Long-term renin-angiotensin blocking therapy in hypertensive patients with normal aorta may attenuate the formation of abdominal aortic aneurysms

Journal of the American Society of Hypertension

Volumn 8, Issue 8, 2014, Pages 571-577

  Silverberg, Daniel ^a   Younis, Anan ^a   Savion, Naphtali ^b   Harari, Gil ^c   Yakubovitch, Dmitry ^a   Sheick Yousif, Basheer ^a   Halak, Moshe ^a   Grossman, Ehud ^a   Schneiderman, Jacob ^a,b  

^a SHEBA MEDICAL CENTER   (Israel)

^b TEL AVIV UNIVERSITY   (Israel)

^c Medistat Ltd Tel Aviv   (Israel)

Author keywords

Angiotensin II; leptin; vascular remodeling

Indexed keywords

ANGIOTENSIN RECEPTOR ANTAGONIST; ANTIHYPERTENSIVE AGENT; BETA ADRENERGIC RECEPTOR BLOCKING AGENT; CALCIUM ANTAGONIST; DIPEPTIDYL CARBOXYPEPTIDASE INHIBITOR; DIURETIC AGENT; HYDROXYMETHYLGLUTARYL COENZYME A REDUCTASE INHIBITOR; ANGIOTENSIN 1 RECEPTOR ANTAGONIST;

ABDOMINAL AORTA; ABDOMINAL AORTA ANEURYSM; AGED; ANTIHYPERTENSIVE THERAPY; ARTICLE; BODY MASS; CONTROLLED STUDY; DIASTOLIC BLOOD PRESSURE; ECHOGRAPHY; FEMALE; HUMAN; HYPERCHOLESTEROLEMIA; HYPERTENSION; MAJOR CLINICAL STUDY; MALE; PRIORITY JOURNAL; RENIN ANGIOTENSIN ALDOSTERONE SYSTEM; SYSTOLIC BLOOD PRESSURE; TREATMENT DURATION; AORTIC ANEURYSM, ABDOMINAL; BLOOD PRESSURE; COMPLICATION; DRUG EFFECTS; DUPLEX DOPPLER ULTRASONOGRAPHY; FOLLOW UP; PATHOPHYSIOLOGY; PROGNOSIS; RETROSPECTIVE STUDY; TIME FACTOR; VASCULAR REMODELING;

AGED; ANGIOTENSIN II TYPE 1 RECEPTOR BLOCKERS; ANGIOTENSIN-CONVERTING ENZYME INHIBITORS; AORTA, ABDOMINAL; AORTIC ANEURYSM, ABDOMINAL; BLOOD PRESSURE; FEMALE; FOLLOW-UP STUDIES; HUMANS; HYPERTENSION; MALE; PROGNOSIS; RENIN-ANGIOTENSIN SYSTEM; RETROSPECTIVE STUDIES; TIME FACTORS; ULTRASONOGRAPHY, DOPPLER, DUPLEX; VASCULAR REMODELING;

EID: 84906938226     PISSN: 19331711     EISSN: 18787436     Source Type: Journal    
DOI: 10.1016/j.jash.2014.04.005     Document Type: Article

References (31)

