메뉴 건너뛰기




Volumn 197, Issue 11, 2008, Pages 1598-1604

Emergence of a dhfr mutation conferring high-level drug resistance in Plasmodium falciparum populations from southwest Uganda

Author keywords

[No Author keywords available]

Indexed keywords

ARTEMETHER PLUS BENFLUMETOL; CHLOROQUINE; FANSIDAR; FOLIC ACID ANTAGONIST;

EID: 43949128393     PISSN: 00221899     EISSN: None     Source Type: Journal    
DOI: 10.1086/587845     Document Type: Article
Times cited : (78)

References (65)
  • 1
    • 0030972041 scopus 로고    scopus 로고
    • Poor efficacy of antimalarial biguanide-dapsone combinations in the treatment of acute uncomplicateds falciparum malaria in Thailand
    • Wilairatana P, Kyle DE, Looareesuwan S, et al. Poor efficacy of antimalarial biguanide-dapsone combinations in the treatment of acute uncomplicateds falciparum malaria in Thailand. Ann Trop Med Parasitol 1997; 91:125-32.
    • (1997) Ann Trop Med Parasitol , vol.91 , pp. 125-132
    • Wilairatana, P.1    Kyle, D.E.2    Looareesuwan, S.3
  • 2
    • 11144323302 scopus 로고    scopus 로고
    • Artesunate-dapsone-proguanil treatment of falciparum malaria: Genotypic determinants of therapeutic response
    • Krudsood S, Imwong M, Wilairatana P, et al. Artesunate-dapsone-proguanil treatment of falciparum malaria: genotypic determinants of therapeutic response. Trans R Soc Trop Med Hyg 2005; 99:142-9.
    • (2005) Trans R Soc Trop Med Hyg , vol.99 , pp. 142-149
    • Krudsood, S.1    Imwong, M.2    Wilairatana, P.3
  • 3
    • 14944343046 scopus 로고    scopus 로고
    • Why has the dihydrofolate reductase 164 mutation not consistently been found in Africa yet?
    • Nzila A, Ochong E, Nduati E, et al. Why has the dihydrofolate reductase 164 mutation not consistently been found in Africa yet? Trans Roy Soc Trop Med Hyg 2005; 99:341-6.
    • (2005) Trans Roy Soc Trop Med Hyg , vol.99 , pp. 341-346
    • Nzila, A.1    Ochong, E.2    Nduati, E.3
  • 5
    • 33746125737 scopus 로고    scopus 로고
    • Antifolate resistance in Plasmodium falciparum: Multiple origins and identification of novel dhfr alleles
    • McCollum AM, Poe AC, Hamel M. Antifolate resistance in Plasmodium falciparum: multiple origins and identification of novel dhfr alleles. J Infect Dis 2006; 194:189-97.
    • (2006) J Infect Dis , vol.194 , pp. 189-197
    • McCollum, A.M.1    Poe, A.C.2    Hamel, M.3
  • 6
    • 0036560268 scopus 로고    scopus 로고
    • Polyclonal Plasmodium falciparum malaria in travellers and selection of antifolate mutations after proguanil prophylaxis
    • Farnert A, Tengstam K, Palme IB, et al. Polyclonal Plasmodium falciparum malaria in travellers and selection of antifolate mutations after proguanil prophylaxis. Am J Trop Med Hyg 2002; 66:487-91.
    • (2002) Am J Trop Med Hyg , vol.66 , pp. 487-491
    • Farnert, A.1    Tengstam, K.2    Palme, I.B.3
  • 7
    • 2442686477 scopus 로고    scopus 로고
    • Relationship between age, molecular markers and response to sulphadoxine- pyrimethamine treatment in Kampala, Uganda
    • Staedke SG, Sendagire H, Lamola S, Kamya MR, Dorsey G, Rosenthal PJ. Relationship between age, molecular markers and response to sulphadoxine- pyrimethamine treatment in Kampala, Uganda. Trop Med Int Health 2004; 9:624-9.
    • (2004) Trop Med Int Health , vol.9 , pp. 624-629
    • Staedke, S.G.1    Sendagire, H.2    Lamola, S.3    Kamya, M.R.4    Dorsey, G.5    Rosenthal, P.J.6
  • 8
    • 24144455319 scopus 로고    scopus 로고
    • Mutations associated with sulfadoxine-pyrimethamine and chlorproguanil resistance in Plasmodium falciparum isolates from Blantyre, Malawi
    • Alker AP, Mwapasa V, Purfield A, et al. Mutations associated with sulfadoxine-pyrimethamine and chlorproguanil resistance in Plasmodium falciparum isolates from Blantyre, Malawi. Antimicrob Agents Chemother 2005; 49:3919-21.
    • (2005) Antimicrob Agents Chemother , vol.49 , pp. 3919-3921
    • Alker, A.P.1    Mwapasa, V.2    Purfield, A.3
  • 9
    • 33645829827 scopus 로고    scopus 로고
    • Menard D, Djalle D, Yapou F, Manirakiza A, Talarmin A. Frequency distribution of antimalarial drug-resistant alleles among isolates of Plasmodium falciparum in Bangui, Central African Republic. Am J Trop Med Hyg 2006; 74:205-10 [erratum: Am J Trop Med Hyg 2006; 74:516].
