-
1
-
-
0020466344
-
5-azacytidine selectively increases gamma-globin synthesis in a patient with beta+ thalassemia
-
Ley TJ, DeSimone J, Anagnou NP, Keller GH, Humphries RK, et al. (1982) 5-azacytidine selectively increases gamma-globin synthesis in a patient with beta+ thalassemia. N Engl J Med 307: 1469-1475.
-
(1982)
N Engl J Med
, vol.307
, pp. 1469-1475
-
-
Ley, T.J.1
DeSimone, J.2
Anagnou, N.P.3
Keller, G.H.4
Humphries, R.K.5
-
2
-
-
0021286875
-
Hydroxyurea enhances fetal hemoglobin production in sickle cell anemia
-
Platt OS, Orkin SH, Dover G, Beardsley GP, Miller B, et al. (1984) Hydroxyurea enhances fetal hemoglobin production in sickle cell anemia. J Clin Invest 74: 652-656.
-
(1984)
J Clin Invest
, vol.74
, pp. 652-656
-
-
Platt, O.S.1
Orkin, S.H.2
Dover, G.3
Beardsley, G.P.4
Miller, B.5
-
3
-
-
84884297091
-
The role of the inherited disorders of hemoglobin, the first "molecular diseases," in the future of human genetics
-
Weatherall DJ (2013) The role of the inherited disorders of hemoglobin, the first "molecular diseases," in the future of human genetics. Annu Rev Genomics Hum Genet 14: 1-24.
-
(2013)
Annu Rev Genomics Hum Genet
, vol.14
, pp. 1-24
-
-
Weatherall, D.J.1
-
4
-
-
58149165358
-
Hemoglobin research and the origins of molecular medicine
-
Schechter AN (2008) Hemoglobin research and the origins of molecular medicine. Blood 112: 3927-3938.
-
(2008)
Blood
, vol.112
, pp. 3927-3938
-
-
Schechter, A.N.1
-
6
-
-
34748864128
-
A QTL influencing F cell production maps to a gene encoding a zinc-finger protein on chromosome 2p15
-
Menzel S, Garner C, Gut I, Matsuda F, Yamaguchi M, et al. (2007) A QTL influencing F cell production maps to a gene encoding a zinc-finger protein on chromosome 2p15. Nat Genet. 39: 1197-1199.
-
(2007)
Nat Genet
, vol.39
, pp. 1197-1199
-
-
Menzel, S.1
Garner, C.2
Gut, I.3
Matsuda, F.4
Yamaguchi, M.5
-
7
-
-
34547450531
-
Intergenic variants of HBS1L-MYB are responsible for a major quantitative trait locus on chromosome 6q23 influencing fetal hemoglobin levels in adults
-
Thein SL, Menzel S, Peng X, Best S, Jiang J, et al. (2007) Intergenic variants of HBS1L-MYB are responsible for a major quantitative trait locus on chromosome 6q23 influencing fetal hemoglobin levels in adults. Proc Natl Acad Sci U S A. 104: 11346-11351.
-
(2007)
Proc Natl Acad Sci U S A
, vol.104
, pp. 11346-11351
-
-
Thein, S.L.1
Menzel, S.2
Peng, X.3
Best, S.4
Jiang, J.5
-
8
-
-
53149150933
-
BCL11A is a major HbF quantitative trait locus in three different populations with betahemoglobinopathies
-
Sedgewick AE, Timofeev N, Sebastiani P, So JC, Ma ES, et al. (2008) BCL11A is a major HbF quantitative trait locus in three different populations with betahemoglobinopathies. Blood Cells Mol Dis. 41: 255-258.
-
(2008)
Blood Cells Mol Dis
, vol.41
, pp. 255-258
-
-
Sedgewick, A.E.1
Timofeev, N.2
Sebastiani, P.3
So, J.C.4
Ma, E.S.5
-
9
-
-
40349092939
-
Genomewide association study shows BCL11A associated with persistent fetal hemoglobin and amelioration of the phenotype of beta-thalassemia
-
Uda M, Galanello R, Sanna S, Lettre G, Sankaran VG, et al. (2008) Genomewide association study shows BCL11A associated with persistent fetal hemoglobin and amelioration of the phenotype of beta-thalassemia. Proc Natl Acad Sci U S A. 105: 1620-1625.
