Exercise-induced expression of peroxisome proliferator-activated receptor γ coactivator-1α isoforms in skeletal muscle of endurance-trained males

Journal of Physiological Sciences

Volumn 64, Issue 5, 2014, Pages 317-323

  Popov, Daniil V ^a   Bachinin, Anton V ^a   Lysenko, Evgeny A ^a   Miller, Tatiana F ^a   Vinogradova, Olga L ^a  

^a INSTITUTE OF BIOMEDICAL PROBLEMS   (Russian Federation)

Author keywords

Alternative promoter; Exercise; Gene expression; PGC 1 gene; Skeletal muscle

Indexed keywords

ISOPROTEIN; MESSENGER RNA; PPARGC1A PROTEIN, HUMAN; TRANSCRIPTION FACTOR;

ENDURANCE; EXERCISE; GENETICS; HUMAN; MALE; METABOLISM; PHYSIOLOGY; SKELETAL MUSCLE;

EXERCISE; HUMANS; MALE; MUSCLE, SKELETAL; PHYSICAL ENDURANCE; PROTEIN ISOFORMS; RNA, MESSENGER; TRANSCRIPTION FACTORS;

EID: 84906944800     PISSN: 18806546     EISSN: None     Source Type: Journal    
DOI: 10.1007/s12576-014-0321-z     Document Type: Article

References (26)