    • Menard D, Djalle D, Yapou F, Manirakiza A, Talarmin A. Frequency distribution of antimalarial drug-resistant alleles among isolates of Plasmodium falciparum in Bangui, Central African Republic. Am J Trop Med Hyg 2006; 74:205-10 [erratum: Am J Trop Med Hyg 2006; 74:516].
  • 10
    • 33645355649 scopus 로고    scopus 로고
    • Geographic differences in antimalarial efficacy in Uganda are explained by differences in endemicity and not by known molecular markers of drug resistance
    • Francis D, Nsobya SL, Talisuna A, et al. Geographic differences in antimalarial efficacy in Uganda are explained by differences in endemicity and not by known molecular markers of drug resistance. J Infect Dis 2006; 193:978-86.
    • (2006) J Infect Dis , vol.193 , pp. 978-986
    • Francis, D.1    Nsobya, S.L.2    Talisuna, A.3
  • 11
    • 6044234396 scopus 로고    scopus 로고
    • Malaria epidemic early warning and detection in African highlands
    • Abeku TA, Hay SI, Ochola S, et al. Malaria epidemic early warning and detection in African highlands. Trends Parasitol 2004; 20:400-5.
    • (2004) Trends Parasitol , vol.20 , pp. 400-405
    • Abeku, T.A.1    Hay, S.I.2    Ochola, S.3
  • 12
    • 0003857217 scopus 로고    scopus 로고
    • Kampala, Uganda: Ministry of Health Resource Centre, Available at:, Accessed 22 April 2008
    • Ministry of Health. Statistical abstract. Kampala, Uganda: Ministry of Health Resource Centre, 2002. Available at: http://www.health.go.ug/docs/ abstract2001.pdf. Accessed 22 April 2008.
    • (2002) Statistical abstract
  • 13
    • 0037378944 scopus 로고    scopus 로고
    • Molecular determination of point mutation haplotypes in the dihydrofolate reductase and dihydropteroate synthase of Plasmodium falciparum in three districts of northern Tanzania
    • Pearce R, Drakeley C, Chandramohan D, Mosha F, Roper C. Molecular determination of point mutation haplotypes in the dihydrofolate reductase and dihydropteroate synthase of Plasmodium falciparum in three districts of northern Tanzania. Antimicrob Agents Chemother 2003; 47:1347-54.
    • (2003) Antimicrob Agents Chemother , vol.47 , pp. 1347-1354
    • Pearce, R.1    Drakeley, C.2    Chandramohan, D.3    Mosha, F.4    Roper, C.5
  • 14
    • 0037420464 scopus 로고    scopus 로고
    • Antifolate antimalarial resistance in southeast Africa
    • Roper C, Pearce R, Bredenkamp B, et al. Antifolate antimalarial resistance in southeast Africa. Lancet 2003; 361:1174-81.
    • (2003) Lancet , vol.361 , pp. 1174-1181
    • Roper, C.1    Pearce, R.2    Bredenkamp, B.3
  • 15
    • 10744222802 scopus 로고    scopus 로고
    • A selective sweep driven by pyrimethamine treatment in Southeast Asian malaria parasites
    • Nair S, Williams JT, Brockman A, et al. A selective sweep driven by pyrimethamine treatment in Southeast Asian malaria parasites. Mol Biol Evol 2003; 20:1526-36.
    • (2003) Mol Biol Evol , vol.20 , pp. 1526-1536
    • Nair, S.1    Williams, J.T.2    Brockman, A.3
  • 17
    • 33748751585 scopus 로고    scopus 로고
    • Defining the origin of Plasmodium falciparum resistant dhfr isolates in Senegal
    • Ndiaye D, Daily JP, Sarr O, et al. Defining the origin of Plasmodium falciparum resistant dhfr isolates in Senegal. Acta Tropica 2006; 99:106-11.
    • (2006) Acta Tropica , vol.99 , pp. 106-111
    • Ndiaye, D.1    Daily, J.P.2    Sarr, O.3
  • 18
    • 34250866370 scopus 로고    scopus 로고
    • A shared Asian origin of the triple-mutant dhfr allele in Plasmodium falciparum from sites across Africa
    • Maïga AA, Djimdé V, Hubert E, et al. A shared Asian origin of the triple-mutant dhfr allele in Plasmodium falciparum from sites across Africa. J Infect Dis 2007; 196:165-72.
    • (2007) J Infect Dis , vol.196 , pp. 165-172
    • Maïga, A.A.1    Djimdé, V.2    Hubert, E.3
  • 19
    • 19344363773 scopus 로고    scopus 로고
    • Exploring the folate pathway in Plasmodium falciparum
    • Hyde JE. Exploring the folate pathway in Plasmodium falciparum. Acta Tropica 2005; 94:191-206.
