A polymorphism near MC4R gene (rs17782313) is associated with serum triglyceride levels in the general Japanese population: The J-MICC Study

Endocrine

Volumn 47, Issue 1, 2014, Pages 81-89

  Katsuura Kamano, Sakurako ^a   Uemura, Hirokazu ^a   Arisawa, Kokichi ^a   Yamaguchi, Miwa ^a   Hamajima, Nobuyuki ^b   Wakai, Kenji ^b   Okada, Rieko ^b   Suzuki, Sadao ^c   Taguchi, Naoto ^d   Kita, Yoshikuni ^e   Ohnaka, Keizo ^f   Kairupan, Tara Sefanya ^g   Matsui, Daisuke ^h   Oze, Isao ⁱ   Mikami, Haruo ^j   Kubo, Michiaki ^k   Tanaka, Hideo ⁱ  

^a UNIVERSITY OF TOKUSHIMA   (Japan)

^b NAGOYA UNIVERSITY GRADUATE SCHOOL OF MEDICINE   (Japan)

^c NAGOYA CITY UNIVERSITY GRADUATE SCHOOL OF MEDICAL SCIENCES   (Japan)

^d SAGA UNIVERSITY   (Japan)

^e SHIGA UNIVERSITY OF MEDICAL SCIENCE   (Japan)

^f KYUSHU UNIVERSITY   (Japan)

^g KAGOSHIMA UNIVERSITY   (Japan)

^h KYOTO PREFECTURAL UNIVERSITY OF MEDICINE   (Japan)

ⁱ AICHI CANCER CENTER HOSPITAL   (Japan)

^j CHIBA CANCER CENTER   (Japan)

^k RIKEN   (Japan)

more..

Author keywords

Body mass index; MC4R; Polymorphism; Triglycerides

Indexed keywords

CHOLESTEROL; MELANOCORTIN 4 RECEPTOR; TRIACYLGLYCEROL; MC4R PROTEIN, HUMAN;

ADULT; AGE; AGED; ALLELE; ARTICLE; BODY HEIGHT; BODY MASS; BODY WEIGHT; CALORIC INTAKE; CHOLESTEROL BLOOD LEVEL; FEMALE; GENOTYPE; HUMAN; JAPANESE (PEOPLE); MACRONUTRIENT; MALE; MC4R GENE; NUTRIENT; OBESITY; PRIORITY JOURNAL; QUESTIONNAIRE; SEX; SINGLE NUCLEOTIDE POLYMORPHISM; TRIACYLGLYCEROL BLOOD LEVEL; WEIGHT CHANGE; ASIAN CONTINENTAL ANCESTRY GROUP; BLOOD; EPIDEMIOLOGY; GENE LOCUS; GENETIC ASSOCIATION; GENETICS; JAPAN; LIPID METABOLISM; MIDDLE AGED; MULTICENTER STUDY (TOPIC); STATISTICS AND NUMERICAL DATA;

ADULT; AGED; ASIAN CONTINENTAL ANCESTRY GROUP; BODY MASS INDEX; FEMALE; GENETIC ASSOCIATION STUDIES; GENETIC LOCI; HUMANS; JAPAN; LIPID METABOLISM; MALE; MIDDLE AGED; MULTICENTER STUDIES AS TOPIC; POLYMORPHISM, SINGLE NUCLEOTIDE; RECEPTOR, MELANOCORTIN, TYPE 4; TRIGLYCERIDES;

EID: 84906935301     PISSN: 1355008X     EISSN: 15590100     Source Type: Journal    
DOI: 10.1007/s12020-014-0306-y     Document Type: Article

References (30)