1. M. Wang, G. Takagi, K. Asai, R.G. Resuello, F.F. Natividad, and D.E. Vatner et al. Aging increases aortic MMP-2 activity and angiotensin II in nonhuman primates Hypertension 41 2003 1308 1316
2. F.J. Miller Jr., W.J. Sharp, X. Fang, L.W. Oberley, T.D. Oberley, and N.L. Weintraub Oxidative stress in human abdominal aortic aneurysms. A potential mediator of aneurysmal remodeling Atheroscler Thromb Vasc Biol 22 2002 560 565
3. M.P. Jacob Extracellular matrix remodeling and matrix metalloproteinases in the vascular wall during aging and in pathological conditions Biomed Pharmacother 57 2003 195 202
4. J. Schneiderman, G.M. Bordin, I. Engelberg, R. Adar, D. Seiffert, and T. Thinnes et al. Expression of fibrinolytic genes in atherosclerotic abdominal aortic aneurysm wall. A possible mechanism for aneurysm expansion J Clin Invest 96 1995 639 645
5. A. Daugherty, M.W. Manning, and L.A. Cassis Angiotensin II promotes atherosclerotic lesions and aneurysms in apolipoprotein E-deficient mice J Clin Invest 105 2000 1605 1612
6. D.N. Muller, and F.C. Luft The renin-angiotensin system in the vessel wall Basic Res Cardiol 93 Suppl2 1998 7 14
7. S. Heeneman, J.C. Sluimer, and M.J.A.P. Daemen Angiotensin-converting enzyme and vascular remodeling Circ Res 101 2007 441 454
8. P.L. Tharaux, C. Chatziantoniou, F. Fakhouri, and J.C. Dussaule Angiotensin activates collagen I gene through mechanism involving the MAP/ER kinase pathway Hypertension 36 2000 330 336
9. J.T. Favreau, B.T. Nguyen, I. Gao, P. Yu, M. Tao, and J. Schneiderman et al. Murine ultrasound imaging for circumferential strain analysis in angiotensin II abdominal aortic aneurysm model J Vasc Surg 56 2012 462 469
10. A. Daugherty, D.L. Rateri, and L.A. Cassis Role of the renin-angiotensin system in the development of abdominal aortic aneurysms in animals and humans NY Acad Sci 1085 2006 82 91
11. R. Cao, T. St. Amand, M.D. Ford, U. Piomelli, and C.D. Funk The murine angiotensin II induced abdominal aortic aneurysm model: rupture risk and inflammatory progression patterns Front Pharma 1 2010 1 7
12. A. Daugherty, M.W. Manning, and L.A. Cassis Antagonism of AT2 receptors augments Angiotensin II-induced abdominal aortic aneurysms and atherosclerosis Br J Pharmacol 134 2001 865 870
13. Sweeting MJ, Thompson SG, Brown LC, Powell JT, on behalf of the RESCAN collaborators. Meta-analysis of individual patient data to examine factors affecting growth and rupture of small abdominal aortic aneurysms. Br J Surg 2012;99:655-665.
14. The AARDVARK trial, http://www1.imperial.ac.uk/clinicaltrialsunit/ cuirrenttrials/aardvark/.
15. A. Thompson, J.A. Cooper, M. Fabrius, S.E. Humphries, H.A. Ashton, and H. Hafez An analysis of drug modulation of abdominal aortic aneurysm growth through 25 years of surveillance J Vasc Surg 52 2010 55 61
16. F.A. Lederle, G.R. Johnson, S.E. Wilson, E.P. Chute, R.J. Hye, and M.S. Makaroun et al. The aneurysm detection and management study screening program: validation cohort and final results. Aneurysm Detection and Management Veterans Affairs Cooperative Study Investigators Arch Inter Med 160 2000 1425 1430
17. M.M. Due, N. Miyama, J. Azuma, G.M. Schultz, M. Sho, and J. Morser et al. Hyperglycemia modulates plasminogen activator inhibitor-1 expression and aortic diameter in experimental aortic aneurysm disease Surgery 148 2010 429 435
18. T.B.M. Wilmink, C.R.G. Quick, and N.E. Day The association between cigarette smoking and abdominal aortic aneurysms J Vasc Surg 30 1999 1099 1105
19. US prevention task force Screening for abdominal aortic aneurysm: recommendation statement Ann Inter Med 142 2005 198 202
20. A.B.M. Wilmink, C.S.F.F. Hubbard, N.E. Day, and C.R.G. Quick Effect of propranolol on the expansion of abdominal aortic aneurysms: a randomized study [abstract] Br J Surg 87 2000 499
21. Y. Lida, B. Xu, G.M. Schultz, V. Chow, J.J. White, and S. Sulaimon et al. Efficacy and mechanism of angiotensin II receptor blocker treatment in experimental abdominal aortic aneurysms Plos one 7 2012 e49642
22. L.A. Cassis, M. Gupte, S. Thayer, X. Zhang, R. Charnigo, and D.A. Howatt et al. Ang II infusion promotes abdominal aortic aneurysms independent of increased blood pressure in hypercholesterolemic mice Am J Physiol 296 2009 H1660 H1665
23. P. Matt, F. Schoenhoff, J. Habashi, T. Holm, C. Van Erp, and D. Loch et al. Circulating transforming growth factor-β in Marfan syndrome Circulation 120 2009 526 532
24. J.P. Habashi, D.P. Judge, T.M. Holm, R.D. Cohn, B.L. Loeys, and T.K. Cooper et al. Losartan, an AT1 antagonist, prevents aortic aneurysm in a mouse model of Marfan syndrome Science 312 2006 117 121
25. Y. Wang, H. Ait-Oufella, O. Herbin, P. Bonnin, B. Ramkhelawon, and S. Taleb et al. TGF-β activity protects against inflammatory aortic aneurysm progression and complications in angiotensin II-infused mice J Clin Invest 120 2010 422 432
26. B.S. Brooke, J.P. Habashi, D.P. Judge, N. Patel, B. Loeys, and H.C. Dietz III Angiotensin II blockade and aortic-root dilation in Marfan's syndrome NEJM 358 2008 2787 2795
27. M. Tao, P. Yu, B.T. Nguyen, B. Mizrahi, N. Savion, and F.D. Kolodgie et al. Locally applied leptin induces regional aortic wall degeneration preceding aneurysm formation in apolipoprotein E-deficient mice Arterioscler Thromb Vasc Biol 33 2013 311 320
28. K. Schäfer, M. Halle, C. Goeschen, C. Dellas, M. Pynn, and D.J. Loskutoff et al. Leptin promotes vascular remodeling and neointimal growth in mice Arterioscler Thromb Vasc Biol 24 2004 112 117
29. B. Nguyen, B. Mizrahi, N. Savion, M. Tao, G.K. Sukhova, and F. Kolodgie et al. Periaortic leptin augments the aneurysmogenic effect of angiotensin II in apolipoprotein E deficient mice Circulation 124 2011 A16562
30. J. Sun, J. Zhang, J.S. Lindholt, G.K. Sukhova, J. Liu, and A. He et al. Critical role of mast cell chymase in mouse abdominal aortic aneurysm formation Circulation 120 2009 973 982
31. M. Li, K. Liu, J. Michalicek, J.A. Angus, J.E. Hunt, and L.J. Dell'Italia et al. Involvement of chymase-mediated angiotensin II generation in blood pressure regulation J Clin Invest 114 2004 112 120