Adhesion of Staphylococcus aureus to the vessel wall under flow is mediated by von Willebrand factor - Binding protein

Blood

Volumn 124, Issue 10, 2014, Pages 1669-1676

  Claes, Jorien ^a   Vanassche, Thomas ^a   Peetermans, Marijke ^a   Liesenborghs, Laurens ^a   Vandenbriele, Christophe ^a   Vanhoorelbeke, Karen ^b   Missiakas, Dominique ^c   Schneewind, Olaf ^c   Hoylaerts, Marc F ^a   Heying, Ruth ^a   Verhamme, Peter ^a  

^a UNIVERSITY OF LEUVEN   (Belgium)

^b UNIVERSITY OF LEUVEN   (Belgium)

^c UNIVERSITY OF CHICAGO   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

BINDING PROTEIN; COLLAGEN; FIBRIN; UNCLASSIFIED DRUG; VON WILLEBRAND FACTOR; VON WILLEBRAND FACTOR BINDING PROTEIN; FIBRINOGEN RECEPTOR; VON WILLEBRAND FACTOR RECEPTOR;

ANIMAL EXPERIMENT; ARTICLE; BACTERIUM ADHERENCE; BLOOD FLOW; BLOOD VESSEL WALL; ENDOTHELIUM CELL; ENZYME ACTIVITY; ENZYME INHIBITION; FIBRIN FORMATION; HUMAN; HUMAN CELL; MESENTERY BLOOD FLOW; MICROTHROMBUS; MOUSE; NONHUMAN; PROTEIN DOMAIN; PROTEIN PROTEIN INTERACTION; SHEAR STRESS; STAPHYLOCOCCUS AUREUS; THROMBOCYTE AGGREGATION; WILD TYPE; ANIMAL; BLOOD VESSEL; C57BL MOUSE; CELL CULTURE; GENETICS; KNOCKOUT MOUSE; MECHANICAL STRESS; METABOLISM; MICROBIOLOGY; PHYSIOLOGY; STAPHYLOCOCCUS INFECTION; TRANSGENIC ORGANISM; UMBILICAL VEIN ENDOTHELIAL CELL; VASCULAR ENDOTHELIUM;

ANIMALS; BACTERIAL ADHESION; BLOOD VESSELS; CELLS, CULTURED; ENDOTHELIUM, VASCULAR; HUMAN UMBILICAL VEIN ENDOTHELIAL CELLS; HUMANS; MICE; MICE, INBRED C57BL; MICE, KNOCKOUT; ORGANISMS, GENETICALLY MODIFIED; PLATELET MEMBRANE GLYCOPROTEINS; REGIONAL BLOOD FLOW; STAPHYLOCOCCAL INFECTIONS; STAPHYLOCOCCUS AUREUS; STRESS, MECHANICAL; VON WILLEBRAND FACTOR;

EID: 84907010433     PISSN: 00064971     EISSN: 15280020     Source Type: Journal    
DOI: 10.1182/blood-2014-02-558890     Document Type: Article

References (30)

