Role of the renin-angiotensin system in the development of abdominal aortic aneurysms in animals and humans

Annals of the New York Academy of Sciences

Volumn 1085, Issue , 2006, Pages 82-91

  Daugherty, Alan ^a   Rateri, Debra L ^a   Cassis, Lisa A ^a  

^a UNIVERSITY OF KENTUCKY   (United States)

Author keywords

Angiotensin; Animal models; Aortic aneurysms

Indexed keywords

1 (4 DIMETHYLAMINO 3 METHYLBENZYL) 5 DIPHENYLACETYL 4,5,6,7 TETRAHYDRO 1H IMIDAZO[4,5 C]PYRIDINE 6 CARBOXYLIC ACID; 5 (4 CHLOROPHENYL) 1 (4 METHOXYPHENYL) 3 TRIFLUOROMETHYL 1H PYRAZOLE; ALPHA TOCOPHEROL; ANGIOTENSIN 1 RECEPTOR ANTAGONIST; ANGIOTENSIN 2 RECEPTOR ANTAGONIST; ANGIOTENSIN II; ANTHRA[1,9 CD]PYRAZOL 6(2H) ONE; ANTIOXIDANT; CAPTOPRIL; CELECOXIB; CHEMOKINE RECEPTOR CCR2; CYCLOOXYGENASE 1 INHIBITOR; CYCLOOXYGENASE 2 INHIBITOR; DOXYCYCLINE; ELASTASE; ENALAPRIL; ESTRADIOL; FASUDIL; LISINOPRIL; LOSARTAN; OLMESARTAN; OSTEOPONTIN; RHO KINASE INHIBITOR; SPIRONOLACTONE; TEMOCAPRIL; UROKINASE; APOLIPOPROTEIN E;

ABDOMINAL AORTA ANEURYSM; AORTA; CONFERENCE PAPER; DISEASE COURSE; DNA POLYMORPHISM; GENETIC ASSOCIATION; HUMAN; IMMUNOCYTOCHEMISTRY; INFLAMMATORY CELL; MACROPHAGE; NONHUMAN; ORCHIECTOMY; OVARIECTOMY; RENIN ANGIOTENSIN ALDOSTERONE SYSTEM; THROMBUS; ANIMAL; BIOLOGICAL MODEL; CHEMICALLY INDUCED DISORDER; GENETICS; METABOLISM; PATHOLOGY; REVIEW;

ANIMALIA; MUS;

ANGIOTENSIN II; ANIMALS; AORTIC ANEURYSM, ABDOMINAL; APOLIPOPROTEINS E; HUMANS; MODELS, BIOLOGICAL; RENIN-ANGIOTENSIN SYSTEM;

EID: 34447574553     PISSN: 00778923     EISSN: 17496632     Source Type: Book Series    
DOI: 10.1196/annals.1383.035     Document Type: Conference Paper

References (39)