-
(2008)
Proc Natl Acad Sci U S A
, vol.105
, pp. 1620-1625
-
-
Uda, M.1
Galanello, R.2
Sanna, S.3
Lettre, G.4
Sankaran, V.G.5
-
10
-
-
57849083996
-
Human fetal hemoglobin expression is regulated by the developmental stage-specific repressor BCL11A
-
Sankaran VG, Menne TF, Xu J, Akie TE, Lettre G, et al. (2008) Human fetal hemoglobin expression is regulated by the developmental stage-specific repressor BCL11A. Science 322: 1839-1842.
-
(2008)
Science
, vol.322
, pp. 1839-1842
-
-
Sankaran, V.G.1
Menne, T.F.2
Xu, J.3
Akie, T.E.4
Lettre, G.5
-
11
-
-
81555205756
-
Correction of sickle cell disease in adult mice by interference with fetal hemoglobin silencing
-
Xu J, Peng C, Sankaran VG, Shao Z, Esrick EB, et al. (2011) Correction of sickle cell disease in adult mice by interference with fetal hemoglobin silencing. Science 334: 993-996.
-
(2011)
Science
, vol.334
, pp. 993-996
-
-
Xu, J.1
Peng, C.2
Sankaran, V.G.3
Shao, Z.4
Esrick, E.B.5
-
12
-
-
84886898377
-
LIN28Bmediated expression of fetal hemoglobin and production of fetal-like erythrocytes from adult human erythroblasts ex vivo
-
Lee YT, de Vasconcellos JF, Yuan J, Byrnes C, Noh SJ, et al. (2013) LIN28Bmediated expression of fetal hemoglobin and production of fetal-like erythrocytes from adult human erythroblasts ex vivo. Blood 122: 1034-1041.
-
(2013)
Blood
, vol.122
, pp. 1034-1041
-
-
Lee, Y.T.1
De Vasconcellos, J.F.2
Yuan, J.3
Byrnes, C.4
Noh, S.J.5
-
13
-
-
77049099101
-
Lin28: A microRNA regulator with a macro role
-
Viswanathan SR, Daley GQ (2010) Lin28: A microRNA regulator with a macro role. Cell 140: 445-449.
-
(2010)
Cell
, vol.140
, pp. 445-449
-
-
Viswanathan, S.R.1
Daley, G.Q.2
-
14
-
-
72549098210
-
Let-7 microRNAs are developmentally regulated in circulating human erythroid cells
-
Noh SJ, Miller SH, Lee YT, Goh SH, Marincola FM, et al. (2009) Let-7 microRNAs are developmentally regulated in circulating human erythroid cells. J Transl Med 7: 98.
-
(2009)
J Transl Med
, vol.7
, pp. 98
-
-
Noh, S.J.1
Miller, S.H.2
Lee, Y.T.3
Goh, S.H.4
Marincola, F.M.5
-
15
-
-
67651043722
-
Identification of TWSG1 as a second novel erythroid regulator of hepcidin expression in murine and human cells
-
Tanno T, Porayette P, Sripichai O, Noh SJ, Byrnes C, et al. (2009) Identification of TWSG1 as a second novel erythroid regulator of hepcidin expression in murine and human cells. Blood. 114: 181-186.
-
(2009)
Blood
, vol.114
, pp. 181-186
-
-
Tanno, T.1
Porayette, P.2
Sripichai, O.3
Noh, S.J.4
Byrnes, C.5
-
16
-
-
78649666290
-
Expression patterns of fetal hemoglobin in sickle cell erythrocytes are both patient- and treatment-specific during childhood
-
Meier ER, Byrnes C, Weissman M, Noel P, Luban NL, et al. (2011) Expression patterns of fetal hemoglobin in sickle cell erythrocytes are both patient- and treatment-specific during childhood. Pediatr Blood Cancer 56: 103-109.
-
(2011)
Pediatr Blood Cancer
, vol.56
, pp. 103-109
-
-
Meier, E.R.1
Byrnes, C.2
Weissman, M.3
Noel, P.4
Luban, N.L.5
-
17
-
-
70349569073
-
Cytokinemediated increases in fetal hemoglobin are associated with globin gene histone modification and transcription factor reprogramming
-
Sripichai O, Kiefer CM, Bhanu NV, Tanno T, Noh SJ, et al. (2009) Cytokinemediated increases in fetal hemoglobin are associated with globin gene histone modification and transcription factor reprogramming. Blood. 114: 2299-2306.
