Molecular evidence of increased resistance to anti-folate drugs in Plasmodium falciparumin North-east India: A signal for potential failure of artemisinin plus sulphadoxine-pyrimethamine combination therapy

PLoS ONE

Volumn 9, Issue 9, 2014, Pages

  Mohapatra, Pradyumna Kishore ^a   Sarma, Devojit Kumar ^a   Prakash, Anil ^a,b   Bora, Khukumoni ^a   Ahmed, Md Atique ^a   Sarma, Bibhas ^a   Goswami, Basanta Kumar ^a   Bhattacharyya, Dibya Ranjan ^a   Mahanta, Jagadish ^a  

^a REGIONAL MEDICAL RESEARCH CENTRE   (India)

^b Kamla Nehru Hospital   (India)

Author keywords

[No Author keywords available]

Indexed keywords

ARTEMISININ; CHLOROQUINE; PRIMAQUINE; PYRIMETHAMINE PLUS SULFADOXINE; ANTIMALARIAL AGENT; ARTEMISININ DERIVATIVE; CARRIER PROTEIN; CODON; DRUG COMBINATION; FANASIL, PYRIMETHAMINE DRUG COMBINATION; MDR1 PROTEIN, PLASMODIUM FALCIPARUM; MULTIDRUG RESISTANCE PROTEIN; PFCRT PROTEIN, PLASMODIUM FALCIPARUM; PROTOZOAL PROTEIN; PYRIMETHAMINE; SULFADOXINE;

ADOLESCENT; ADULT; ANTIMALARIAL DRUG RESISTANCE; ARTICLE; CHILD; CODON; CONTROLLED STUDY; DHPS GENE; DNA ISOLATION; DRUG EFFICACY; FEMALE; GENE; GENE LOCUS; GENOTYPE; GEOGRAPHIC DISTRIBUTION; HAPLOTYPE; HUMAN; IN VIVO STUDY; INDIA; MAJOR CLINICAL STUDY; MALARIA FALCIPARUM; MALE; MOLECULAR DYNAMICS; PLASMODIUM FALCIPARUM; POINT MUTATION; POLYMERASE CHAIN REACTION; SINGLE DRUG DOSE; TREATMENT FAILURE; TREATMENT RESPONSE; DRUG COMBINATION; DRUG EFFECTS; DRUG RESISTANCE; GENETICS; GROWTH, DEVELOPMENT AND AGING; MALARIA, FALCIPARUM; MIDDLE AGED; MUTATION; PARASITOLOGY; PRESCHOOL CHILD;

ADOLESCENT; ADULT; ANTIMALARIALS; ARTEMISININS; CHILD; CHILD, PRESCHOOL; CHLOROQUINE; CODON; DRUG COMBINATIONS; DRUG RESISTANCE; DRUG THERAPY, COMBINATION; FEMALE; HAPLOTYPES; HUMANS; INDIA; MALARIA, FALCIPARUM; MALE; MEMBRANE TRANSPORT PROTEINS; MIDDLE AGED; MULTIDRUG RESISTANCE-ASSOCIATED PROTEINS; MUTATION; PLASMODIUM FALCIPARUM; PROTOZOAN PROTEINS; PYRIMETHAMINE; SULFADOXINE;

EID: 84906987233     PISSN: None     EISSN: 19326203     Source Type: Journal    
DOI: 10.1371/journal.pone.0105562     Document Type: Article

References (42)