    • (2005) Acta Tropica , vol.94 , pp. 191-206
    • Hyde, J.E.1
  • 20
    • 34249934338 scopus 로고    scopus 로고
    • Characterisation of exogenous folate transport in Plasmodium falciparum
    • Wang P, Wang Q, Sims PFG, Hyde JE. Characterisation of exogenous folate transport in Plasmodium falciparum. Mol Biochem Parasitol 2007; 154:40-51.
    • (2007) Mol Biochem Parasitol , vol.154 , pp. 40-51
    • Wang, P.1    Wang, Q.2    Sims, P.F.G.3    Hyde, J.E.4
  • 21
    • 33845875437 scopus 로고    scopus 로고
    • A genome-wide map of diversity in Plasmodium falciparum
    • Volkman SK, Sabeti PC, Decaprio D, et al. A genome-wide map of diversity in Plasmodium falciparum. Nat Genet 2007; 39:113-9.
    • (2007) Nat Genet , vol.39 , pp. 113-119
    • Volkman, S.K.1    Sabeti, P.C.2    Decaprio, D.3
  • 22
    • 36049010956 scopus 로고    scopus 로고
    • The implication of dihydrofolate reductase and dihydropteroate synthetase gene mutations in modification of Plasmodium falciparum characteristics
    • A-Elbasit IE, Alifrangis M, Khalil IF, et al. The implication of dihydrofolate reductase and dihydropteroate synthetase gene mutations in modification of Plasmodium falciparum characteristics. Malar J 2007; 6:108.
    • (2007) Malar J , vol.6 , pp. 108
    • A-Elbasit, I.E.1    Alifrangis, M.2    Khalil, I.F.3
  • 23
    • 0346216115 scopus 로고    scopus 로고
    • Molecular assessment of drug resistance in Plasmodium falciparum from Bahr El Gazal province, Sudan
    • Anderson TJ, Nair S, Jacobzone C, Zavai A, Balkan S. Molecular assessment of drug resistance in Plasmodium falciparum from Bahr El Gazal province, Sudan. Trop Med Int Health 2003; 8:1068-73.
    • (2003) Trop Med Int Health , vol.8 , pp. 1068-1073
    • Anderson, T.J.1    Nair, S.2    Jacobzone, C.3    Zavai, A.4    Balkan, S.5
  • 24
    • 0036807787 scopus 로고    scopus 로고
    • Molecular epidemiology of malaria in Cameroon. XI. Geographic distribution of Plasmodium falciparum isolates with dihydrofolate reductase gene mutations in southern and central Cameroon
    • Basco LK, Ndounga M, Tejiokem M, et al. Molecular epidemiology of malaria in Cameroon. XI. Geographic distribution of Plasmodium falciparum isolates with dihydrofolate reductase gene mutations in southern and central Cameroon. Am J Trop Med Hyg 2002; 67:378-82.
    • (2002) Am J Trop Med Hyg , vol.67 , pp. 378-382
    • Basco, L.K.1    Ndounga, M.2    Tejiokem, M.3
  • 25
    • 0033836608 scopus 로고    scopus 로고
    • Sequence variations in the genes encoding dihydropteroate synthase and dihydrofolate reductase and clinical response to sulfadoxine-pyrimethamine in patients with acute uncomplicated falciparum malaria
    • Basco LK, Tahar R, Keundjian A, Ringwald P. Sequence variations in the genes encoding dihydropteroate synthase and dihydrofolate reductase and clinical response to sulfadoxine-pyrimethamine in patients with acute uncomplicated falciparum malaria. J Infect Dis 2000; 182:624-8.
    • (2000) J Infect Dis , vol.182 , pp. 624-628
    • Basco, L.K.1    Tahar, R.2    Keundjian, A.3    Ringwald, P.4
  • 26
    • 0031807606 scopus 로고    scopus 로고
    • Molecular basis of in vivo resistance to sulfadoxine-pyrimethamine in African adult patients infected with Plasmodium falciparum malaria parasites
    • Basco LK, Tahar R, Ringwald P. Molecular basis of in vivo resistance to sulfadoxine-pyrimethamine in African adult patients infected with Plasmodium falciparum malaria parasites. Antimicrob Agents Chemother 1998; 42:1811- 4.
    • (1998) Antimicrob Agents Chemother , vol.42 , pp. 1811-1814
    • Basco, L.K.1    Tahar, R.2    Ringwald, P.3
  • 27
    • 26944437471 scopus 로고    scopus 로고
    • Malaria cure with sulphadoxine/ pyrimethamine combination in 12 semi-immune adults from West-Central Africa with high rates of point mutations in Plasmodium falciparum dhfr and dhps genes
    • Berzosa PJ, Puente S, Benito A. Malaria cure with sulphadoxine/ pyrimethamine combination in 12 semi-immune adults from West-Central Africa with high rates of point mutations in Plasmodium falciparum dhfr and dhps genes. Parasitol Res 2005; 97:287-9.
