Acute oral toxicity of the ethyl acetate fraction of Orostachys japonicus in mice

Pharmaceutical Biology

Volumn 52, Issue 10, 2014, Pages 1345-1350

  Kim, Seon Hee ^a   Ryu, Deok Seon ^a   Lee, Hyeong Seon ^a   Shin, Hye Ryoung ^a   Kwon, Ji Hye ^a   Lee, Dong Seok ^a  

^a Inje University   (South Korea)

Author keywords

Acute toxicity; Histopathology; Serum biochemistry; Single dose

Indexed keywords

ACETIC ACID ETHYL ESTER; ALANINE AMINOTRANSFERASE; ALKALINE PHOSPHATASE; ASPARTATE AMINOTRANSFERASE; CHOLESTEROL; CREATININE; GLOBULIN; NITROGEN; OROSTACHYS JAPONICUS EXTRACT; PLANT EXTRACT; TRIACYLGLYCEROL; UNCLASSIFIED DRUG; UREA; ACETIC ACID DERIVATIVE;

ACUTE TOXICITY; ALANINE AMINOTRANSFERASE BLOOD LEVEL; ALKALINE PHOSPHATASE BLOOD LEVEL; ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; ASPARTATE AMINOTRANSFERASE BLOOD LEVEL; CHOLESTEROL BLOOD LEVEL; CONTROLLED STUDY; CRASSULACEAE; CREATININE BLOOD LEVEL; DRUG SAFETY; FEMALE; GLOBULIN BLOOD LEVEL; HISTOPATHOLOGY; LD 50; MALE; MOUSE; NEUTROPHIL CHEMOTAXIS; NONHUMAN; ORGAN WEIGHT; OROSTACHYS JAPONICUS; SINGLE DRUG DOSE; TOXICITY TESTING; TRIACYLGLYCEROL BLOOD LEVEL; UREA NITROGEN BLOOD LEVEL; WEIGHT CHANGE; ANIMAL; BAGG ALBINO MOUSE; BODY WEIGHT; DRUG EFFECTS; ISOLATION AND PURIFICATION; MORTALITY; ORAL DRUG ADMINISTRATION; PROCEDURES; RANDOMIZATION; TRENDS;

ACETATES; ADMINISTRATION, ORAL; ANIMALS; BODY WEIGHT; CRASSULACEAE; FEMALE; MALE; MICE; MICE, INBRED BALB C; MORTALITY; PLANT EXTRACTS; RANDOM ALLOCATION; TOXICITY TESTS, ACUTE;

EID: 84907048156     PISSN: 13880209     EISSN: 17445116     Source Type: Journal    
DOI: 10.3109/13880209.2014.892142     Document Type: Article

References (29)