1. Vanassche T, Peetermans WE, Herregods MC, Herijgers P, Verhamme P. Anti-thrombotic therapy in infective endocarditis. Expert Rev Cardiovasc Ther. 2011;9(9):1203-1219.
2. Kern WV. Management of Staphylococcus aureus bacteremia and endocarditis: progresses and challenges. Curr Opin Infect Dis. 2010;23(4): 346-358.
3. Corey GR. Staphylococcus aureus bloodstream infections: definitions and treatment. Clinical Infect Dis. 2009;48(Suppl 4):S254-259.
4. Bjerketorp J, Jacobsson K, Frykberg L. The von Willebrand factor-binding protein (vWbp) of Staphylococcus aureus is a coagulase. FEMS Microbiol Lett. 2004;234(2):309-314.
5. Sadler JE. Biochemistry and genetics of von Willebrand factor. Annu Rev Biochem. 1998; 67:395-424.
6. Pappelbaum KI, Gorzelanny C, Grässle S, et al. Ultralarge von Willebrand factor fibers mediate luminal Staphylococcus aureus adhesion to an intact endothelial cell layer under shear stress. Circulation. 2013;128(1):50-59.
7. Bjerketorp J, Nilsson M, Ljungh A, Flock JI, Jacobsson K, Frykberg L. A novel von Willebrand factor binding protein expressed by Staphylococcus aureus. Microbiology. 2002;148(Pt 7):2037-2044.
8. Kroh HK, Panizzi P, Bock PE. Von Willebrand factor-binding protein is a hysteretic conformational activator of prothrombin. Proc Natl Acad Sci USA. 2009;106(19):7786-7791.
9. Thomer L, Schneewind O, Missiakas D. Multiple ligands of von Willebrand factor-binding protein (vWbp) promote Staphylococcus aureus clot formation in human plasma. J Biol Chem. 2013;288(39):28283-28292.
10. Bas BM, Muller AD, Hemker HC. Purification and properties of staphylocoagulase. Biochim Biophys Acta. 1975;379(1):164-171.
11. Friedrich R, Panizzi P, Fuentes-Prior P, et al. Staphylocoagulase is a prototype for the mechanism of cofactor-induced zymogen activation. Nature. 2003;425(6957):535-539.
12. Cheng AG, McAdow M, Kim HK, Bae T, Missiakas DM, Schneewind O. Contribution of coagulases towards Staphylococcus aureus disease and protective immunity. PLoS Pathog. 2010;6(8):e1001036.
13. McAdow M, Kim HK, Dedent AC, Hendrickx AP, Schneewind O, Missiakas DM. Preventing Staphylococcus aureus sepsis through the inhibition of its agglutination in blood. PLoS Pathog. 2011;7(10):e1002307.
14. Vanassche T, Kauskot A, Verhaegen J, et al. Fibrin formation by staphylothrombin facilitates Staphylococcus aureus-induced platelet aggregation. Thromb Haemost. 2012;107(6):1107-1121.
15. Vanassche T, Peetermans M, Van Aelst LN, et al. The role of staphylothrombin-mediated fibrin deposition in catheter-related Staphylococcus aureus infections. J Infect Dis. 2013;208(1):92-100.
16. Vanassche T, Verhaegen J, Peetermans WE, et al. Inhibition of staphylothrombin by dabigatran reduces Staphylococcus aureus virulence. J Thromb Haemost. 2011;9(12):2436-2446.
17. Theilmeier G, Lenaerts T, Remacle C, Collen D, Vermylen J, Hoylaerts MF. Circulating activated platelets assist THP-1 monocytoid/endothelial cell interaction under shear stress. Blood. 1999;94(8):2725-2734.
18. Ruggeri ZM. The role of von Willebrand factor in thrombus formation. Thromb Res. 2007;120(Suppl 1):S5-S9.
19. Cox D. Bacteria-platelet interactions. J Thromb Haemost. 2009;7(11):1865-1866.
20. Baddour LM. Infective endocarditis: new concepts in pathogenesis. Curr Opin Infect Dis. 1999;12(3):201-204.
21. Thiene G, Basso C. Pathology and pathogenesis of infective endocarditis in native heart valves. Cardiovasc Pathol. 2006;15(5):256-263.
22. De Ceunynck K, De Meyer SF, Vanhoorelbeke K. Unwinding the von Willebrand factor strings puzzle. Blood. 2013;121(2):270-277.
23. Herrmann M, Hartleib J, Kehrel B, Montgomery RR, Sixma JJ, Peters G. Interaction of von Willebrand factor with Staphylococcus aureus. J Infect Dis. 1997;176(4):984-991.
24. Hartleib J, Köhler N, Dickinson RB, et al. Protein A is the von Willebrand factor binding protein on Staphylococcus aureus. Blood. 2000;96(6):2149-2156.
25. O'Seaghdha M, van Schooten CJ, Kerrigan SW, et al. Staphylococcus aureus protein A binding to von Willebrand factor A1 domain is mediated by conserved IgG binding regions. FEBS J. 2006;273(21):4831-4841.
26. Siedlecki CA, Lestini BJ, Kottke-Marchant KK, Eppell SJ, Wilson DL, Marchant RE. Shear-dependent changes in the three-dimensional structure of human von Willebrand factor. Blood. 1996;88(8):2939-2950.
27. Romijn RA, Bouma B, Wuyster W, et al. Identification of the collagen-binding site of the von Willebrand factor A3-domain. J Biol Chem. 2001;276(13):9985-9991.
28. Melis E, Bonnefoy A, Daenens K, Yamamoto H, Vermylen J, Hoylaerts MF. alphaIIbbeta3 antagonism vs. antiadhesive treatment to prevent platelet interactions with vascular subendothelium. J Thromb Haemost. 2004;2(6):993-1002.
29. Sixma JJ, Schiphorst ME, Verweij CL, Pannekoek H. Effect of deletion of the A1 domain of von Willebrand factor on its binding to heparin, collagen and platelets in the presence of ristocetin. Eur J Biochem/FEBS. 1991;196(2):369-375.
30. Moreillon P, Entenza JM, Francioli P, et al. Role of Staphylococcus aureus coagulase and clumping factor in pathogenesis of experimental endocarditis. Infect Immun. 1995;63(12):4738-4743.