KIR4.1: Another misleading expectation in multiple sclerosis?

The Lancet Neurology

Volumn 13, Issue 8, 2014, Pages 753-755

  Filippi, Massimo ^a   Rocca, Maria A ^a   Lassmann, Hans ^b  

^a SAN RAFFAELE HOSPITAL   (Italy)

^b Medical University of Vienna   (Austria)

Author keywords

[No Author keywords available]

Indexed keywords

AQUAPORIN 4; IMMUNOGLOBULIN G ANTIBODY; INWARDLY RECTIFYING POTASSIUM CHANNEL; INWARDLY RECTIFYING POTASSIUM CHANNEL SUBUNIT KIR4.1; MYELIN OLIGODENDROCYTE GLYCOPROTEIN; UNCLASSIFIED DRUG; AUTOANTIBODY; BIOLOGICAL MARKER; POTASSIUM CHANNEL KIR4.1; VOLTAGE GATED POTASSIUM CHANNEL;

ANTIBODY BLOOD LEVEL; ASTROCYTE; CEREBROSPINAL FLUID; CEREBROSPINAL FLUID CYTOLOGY; DEMYELINATING DISEASE; DIAGNOSTIC ERROR; DISEASE COURSE; ENZYME LINKED IMMUNOSORBENT ASSAY; EXTRACELLULAR SPACE; HUMAN; IMMUNOCYTOCHEMISTRY; MULTIPLE SCLEROSIS; NEUROLOGIC DISEASE; NOTE; PRIORITY JOURNAL; DEMYELINATION; EXPECTATION; GASTROINTESTINAL SYMPTOM;

AUTOANTIGENS; FEMALE; HUMANS; MALE; MULTIPLE SCLEROSIS; POTASSIUM CHANNELS, INWARDLY RECTIFYING;

EID: 84907032574     PISSN: 14744422     EISSN: 14744465     Source Type: Journal    
DOI: 10.1016/S1474-4422(14)70149-8     Document Type: Note

References (12)

1. Lennon VA, Wingerchuk DM, Kryzer TJ, et al. A serum autoantibody marker of neuromyelitis optica: distinction from multiple sclerosis. Lancet 2004, 364:2106-2112.
2. Srivastava R, Aslam M, Kalluri SR, et al. Potassium channel KIR4.1 as an immune target in multiple sclerosis. N Engl J Med 2012, 367:115-123.
3. Bradl M, Misu T, Takahashi T, et al. Neuromyelitis optica: pathogenicity of patient immunoglobulin in vivo. Ann Neurol 2009, 66:630-643.
4. Kraus V, Srivastava R, Kalluri SR, et al. Potassium channel KIR4.1-specific antibodies in children with acquired demyelinating CNS disease. Neurology 2014, 82:470-473.
5. Lucchinetti C, Bruck W, Parisi J, Scheithauer B, Rodriguez M, Lassmann H Heterogeneity of multiple sclerosis lesions: implications for the pathogenesis of demyelination. Ann Neurol 2000, 47:707-717.
6. Lily O, Palace J, Vincent A Serum autoantibodies to cell surface determinants in multiple sclerosis: a flow cytometric study. Brain 2004, 127:269-279.
7. Nerrant E, Salsac C, Charif M, et al. Lack of confirmation of anti-inward rectifying potassium channel 4.1 antibodies as reliable markers of multiple sclerosis. Mult Scler 2014, published online April 22. 10.1177/1352458514531086.
8. Brickshawana A, Hinson SR, Romero MF, et al. Investigation of the KIR4.1 potassium channel as a putative antigen in patients with multiple sclerosis: a comparative study. Lancet Neurol 2014, published online July 7. http://dx.doi.org/10.1016/S1474-4422(14)70141-3.
9. Jin X, Yu L, Wu Y, et al. S-Glutathionylation underscores the modulation of the heteromeric Kir4.1-Kir5.1 channel in oxidative stress. J Physiol 2012, 590:5335-5348.
10. Banati M, Csecsei P, Koszegi E, et al. Antibody response against gastrointestinal antigens in demyelinating diseases of the central nervous system. Eur J Neurol 2013, 20:1492-1495.
11. Schirmer L, Srivastava R, Kalluri SR, et al. Differential loss of KIR4.1 immunoreactivity in multiple sclerosis lesions. Ann Neurol 2014, published online April 29. 10.1002/ana.24168.
12. Sharma R, Fischer MT, Bauer J, et al. Inflammation induced by innate immunity in the central nervous system leads to primary astrocyte dysfunction followed by demyelination. Acta Neuropathol 2010, 120:223-236.