Role for the nuclear receptor-binding SET domain protein 1 (NSD1) methyltransferase in coordinating lysine 36 methylation at histone 3with RNApolymerase II function

Proceedings of the National Academy of Sciences of the United States of America

Volumn 107, Issue 39, 2010, Pages 16952-16957

  Lucio Eterovic, Agda Karina ^a   Singh, Melissa M ^a,c   Gardner, Jeffrey E ^a   Veerappan, Chendhore S ^b   Rice, Judd C ^b   Carpenter, Phillip B ^a  

^a UNIVERSITY OF TEXAS MEDICAL SCHOOL   (United States)

^b UNIVERSITY OF SOUTHERN CALIFORNIA   (United States)

^c UNIVERSITY OF TEXAS MD ANDERSON CANCER CENTER   (United States)

Author keywords

C terminal domain; ChIP on chip; Elongation; Histone code; Initiation

Indexed keywords

BONE MORPHOGENETIC PROTEIN 4; HISTONE H3; HISTONE LYSINE METHYLTRANSFERASE; ISOPROTEIN; LYSINE; METHYLTRANSFERASE; NUCLEAR RECEPTOR BINDING SET DOMAIN PROTEIN 1; RNA POLYMERASE II; SERINE; SHORT HAIRPIN RNA; TRISTETRAPROLIN; UNCLASSIFIED DRUG; BMP4 PROTEIN, HUMAN; BUTYRATE RESPONSE FACTOR 1; HISTONE; NSD1 PROTEIN, HUMAN; NUCLEAR PROTEIN; SIGNAL PEPTIDE; ZFP36L1 PROTEIN, HUMAN;

ARTICLE; CARBOXY TERMINAL SEQUENCE; GENE CONTROL; GENE EXPRESSION; GENE TARGETING; GENETIC TRANSCRIPTION; HUMAN; HUMAN CELL; METHYLATION; PRIORITY JOURNAL; PROTEIN ANALYSIS; PROTEIN BINDING; PROTEIN DEPLETION; PROTEIN FUNCTION; PROTEIN PHOSPHORYLATION; PROTEIN TARGETING; GENE EXPRESSION REGULATION; GENE REGULATORY NETWORK; GENE SILENCING; GENETICS; METABOLISM; PROMOTER REGION;

BONE MORPHOGENETIC PROTEIN 4; BUTYRATE RESPONSE FACTOR 1; GENE EXPRESSION REGULATION; GENE KNOCKDOWN TECHNIQUES; GENE REGULATORY NETWORKS; HISTONES; HUMANS; INTRACELLULAR SIGNALING PEPTIDES AND PROTEINS; LYSINE; METHYLATION; METHYLTRANSFERASES; NUCLEAR PROTEINS; PROMOTER REGIONS, GENETIC; RNA POLYMERASE II;

EID: 78049275346     PISSN: 00278424     EISSN: 10916490     Source Type: Journal    
DOI: 10.1073/pnas.1002653107     Document Type: Article

References (45)