-
(2009)
Blood
, vol.114
, pp. 2299-2306
-
-
Sripichai, O.1
Kiefer, C.M.2
Bhanu, N.V.3
Tanno, T.4
Noh, S.J.5
-
18
-
-
77349087595
-
Low physiologic oxygen tensions reduce proliferation and differentiation of human multipotent mesenchymal stromal cells
-
Holzwarth C, Vaegler M, Gieseke F, Pfister SM, Handgretinger R, et al. (2010) Low physiologic oxygen tensions reduce proliferation and differentiation of human multipotent mesenchymal stromal cells. BMC Cell Biol 11: 11.
-
(2010)
BMC Cell Biol
, vol.11
, pp. 11
-
-
Holzwarth, C.1
Vaegler, M.2
Gieseke, F.3
Pfister, S.M.4
Handgretinger, R.5
-
19
-
-
77956630402
-
KLF1 regulates BCL11A expression and gamma- to beta-globin gene switching
-
Zhou D, Liu K, Sun CW, Pawlik KM, Townes TM (2010) KLF1 regulates BCL11A expression and gamma- to beta-globin gene switching. Nat Genet. 42: 742-744.
-
(2010)
Nat Genet
, vol.42
, pp. 742-744
-
-
Zhou, D.1
Liu, K.2
Sun, C.W.3
Pawlik, K.M.4
Townes, T.M.5
-
20
-
-
0025308742
-
Morphologic studies of sickle erythrocytes by image analysis
-
Horiuchi K, Ohata J, Hirano Y, Asakura T (1990) Morphologic studies of sickle erythrocytes by image analysis. J Lab Clin Med 115: 613-620.
-
(1990)
J Lab Clin Med
, vol.115
, pp. 613-620
-
-
Horiuchi, K.1
Ohata, J.2
Hirano, Y.3
Asakura, T.4
-
21
-
-
0030970775
-
The cold shock domain protein LIN-28 controls developmental timing in C. elegans and is regulated by the lin-4 RNA
-
Moss EG, Lee RC, Ambros V (1997) The cold shock domain protein LIN-28 controls developmental timing in C. elegans and is regulated by the lin-4 RNA. Cell. 88: 637-646.
-
(1997)
Cell
, vol.88
, pp. 637-646
-
-
Moss, E.G.1
Lee, R.C.2
Ambros, V.3
-
22
-
-
36749043230
-
Induced pluripotent stem cell lines derived from human somatic cells
-
Yu J, Vodyanik MA, Smuga-Otto K, Antosiewicz-Bourget J, Frane JL, et al. (2007) Induced pluripotent stem cell lines derived from human somatic cells. Science. 318: 1917-1920.
-
(2007)
Science
, vol.318
, pp. 1917-1920
-
-
Yu, J.1
Vodyanik, M.A.2
Smuga-Otto, K.3
Antosiewicz-Bourget, J.4
Frane, J.L.5
-
23
-
-
34247589770
-
Lin-28 binds IGF-2 mRNA and participates in skeletal myogenesis by increasing translation efficiency
-
Polesskaya A, Cuvellier S, Naguibneva I, Duquet A, Moss EG, et al. (2007) Lin-28 binds IGF-2 mRNA and participates in skeletal myogenesis by increasing translation efficiency. Genes Dev 21: 1125-1138.
-
(2007)
Genes Dev
, vol.21
, pp. 1125-1138
-
-
Polesskaya, A.1
Cuvellier, S.2
Naguibneva, I.3
Duquet, A.4
Moss, E.G.5
-
24
-
-
42649092874
-
Identification of ten loci associated with height highlights new biological pathways in human growth
-
Lettre G, Jackson AU, Gieger C, Schumacher FR, Berndt SI, et al. (2008) Identification of ten loci associated with height highlights new biological pathways in human growth. Nat Genet. 40: 584-591.