1. DAUGHERTY, A. & L. CASSIS. 2004. Angiotensin II and abdominal aortic aneurysms. Curr. Hypertens. Rep. 6: 442-446.
2. DAUGHERTY, A. & L. CASSIS. 1999. Chronic angiotensin II infusion promotes atherogenesis in low density lipoprotein receptor -/- mice. Ann. N. Y. Acad. Sci. 892: 108-118.
3. DAUGHERTY, A., M.W. MANNING, & L.A. CASSIS. 2000. Angiotensin II promotes atherosclerotic lesions and aneurysms in apolipoprotein E-deficient mice. J. Clin. Invest. 105: 1605-1612.
4. WANG, Y.X., B. MARTIN MCNULTY, A.D. FREAY, et al. 2001. Angiotensin II increases urokinase-type plasminogen activator expression and induces aneurysm in the abdominal aorta of apolipoprotein E-deficient mice. Am. J. Pathol. 159: 1455-1464.
5. BRUEMMER, D., A.R. COLLINS, G. NOH, et al. 2003. Angiotensin II-accelerated atherosclerosis and aneurysm formation is attenuated in osteopontin-deficient mice. J. Clin. Invest. 112: 1318-1331.
6. ISHIBASHI, M., K. EGASHIRA, Q. ZHAO, et al. 2004. Bone marrow-derived monocyte chemoattractant protein-1 receptor CCR2 is critical in angiotensin II-induced acceleration of atherosclerosis and aneurysm formation in hypercholesterolemic mice. Arterioscler. Thromb. Vasc. Biol. 24: e174-e178.
7. GAVRILA, D., W.G. LI, M.L. MCCORMICK, et al. 2005.Vitamin E inhibits abdominal aortic aneurysm formation in angiotensin ii-infused, apolipoprotein E-deficient mice. Arterioscler. Thromb. Vasc. Biol. 25: 1671-1677.
8. AYABE, N., V.R. BABAEV, Y. TANG, et al. 2005.Transiently heightened angiotensin II has distinct effects on atherosclerosis and aneurysm formation in hyperlipidemic mice. Atherosclerosis 184: 312-321.
9. DENG, G.G., B. MARTIN-MCNULTY, D.A. SUKOVICH, et al. 2003. Urokinase-type plasminogen activator plays a critical role in angiotensin II-induced abdominal aortic aneurysm. Circ. Res. 92: 510-517.
10. MANNING, M.W., L.A. CASSIS, J. HUANG, et al. 2002. Abdominal aortic aneurysms: fresh insights from a novel animal model of the disease. Vasc. Med. 7: 45-54.
11. HENRIQUES, T.A., J. HUANG, S.S. D'SOUZA, et al. 2004. Orchiectomy, but not ovariectomy, regulates angiotensin ii-induced vascular diseases in apolipoprotein E deficient mice. Endocrinology 145: 3866-3872.
12. TANGIRALA, R.K., E.M. RUBIN & W. PALINSKI. 1995. Quantitation of atherosclerosis in murine models: correlation between lesions in the aortic origin and in the entire aorta, and differences in the extent of lesions between sexes in LDL receptor-deficient and apolipoprotein E-deficient mice. J. Lipid Res. 36: 2320-2328.
13. CARMELIET, P., L. MOONS, R. LIJNEN, et al. 1997. Urokinase-generated plasmin activates matrix metalloproteinases during aneurysm formation. Nature Genet. 17: 439-444.
14. DAUGHERTY, A. & L.A. CASSIS. 2004. Mouse models of abdominal aortic aneurysms. Arterioscler. Thromb. Vasc. Biol. 24: 429-434.
15. KUHLENCORDT, P.J., R. GYURKO, F. HAN, et al. 2001. Accelerated atherosclerosis, aortic aneurysm formation, and ischemic heart disease in apolipoprotein E/endothelial nitric oxide synthase double-knockout mice. Circulation 104: 448-454.
16. MANNING, M.W., L.A. CASSIS, & A. DAUGHERTY. 2003. Differential effects of doxycycline, a broad-spectrum matrix metalloproteinase inhibitor, on angiotensin II-induced atherosclerosis and abdominal aortic aneurysms. Arterioscler. Thromb. Vasc. Biol. 23: 483-488.
17. SARAFF, K., F. BABAMUSTA, L.A. CASSIS & A. DAUGHERTY. 2003. Aortic dissection precedes formation of aneurysms and atherosclerosis in angiotensin II-infused, apolipoprotein E-deficient mice. Arterioscler. Thromb. Vasc. Biol. 23: 1621-1626.
18. BARISIONE, C., R.J. CHARNIGO, D.A. HOWATT, et al. 2006. Rapid dilation of the abdominal aorta during infusion of angiotensin II detected by noninvasive high frequency ultrasound. J. Vasc. Surg. 44: 372-376.
19. MARTIN-MCNULTY, B., J. VINCELETTE, R. VERGONA, et al. 2005. Noninvasive measurement of abdominal aortic aneurysms in intact mice by a high frequency ultrasound imaging system. Ultrasound Med. Biol. 31: 746-749.
