Effect of orostachys japonicus on cell growth and apoptosis in human hepatic stellate cell line LX2

American Journal of Chinese Medicine

Volumn 39, Issue 3, 2011, Pages 601-613

  Kim, Young Il ^a   Park, Seung Won ^b   Choi, In Hwa ^a   Lee, Jang Hoon ^c   Woo, Hong Jung ^c   Kim, Youngchul ^c  

^a Kyung Hee University College of Medicine   (South Korea)

^b National Academy of Agricultural Science   (South Korea)

^c Kyung Hee University   (South Korea)

Author keywords

Apoptosis; Caspase Activity; Immortalized Human Hepatic Stellate Cells LX2; MEK ERK; Orostachys japonicus

Indexed keywords

CASPASE 3; CASPASE INHIBITOR; HERBACEOUS AGENT; MESSENGER RNA; MITOGEN ACTIVATED PROTEIN KINASE; OROSTACHYS JAPONICUS EXTRACT; PROTEIN BAX; PROTEIN BCL 2; PROTEIN MCL 1; UNCLASSIFIED DRUG; WATER;

APOPTOSIS; ARTICLE; CELL CYCLE PROGRESSION; CELL GROWTH; CELL LINE; CELL PROLIFERATION; CONTROLLED STUDY; DNA FRAGMENTATION; DOWN REGULATION; ENZYME ACTIVATION; ENZYME ACTIVITY; ENZYME PHOSPHORYLATION; GROWTH INHIBITION; HUMAN; HUMAN CELL; MEDICINAL PLANT; OROSTACHYS JAPONICUS; PROTEIN BLOOD LEVEL; STELLATE CELL;

APOPTOSIS; APOPTOSIS REGULATORY PROTEINS; BCL-2-ASSOCIATED X PROTEIN; CASPASE 3; CASPASES; CELL CYCLE; CELL LINE; CELL PROLIFERATION; CRASSULACEAE; DNA FRAGMENTATION; DOSE-RESPONSE RELATIONSHIP, DRUG; DOWN-REGULATION; ENZYME INHIBITORS; EXTRACELLULAR SIGNAL-REGULATED MAP KINASES; HEPATIC STELLATE CELLS; HUMANS; MITOGEN-ACTIVATED PROTEIN KINASES; PHOSPHORYLATION; PLANT EXTRACTS; PROTO-ONCOGENE PROTEINS C-BCL-2; RNA, MESSENGER; SIGNAL TRANSDUCTION;

EID: 79957447905     PISSN: 0192415X     EISSN: 0192415X     Source Type: Journal    
DOI: 10.1142/S0192415X11009068     Document Type: Article

References (29)

