Acute and subchronic oral toxicities of Calendula officinalis extract in Wistar rats

Experimental and Toxicologic Pathology

Volumn 63, Issue 4, 2011, Pages 387-391

  Lagarto, Alicia ^a   Bueno, Viviana ^a   Guerra, Isbel ^a   Valdés, Odalys ^a   Vega, Yamile ^a   Torres, Leonid ^a  

^a CENTRO DE INVESTIGACIÓN Y DESARROLLO DE MEDICAMENTOS CIDEM   (Cuba)

Author keywords

Acute; Calendula officinalis; Subchronic; Toxicity; Wistar rats

Indexed keywords

ALANINE AMINOTRANSFERASE; ALKALINE PHOSPHATASE; ASPARTATE AMINOTRANSFERASE; CALENDULA OFFICINALIS EXTRACT; GLUCOSE; PLANT EXTRACT; UNCLASSIFIED DRUG;

ACUTE TOXICITY; ALANINE AMINOTRANSFERASE BLOOD LEVEL; ALKALINE PHOSPHATASE BLOOD LEVEL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; ASPARTATE AMINOTRANSFERASE BLOOD LEVEL; BLOOD CLOTTING TIME; BODY WEIGHT; CHRONIC TOXICITY; CONTROLLED STUDY; ERYTHROCYTE COUNT; FEMALE; FLUID INTAKE; FOOD INTAKE; GLUCOSE BLOOD LEVEL; HEMATOCRIT; HEMOGLOBIN DETERMINATION; HISTOPATHOLOGY; LEUKOCYTE DIFFERENTIAL COUNT; MALE; MARIGOLD; NONHUMAN; ORGAN WEIGHT; RAT; TOXICITY TESTING; WISTAR RAT;

ANIMALS; CALENDULA; FEMALE; FLOWERS; MALE; NO-OBSERVED-ADVERSE-EFFECT LEVEL; PLANT EXTRACTS; RATS; RATS, WISTAR;

ANIMALIA; CALENDULA OFFICINALIS; RATTUS NORVEGICUS;

EID: 79953767029     PISSN: 09402993     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.etp.2010.02.015     Document Type: Article

References (14)

1. Bashir S, Janbaz KH, Jabeen Q, Gilani AH Studies on spasmogenic and spasmolytic activities of Calendula officinalis flowers. Phytother Res 2006, 20:906-910.
2. Chudnicka A, Matysik G. Research of enzymatic activities of fresh juice and water infusions from dry herbs. J Ethnopharmacol 2005, 99:281-286.
3. Cordova CA, Siqueira IR, Netto CA, Yunes RA, Volpato AM, Cechinel Filho V, Curi-Pedrosa R, Creczynski Pasa TB Protective properties of butanolic extract of the Calendula officinalis L. (marigold) against lipid peroxidation of rat liver microsomes and action as free radical scavenger. Redos Rep 2002, 7:95-102.
4. Lastra H, Piquet R Calendula officinalis. Rev Cubana Farm 1999, 33:15-18.
5. Matysik G, Wójciak-Kosior M, Paduch R. The influence of Calendulae officinalis flos extracts on cell cultures, and the chromatographic analysis of extracts. J Pharm Biomed Anal 2005, 38:285-292.
6. Mosberg AT, Hayes AW Subchronic toxicity testing. Principles and methods of toxicology 1989, 222-224. Raven Press, New York. A.W. Hayes (Ed.).
7. OECD Guideline for testing of chemicals. 408 subchronic oral toxicity-rodent: 90 day study, 1998.
8. OECD. Guideline for testing of chemicals. 423 acute oral toxicity-acute toxic class method, 2001.
9. Pommier P, Gómez F, Sunyach MP, D'Hombres A, Carrie C, Montbarbon X. Phase III randomized trial of Calendula officinalis compared with trolamine for the prevention of acute dermatitis during irradiation for breast cancer. J Clin Oncol 2004, 22:1447-1453.
10. Rusu MA, Tamas M, Puica C, Roman I, Sabadas M. The hepatoprotective action of ten herbal extracts in CCl4 intoxicated liver. Phytother Res 2005, 19:744-749.
11. Suber RL Clinical pathology for toxicologists. Principles and methods of toxicology 1989, 492-503. Raven Press, New York. A.W. Hayes (Ed.).
12. Taylor, Francis Health Sciences Final report on the safety assessment of Calendula officinalis extract and Calendula officinalis. Int J Toxicol 2001, 20(Suppl. 2):13-20.
13. Visser LE, Bleumink GS, Trienekens PH, Vulto AG, Hofman A Stricker BHCh. The risk of overcoagulation in patients with heart failure on coumarin anticoagulants. Br J Hematol 2004, 127:85-89.
14. Yoshikawa M, Murakami T, Kishi A, Kageura T, Metsuda H. Medicinal flowers. III. Marigold. (1): Hypoglycemic, gastric emptying inhibitory, and gastroprotective principles and new oleanane type triterpene oligoglycosides, calendasaponins A, B, C, and D, from Egyptian Calendula officinalis. Chem Pharm Bull (Tokyo) 2001, 49:863-870.