    • (2005) Parasitol Res , vol.97 , pp. 287-289
    • Berzosa, P.J.1    Puente, S.2    Benito, A.3
  • 28
    • 0037343848 scopus 로고    scopus 로고
    • High prevalence of quintuple mutant dhps/dhfr genes in Plasmodium falciparum infections seven years after introduction of sulfadoxine and pyrimethamine as first line treatment in Malawi
    • Bwijo B, Kaneko A, Takechi M, et al. High prevalence of quintuple mutant dhps/dhfr genes in Plasmodium falciparum infections seven years after introduction of sulfadoxine and pyrimethamine as first line treatment in Malawi. Acta Trop 2003; 85:363-73.
    • (2003) Acta Trop , vol.85 , pp. 363-373
    • Bwijo, B.1    Kaneko, A.2    Takechi, M.3
  • 29
    • 0031900990 scopus 로고    scopus 로고
    • In vivo selection for a specific genotype of dihydropteroate synthetase of Plasmodium falciparum by pyrimethamine-sulfadoxine but not chlorproguanil-dapsone treatment
    • Curtis J, Duraisingh MT, Warhurst DC. In vivo selection for a specific genotype of dihydropteroate synthetase of Plasmodium falciparum by pyrimethamine-sulfadoxine but not chlorproguanil-dapsone treatment. J Infect Dis 1998; 177:1429-33.
    • (1998) J Infect Dis , vol.177 , pp. 1429-1433
    • Curtis, J.1    Duraisingh, M.T.2    Warhurst, D.C.3
  • 30
    • 0032961360 scopus 로고    scopus 로고
    • Pyrimethamine-sulfadoxine efficacy and selection for mutations in Plasmodium falciparum dihydrofolate reductase and dihydropteroate synthase in Mali
    • Diourte Y, Djimde A, Doumbo OK, et al. Pyrimethamine-sulfadoxine efficacy and selection for mutations in Plasmodium falciparum dihydrofolate reductase and dihydropteroate synthase in Mali. Am J Trop Med Hyg 1999; 60:475-8.
    • (1999) Am J Trop Med Hyg , vol.60 , pp. 475-478
    • Diourte, Y.1    Djimde, A.2    Doumbo, O.K.3
  • 31
    • 34548181341 scopus 로고    scopus 로고
    • Sulfadoxine-pyrimethamine susceptibilities and analysis of the dihydrofolate reductase and dihydropteroate synthase of Plasmodium falciparum isolates from Cote d'Ivoire
    • Djaman JA, Mazabraud A, Basco L. Sulfadoxine-pyrimethamine susceptibilities and analysis of the dihydrofolate reductase and dihydropteroate synthase of Plasmodium falciparum isolates from Cote d'Ivoire. Ann Trop Med Parasitol 2007; 101:103-12.
    • (2007) Ann Trop Med Parasitol , vol.101 , pp. 103-112
    • Djaman, J.A.1    Mazabraud, A.2    Basco, L.3
  • 32
    • 33747175413 scopus 로고    scopus 로고
    • Roles of specific Plasmodium falciparum mutations in resistance to amodiaquine and sulfadoxine-pyrimethamine in Burkina Faso
    • Dokomajilar C, Lankoande ZM, Dorsey G, Zongo I, Ouedraogo JB, Rosenthal PJ. Roles of specific Plasmodium falciparum mutations in resistance to amodiaquine and sulfadoxine-pyrimethamine in Burkina Faso. Am J Trop Med Hyg 2006; 75:162-5.
    • (2006) Am J Trop Med Hyg , vol.75 , pp. 162-165
    • Dokomajilar, C.1    Lankoande, Z.M.2    Dorsey, G.3    Zongo, I.4    Ouedraogo, J.B.5    Rosenthal, P.J.6
  • 33
    • 0033823662 scopus 로고    scopus 로고
    • Rapid selection of Plasmodium falciparum dihydrofolate reductase mutants by pyrimethamine prophylaxis
    • Doumbo OK, Kayentao K, Djimde A, et al. Rapid selection of Plasmodium falciparum dihydrofolate reductase mutants by pyrimethamine prophylaxis. J Infect Dis 2000; 182:993-6.
    • (2000) J Infect Dis , vol.182 , pp. 993-996
    • Doumbo, O.K.1    Kayentao, K.2    Djimde, A.3
  • 34
    • 0034777348 scopus 로고    scopus 로고
    • Prevalence of polymorphisms in the dihydrofolate reductase and dihydropteroate synthetase genes of Plasmodium falciparum isolates from southern Mauritania
    • Eberl KJ, Jelinek T, Aida AO, et al. Prevalence of polymorphisms in the dihydrofolate reductase and dihydropteroate synthetase genes of Plasmodium falciparum isolates from southern Mauritania. Trop Med Int Health 2001; 6:756-60.
    • (2001) Trop Med Int Health , vol.6 , pp. 756-760
    • Eberl, K.J.1    Jelinek, T.2    Aida, A.O.3
  • 35
    • 34247521013 scopus 로고    scopus 로고
    • Analysis of sulphadoxine/pyrimethamine resistance-conferring mutations of Plasmodium falciparum from Mozambique reveals the absence of the dihydrofolate reductase 164L mutant
    • Fernandes N, Figueiredo P, do Rosario VE, Cravo P. Analysis of sulphadoxine/pyrimethamine resistance-conferring mutations of Plasmodium falciparum from Mozambique reveals the absence of the dihydrofolate reductase 164L mutant. Malar J 2007; 6:35.
