Prognostic value of LGR5 in colorectal cancer: A meta-analysis

PLoS ONE

Volumn 9, Issue 9, 2014, Pages

  Chen, Qing ^a   Zhang, Xin ^a   Li, Wei Min ^a   Ji, Yu Qiang ^b   Cao, Hao Zhe ^a   Zheng, Pengsheng ^a  

^a XI'AN JIAOTONG UNIVERSITY   (China)

^b First Hosp of Xi'an Jiaotong Univ   (China)

Author keywords

[No Author keywords available]

Indexed keywords

G PROTEIN COUPLED RECEPTOR; LEUCINE RICH REPEAT CONTAINING G PROTEIN COUPLED RECEPTOR 5; UNCLASSIFIED DRUG; LGR5 PROTEIN, HUMAN; TUMOR MARKER;

ARTICLE; CANCER PATIENT; CANCER PROGNOSIS; COLORECTAL CANCER; DATA BASE; DISEASE FREE SURVIVAL; FOLLOW UP; HAZARD RATIO; HUMAN; IMMUNOHISTOCHEMISTRY; OUTCOME ASSESSMENT; OVERALL SURVIVAL; PROTEIN EXPRESSION; PUBLISHING; SENSITIVITY ANALYSIS; SYSTEMATIC REVIEW; COLORECTAL NEOPLASMS; META ANALYSIS; METABOLISM; MORTALITY; PREDICTIVE VALUE; PROGNOSIS; SURVIVAL;

BIOMARKERS, TUMOR; COLORECTAL NEOPLASMS; HUMANS; PREDICTIVE VALUE OF TESTS; PROGNOSIS; RECEPTORS, G-PROTEIN-COUPLED; SURVIVAL ANALYSIS;

EID: 84906995242     PISSN: None     EISSN: 19326203     Source Type: Journal    
DOI: 10.1371/journal.pone.0107013     Document Type: Article

References (39)

