Modulation of endotoxicity of Shigella Generalized Modules for Membrane Antigens (GMMA) by genetic lipid A modifications: Relative activation of TLR4 and TLR2 pathways in different mutants

Journal of Biological Chemistry

Volumn 289, Issue 36, 2014, Pages 24922-24935

  Rossi, Omar ^a   Pesce, Isabella ^a   Giannelli, Carlo ^a   Aprea, Susanna ^a   Caboni, Mariaelena ^a   Citiulo, Francesco ^a   Valentini, Sara ^a   Ferlenghi, Ilaria ^a   MacLennan, Calman Alexander ^a   D'Oro, Ugo ^a   Saul, Allan ^a   Gerke, Christiane ^a  

^a NOVARTIS VACCINES AND DIAGNOSTICS   (Italy)

Author keywords

[No Author keywords available]

Indexed keywords

ANTIGENS; BACTERIA; BLOOD; CELL CULTURE; CHEMICAL ACTIVATION; INTERFERONS; VACCINES;

GRAM-NEGATIVE BACTERIA; HUMAN PERIPHERAL BLOOD; INFLAMMATORY CYTOKINES; LIPOPOLYSACCHARIDES; PERIPHERAL BLOOD MONONUCLEAR CELLS; RELATIVE CONTRIBUTION; TOLL-LIKE RECEPTOR 4; VACCINE DEVELOPMENT;

ACYLATION;

BACTERIAL ANTIGEN; GENERALIZED MODULES FOR MEMBRANE ANTIGEN; LIPID A; TOLL LIKE RECEPTOR 2; TOLL LIKE RECEPTOR 4; UNCLASSIFIED DRUG; ACYLTRANSFERASE; BACTERIAL PROTEIN; CYTOKINE; OUTER MEMBRANE PROTEIN;

ACYLATION; ARTICLE; BACTERIAL GENE; BACTERIAL STRAIN; CONTROLLED STUDY; CYTOKINE PRODUCTION; DNA MODIFICATION; DRUG RESPONSE; ENDOTOXICITY; GENE ACTIVATION; GENE DELETION; GENETIC TRANSFECTION; HTRB GENE; HUMAN; HUMAN CELL; MSBB GENE; NONHUMAN; PALMITOLEOYLATION; PERIPHERAL BLOOD MONONUCLEAR CELL; PROTEIN INDUCTION; REACTOGENICITY; SHIGELLA FLEXNERI; SHIGELLA SONNEI; TOXICITY; CELL CULTURE; GENETICS; HEK293 CELL LINE; IMMUNOLOGY; MASS SPECTROMETRY; METABOLISM; MONOCYTE; MUTATION; POLYACRYLAMIDE GEL ELECTROPHORESIS; SHIGELLA; SIGNAL TRANSDUCTION; TRANSMISSION ELECTRON MICROSCOPY;

ACYLATION; ACYLTRANSFERASES; ANTIGENS, BACTERIAL; BACTERIAL OUTER MEMBRANE PROTEINS; BACTERIAL PROTEINS; CELLS, CULTURED; CYTOKINES; ELECTROPHORESIS, POLYACRYLAMIDE GEL; HEK293 CELLS; HUMANS; LIPID A; MICROSCOPY, ELECTRON, TRANSMISSION; MONOCYTES; MUTATION; SHIGELLA; SHIGELLA FLEXNERI; SHIGELLA SONNEI; SIGNAL TRANSDUCTION; SPECTROMETRY, MASS, MATRIX-ASSISTED LASER DESORPTION-IONIZATION; TOLL-LIKE RECEPTOR 2; TOLL-LIKE RECEPTOR 4;

EID: 84906965436     PISSN: 00219258     EISSN: 1083351X     Source Type: Journal    
DOI: 10.1074/jbc.M114.566570     Document Type: Article

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