Locally applied leptin induces regional aortic wall degeneration preceding aneurysm formation in apolipoprotein E-deficient mice

Arteriosclerosis, Thrombosis, and Vascular Biology

Volumn 33, Issue 2, 2013, Pages 311-320

  Tao, Ming ^a   Yu, Peng ^a   Nguyen, Binh T ^a   Mizrahi, Boaz ^b   Savion, Naphtali ^c   Kolodgie, Frank D ^d   Virmani, Renu ^d   Hao, Shuai ^a   Ozaki, C Keith ^a   Schneiderman, Jacob ^a,c  

^a HARVARD MEDICAL SCHOOL   (United States)

^b BOSTON CHILDREN S HOSPITAL   (United States)

^c TEL AVIV UNIVERSITY   (Israel)

^d CVPATH INSTITUTE   (United States)

Author keywords

abdominal aortic aneurysm; angiotensin II; leptin; transforming growth factor ; vessel wall remodeling

Indexed keywords

ANGIOTENSIN II; APOLIPOPROTEIN E; GELATINASE B; LEPTIN; LEPTIN RECEPTOR; MACROPHAGE ELASTASE; MESSENGER RNA; TRANSFORMING GROWTH FACTOR BETA;

ABDOMINAL AORTA ANEURYSM; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; AORTIC WALL DEGENERATION; ARTICLE; ATHEROSCLEROSIS; CONTROLLED STUDY; ECHOGRAPHY; IN VIVO STUDY; MALE; MOUSE; NONHUMAN; PRIORITY JOURNAL; PROTEIN SYNTHESIS;

ANGIOTENSIN II; ANIMALS; AORTA, ABDOMINAL; AORTIC ANEURYSM, ABDOMINAL; APOLIPOPROTEINS E; DELAYED-ACTION PREPARATIONS; DILATATION, PATHOLOGIC; DISEASE MODELS, ANIMAL; HUMANS; LEPTIN; MACROPHAGES; MALE; MATRIX METALLOPROTEINASE 12; MATRIX METALLOPROTEINASE 9; MICE; MICE, INBRED C57BL; MICE, KNOCKOUT; RECEPTORS, LEPTIN; RNA, MESSENGER; TIME FACTORS; TRANSFORMING GROWTH FACTOR BETA;

EID: 84872959139     PISSN: 10795642     EISSN: 15244636     Source Type: Journal    
DOI: 10.1161/ATVBAHA.112.300543     Document Type: Article

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