1. Jemal A, Bray F, Center MM, Ferlay J, Ward E, et al. (2011) Global cancer statistics. CA: a cancer journal for clinicians 61: 69-90.
2. Ahlquist DA, Zou H, Domanico M, Mahoney DW, Yab TC, et al. (2012) Nextgeneration stool DNA test accurately detects colorectal cancer and large adenomas. Gastroenterology 142: 248-256.
3. Jemal A, Siegel R, Xu J, Ward E (2010) Cancer statistics. CA: a cancer journal for clinicians 60: 277-300.
4. Kobayashi H, Mochizuki H, Sugihara K, Morita T, Kotake K, et al. (2007) Characteristics of recurrence and surveillance tools after curative resection for colorectal cancer: a multicenter study. Surgery 141: 67-75.
5. Reya T, Morrison SJ, Clarke MF, Weissman IL (2001) Stem cells, cancer, and cancer stem cells. Nature 414: 105-111.
6. Visvader JE, Lindeman GJ (2008) Cancer stem cells in solid tumours: accumulating evidence and unresolved questions. Nature Reviews Cancer 8: 755-768.
7. Becker L, Huang Q, Mashimo H (2008) Immunostaining of Lgr5, an intestinal stem cell marker, in normal and premalignant human gastrointestinal tissue. The Scientific World Journal 8: 1168-1176.
8. Hsu SY, Liang SG, Hsueh AJ (1998) Characterization of two LGR genes homologous to gonadotropin and thyrotropin receptors with extracellular leucine-rich repeats and a G protein-coupled, seven-transmembrane region. Molecular endocrinology (Baltimore, Md) 12: 1830-1845.
9. Yamamoto Y, Sakamoto M, Fujii G, Tsuiji H, Kenetaka K, et al. (2003) Overexpression of orphan G-protein-coupled receptor, Gpr49, in human hepatocellular carcinomas with beta-catenin mutations. Hepatology (Baltimore, Md) 37: 528-533
10. Uchida H, Yamazaki K, Fukuma M, Yamada T, Hayashida T, et al. (2010) Overexpression of leucine-rich repeat-containing G protein-coupled receptor 5 in colorectal cancer. Cancer science 101: 1731-1737.
11. Colon H, Tumors OP, Mcclanahan T, Koseoglu S, Smith K, et al. (2006) Identification of Overexpression of Orphan G Protein-Coupled Receptor GPR49 in Human Colon and Ovarian Primary Tumors. Cancer biology & therapy 5: 419-426.
12. Tanese K, Fukuma M, Yamada T, Mori T, Yoshikawa T, et al. (2008) Gprotein-coupled receptor GPR49 is up-regulated in basal cell carcinoma and promotes cell proliferation and tumor formation. The American journal of pathology 173: 835-843.
13. Liu Z, Dai W, Jiang L, Cheng Y (2014) Over-expression of LGR5 correlates with poor survival of colon cancer in mice as well as in patients. Neoplasma 61: 177-185.
14. Saigusa S, Inoue Y, Tanaka K, Toiyama Y, Matsushita K, et al. (2012) Clinical significance of LGR5 and CD44 expression in locally advanced rectal cancer after preoperative chemoradiotherapy. International journal of oncology 41: 1643-1652.
15. Wu XS, Xi HQ, Chen L (2012) Lgr5 is a potential marker of colorectal carcinoma stem cells that correlates with patient survival. World journal of surgical oncology 10: 244.
16. Hsu HC, Liu YS, Tseng KC, Hsu CL, Liang Y, et al. (2013) Overexpression of Lgr5 correlates with resistance to 5-FU-based chemotherapy in colorectal cancer. International journal of colorectal disease 28: 1535-1546.
17. Saigusa S, Inoue Y, Tanaka K, Toiyama Y, Kawamura M, et al. (2013) Significant correlation between LKB1 and LGR5 gene expression and the association with poor recurrence-free survival in rectal cancer after preoperative chemoradiotherapy. Journal of cancer research and clinical oncology 139: 131-138.
18. Valladares-Ayerbes M, Blanco-Calvo M, Reboredo M, Lorenzo-Patiño MJ, Iglesias-Díaz P, et al. (2012) Evaluation of the Adenocarcinoma-Associated Gene AGR2 and the Intestinal Stem Cell Marker LGR5 as Biomarkers in Colorectal Cancer. International journal of molecular sciences 13: 4367-4387.
19. Kleist B, Xu L, Kersten C, Seel V, Li G, et al. (2012) Single nucleotide polymorphisms of the adult intestinal stem cell marker Lgr5 in primary and metastatic colorectal cancer. American journal of translational research 4: 279-290.
20. Ziskin JL, Dunlap D, Yaylaoglu M, Fodor IK, Forrest WF, et al. (2012) In situ validation of an intestinal stem cell signature in colorectal cancer. Gut.
21. Stang A (2010) Critical evaluation of the Newcastle-Ottawa scale for the assessment of the quality of nonrandomized studies in meta-analyses. European Journal of Epidemiology 25: 603-605.
22. Handoll HH (2006) Systematic reviews on rehabilitation interventions. Archives of physical medicine and rehabilitation 87: 875.
23. Higgins JP, Thompson SG, Deeks JJ, Altman DG (2003) Measuring inconsistency in meta-analyses. BMJ: British Medical Journal 327: 557.
24. Egger M, Smith GD, Schneider M, Minder C (1997) Bias in meta-analysis detected by a simple, graphical test. Bmj 315: 629-634.
25. Begg CB, Mazumdar M (1994) Operating characteristics of a rank correlation test for publication bias. Biometrics: 1088-1101.
26. Pitule P, Vycital O, Bruha J, Novak P, Hosek P, et al. (2013) Differential expression and prognostic role of selected genes in colorectal cancer patients. Anticancer research 33: 4855-4865.
27. Fan X-S, Wu H-Y, Yu H-P, Zhou Q, Zhang Y-F, et al. (2010) Expression of Lgr5 in human colorectal carcinogenesis and its potential correlation with betacatenin. International journal of colorectal disease 25: 583-590.
28. Kleist B, Xu L, Li G, Kersten C (2011) Expression of the adult intestinal stem cell marker Lgr5 in the metastatic cascade of colorectal cancer. International journal of clinical and experimental pathology 4: 327-335.
29. Chai N, Zhang W, Wang Y, Zhou Z, Zhang Y, et al. (2013) Lgr5 and CD44 expressions in different types of intestinal polyps and colorectal cancer. Nan fang yi ke da xue xue bao = Journal of Southern Medical University 33: 972-976.
30. Gerger A, Zhang W, Yang D, Bohanes P, Ning Y, et al. (2011) Common cancer stem cell gene variants predict colon cancer recurrence. Clinical cancer research: an official journal of the American Association for Cancer Research 17: 6934-6943.
31. He S, Zhou H, Zhu X, Hu S, Fei M, et al. (2014) Expression of Lgr5, a marker of intestinal stem cells, in colorectal cancer and its clinicopathological significance. Biomedicine & pharmacotherapy. http://dx.doi.org/10.1016/j. biopha.2014.03.016 [pii: S0753-3322(14)00044-4, Epub ahead of print].
32. Takahashi H, Ishii H, Nishida N, Takemasa I, Mizushima T, et al. (2011) Significance of Lgr5 (+ve) cancer stem cells in the colon and rectum. Annals of surgical oncology 18: 1166-1174.
33. Peng L, Liang C, Liang Y, Hu JJ, Wang J, et al. (2010) Higher expression of Lgr5 predicts poor prognosis in human colorectal cancer. Modern Digestion & Intervention 15: 284-287.
34. Barker N, van Es JH, Kuipers J, Kujala P, van den Born M, et al. (2007) Identification of stem cells in small intestine and colon by marker gene Lgr5. Nature 449: 1003-1007.
35. Haegebarth A, Clevers H (2009) Wnt signaling, lgr5, and stem cells in the intestine and skin. The American journal of pathology 174: 715-721.
36. Merlos-Suárez A, Barriga FM, Jung P, Iglesias M, Céspedes MV, et al. (2011) The intestinal stem cell signature identifies colorectal cancer stem cells and predicts disease relapse. Cell stem cell 8: 511-524.
37. Nakata S, Campos B, Bageritz J, Bermejo JL, Becker N, et al. (2013) LGR5 is a marker of poor prognosis in glioblastoma and is required for survival of brain cancer stem-like cells. Brain pathology 23: 60-72.
38. Yamanoi K, Fukuma M, Uchida H, Kushima R, Yamazaki K, et al. (2013) Overexpression of leucine-rich repeat-containing G protein-coupled receptor 5 in gastric cancer. Pathology international 63: 13-19.
39. Uchida H, Yamazaki K, Fukuma M, Yamada T, Hayashida T, et al. (2010) Overexpression of leucine-rich repeat-containing G protein-coupled receptor 5 in colorectal cancer. Cancer science 101: 1731-1737.