    • (2007) Malar J , vol.6 , pp. 35
    • Fernandes, N.1    Figueiredo, P.2    do Rosario, V.E.3    Cravo, P.4
  • 36
    • 29844438495 scopus 로고    scopus 로고
    • Molecular surveillance of mutations in dihydrofolate reductase and dihydropteroate synthase genes of Plasmodium falciparum in Ethiopia
    • Gebru-Woldearegai T, Hailu A, Grobusch MP, Kun JF. Molecular surveillance of mutations in dihydrofolate reductase and dihydropteroate synthase genes of Plasmodium falciparum in Ethiopia. Am J Trop Med Hyg 2005; 73:1131-4.
    • (2005) Am J Trop Med Hyg , vol.73 , pp. 1131-1134
    • Gebru-Woldearegai, T.1    Hailu, A.2    Grobusch, M.P.3    Kun, J.F.4
  • 37
    • 18844407314 scopus 로고    scopus 로고
    • Malaria in the Nuba Mountains of Sudan: Baseline genotypic resistance and efficacy of the artesunate plus sulfadoxine-pyrimethamine and artesunate plus amodiaquine combinations
    • Hamour S, Melaku Y, Keus K, et al. Malaria in the Nuba Mountains of Sudan: baseline genotypic resistance and efficacy of the artesunate plus sulfadoxine-pyrimethamine and artesunate plus amodiaquine combinations. Trans R Soc Trop Med Hyg 2005; 99:548-54.
    • (2005) Trans R Soc Trop Med Hyg , vol.99 , pp. 548-554
    • Hamour, S.1    Melaku, Y.2    Keus, K.3
  • 38
    • 23944484432 scopus 로고    scopus 로고
    • Polymorphisms in Plasmodium falciparum dhfr and dhps genes and age related in vivo sulfadoxine-pyrimethamine resistance in malaria-infected patients from Nigeria
    • Happi CT, Gbotosho GO, Folarin OA, et al. Polymorphisms in Plasmodium falciparum dhfr and dhps genes and age related in vivo sulfadoxine-pyrimethamine resistance in malaria-infected patients from Nigeria. Acta Trop 2005; 95:183-93.
    • (2005) Acta Trop , vol.95 , pp. 183-193
    • Happi, C.T.1    Gbotosho, G.O.2    Folarin, O.A.3
  • 39
    • 0032842337 scopus 로고    scopus 로고
    • Plasmodium falciparum resistance to sulfadoxine/pyrimethamine in Uganda: Correlation with polymorphisms in the dihydrofolate reductase and dihydropteroate synthetase genes
    • Jelinek T, Kilian AH, Kabagambe G, von Sonnenburg F. Plasmodium falciparum resistance to sulfadoxine/pyrimethamine in Uganda: correlation with polymorphisms in the dihydrofolate reductase and dihydropteroate synthetase genes. Am J Trop Med Hyg 1999; 61:463-6.
    • (1999) Am J Trop Med Hyg , vol.61 , pp. 463-466
    • Jelinek, T.1    Kilian, A.H.2    Kabagambe, G.3    von Sonnenburg, F.4
  • 40
    • 0032787601 scopus 로고    scopus 로고
    • Population structure of recrudescent Plasmodium falciparum isolates from western Uganda
    • Jelinek T, Kilian AH, Westermeier A, et al. Population structure of recrudescent Plasmodium falciparum isolates from western Uganda. Trop Med Int Health 1999; 4:476-80.
    • (1999) Trop Med Int Health , vol.4 , pp. 476-480
    • Jelinek, T.1    Kilian, A.H.2    Westermeier, A.3
  • 41
    • 0031856277 scopus 로고    scopus 로고
    • Polymorphisms in the dihydrofolate reductase (DHFR) and dihydropteroate synthetase (DHPS) genes of Plasmodium falciparum and in vivo resistance to sulphadoxine/pyrimethamine in isolates from Tanzania
    • Jelinek T, Ronn AM, Lemnge MM, et al. Polymorphisms in the dihydrofolate reductase (DHFR) and dihydropteroate synthetase (DHPS) genes of Plasmodium falciparum and in vivo resistance to sulphadoxine/pyrimethamine in isolates from Tanzania. Trop Med Int Health 1998; 3:605-9.
    • (1998) Trop Med Int Health , vol.3 , pp. 605-609
    • Jelinek, T.1    Ronn, A.M.2    Lemnge, M.M.3
  • 42
    • 0030678031 scopus 로고    scopus 로고
    • High prevalence of mutations in the dihydrofolate reductase gene of Plasmodium falciparum in isolates from Tanzania without evidence of an association to clinical sulfadoxine/ pyrimethamine resistance
    • Jelinek T, Ronn AM, Curtis J, et al. High prevalence of mutations in the dihydrofolate reductase gene of Plasmodium falciparum in isolates from Tanzania without evidence of an association to clinical sulfadoxine/ pyrimethamine resistance. Trop Med Int Health 1997; 2:1075-9.