1. Egan B, Carson BP, Garcia-Roves PM, Chibalin AV, Sarsfield FM, Barron N, McCaffrey N, Moyna NM, Zierath JR, O'Gorman DJ (2010) Exercise intensity-dependent regulation of peroxisome proliferator-activated receptor coactivator-1 mRNA abundance is associated with differential activation of upstream signalling kinases in human skeletal muscle. J Physiol 588:1779-1790
2. Sriwijitkamol A, Coletta DK, Wajcberg E, Balbontin GB, Reyna SM, Barrientes J, Eagan PA, Jenkinson CP, Cersosimo E, DeFronzo RA, Sakamoto K, Musi N (2007) Effect of acute exercise on AMPK signaling in skeletal muscle of subjects with type 2 diabetes: a time-course and dose-response study. Diabetes 56:836-848
3. Chen ZP, Stephens TJ, Murthy S, Canny BJ, Hargreaves M, Witters LA, Kemp BE, McConell GK (2003) Effect of exercise intensity on skeletal muscle AMPK signaling in humans. Diabetes 52:2205-2212
4. Olesen J, Kiilerich K, Pilegaard H (2010) PGC-1alpha-mediated adaptations in skeletal muscle. Pflugers Arch 460:153-162
5. Dumke CL, Mark DJ, Angela ME, Nieman DC, Carmichael MD, Quindry JC, Travis TN, Utter AC, Gross Gowin SJ, Henson DA, McAnulty SR, McAnulty LS (2009) Successive bouts of cycling stimulates genes associated with mitochondrial biogenesis. Eur J Appl Physiol 107:419-427
6. Wang L, Psilander N, Tonkonogi M, Ding S, Sahlin K (2009) Similar expression of oxidative genes after interval and continuous exercise. Med Sci Sports Exerc 41:2136-2144
7. Handschin C, Rhee J, Lin J, Tarr PT, Spiegelman BM (2003) An autoregulatory loop controls peroxisome proliferator-activated receptor gamma coactivator 1alpha expression in muscle. Proc Natl Acad Sci USA 100:7111-7116
8. Civitarese AE, Hesselink MK, Russell AP, Ravussin E, Schrauwen P (2005) Glucose ingestion during exercise blunts exercise-induced gene expression of skeletal muscle fat oxidative genes. Am J Physiol Endocrinol Metab 289:E1023-E1029
9. Pilegaard H, Saltin B, Neufer PD (2003) Exercise induces transient transcriptional activation of the PGC-1alpha gene in human skeletal muscle. J Physiol 546:851-858
10. Tadaishi M, Miura S, Kai Y, Kawasaki E, Koshinaka K, Kawanaka K, Nagata J, Oishi Y, Ezaki O (2011) Effect of exercise intensity and AICAR on isoform-specific expressions of murine skeletal muscle PGC-1alpha mRNA: a role of beta(2)-adrenergic receptor activation. Am J Physiol Endocrinol Metab 300:E341-E349
11. Baar K, Wende AR, Jones TE, Marison M, Nolte LA, Chen M, Kelly DP, Holloszy JO (2002) Adaptations of skeletal muscle to exercise: rapid increase in the transcriptional coactivator PGC-1. FASEB J 16:1879-1886
12. Zhang Y, Huypens P, Adamson AW, Chang JS, Henagan TM, Boudreau A, Lenard NR, Burk D, Klein J, Perwitz N, Shin J, Fasshauer M, Kralli A, Gettys TW (2009) Alternative mRNA splicing produces a novel biologically active short isoform of PGC-1alpha. J Biol Chem 284:32813-32826
13. Chang JS, Fernand V, Zhang Y, Shin J, Jun HJ, Joshi Y, Gettys TW (2012) NT-PGC-1alpha protein is sufficient to link beta3-adrenergic receptor activation to transcriptional and physiological components of adaptive thermogenesis. J Biol Chem 287:9100-9111
14. Chang JS, Huypens P, Zhang Y, Black C, Kralli A, Gettys TW (2010) Regulation of NT-PGC-1alpha subcellular localization and function by protein kinase A-dependent modulation of nuclear export by CRM1. J Biol Chem 285:18039-18050
15. Shen T, Liu Y, Schneider MF (2012) Localization and regulation of the N terminal splice variant of PGC-1alpha in adult skeletal muscle fibers. J Biomed Biotechnol 2012:989263
16. Thom R, Rowe GC, Jang C, Safdar A, Arany Z (2014) Hypoxic induction of vascular endothelial growth factor (VEGF) and angiogenesis in muscle by truncated peroxisome proliferator-activated receptor gamma coactivator (PGC)-1alpha. J Biol Chem 289(13):8810-8817
17. Ruas JL, White JP, Rao RR, Kleiner S, Brannan KT, Harrison BC, Greene NP, Wu J, Estall JL, Irving BA, Lanza IR, Rasbach KA, Okutsu M, Nair KS, Yan Z, Leinwand LA, Spiegelman BM (2012) A PGC-1alpha isoform induced by resistance training regulates skeletal muscle hypertrophy. Cell 151:1319-1331
18. Norrbom J, Sallstedt EK, Fischer H, Sundberg CJ, Rundqvist H, Gustafsson T (2011) Alternative splice variant PGC-1alpha-b is strongly induced by exercise in human skeletal muscle. Am J Physiol Endocrinol Metab 301:E1092-E1098
19. Perry CG, Lally J, Holloway GP, Heigenhauser GJ, Bonen A, Spriet LL (2010) Repeated transient mRNA bursts precede increases in transcriptional and mitochondrial proteins during training in human skeletal muscle. J Physiol 588:4795-4810
20. Hayot M, Michaud A, Koechlin C, Caron MA, LeBlanc P, Prefaut C, Maltais F (2005) Skeletal muscle microbiopsy: a validation study of a minimally invasive technique. Eur Respir J 25:431-440
21. Miura S, Kai Y, Kamei Y, Ezaki O (2008) Isoform-specific increases in murine skeletal muscle peroxisome proliferator-activated receptor-gamma coactivator-1alpha (PGC-1alpha) mRNA in response to beta2-adrenergic receptor activation and exercise. Endocrinology 149:4527-4533
22. Felder TK, Soyal SM, Oberkofler H, Hahne P, Auer S, Weiss R, Gadermaier G, Miller K, Krempler F, Esterbauer H, Patsch W (2011) Characterization of novel peroxisome proliferator-activated receptor gamma coactivator-1alpha (PGC-1alpha) isoform in human liver. J Biol Chem 286:42923-42936
23. Soyal SM, Felder TK, Auer S, Hahne P, Oberkofler H, Witting A, Paulmichl M, Landwehrmeyer GB, Weydt P, Patsch W (2012) A greatly extended PPARGC1A genomic locus encodes several new brain-specific isoforms and influences Huntington disease age of onset. Hum Mol Genet 21:3461-3473
24. Richter EA, Ruderman NB (2009) AMPK and the biochemistry of exercise: implications for human health and disease. Biochem J 418:261-275
25. Chinsomboon J, Ruas J, Gupta RK, Thom R, Shoag J, Rowe GC, Sawada N, Raghuram S, Arany Z (2009) The transcriptional coactivator PGC-1alpha mediates exercise-induced angiogenesis in skeletal muscle. Proc Natl Acad Sci USA 106:21401-21406
26. Miura S, Kawanaka K, Kai Y, Tamura M, Goto M, Shiuchi T, Minokoshi Y, Ezaki O (2007) An increase in murine skeletal muscle peroxisome proliferator-activated receptor-gamma coactivator-1alpha (PGC-1alpha) mRNA in response to exercise is mediated by beta-adrenergic receptor activation. Endocrinology 148:3441-3448