1. NVBDCP (2013) Malaria situation in India. Available: http://www.nvbdcp. gov. in/Doc/mal-situation-July13.pdf. Accessed 2013 Sept 16.
2. Mohapatra PK, Prakash A, Taison K, Negmu K, Gohain AC, et al. (2005) Evaluation of chloroquine (CQ) and sulphadoxine/pyrimethamine (SP) therapy in uncomplicated falciparum malaria in Indo-Myanmar border areas. Trop Med Int Health 10:478-483.
3. Young M, Moore D (1961) Chloroquine resistance in Plasmodium falciparum. Am J Trop Med Hyg 10:317-320.
4. Wernsdorfer WH, Payne D (1991) The dynamics of drug resistance in Plasmodium falciparum. Pharmacol Ther 50:95-121.
5. Sehgal PN, Sharma MID, Sharma SL, Gogai S (1975) Resistance to chloroquine in falciparum malaria in Assam state, India. J Commun Dis 5:175-180.
6. Farooq U, Mahajan RC (2004) Drug resistance in malaria. J Vector Borne Dis 41:45-53.
7. Bjorkman A, Phillips-Howard PA (1990) The epidemiology of drug-resistant malaria. Trans R Soc Trop Med Hyg 84:177-80.
8. Das S, Barkakaty BN, Roy JR, Guha AK, Rastogi AC, et al. (1981) Pyrimethamine in combination with sulfadoxine or sulfalene in P. falciparum infected cases in India. Indian J Malariol 18:109-116.
9. NMEP (1997) Drug resistance and chemotherapy of malaria in India, an update. In: National Malaria Eradication Programme (Enhanced Malaria Control Project) (eds GPS. Dhillon, GS. Sonal, U. Arora & J. Nandi) Ministry of Health & Family Welfare, Government of India, New Delhi, pp. 14-18.
10. Mohapatra PK, Namchoom NS, Prakash A, Bhattacharyya DR, Goswami BK, et al. (2003) Therapeutic efficacy of antimalarials in Plasmodium falciparum malaria in an Indo-Myanmar border area of Arunachal Pradesh. Indian J Med Res 118:71-76.
11. Ouellette M (2001) Biochemical and molecular mechanisms of drug resistance in parasites. Trop Med Int Health 6:874-876.
12. Warhurst D (1999) Drug resistance in Plasmodium falciparum malaria. Infection 27:S55-58.
13. Wellems T, Plowe CV (2001) Chloroquine-resistant malaria. J Infect Dis 184:770-776.
14. Fidock DA, Nomura T, Talley AK, Cooper RA, Dzekunov SM, et al. (2000) Mutations in the P. falciparum digestive vacuole transmembrane protein PfCRT and evidence for their role in chloroquine resistance. Mol Cell 6:861-871.
15. Sa JM, Twu O, Hayton K, Reyes S, Fay MP, et al. (2009) Geographic patterns of Plasmodium falciparum drug resistance distinguished by differential responses to amodiaquine and chloroquine. Proc Natl Acad Sci U S A 106:18883-18889.
16. Pickard AL, Wongsrichanalai C, Purfield A, Kamwendo D, Emery K, et al. (2003) Resistance to antimalarials in Southeast Asia and genetic polymorphisms in pfmdr1. Antimicrob Agents Chemother 47:2418-2423.
17. Anderson AC (2005) Targeting DHFR in parasitic protozoa. Drug Discov Today 10:121-128.
18. Gregson A, Plowe CV (2005) Mechanisms of resistance of malaria parasites to antifolates. Pharmacol Rev 57:117-145.
19. Wu Y, Kirkman LA, Wellems TE (1996) Transformation of Plasmodium falciparum malaria parasites by homologous integration of plasmids that confer resistance to pyrimethamine. Proc Natl Acad Sci USA 93:1130-1134.
20. Lynch C, Pearce R, Pota H, Cox J, Abeku TA, et al. (2008) Emergence of a dhfr mutation conferring high-level drug resistance in Plasmodium falciparum populations from southwest Uganda. J Infect Dis 197:1598-1604.
21. Trigilia T, Menting JGT, Wilson C, Cowman AF (1997) Mutations in dihydropteroate synthase are responsible for sulfone and sulfonamide resistance in Plasmodium falciparum. Proc Natl Acad Sci USA 94:13944-13949.
22. Biswas S, Escalante A, Chaiyaroj S, Angkasekwinai P, Lai AA (2000) Prevalence of point mutations in the dihydrofolate reductase and dihydropteroate synthetase genes of Plasmodium falciparum isolates from India and Thailand: a molecular epidemiologic study. Trop Med Int Health 5:737-743.
23. Ndiaye D, Daily JP, Sarr O, Ndir O, Gaye O, et al. (2005) Mutations in Plasmodium falciparum dihydrofolate reductase and dihydropteroate synthase genes in Senegal. Trop Med Int Health 10:1176-1179.