    • (1997) Trop Med Int Health , vol.2 , pp. 1075-1079
    • Jelinek, T.1    Ronn, A.M.2    Curtis, J.3
  • 43
    • 0037794109 scopus 로고    scopus 로고
    • Dihydrofolate reductase and dihydropteroate synthase genotypes associated with in vitro resistance of Plasmodium falciparum to pyrimethamine, trimethoprim, sulfadoxine, and sulfamethoxazole
    • Khalil I, Ronn AM, Alifrangis M, Gabar HA, Satti GM, Bygbjerg IC. Dihydrofolate reductase and dihydropteroate synthase genotypes associated with in vitro resistance of Plasmodium falciparum to pyrimethamine, trimethoprim, sulfadoxine, and sulfamethoxazole. Am J Trop Med Hyg 2003; 68:586-9.
    • (2003) Am J Trop Med Hyg , vol.68 , pp. 586-589
    • Khalil, I.1    Ronn, A.M.2    Alifrangis, M.3    Gabar, H.A.4    Satti, G.M.5    Bygbjerg, I.C.6
  • 44
    • 0036748522 scopus 로고    scopus 로고
    • Pyrimethamine/sulfadoxine combination in the treatment of uncomplicated falciparum malaria: Relation between dihydropteroate synthase/dihydrofolate reductase genotypes, sulfadoxine plasma levels, and treatment outcome
    • Khalil I, Alifrangis M, Ronn AM, et al. Pyrimethamine/sulfadoxine combination in the treatment of uncomplicated falciparum malaria: relation between dihydropteroate synthase/dihydrofolate reductase genotypes, sulfadoxine plasma levels, and treatment outcome. Am J Trop Med Hyg 2002; 67:225-9.
    • (2002) Am J Trop Med Hyg , vol.67 , pp. 225-229
    • Khalil, I.1    Alifrangis, M.2    Ronn, A.M.3
  • 45
    • 12644310315 scopus 로고    scopus 로고
    • Antifolate drug resistance and point mutations in Plasmodium falciparum in Kenya
    • Khan B, Omar S, Kanyara JN, et al. Antifolate drug resistance and point mutations in Plasmodium falciparum in Kenya. Trans R Soc Trop Med Hyg 1997; 91:456-60.
    • (1997) Trans R Soc Trop Med Hyg , vol.91 , pp. 456-460
    • Khan, B.1    Omar, S.2    Kanyara, J.N.3
  • 46
    • 33750588337 scopus 로고    scopus 로고
    • Effect of cotrimoxazole prophylaxis taken by human immunodeficiency virus (HIV)-infected persons on the selection of sulfadoxine-pyrimethamine-resistant malaria parasites among HIV-uninfected household members
    • Malamba SS, Mermin J, Reingold A, et al. Effect of cotrimoxazole prophylaxis taken by human immunodeficiency virus (HIV)-infected persons on the selection of sulfadoxine-pyrimethamine-resistant malaria parasites among HIV-uninfected household members. Am J Trop Med Hyg 2006; 75:375-80.
    • (2006) Am J Trop Med Hyg , vol.75 , pp. 375-380
    • Malamba, S.S.1    Mermin, J.2    Reingold, A.3
  • 47
  • 48
    • 24744460267 scopus 로고    scopus 로고
    • Plasmodium falciparum dhfr but not dhps mutations associated with sulphadoxine-pyrimethamine treatment failure and gametocyte carriage in northern Ghana
    • Mockenhaupt FP, Teun Bousema J, Eggelte TA, et al. Plasmodium falciparum dhfr but not dhps mutations associated with sulphadoxine-pyrimethamine treatment failure and gametocyte carriage in northern Ghana. Trop Med Int Health 2005; 10:901-8.
    • (2005) Trop Med Int Health , vol.10 , pp. 901-908
    • Mockenhaupt, F.P.1    Teun Bousema, J.2    Eggelte, T.A.3
  • 49
    • 19944425994 scopus 로고    scopus 로고
    • Therapeutic efficacy of sulfadoxine-pyrimethamine and prevalence of resistance markers in Tanzania prior to revision of malaria treatment policy: Plasmodium falciparum dihydrofolate reductase and dihydropteroate synthase mutations in monitoring in vivo resistance
    • Mugittu K, Ndejembi M, Malisa A, et al. Therapeutic efficacy of sulfadoxine-pyrimethamine and prevalence of resistance markers in Tanzania prior to revision of malaria treatment policy: Plasmodium falciparum dihydrofolate reductase and dihydropteroate synthase mutations in monitoring in vivo resistance. Am J Trop Med Hyg 2004; 71:696-702.
    • (2004) Am J Trop Med Hyg , vol.71 , pp. 696-702
    • Mugittu, K.1    Ndejembi, M.2    Malisa, A.3
  • 50
    • 0035856231 scopus 로고    scopus 로고
    • Chlorproguanil-dapsone for treatment of drug-resistant falciparum malaria in Tanzania
    • Mutabingwa T, Nzila A, Mberu E, et al. Chlorproguanil-dapsone for treatment of drug-resistant falciparum malaria in Tanzania. Lancet 2001; 358:1218-23.
