-ASSOCIATED FACTOR; TRANSCRIPTION FACTOR RUNX1; WHSC1 PROTEIN, MOUSE;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; BONE DEVELOPMENT; BONE MALFORMATION; COL1A1 GENE; CONTROLLED STUDY; EMBRYO; ENZYME ACTIVITY; GENE; GENE ACTIVATION; GENE EXPRESSION REGULATION; GENE INTERACTION; GENE SILENCING; HISTONE ACETYLATION; HISTONE METHYLATION; KNOCKOUT MOUSE; MOUSE; NONHUMAN; OCCIPITAL BONE; OPN GENE; OSSIFICATION; OSTEOBLAST; PROTEIN PROTEIN INTERACTION; STERNUM; TRANSCRIPTION REGULATION; ANIMAL; BONE; CELL LINE; GENETICS; METABOLISM;

ANIMALS; BONE AND BONES; CELL LINE; CORE BINDING FACTOR ALPHA 1 SUBUNIT; CORE BINDING FACTOR ALPHA 2 SUBUNIT; HISTONE-LYSINE N-METHYLTRANSFERASE; HISTONES; LYSINE; MICE; MICE, KNOCKOUT; P300-CBP TRANSCRIPTION FACTORS;

EID: 84907068203     PISSN: None     EISSN: 19326203     Source Type: Journal    
DOI: 10.1371/journal.pone.0106661     Document Type: Article

References (37)

