Cytoprotective pyridinol antioxidants as potential therapeutic agents for neurodegenerative and mitochondrial diseases

Bioorganic and Medicinal Chemistry

Volumn 22, Issue 17, 2014, Pages 4935-4947

  Alam, Mohammad Parvez ^a   Khdour, Omar M ^a   Arce, Pablo M ^a   Chen, Yana ^a   Roy, Basab ^a   Johnson, Walter G ^a   Dey, Sriloy ^a   Hecht, Sidney M ^a  

^a Arizona State University   (United States)

Author keywords

Cytoprotection; Lipid peroxidation; Microsomal stability; Mitochondria; Reactive oxygen species

Indexed keywords

6 (AZETIDIN 1 YL) 2 HEXADECYL 4,5 DIMETHYLPYRIDIN 3 OL; 6 (AZETIDIN 1 YL) 4 HEXADECYL 2,5 DIMETHYLPYRIDIN 3 OL; 6 N,N DIMETHYLAMINO 2 DECYL 4,5 DIMETHYLPYRIDIN 3 OL; 6 N,N DIMETHYLAMINO 2 HEXADECYL 4,5 DIMETHYLPYRIDIN 3 OL; 6 N,N DIMETHYLAMINO 2 NONADECYL 4,5 DIMETHYLPYRIDIN 3 OL; 6 N,N DIMETHYLAMINO 4 DECYL 2,5 DIMETHYLPYRIDIN 3 OL; 6 N,N DIMETHYLAMINO 4 HEXADECYL 2,5 DIMETHYLPYRIDIN 3 OL; 6 N,N DIMETHYLAMINO 4 NONADECYL 2,5 DIMETHYLPYRIDIN 3 OL; ADENOSINE TRIPHOSPHATE; ANTIOXIDANT; AZETIDINE; PYRIDINOL; REACTIVE OXYGEN METABOLITE; UNCLASSIFIED DRUG; NEUROPROTECTIVE AGENT; PYRIDINE DERIVATIVE;

ANIMAL CELL; ANTIOXIDANT ACTIVITY; ARTICLE; CELL PROTECTION; CONTROLLED STUDY; DEGENERATIVE DISEASE; DISORDERS OF MITOCHONDRIAL FUNCTIONS; DRUG METABOLISM; DRUG STRUCTURE; DRUG SYNTHESIS; HUMAN; HUMAN CELL; IN VITRO STUDY; LIPID PEROXIDATION; MITOCHONDRIAL MEMBRANE POTENTIAL; NONHUMAN; OXIDATION REDUCTION STATE; ANIMAL; ANTAGONISTS AND INHIBITORS; BOVINAE; CELL CULTURE; CHEMICAL STRUCTURE; CHEMISTRY; DOSE RESPONSE; DRUG EFFECTS; LIVER MICROSOME; LYMPHOCYTE; METABOLISM; MITOCHONDRIAL DISEASES; NEURODEGENERATIVE DISEASES; PATHOLOGY; STRUCTURE ACTIVITY RELATION; SYNTHESIS;

BOVINAE;

ANIMALS; ANTIOXIDANTS; CATTLE; CELLS, CULTURED; CYTOPROTECTION; DOSE-RESPONSE RELATIONSHIP, DRUG; HUMANS; LIPID PEROXIDATION; LYMPHOCYTES; MEMBRANE POTENTIAL, MITOCHONDRIAL; MICROSOMES, LIVER; MITOCHONDRIAL DISEASES; MOLECULAR STRUCTURE; NEURODEGENERATIVE DISEASES; NEUROPROTECTIVE AGENTS; PYRIDINES; REACTIVE OXYGEN SPECIES; STRUCTURE-ACTIVITY RELATIONSHIP;

EID: 84906936978     PISSN: 09680896     EISSN: 14643391     Source Type: Journal    
DOI: 10.1016/j.bmc.2014.06.040     Document Type: Article

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