1. L, and Mcl-1 and promotes survival of human pancreatic cancer cells. J. Cell. Biochem. 79: 355-369, 2000.
2. Che, X.H., E.J. Park, Y.Z. Zhao, W.H. Kim and D.H. Sohn. Tanshinone II A induces apoptosis and S phase cell cycle arrest in activated rat hepatic stellate cells. Basic Clin. Pharmacol. Toxicol. 106: 30-37, 2010.
3. Chor, S.Y., A.Y. Hui, K.F. To, K.K. Chan, Y.Y. Go, H.L. Chan, W.K. Leung and J.J. Sung. Antiproliferative and pro-apoptotic effects of herbal medicine on hepatic stellate cell. J. Ethno-pharmacol. 100: 180-186, 2005. (Pubitemid 41073543)
4. Davis, R.J., The mitogen-activated protein kinase signal transduction pathway. J. Biol. Chem. 268: 14553-14556, 1993. (Pubitemid 23206581)
5. Fan, M. and T.C. Chambers. Role of mitogen-activated protein kinases in the response of tumor cells to chemotherapy. Drug Resist. Updat. 4: 253-267, 2001. (Pubitemid 34456379)
6. Fleischer, B., H. Schulze-Bergkamen, M. Schuchmann, A. Weber, S. Biesterfeld, M. Miiller, P.H. Krammer and P.R. Galle. Mcl-1 is an anti-apoptotic factor for human hepatocellular carcinoma. Int. J. Oncol. 28: 25-32, 2006.
7. Friedman, S.L., The cellular basis of hepatic fibrosis. Mechanisms and treatment strategies. N. Engl. J. Med. 328: 1828-1835, 1993.
8. Friedman, S.L., Molecular regulation of hepatic fibrosis, an integrated cellular response to tissue injury. J. Biol. Chem. 275: 2247-2250, 2000. (Pubitemid 30081976)
9. Gong, W., A. Pecci, S. Roth, B. Lahme, M. Beato and A.M. Gressner. Transformation-dependent susceptibility of rat hepatic stellate cells to apoptosis induced by soluble Fas ligand. Hepatology 28: 492-502, 1998. (Pubitemid 28363678)
10. Hahm, E.R., J.A. Arlotti, S.W. Marynowski and S.V. Singh. Honokiol, a constituent of oriental medicinal herb magnolia officinalis, inhibits growth of PC-3 xenografts in vivo in association with apoptosis induction. Clin. Cancer Res. 14: 1248-1257, 2008. (Pubitemid 351302574)
11. Hur, J.M. and J.C. Park. Effects of the aerial parts of Orostachys japonicus and its bioactive component on hepatic alcohol-metabolizing enzyme system. J. Med. Food 9: 336-341, 2006.
12. Jung, B.S. and M.K. Shin. Dictionary of the Medical Plants. Younglim-Sa, Seoul, 1990, pp. 600-601.
13. Jung, H.J., J. Choi, J.H. Nam and H.J. Park. Anti-ulcerogenic effects of the flavonoid-rich fraction from the extract of Orostachys japonicus in mice. J. Med. Food 10: 702-706, 2007.
14. Kim, J.B. Illustrated National Drug's Encyclopedia. Nam San Dang, Seoul, 1984, p. 447.
15. Kren, B.T., J.H. Trembley, G Fan and C.J. Steer. Molecular regulation of liver regeneration. Ann. N Y Acad. Sci. 831: 361-381, 1997. (Pubitemid 28045291)
16. Li, W.Y., L.C. Chiu, W.S. Lam, W.Y. Wong, Y.T. Chan, Y.P. Ho, EY. Wong, Y.S. Wong and V.E. Ooi. Ethyl acetate extract of Chinese medicinal herb Sarcandra glabra induces growth inhibition on human leukemic HL-60 cells, associated with cell cycle arrest and up-regulation of pro-apoptotic Bax/Bcl-2 ratio. Oncol. Rep. 17: 425-31, 2007.
17. Lian, L.H., E.J. Park, H.S. Piao, Y.Z. Zhao and D.H. Sohn. Aloe emodin-induced apoptosis in t-HSC/Cl-6 cells involves a mitochondria-mediated pathway. Basic. Clint. Pharmacol. Toxicol. 96: 495-502, 2005. (Pubitemid 40835706)
18. Michels J., J.W. O'Neill, C.L. Dallman, A. Mouzakiti, F. Habens, M. Brimmell, K.Y.J. Zhang, R.W. Craig, E.G. Marcusson, P.W.M. Johnson and G. Packham. Mcl-1 is required for Akata6 B-lymphoma cell survival and is converted to a cell death molecule by efficient caspase-mediated cleavage. Oncogene 23: 4818-1827, 2004.
19. Park, J.C, W.D. Han, J.R. Park, S.H. Choi and J.W. Choi. Changes in hepatic drug metabolizing enzymes and lipid peroxidation by methanol extract and major compound of Orostachys japonicus. J. Ethnopharmacol. 102: 313-318, 2005. (Pubitemid 41571837)
20. Rubinfeld, H. and R. Seger. The ERK cascade: a prototype of MAPK signaling. Mol. Biotechnol. 31: 151-174, 2005. (Pubitemid 41306584)
21. Sa, F., J.L. Gao, K.P. Fung, Y. Zheng, S.M. Lee and Y.T. Wang. Anti-proliferative and pro-apoptotic effect of Smilax glabra Roxb. extract on hepatoma cell lines. Chem. Biol. Interact. Ill: 1-14, 2008. (Pubitemid 350191844)
22. Saile, B., P. DiRocco, J. Dudas, H. El-Armouche, H. Sebb, C. Eisenbach, K. Neubauer and G. Ramadori. IGF-I induces DNA synthesis and apoptosis in rat liver hepatic stellate cells (HSC) but DNA synthesis and proliferation in rat liver myofibroblasts (rMF). Lab. Invest. 84: 1037-1049, 2004. (Pubitemid 39025038)
23. Shin, G.C., C. Kim, J.M. Lee, W.S. Cho, S.G. Lee, M. Jeong, J. Cho and K. Lee. Apigenin-induced apoptosis is mediated by reactive oxygen species and activation of ERK1/2 in rheumatoid fibroblast-like synoviocytes. Chem. Biol. Interact. 182: 29-36, 2009.
24. Sieghart, W., D. Losert, S. Strommer, D. Cejka, K. Schmid, S. Rasoul-Rockenschaub, M. Bod-ingbauer, R. Crevenna, B.P. Monia, M. Peck-Radosavljevic and V. Wacheck. Mcl-1 over-expression in hepatocellular carcinoma: a potential target for antisense therapy. J. Hepatol. 44: 151-157, 2006. (Pubitemid 41772529)
25. Stanciu, M., Y. Wang, R. Kentor, N. Burke, S. Watkins, G. Kress, I. Reynolds, E. Klann, M.R. Angiolieri, J.W. Johnson and D.B. DeFranco. Persistent activation of ERK contributes to glutamate-induced oxidative toxicity in a neuronal cell line and primary cortical neuron cultures. J. Biol. Chem. 275: 12200-12206, 2000. (Pubitemid 30237798)
26. Tang, Y.J., J.S. Yang, C.F. Lin, W.C. Shyu, M. Tsuzuki, C.C. Lu, Y.F. Chen and K.C. Lai. Hout-tuynia cordata Thunb extract induces apoptosis through mitochondrial-dependent pathway in HT-29 human colon adenocarcinoma cells. Oncol Rep 22: 1051-1056, 2009.
27. Wang, X., J.L. Martindale and N.J. Holbrook. Requirement for ERK activation in cisplatin-induced apoptosis. J. Biol. Chem. 275: 39435-39443, 2000. (Pubitemid 32058968)
28. Xu, L., AY. Hui, E. Albanis, M.J. Arthur, S.M. O'Byrne, W.S. Blaner, P. Mukherjee, SL. Friedman and F.J. Eng. Human hepatic stellate cell lines, LX-1 and LX-2: new tools for analysis of hepatic fibrosis. Gut 54: 142-151, 2005. (Pubitemid 40007234)
29. 2C>2-induced apoptosis in GT1-1 mouse hypothalamic neuronal cell line. J. Ethnopharmacol. 69: 73-78, 2000. (Pubitemid 29505294)