1. Skinner MK (2011) Role of epigenetics in developmental biology and transgenerational inheritance. Birth Defects Res Part C Embryo Today Rev 93: 51-55. doi:10.1002/bdrc.20199.
2. Cantone I, Fisher AG (2013) Epigenetic programming and reprogramming during development. Nat Struct Mol Biol 20: 282-289. doi:10.1038/nsmb.2489.
3. Bergemann AD, Cole F, Hirschhorn K (2005) The etiology of Wolf-Hirschhorn syndrome. Trends Genet 21: 188-195. doi:16/j.tig.2005.01.008.
4. Zollino M, Murdolo M, Marangi G, Pecile V, Galasso C, et al. (2008) On the nosology and pathogenesis of Wolf-Hirschhorn syndrome: Genotype-phenotype correlation analysis of 80 patients and literature review. Am J Med Genet C Semin Med Genet 148C: 257-269. doi:10.1002/ajmg.c.30190.
5. Nimura K, Ura K, Shiratori H, Ikawa M, Okabe M, et al. (2009) A histone H3 lysine 36 trimethyltransferase links Nkx2-5 to Wolf-Hirschhorn syndrome. Nature 460: 287-291. doi:10.1038/nature08086.
6. Andersen EF, Carey JC, Earl DL, Corzo D, Suttie M, et al. (2013) Deletions involving genes WHSC1 and LETM1 may be necessary, but are not sufficient to cause Wolf-Hirschhorn syndrome. Eur J Hum Genet EJHG. doi:10.1038/ejhg.2013.192.
7. Barron BJ, Robinson L, Tran HD, Lamki L (1994) Scintigraphic Manifestations of "Sternal Cupping." J Nucl Med 35: 1167-1169.
8. Mazzeu JF, Krepischi-Santos AC, Rosenberg C, Lourenço CM, et al. (2007) Widening the clinical spectrum of Pitt-Rogers-Danks/Wolf-Hirschhorn syndromes.Genet Mol Biol 30: 339-342. doi:10.1590/S1415-47572007000300007.
9. Komori T, Yagi H, Nomura S, Yamaguchi A, Sasaki K, et al. (1997) Targeted disruption of Cbfa1 results in a complete lack of bone formation owing to maturational arrest of osteoblasts. Cell 89: 755-764.
10. Chuang LSH, Ito K, Ito Y (2013) RUNX family: Regulation and diversification of roles through interacting proteins. Int J Cancer 132: 1260-1271. doi:10.1002/ijc.27964.
11. Liakhovitskaia A, Lana-Elola E, Stamateris E, Rice DP, van't Hof RJ, et al. (2010) The essential requirement for Runx1 in the development of the sternum. Dev Biol 340: 539-546. doi:16/j.ydbio.2010.02.005.
12. Kimura A, Inose H, Yano F, Fujita K, Ikeda T, et al. (2010) Runx1 and Runx2 cooperate during sternal morphogenesis. Development 137: 1159-1167. doi:10.1242/dev.045005.
13. Wang Y, Belflower RM, Dong Y, Schwarz EM, O'Keefe RJ, et al. (2005) Runx1/Aml1/Cbfa2 Mediates Onset of Mesenchymal Cell Differentiation Toward Chondrogenesis. J Bone Miner Res 20: 1624-1636. doi:10.1359/JBMR.050516.
14. Schroeder TM, Kahler RA, Li X, Westendorf JJ (2004) Histone deacetylase 3 interacts with runx2 to repress the osteocalcin promoter and regulate osteoblast differentiation. J Biol Chem 279: 41998-42007. doi:10.1074/jbc.M403702200.
15. Lee M, Partridge NC (2010) Parathyroid hormone activation of matrix metalloproteinase-13 transcription requires the histone acetyltransferase activity of p300 and PCAF and p300-dependent acetylation of PCAF. J Biol Chem 285: 38014-38022. doi:10.1074/jbc.M110.142141.
16. Kato S, Inoue K, Youn M-Y (2010) Emergence of the osteo-epigenome in bone biology. IBMS BoneKEy 7: 314-324. doi:10.1138/20100464.
17. Mikkelsen TS, Ku M, Jaffe DB, Issac B, Lieberman E, et al. (2007) Genome-wide maps of chromatin state in pluripotent and lineage-committed cells. Nature 448: 553-560. doi:10.1038/nature06008.
18. Barski A, Cuddapah S, Cui K, Roh T-Y, Schones DE, et al. (2007) High-Resolution Profiling of Histone Methylations in the Human Genome. Cell 129: 823-837. doi:10.1016/j.cell.2007.05.009.
19. Lucio-Eterovic AK, Singh MM, Gardner JE, Veerappan CS, Rice JC, et al. (2010) Role for the nuclear receptor-binding SET domain protein 1 (NSD1) methyltransferase in coordinating lysine 36 methylation at histone 3 with RNA polymerase II function. Proc Natl Acad Sci USA 107: 16952-16957. doi:10.1073/pnas.1002653107.
20. Hu M, Sun X-J, Zhang Y-L, Kuang Y, Hu C-Q, et al. (2010) Histone H3 lysine 36 methyltransferase Hypb/Setd2 is required for embryonic vascular remodeling. Proc Natl Acad Sci 107: 2956-2961. doi:10.1073/pnas.0915033107.
21. Edmunds JW, Mahadevan LC, Clayton AL (2007) Dynamic histone H3 methylation during gene induction: HYPB/Setd2 mediates all H3K36 trimethylation. EMBO J 27: 406-420. doi:10.1038/sj.emboj.7601967.
22. Carrozza MJ, Li B, Florens L, Suganuma T, Swanson SK, et al. (2005) Histone H3 Methylation by Set2 Directs Deacetylation of Coding Regions by Rpd3S to Suppress Spurious Intragenic Transcription. Cell 123: 581-592. doi:10.1016/j.cell.2005.10.023.
23. Venkatesh S, Smolle M, Li H, Gogol MM, Saint M, et al. (2012) Set2 methylation of histone H3 lysine 36 suppresses histone exchange on transcribed genes. Nature 489: 452-455. doi:10.1038/nature11326.
24. Pinney DF, Emerson CP (1989) 10T1/2 cells: an in vitro model for molecular genetic analysis of mesodermal determination and differentiation. Environ Health Perspect 80: 221-227.
25. Czekanska EM, Stoddart MJ, Richards RG, Hayes JS (2012) In search of an osteoblast cell model for in vitro research. Eur Cell Mater 24: 1-17.
26. Nimura K, Ishida C, Koriyama H, Hata K, Yamanaka S, et al. (2006) Dnmt3a2 targets endogenous Dnmt3L to ES cell chromatin and induces regional DNA methylation. Genes Cells 11: 1225-1237. doi:10.1111/j.1365-2443.2006.010 12.x.
27. Takeichi M, Nimura K, Mori M, Nakagami H, Kaneda Y (2013) The transcription factors Tbx18 and Wt1 control the epicardial epithelialmesenchymal transition through bi-directional regulation of Slug in murine primary epicardial cells. PloS One 8: e57829. doi:10.1371/journal.pone.0057829.
28. Miyazono K, Maeda S, Imamura T (2004) Coordinate regulation of cell growth and differentiation by TGF-β superfamily and Runx proteins. Oncogene 23: 4232-4237. doi:10.1038/sj.onc.1207131.
29. Ducy P, Zhang R, Geoffroy V, Ridall AL, Karsenty G (1997) Osf2/Cbfa1: A Transcriptional Activator of Osteoblast Differentiation. Cell 89: 747-754. doi:10.1016/S0092-8674(00)80257-3.
30. Kitabayashi I (1998) Interaction and functional cooperation of the leukemia-associated factors AML1 and p300 in myeloid cell differentiation. EMBO J 17: 2994-3004. doi:10.1093/emboj/17.11.2994.
31. Boumah CE, Lee M, Selvamurugan N, Shimizu E, Partridge NC (2009) Runx2 recruits p300 to mediate parathyroid hormone's effects on histone acetylation and transcriptional activation of the matrix metalloproteinase-13 gene. Mol Endocrinol Baltim Md 23: 1255-1263. doi:10.1210/me.2008-0217.
32. Javed A, Gutierrez S, Montecino M, van Wijnen AJ, Stein JL, et al. (1999) Multiple Cbfa/AML Sites in the Rat Osteocalcin Promoter Are Required for Basal and Vitamin D-Responsive Transcription and Contribute to Chromatin Organization. Mol Cell Biol 19: 7491-7500.
33. Yoh SM, Lucas JS, Jones KA (2008) The Iws1:Spt6:CTD complex controls cotranscriptional mRNA biosynthesis and HYPB/Setd2-mediated histone H3K36 methylation. Genes Dev 22: 3422-3434. doi:10.1101/gad.1720008.
34. Komori T (2006) Regulation of osteoblast differentiation by transcription factors. J Cell Biochem 99: 1233-1239. doi:10.1002/jcb.20958.
35. Grunstein M (1997) Histone acetylation in chromatin structure and transcription. Nature 389: 349-352. doi:10.1038/38664.
36. Zhang S, Xiao Z, Luo J, He N, Mahlios J, et al. (2009) Dose-Dependent Effects of Runx2 on Bone Development. J Bone Miner Res 24: 1889-1904. doi:10.1359/JBMR.090502.
37. Lou Y, Javed A, Hussain S, Colby J, Frederick D, et al. (2009) A Runx2 threshold for the cleidocranial dysplasia phenotype. Hum Mol Genet 18: 556-568. doi:10.1093/hmg/ddn383.