    • (2001) Lancet , vol.358 , pp. 1218-1223
    • Mutabingwa, T.1    Nzila, A.2    Mberu, E.3
  • 51
    • 27844540752 scopus 로고    scopus 로고
    • Mutations in Plasmodium falciparum dihydrofolate reductase and dihydropteroate synthase genes in Senegal
    • Ndiaye D, Daily JP, Sarr O, et al. Mutations in Plasmodium falciparum dihydrofolate reductase and dihydropteroate synthase genes in Senegal. Trop Med Int Health 2005; 10:1176-9.
    • (2005) Trop Med Int Health , vol.10 , pp. 1176-1179
    • Ndiaye, D.1    Daily, J.P.2    Sarr, O.3
  • 52
    • 35448932054 scopus 로고    scopus 로고
    • Therapeutic efficacy of sulfadoxine-pyrimethamine and the prevalence of molecular markers of resistance in under 5-year olds in Brazzaville, Congo
    • Ndounga M, Tahar R, Basco LK, Casimiro PN, Malonga DA, Ntoumi F. Therapeutic efficacy of sulfadoxine-pyrimethamine and the prevalence of molecular markers of resistance in under 5-year olds in Brazzaville, Congo. Trop Med Int Health 2007; 12:1164-71.
    • (2007) Trop Med Int Health , vol.12 , pp. 1164-1171
    • Ndounga, M.1    Tahar, R.2    Basco, L.K.3    Casimiro, P.N.4    Malonga, D.A.5    Ntoumi, F.6
  • 53
    • 34250178810 scopus 로고    scopus 로고
    • Molecular surveillance for drug-resistant Plasmodium falciparum malaria in Malawi
    • Nkhoma S, Molyneux M, Ward S. Molecular surveillance for drug-resistant Plasmodium falciparum malaria in Malawi. Acta Trop 2007; 102:138-42.
    • (2007) Acta Trop , vol.102 , pp. 138-142
    • Nkhoma, S.1    Molyneux, M.2    Ward, S.3
  • 54
    • 0034065697 scopus 로고    scopus 로고
    • Towards an understanding of the mechanism of pyrimethamine-sulfadoxine resistance in Plasmodium falciparum: Genotyping of dihydrofolate reductase and dihydropteroate synthase of Kenyan parasites
    • Nzila AM, Mberu EK, Sulo J, et al. Towards an understanding of the mechanism of pyrimethamine-sulfadoxine resistance in Plasmodium falciparum: genotyping of dihydrofolate reductase and dihydropteroate synthase of Kenyan parasites. Antimicrob Agents Chemother 2000; 44:991-6.
    • (2000) Antimicrob Agents Chemother , vol.44 , pp. 991-996
    • Nzila, A.M.1    Mberu, E.K.2    Sulo, J.3
  • 55
    • 0031963057 scopus 로고    scopus 로고
    • Nzila-Mounda A, Mberu EK, Sibley CH, Plowe CV, Winstanley PA, Watkins WM. Kenyan Plasmodium falciparum field isolates: correlation between pyrimethamine and chlorcycloguanil activity in vitro and point mutations in the dihydrofolate reductase domain. Antimicrob Agents Chemother 1998; 42:164-9.
    • Nzila-Mounda A, Mberu EK, Sibley CH, Plowe CV, Winstanley PA, Watkins WM. Kenyan Plasmodium falciparum field isolates: correlation between pyrimethamine and chlorcycloguanil activity in vitro and point mutations in the dihydrofolate reductase domain. Antimicrob Agents Chemother 1998; 42:164-9.
  • 56
    • 3042595929 scopus 로고    scopus 로고
    • Molecular monitoring of the Leu-164 mutation of dihydrofolate reductase in a highly sulfadoxine/pyrimethamine- resistant area in Africa
    • Ochong E, Nzila A, Kimani S, et al. Molecular monitoring of the Leu-164 mutation of dihydrofolate reductase in a highly sulfadoxine/pyrimethamine- resistant area in Africa. Malar J 2003; 2:46.
    • (2003) Malar J , vol.2 , pp. 46
    • Ochong, E.1    Nzila, A.2    Kimani, S.3
  • 57
    • 0035350481 scopus 로고    scopus 로고
    • Can pretreatment screening for dhps and dhfr point mutations in Plasmodium falciparum infections be used to predict sulfadoxine-pyrimethamine treatment failure?
    • Omar SA, Adagu IS, Warhurst DC. Can pretreatment screening for dhps and dhfr point mutations in Plasmodium falciparum infections be used to predict sulfadoxine-pyrimethamine treatment failure? Trans R Soc Trop Med Hyg 2001; 95:315-9.
    • (2001) Trans R Soc Trop Med Hyg , vol.95 , pp. 315-319
    • Omar, S.A.1    Adagu, I.S.2    Warhurst, D.C.3
  • 58
    • 0030720799 scopus 로고    scopus 로고
    • Mutations in Plasmodium falciparum dihydrofolate reductase and dihydropteroate synthase and epidemiologic patterns of pyrimethamine-sulfadoxine use and resistance
    • Plowe CV, Cortese JF, Djimde A, et al. Mutations in Plasmodium falciparum dihydrofolate reductase and dihydropteroate synthase and epidemiologic patterns of pyrimethamine-sulfadoxine use and resistance. J Infect Dis 1997; 176:1590-6.