-
(2008)
Nat Genet
, vol.40
, pp. 584-591
-
-
Lettre, G.1
Jackson, A.U.2
Gieger, C.3
Schumacher, F.R.4
Berndt, S.I.5
-
25
-
-
66649105485
-
Genetic variation in LIN28B is associated with the timing of puberty
-
Ong KK, Elks CE, Li S, Zhao JH, Luan J, et al. (2009) Genetic variation in LIN28B is associated with the timing of puberty. Nat Genet. 41: 729-733.
-
(2009)
Nat Genet
, vol.41
, pp. 729-733
-
-
Ong, K.K.1
Elks, C.E.2
Li, S.3
Zhao, J.H.4
Luan, J.5
-
26
-
-
66649090056
-
Genome-wide association studies identify loci associated with age at menarche and age at natural menopause
-
He C, Kraft P, Chen C, Buring JE, Pare G, et al. (2009) Genome-wide association studies identify loci associated with age at menarche and age at natural menopause. Nat Genet. 41: 724-728.
-
(2009)
Nat Genet
, vol.41
, pp. 724-728
-
-
He, C.1
Kraft, P.2
Chen, C.3
Buring, J.E.4
Pare, G.5
-
28
-
-
84873589744
-
Candidate sequence variants and fetal hemoglobin in children with sickle cell disease treated with hydroxyurea
-
Green NS, Ender KL, Pashankar F, Driscoll C, Giardina PJ, et al. (2013) Candidate sequence variants and fetal hemoglobin in children with sickle cell disease treated with hydroxyurea. PLoS One. 8:e55709.
-
(2013)
PLoS One
, vol.8
, pp. e55709
-
-
Green, N.S.1
Ender, K.L.2
Pashankar, F.3
Driscoll, C.4
Giardina, P.J.5
-
29
-
-
84859209995
-
Hydroxycarbamide alters erythroid gene expression in children with sickle cell anaemia
-
Flanagan JM, Steward S, Howard TA, Mortier NA, Kimble AC, et al. (2012) Hydroxycarbamide alters erythroid gene expression in children with sickle cell anaemia. Br J Haematol. 157: 240-248.
-
(2012)
Br J Haematol
, vol.157
, pp. 240-248
-
-
Flanagan, J.M.1
Steward, S.2
Howard, T.A.3
Mortier, N.A.4
Kimble, A.C.5
-
30
-
-
77950930726
-
Transcriptional silencing of {gamma}-globin by BCL11A involves long-range interactions and cooperation with SOX6
-
Xu J, Sankaran VG, Ni M, Menne TF, Puram RV, et al. (2010) Transcriptional silencing of {gamma}-globin by BCL11A involves long-range interactions and cooperation with SOX6. Genes Dev 24: 783-798.
-
(2010)
Genes Dev
, vol.24
, pp. 783-798
-
-
Xu, J.1
Sankaran, V.G.2
Ni, M.3
Menne, T.F.4
Puram, R.V.5
-
32
-
-
0019805795
-
The intracellular polymerization of sickle hemoglobin and its relevance to sickle cell disease
-
Noguchi CT, Schechter AN (1981) The intracellular polymerization of sickle hemoglobin and its relevance to sickle cell disease. Blood 58: 1057-1068.
-
(1981)
Blood
, vol.58
, pp. 1057-1068
-
-
Noguchi, C.T.1
Schechter, A.N.2
-
33
-
-
84900342698
-
Direct measurement of local oxygen concentration in the bone marrow of live animals
-
Spencer JA, Ferraro F, Roussakis E, Klein A, Wu J, et al. (2014) Direct measurement of local oxygen concentration in the bone marrow of live animals. Nature 508: 269-273.
-
(2014)
Nature
, vol.508
, pp. 269-273
-
-
Spencer, J.A.1
Ferraro, F.2
Roussakis, E.3
Klein, A.4
Wu, J.5
-
35
-
-
0021931288
-
Hemoglobin S polymerization: Primary determinant of the hemolytic and clinical severity of the sickling syndromes
-
Brittenham GM, Schechter AN, Noguchi CT (1985) Hemoglobin S polymerization: primary determinant of the hemolytic and clinical severity of the sickling syndromes. Blood 65: 183-189.
-
(1985)
Blood
, vol.65
, pp. 183-189
-
-
Brittenham, G.M.1
Schechter, A.N.2
Noguchi, C.T.3
|