24. Fernandes N, Figueiredo P, do Rosário VE, Cravo P (2007) Analysis of sulphadoxine/pyrimethamine resistance-conferring mutations of Plasmodium falciparum from Mozambique reveals the absence of the dihydrofolate reductase 164L mutant. Malaria J 6:35.
25. Figueiredo P, Benchimo C, Lopes D, Bernardino L, do Rosário VE, et al. (2008) Prevalence of pfmdr1, pfcrt, pfdhfr and pfdhps mutations associated with drug resistance, in Luanda, Angola. Malaria J. 7:236
26. Sharma YD (2012) Molecular surveillance of drug-resistant malaria in India. Curr Sci 102:696-703.
27. WHO (2009) Report of Technical Consultation: Defining and validating a measure of parasite resistance to sulfadoxinepyrimethamine (SP) that would be indicative of the protective efficacy of SP for intermittent preventive treatment in infancy (SP-IPTi), Geneva: World Health Organization.
28. WHO (2003) World Health Organization: Assessment and monitoring of antimalarial drug efficacy for the treatment of uncomplicated falciparum malaria. Geneva: World Health Organization.
29. Snounou G, Viriyakosol S, Zhu XP, Jarra W, Pinheiro L, et al. (1993) High sensitivity of detection of human malaria parasites by the use of nested polymerase chain reaction. Mol Biochem Parasitol 61:315-320.
30. Shah NK, Dhillon GP, Dash AP, Arora U, Meshnick SR, et al. (2011). Antimalarial drug resistance of Plasmodium falciparum in India: changes over time and space. Lancet Infect Dis 11:57-64.
31. Plowe CV, Roper C, Barnwell JW, Happi CT, Joshi HH, et al. (2007) World Antimalarial Resistance Network (WARN) III: molecular markers for drug resistant malaria. Malar J 6:121.
32. Goswami D, Dhiman S, Rabha B, Kumar D, Baruah I, et al. (2014) Pfcrt mutant haplotypes may not correspond with chloroquine resistance. J Infect Dev Ctries 8:768-773.
33. Zakeri S, Afsharpad M, Kazemzadeh T, Mehdizadeh K, Shabani A, et al. (2008) Association of pfcrt but not pfmdr1 alleles with chloroquine resistance in Iranian isolates of Plasmodium falciparum. Am J Trop Med Hyg 78:633-640.
34. Lumb V, Das MK, Mittra P, Ahmed A, Kumar M, et al. (2009) Emergence of an unusual sulphadoxinepyrimethamine resistance pattern and a novel K540N mutation in dihydropteroate synthetase in Plasmodium falciparum isolates obtained from Car Nicobar Island, India, after the 2004 Tsunami. J Infect Dis 199:1064-1073.
35. Ahmed A, Bararia D, Vinayak S, Yameen M, Biswas S, et al. (2004) Plasmodium falciparum isolates in India exhibit a progressive increase in mutations associated with sulphadoxine-pyrimethamine resistance. Antimicrob Agents Chemother 48:879-889.
36. Biswas S (2004) Associations of antifolate resistance in vitro andpointmutations in dihydrofolate reductase and dihydropteroate synthetase genes of Plasmodium falciparum. J Postgrad Med 50:17-20.
37. Ahmed A, Lumb V, Das MK, Dev V, Wajihullah, et al. (2006) Prevalence of mutations associated with higher levels of sulfadoxine-pyrimethamine resistance in Plasmodium falciparum isolates from Car Nicobar Island and Assam, India. Antimicrob Agents Chemother 50:3934-3938.
38. Ahmed A, Das MK, Dev V, Saifi MA, Wajihullah, et al. (2006) Quadruple mutations in dihydrofolate reductase of Plasmodium falciparum isolates from Car Nicobar Island, India. Antimicrob Agents Chemother 50:1546-1549.
39. Lin JT, Juliano JJ, Wongsrichanalai C (2010) Drug-Resistant Malaria: The Era of ACT. Curr Infect Dis Rep 12:165-173.
40. Dondorp AM, Nosten F, Yi P, Das D, Phyo AP, et al. (2009) Artemisinin resistance in Plasmodium falciparum malaria. N Engl J Med 361:455-467.
41. O'Brien C, Henrich PP, Passi N, Fidock DA (2011) Recent clinical and molecular insights into emerging artemisinin resistance in Plasmodium falciparum. Curr Opin Infect Dis 24:570-577.
42. National Vector Borne Disease Control Programme. National Drug Policy on malaria. Directorate of National Vector Borne Disease Control Programme, Directorate General of Health Services, Ministry of Health and Family Welfare, Government of India, 2013. Available: http://nvbdcp.gov.in/Doc/National-Drug-Policy-2013.pdf. Accessed 2014 Jul. 19.