Ursolic acid inhibits nuclear factor-κB signaling in intestinal epithelial cells and macrophages, and attenuates experimental colitis in mice

Life Sciences

Volumn 110, Issue 1, 2014, Pages 23-34

  Chun, Jaeyoung ^a   Lee, Changhyun ^a,b   Hwang, Sung Wook ^a   Im, Jong Pil ^a   Kim, Joo Sung ^a  

^a Seoul National University   (South Korea)

^b Seoul National University Hospital   (South Korea)

Author keywords

Inflammatory bowel disease; Murine colitis; NF B; Ursolic acid

Indexed keywords

DEXTRAN SULFATE; I KAPPA B ALPHA; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; INTERLEUKIN 10; INTERLEUKIN 12; INTERLEUKIN 6; INTERLEUKIN 8; TUMOR NECROSIS FACTOR ALPHA; URSOLIC ACID; CYTOKINE; I KAPPA B; NF KAPPAB INHIBITOR ALPHA; NF-KAPPAB INHIBITOR ALPHA; TRITERPENE;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CONTROLLED STUDY; CYTOKINE PRODUCTION; DISEASE ACTIVITY; DNA BINDING; DOWN REGULATION; DRUG EFFECT; DRUG MECHANISM; EXPERIMENTAL COLITIS; GEL MOBILITY SHIFT ASSAY; HISTOPATHOLOGY; HUMAN; HUMAN CELL; IN VIVO STUDY; INTESTINE EPITHELIUM CELL; MALE; MOUSE; NONHUMAN; PERITONEUM MACROPHAGE; PROTEIN DEGRADATION; PROTEIN EXPRESSION; PROTEIN PHOSPHORYLATION; SIGNAL TRANSDUCTION; WEIGHT CHANGE; ANIMAL; C57BL MOUSE; CELL LINE; COLITIS; DISEASE MODEL; EPITHELIUM CELL; GENETICS; INFLAMMATORY BOWEL DISEASE; INTESTINE MUCOSA; KNOCKOUT MOUSE; METABOLISM; MURINE COLITIS; NFΚB; PATHOLOGY; PATHOPHYSIOLOGY; PHOSPHORYLATION; SEVERITY OF ILLNESS INDEX;

MURINAE; MUS;

INFLAMMATORY BOWEL DISEASE; MURINE COLITIS; NFΚB; URSOLIC ACID;

ANIMALS; CELL LINE; COLITIS; CYTOKINES; DEXTRAN SULFATE; DISEASE MODELS, ANIMAL; EPITHELIAL CELLS; HUMANS; I-KAPPA B PROTEINS; INTERLEUKIN-10; INTESTINAL MUCOSA; MACROPHAGES, PERITONEAL; MALE; MICE; MICE, INBRED C57BL; MICE, KNOCKOUT; NF-KAPPA B; PHOSPHORYLATION; SEVERITY OF ILLNESS INDEX; SIGNAL TRANSDUCTION; TRITERPENES;

EID: 84907030426     PISSN: 00243205     EISSN: 18790631     Source Type: Journal    
DOI: 10.1016/j.lfs.2014.06.018     Document Type: Article

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