    • (1997) J Infect Dis , vol.176 , pp. 1590-1596
    • Plowe, C.V.1    Cortese, J.F.2    Djimde, A.3
  • 59
    • 23944485879 scopus 로고    scopus 로고
    • Rapid increase in resistance of Plasmodium falciparum to chloroquine-Fansidar in Uganda and the potential of amodiaquine-Fansidar as a better alternative
    • Sendagire H, Kaddumukasa M, Ndagire D, et al. Rapid increase in resistance of Plasmodium falciparum to chloroquine-Fansidar in Uganda and the potential of amodiaquine-Fansidar as a better alternative. Acta Trop 2005; 95:172-82.
    • (2005) Acta Trop , vol.95 , pp. 172-182
    • Sendagire, H.1    Kaddumukasa, M.2    Ndagire, D.3
  • 60
    • 33846545030 scopus 로고    scopus 로고
    • Molecular surveillance of drug-resistance associated mutations of Plasmodium falciparum in south-west Tanzania
    • Schonfeld M, Barreto Miranda I, Schunk M, et al. Molecular surveillance of drug-resistance associated mutations of Plasmodium falciparum in south-west Tanzania. Malar J 2007; 6:2.
    • (2007) Malar J , vol.6 , pp. 2
    • Schonfeld, M.1    Barreto Miranda, I.2    Schunk, M.3
  • 61
    • 33750586478 scopus 로고    scopus 로고
    • Molecular epidemiology of malaria in Cameroon. XXII. Geographic mapping and distribution of Plasmodium falciparum dihydrofolate reductase (dhfr) mutant alleles
    • Tahar R, Basco LK. Molecular epidemiology of malaria in Cameroon. XXII. Geographic mapping and distribution of Plasmodium falciparum dihydrofolate reductase (dhfr) mutant alleles. Am J Trop Med Hyg 2006; 75:396-401.
    • (2006) Am J Trop Med Hyg , vol.75 , pp. 396-401
    • Tahar, R.1    Basco, L.K.2
  • 62
    • 34548048153 scopus 로고    scopus 로고
    • Molecular epidemiology of malaria in Cameroon. XXVII. Clinical and parasitological response to sulfadoxine-pyrimethamine treatment and Plasmodium falciparum dihydrofolate reductase and dihydropteroate synthase alleles in Cameroonian children
    • Tahar R, Basco LK. Molecular epidemiology of malaria in Cameroon. XXVII. Clinical and parasitological response to sulfadoxine-pyrimethamine treatment and Plasmodium falciparum dihydrofolate reductase and dihydropteroate synthase alleles in Cameroonian children. Acta Trop 2007; 103:81-9.
    • (2007) Acta Trop , vol.103 , pp. 81-89
    • Tahar, R.1    Basco, L.K.2
  • 63
    • 0142061643 scopus 로고    scopus 로고
    • Chloroquine, sulfadoxine-pyrimethamine and amodiaquine efficacy for the treatment of uncomplicated Plasmodium falciparum malaria in Upper Nile, south Sudan
    • van den Broek IV, Gatkoi T, Lowoko B, Nzila A, Ochong E, Keus K. Chloroquine, sulfadoxine-pyrimethamine and amodiaquine efficacy for the treatment of uncomplicated Plasmodium falciparum malaria in Upper Nile, south Sudan. Trans R Soc Trop Med Hyg 2003; 97:229-35.
    • (2003) Trans R Soc Trop Med Hyg , vol.97 , pp. 229-235
    • van den Broek, I.V.1    Gatkoi, T.2    Lowoko, B.3    Nzila, A.4    Ochong, E.5    Keus, K.6
  • 64
    • 0030801206 scopus 로고    scopus 로고
    • Resistance to antifolates in Plasmodium falciparum monitored by sequence analysis of dihydropteroate synthetase and dihydrofolate reductase alleles in a large number of field samples of diverse origins
    • Wang P, Lee CS, Bayoumi R, et al. Resistance to antifolates in Plasmodium falciparum monitored by sequence analysis of dihydropteroate synthetase and dihydrofolate reductase alleles in a large number of field samples of diverse origins. Mol Biochem Parasitol 1997; 89:161-77.
    • (1997) Mol Biochem Parasitol , vol.89 , pp. 161-177
    • Wang, P.1    Lee, C.S.2    Bayoumi, R.3
  • 65
    • 27644582620 scopus 로고    scopus 로고
    • Wilson PE, Kazadi W, Alker AP, Meshnick SR. Rare Congolese Plasmodium falciparum DHFR alleles. Mol Biochem Parasitol 2005; 144:227-9.
    • Wilson PE, Kazadi W, Alker AP, Meshnick SR. Rare Congolese Plasmodium falciparum DHFR alleles. Mol Biochem Parasitol 2005; 144:227-9.


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.