1. Asare GA, Addo P, Bugyei K, et al. (2011). Acute toxicity studies of aqueous leaf extract of Phyllanthus niruri. Interdiscip Toxicol 4: 206-10.
2. Black H. (2002). Handbook of Toxicologic Pathology, Preparation of the report for a toxicology/pathology study. San Diego: Acad. Press.
3. Choi SY, Chung MJ, Seo WD, et al. (2006). Inhibitory effects of Orostachys japonicus extract on the formation of N-nitrosodimethylamine. J Agric Food Chem 54:6075-8.
4. Dietrich L. (1983). A new approach to practical acute toxicity testing. Arch Toxicol 54:275-87.
5. Gao Y, Zhang S, Li C, et al. (2012). Acute and subchronic toxicity of xylo-oligosaccharide in mice and rats. Toxicol Mech Meth 22: 605-10.
6. Hamid R, Jaouad E, Zafar HI, Badiaa L. (2008). Acute and sub-chronic toxicity of an aqueous extract of the leaves of Herniaria glabra in rodents. J Ethnophamacol 118:378-86.
7. Harizal SN, Mansor SM, Hasnan J, et al. (2010). Acute toxicity study of the standardized methanolic extract of Mitragyna speciosa Korth in rodent. J Ethnopharmacol 131:404-9.
8. Hong CO, Rhee CH, Won NH, et al. (2013). Protective effect of 70% ethanolic extract of Lindera obtusiloba Blume on tert-butyl hydroperoxide-induced oxidative hepatotoxicity in rats. Food Chem Toxicol 53:214-20.
9. Jacob HJ, Sigmund CD, Shockley TR, et al. (1991). Renin promoter SV40 T-antigen transgenic mouse. A model of primary renal vascular hyperplasia. Hypertension 17:1167-2.
10. Jeong JH, Ryu DS, Suk DH, Lee DS. (2011). Anti-inflammatory effects of ethanol extract from Orostachys japonicus on modulation of signal pathway in LPS-stimulated RAW 264.7 cells. BMB Rep 44: 399-404.
11. Johnston DE. (1999). Special consideration in interpreting liver function tests. Am Fam Physician 59:2223-30.
12. Kaneko JJ, Harvey JW, Bruss ML, eds. (1997). Serum proteins and the dysproteinemias. In: Clinical Biochemistry of Domestic Animals, 5th ed. San Diego: Acad. Press, 117-38.
13. Kim YI, Park SW, Choi IH, et al. (2011). Effect of Orostachys japonicus on cell growth and apoptosis in human hepatic stellate cell line LX2. Am J Chin Med 39:601-13.
14. Korea Food and Drug Administration. (2009). Testing Guidelines for Safety Evaluation of Drugs. Notification No. 2009-116, issued by the Korea Food and Drug Administration of August 24, 2009.
15. Lagarto A, Bueno V, Guerra I, et al. (2011). Acute and subchronic oral toxicities of Calendula Officinalis extract in Wistar rats. Exp Toxicol Pathol 63:387-91.
16. Lee HS, Ryu DS, Lee KS, Lee DS. (2012). Anti-inflammatory effects of dichloromethane fraction from Orostachys japonicus in RAW 264.7 cells: Suppression of NF-kB activation and MAPK signaling. J Ethnopharmacol 140:271-6.
17. Lee JH, Lee SJ, Park S, et al. (2011a). Characterization of flavonoids in Orostachys japonicus A. Berger using HPLC-MS/MS: Contribution to the overall antioxidant effect. Food Chem 124:1627-33.
18. Lee SJ, Zhang GF, Sung NJ. (2011b). Hypolipidemic and hypoglycemic effects of Orostachys japonicus A. Berger extracts in streptozotocin-induced diabetic rats. Nutr Res Pract 5:301-7.
19. Ma CJ, Jung WJ, Lee KY, et al. (2009). Calpain inhibitory flavonoids isolated from Orostachys japonicus. J Enzyme Inhib Med Chem 24: 676-9.
20. OECD. (2007). OECD Guideline for Testing of Chemicals. Acute Oral Toxicity-Fixed Dose Procedure. OECD/OEDC.
21. Park JC, Han WD, Park JR, et al. (2005). Changes in hepatic drug metabolizing enzymes and lipid peroxidation by methanol extract and major compound of Orostachys japonicus. J Ethnopharmacol 102: 313-18.
22. Ryu DS, Baek GO, Kim EY, et al. (2009). Effects of polysaccharides derived from Orostachys japonicus on induction of cell cycle arrest and apoptotic cell death in human colon cancer cells. BMB Rep 43: 750-5.
23. Ryu DS, Lee HS, Lee GS, Lee DS. (2012). Effects of the ethyl acetate extract of Orostachys japonicus on induction of apoptosis through the p53-mediated signaling pathway in human gastric cancer cells. Biol Pharm Bull 35:660-5.
24. Singh T, Shnha N, Singh A. (2013). Biochemical and histological effects in liver due to acute oral toxicity of aqueous leaf extract of Ecliptaalba on female Swiss albino mice. Indian J Phamacol 45: 61-5.
25. Stein U, Greyer H, Hentschl H. (2001). Nutmeg (myristicin) poisoning report on a fetal case and a series of cases recorded by a poison information centre. Forensic Sci Int 118:87-90.
26. Turner RA. (1965). Screening Methods in Pharmacology. California: Academic Press.
27. Thapa BR, Walia A. (2007). Liver function tests and their interpretation. Indian J Rediatr 74:663-71.
28. Wallach JB. (2007). Interpretation of Diagnostic Tests. Philadelphia: Lippincott Williams & Wilkins.
29. Wirth JH, Hudgins JC, Paice JA. (2005). Use of herbal therapies to relieve pain: A review of efficacy and adverse effects. Pain Manag Nurs 6:145-67.