1. Angrand PO, et al. (2001) NSD3, a new SET domain-containing gene, maps to 8p12 and is amplified in human breast cancer cell lines. Genomics 74:79-88.
2. Battaglia A, Filippi T, Carey JC (2008) Update on the clinical features and natural history of Wolf-Hirschhorn (4p-) syndrome: Experience with 87 patients and recommendations for routine health supervision. Am J Med Genet C Semin Med Genet 148C:246-251.
3. Berdasco M, et al. (2009) Epigenetic inactivation of the Sotos overgrowth syndrome gene histone methyltransferase NSD1 in human neuroblastoma and glioma. Proc Natl Acad Sci USA 106:21830-21835.
4. Bergemann AD, Cole F, Hirschhorn K (2005) The etiology of Wolf-Hirschhorn syndrome. Trends Genet 21:188-195.
5. Keats JJ, et al. (2005) Overexpression of transcripts originating from the MMSET locus characterizes all t(4;14)(p16;q32)-positive multiple myeloma patients. Blood 105:4060-4069.
6. Stec I, et al. (1998) WHSC1, a 90 kb SET domain-containing gene, expressed in early development and homologous to a Drosophila dysmorphy gene maps in the Wolf-Hirschhorn syndrome critical region and is fused to IgH in t(4;14) multiple myeloma. Hum Mol Genet 7:1071-1082. (Pubitemid 28306870)
7. Zhao Q, et al. (2009) Transcriptome-guided characterization of genomic rearrangements in a breast cancer cell line. Proc Natl Acad Sci USA 106:1886-1891.
8. Huang N, et al. (1998) Two distinct nuclear receptor interaction domains in NSD1, a novel SET protein that exhibits characteristics of both corepressors and coactivators. EMBO J 17:3398-3412. (Pubitemid 28279513)
9. Rayasam GV, et al. (2003) NSD1 is essential for early post-implantation development and has a catalytically active SET domain. EMBO J 22:3153-3163.
10. Wang GG, Cai L, Pasillas MP, Kamps MP (2007) NUP98-NSD1 links H3K36 methylation to Hox-A gene activation and leukaemogenesis. Nat Cell Biol 9:804-812. (Pubitemid 47019467)
11. Kurotaki N, et al. (2002) Haploinsufficiency of NSD1 causes Sotos syndrome. Nat Genet 30:365-366.
12. Leventopoulos G, et al. (2009) A clinical study of Sotos syndrome patients with review of the literature. Pediatr Neurol 40:357-364.
13. Jenuwein T, Allis CD (2001) Translating the histone code. Science 293:1074-1080.
14. Shilatifard A (2006) Chromatin modifications by methylation and ubiquitination: implications in the regulation of gene expression. Annu Rev Biochem 75:243-269. (Pubitemid 44118033)
15. Turner BM (2002) Cellular memory and the histone code. Cell 111:285-291.
16. Bell O, et al. (2007) Localized H3K36 methylation states define histone H4K16 acetylation during transcriptional elongation in Drosophila. EMBO J 26:4974-4984. (Pubitemid 350261289)
17. Bender LB, et al. (2006) MES-4: An autosome-associated histone methyltransferase that participates in silencing the X chromosomes in the C. elegans germ line. Development 133:3907-3917.
18. Li Y, et al. (2009) The target of the NSD family of histone lysine methyltransferases depends on the nature of the substrate. J Biol Chem 284:34283-34295.
19. Stabell M, Larsson J, Aalen RB, Lambertsson A (2007) Drosophila dSet2 functions in H3-K36 methylation and is required for development. Biochem Biophys Res Commun 359:784-789. (Pubitemid 46899018)
20. Lu T, et al. (2010) Regulation of NF-kappaB by NSD1/FBXL11-dependent reversible lysine methylation of p65. Proc Natl Acad Sci USA 107:46-51.
21. Kolasinska-Zwierz P, et al. (2009) Differential chromatin marking of introns and expressed exons by H3K36me3. Nat Genet 41:376-381.
22. Sims RJ, 3rd, Reinberg D (2009) Processing the H3K36me3 signature. Nat Genet 41:270-271.
23. Spies N, Nielsen CB, Padgett RA, Burge CB (2009) Biased chromatin signatures around polyadenylation sites and exons. Mol Cell 36:245-254.
24. Larschan E, et al. (2007) MSL complex is attracted to genes marked by H3K36 trimethylation using a sequence-independent mechanism. Mol Cell 28:121-133. (Pubitemid 47531971)
25. Carrozza MJ, et al. (2005) Histone H3 methylation by Set2 directs deacetylation of coding regions by Rpd3S to suppress spurious intragenic transcription. Cell 123:581-592.
26. Joshi AA, Struhl K (2005) Eaf3 chromodomain interaction with methylated H3-K36 links histone deacetylation to Pol II elongation. Mol Cell 20:971-978.
27. Kaplan CD, Laprade L, Winston F (2003) Transcription elongation factors repress transcription initiation from cryptic sites. Science 301:1096-1099. (Pubitemid 37022311)
28. Kizer KO, et al. (2005) A novel domain in Set2 mediates RNA polymerase II interaction and couples histone H3 K36 methylation with transcript elongation. Mol Cell Biol 25:3305-3316.
29. Lee JS, Shilatifard A (2007) A site to remember: H3K36 methylation a mark for histone deacetylation. Mutat Res 618:130-134.
30. Li B, et al. (2009) Histone H3 lysine 36 dimethylation (H3K36me2) is sufficient to recruit the Rpd3s histone deacetylase complex and to repress spurious transcription. J Biol Chem 284:7970-7976.
31. Morris SA, et al. (2005) Histone H3 K36 methylation is associated with transcription elongation in Schizosaccharomyces pombe. Eukaryot Cell 4:1446-1454. (Pubitemid 41176698)
32. Xu L, et al. (2008) Di- and tri- but not monomethylation on histone H3 lysine 36 marks active transcription of genes involved in flowering time regulation and other processes in Arabidopsis thaliana. Mol Cell Biol 28:1348-1360. (Pubitemid 351214136)
33. Bannister AJ, et al. (2005) Spatial distribution of di- and tri-methyl lysine 36 of histone H3 at active genes. J Biol Chem 280:17732-17736.
34. Kim A, Kiefer CM, Dean A (2007) Distinctive signatures of histone methylation in transcribed coding and noncoding human beta-globin sequences. Mol Cell Biol 27:1271-1279. (Pubitemid 46239811)
35. Song JS, et al. (2007) Model-based analysis of two-color arrays (MA2C). Genome Biol 8:R178.
36. Bell SE, et al. (2006) The RNA binding protein Zfp36l1 is required for normal vascularisation and post-transcriptionally regulates VEGF expression. Dev Dyn 235:3144-3155.
37. Chen D, Zhao M, Mundy GR (2004) Bone morphogenetic proteins. Growth Factors 22:233-241.
38. Simmen RC, et al. (2010) The emerging role of Krüppel-like factors in endocrineresponsive cancers of female reproductive tissues. J Endocrinol 204:223-231.
39. van der Maarel SM, et al. (1996) Cloning and characterization of DXS6673E, a candidate gene for X-linked mental retardation in Xq13.1. Hum Mol Genet 5:887-897.
40. Komarnitsky P, Cho EJ, Buratowski S (2000) Different phosphorylated forms of RNA polymerase II and associated mRNA processing factors during transcription. Genes Dev 14:2452-2460.
41. Buratowski S (2009) Progression through the RNA polymerase II CTD cycle. Mol Cell 36:541-546.
42. Nimura K, et al. (2009) A histone H3 lysine 36 trimethyltransferase links Nkx2-5 to Wolf-Hirschhorn syndrome. Nature 460:287-291.
43. Edmunds JW, Mahadevan LC, Clayton AL (2008) Dynamic histone H3 methylation during gene induction: HYPB/Setd2 mediates all H3K36 trimethylation. EMBO J 27:406-420.
44. Nielsen AL, et al. (2004) Nizp1, a novel multitype zinc finger protein that interacts with the NSD1 histone lysine methyltransferase through a unique C2HR motif. Mol Cell Biol 24:5184-5196.
45. Ptashne M, Gann A (1997) Transcriptional activation by recruitment. Nature 386:569-577.