20. ANIDJAR, S., P.B. DOBRIN, M. EICHORST, et al. 1992. Correlation of inflammatory infiltrate with the enlargement of experimental aortic aneurysms. J. Vasc. Surg. 16: 139-147.
21. PYO, R., J.K. LEE, J.M. SHIPLEY, et al. 2000. Targeted gene disruption of matrix metalloproteinase-9 (gelatinase B) suppresses development of experimental abdominal aortic aneurysms. J. Clin. Invest. 105: 1641-1649.
22. SINHA, I., K.K. HANNAWA, G. AILAWADI, et al. 2006. The nitric oxide donor DETANONOate decreases matrix metalloproteinase-9 expression and activity in rat aortic smooth muscle and abdominal aortic explants. Ann. Vasc. Surg. 20: 92-98.
23. LIAO, S., M. MIRALLES, B.J. KELLEY, et al. 2001. Suppression of experimental abdominal aortic aneurysms in the rat by treatment with angiotensin-converting enzyme inhibitors. J. Vasc. Surg. 33: 1057-1064.
24. NAGASHIMA, H., K. UTO, Y. SAKOMURA, et al. 2002. An angiotensin-converting enzyme inhibitor, not an angiotensin II type-1 receptor blocker, prevents betaaminopropionitrile monofumarate-induced aortic dissection in rats. J.Vasc. Surg. 36: 818-823.
25. HUANG, W., F. ALHENC GELAS & M.J. OSBORNE-PELLEGRIN. 1998. Protection of the arterial internal elastic lamina by inhibition of the renin-angiotensin system in the rat. Circ. Res. 82: 879-890.
26. FATINI, C., G. PRATESI, F. SOFI, et al. 2005. ACE DD genotype: a predisposing factor for abdominal aortic aneurysm. Eur. J. Vasc. Endovasc. Surg. 29: 227-232.
27. POLA, R., E. GAETANI, A. SANTOLIQUIDO, et al. 2001. Abdominal aortic aneurysm in normotensive patients: association with angiotensin-converting enzyme gene polymorphism. Eur. J. Vasc. Endovasc. Surg. 21: 445-449.
28. HAMANO, K., M. OHISHI, M. UEDA, et al. 1999. Deletion polymorphism in the gene for angiotensin-converting enzyme is not a risk factor predisposing to abdominal aortic aneurysm. Eur. J. Vasc. Endovasc. Surg. 18: 158-161.
29. YEUNG, J.M., M. HEELEY, S. GRAY, et al. 2002. Does the angiotensin-converting enzyme (ACE) gene polymorphism affect rate of abdominal aortic aneurysm expansion? Eur. J. Vasc. Endovasc. Surg. 24: 69-71.
30. IHARA, M., H. URATA, A. KINOSHITA, et al. 1999. Increased chymase-dependent angiotensin II formation in human atherosclerotic aorta. Hypertension 33: 1399-1405.
31. NISHIMOTO, M., S. TAKAI, H. FUKUMOTO, et al. 2002. Increased local angiotensin II formation in aneurysmal aorta. Life Sciences 71: 2195-2205.
32. MORAN, C.S., M. MCCANN, M. KARAN, et al. 2005. Association of osteoprotegerin with human abdominal aortic aneurysm progression. Circulation 111: 3119-3125.
33. AZIZI, M., R. WEBB, J. NUSSBERGER & N.K. HOLLENBERG. 2006. Renin inhibition with aliskiren: where are we now, and where are we going? J. Hypertens. 24: 243-256.
34. DAUGHERTY, A., M.W. MANNING & L.A. CASSIS. 2001. Antagonism of AT2 receptors augments Angiotensin II-induced abdominal aortic aneurysms and atherosclerosis. Br. J. Pharmacol. 134: 865-870.
35. MARTIN-MCNULTY, B., D.M. THAM, V. DA CUNHA, et al. 2003. 17 beta-estradiol attenuates development of angiotensin II induced aortic abdominal aneurysm in apolipoprotein E deficient mice. Arterioscler. Thromb. Vasc. Biol. 23: 1627-1632.
36. CASSIS, L.A., M.J. HELTON, D.A. HOWATT, et al. 2005. Aldosterone does not mediate angiotensin II-induced atherosclerosis and abdominal aortic aneurysms. Br. J. Pharmacol. 144: 443-448.
37. WANG, Y.X., B. MARTIN-MCNULTY, V. DA CUNHA, et al. 2005. Fasudil, a Rhokinase inhibitor, attenuates angiotensin II-induced abdominal aortic aneurysm in apolipoprotein E-deficient mice by inhibiting apoptosis and proteolysis. Circulation 111: 2219-2226.
38. YOSHIMURA, K., H. AOKI, Y. IKEDA, et al. 2005. Regression of abdominal aortic aneurysm by inhibition of c-Jun N-terminal kinase. Nat. Med. 11: 1330-1338.
39. KING, V.L., D. TRIVEDI, J.M. GITLIN, & C.D. LOFTIN. 2006. Selective cyclooxygenase-2 inhibition with celecoxib decreases angiotensin II-induced abdominal aortic aneurysm formation in mice. Arterioscler Thromb. Vasc. Biol. 26: 1137-1143.