1. J.B. Dixon, The effect of obesity on health outcomes. Mol. Cell. Endocrinol. 316(2), 104-108 (2010). doi:10.1016/j.mce.2009.07.008
2. H.H. Maes, M.C. Neale, L.J. Eaves, Genetic and environmental factors in relative body weight and human adiposity. Behav. Genet. 27(4), 325-351 (1997)
3. M.M. Hetherington, J.E. Cecil, Gene-environment interactions in obesity. Forum Nutr. 63, 195-203 (2009). doi:10.1159/000264407
4. C. Bouchard, Gene-environment interactions in the etiology of obesity: defining the fundamentals. Obesity (Silver Spring) 16(Suppl 3), S5-S10 (2008). doi:10.1038/oby.2008.528
5. R.J. Loos, C.M. Lindgren, S. Li, E. Wheeler, J.H. Zhao, I. Prokopenko, M. Inouye, R.M. Freathy, A.P. Attwood, J.S. Beckmann, S.I. Berndt, K.B. Jacobs, S.J. Chanock, R.B. Hayes, S. Bergmann, A.J. Bennett, S.A. Bingham, M. Bochud, M. Brown, S. Cauchi, J.M. Connell, C. Cooper, G.D. Smith, I. Day, C. Dina, S. De, E.T. Dermitzakis, A.S. Doney, K.S. Elliott, P. Elliott, D.M. Evans, I. Sadaf Farooqi, P. Froguel, J. Ghori, C.J. Groves, R. Gwilliam, D. Hadley, A.S. Hall, A.T. Hattersley, J. Hebebrand, I.M. Heid, C. Lamina, C. Gieger, T. Illig, T. Meitinger, H.E. Wichmann, B. Herrera, A. Hinney, S.E. Hunt, M.R. Jarvelin, T. Johnson, J.D. Jolley, F. Karpe, A. Keniry, K.T. Khaw, R.N. Luben, M. Mangino, J. Marchini, W.L. McArdle, R. McGinnis, D. Meyre, P.B. Munroe, A.D. Morris, A.R. Ness, M.J. Neville, A.C. Nica, K.K. Ong, S. O'Rahilly, K.R. Owen, C.N. Palmer, K. Papadakis, S. Potter, A. Pouta, L. Qi, J.C. Randall, N.W. Rayner, S.M. Ring, M.S. Sandhu, A. Scherag, M.A. Sims, K. Song, N. Soranzo, E.K. Speliotes, H.E. Syddall, S.A. Teichmann, N.J. Timpson, J.H. Tobias, M. Uda, C.I. Vogel, C. Wallace, D.M. Waterworth, M.N. Weedon, C.J. Willer, Wraight, X. Yuan, E. Zeggini, J.N. Hirschhorn, D.P. Strachan, W.H. Ouwehand, M.J. Caulfield, N.J. Samani, T.M. Frayling, P. Vollenweider, G. Waeber, V. Mooser, P. Deloukas, M.I. McCarthy, N.J. Wareham, I. Barroso, P. Kraft, S.E. Hankinson, D.J. Hunter, F.B. Hu, H.N. Lyon, B.F. Voight, M. Ridderstrale, L. Groop, P. Scheet, S. Sanna, G.R. Abecasis, G. Albai, R. Nagaraja, D. Schlessinger, A.U. Jackson, J. Tuomilehto, F.S. Collins, M. Boehnke, K.L. Mohlke, Common variants near MC4R are associated with fat mass, weight and risk of obesity. Nat Genet 40(6), 768-775 (2008). doi:10.1038/ng.140
6. A. Kask, L. Rago, J.E. Wikberg, H.B. Schioth, Evidence for involvement of the melanocortin MC4 receptor in the effects of leptin on food intake and body weight. Eur. J. Pharmacol. 360(1), 15-19 (1998)
7. C. Vaisse, K. Clement, E. Durand, S. Hercberg, B. Guy-Grand, P. Froguel, Melanocortin-4 receptor mutations are a frequent and heterogeneous cause of morbid obesity. J. Clin. Invest. 106(2), 253-262 (2000). doi:10.1172/JCI9238
8. I.S. Farooqi, G.S. Yeo, J.M. Keogh, S. Aminian, S.A. Jebb, G. Butler, T. Cheetham, S. O'Rahilly, Dominant and recessive inheritance of morbid obesity associated with melanocortin 4 receptor deficiency. J. Clin. Invest. 106(2), 271-279 (2000). doi:10.1172/JCI9397
9. D.P. Zobel, C.H. Andreasen, N. Grarup, H. Eiberg, T.I. Sorensen, A. Sandbaek, T. Lauritzen, K. Borch-Johnsen, T. Jorgensen, O. Pedersen, T. Hansen, Variants near MC4R are associated with obesity and influence obesity-related quantitative traits in a population of middle-aged people: studies of 14,940 Danes. Diabetes 58(3), 757-764 (2009). doi:10.2337/db08-0620
10. B. Xi, F. Takeuchi, G.R. Chandak, N. Kato, H.W. Pan, D.H. Zhou, H.Y. Pan, J. Mi, Common polymorphism near the MC4R gene is associated with type 2 diabetes: data from a meta-analysis of 123,373 individuals. Diabetologia 55(10), 2660-2666 (2012). doi:10.1007/s00125-012-2655-5
11. B. Xi, G.R. Chandak, Y. Shen, Q. Wang, D. Zhou, Association between common polymorphism near the MC4R gene and obesity risk: a systematic review and meta-analysis. PLoS ONE 7(9), e45731 (2012)
12. K. Hotta, M. Nakamura, T. Nakamura, T. Matsuo, Y. Nakata, S. Kamohara, N. Miyatake, K. Kotani, R. Komatsu, N. Itoh, I. Mineo, J. Wada, H. Masuzaki, M. Yoneda, A. Nakajima, T. Funahashi, S. Miyazaki, K. Tokunaga, M. Kawamoto, T. Ueno, K. Hamaguchi, K. Tanaka, K. Yamada, T. Hanafusa, S. Oikawa, H. Yoshimatsu, K. Nakao, T. Sakata, Y. Matsuzawa, N. Kamatani, Y. Nakamura, Association between obesity and polymorphisms in SEC16B, TMEM18, GNPDA2, BDNF, FAIM2 and MC4R in a Japanese population. J. Hum. Genet. 54(12), 727-731 (2009). doi:10.1038/jhg.2009.106
13. Y. Tabara, H. Osawa, H. Guo, R. Kawamoto, H. Onuma, I. Shimizu, Y. Takara, W. Nishida, M. Yamamoto, H. Makino, K. Kohara, T. Miki, Prognostic significance of FTO genotype in the development of obesity in Japanese: the J-SHIPP study. Int. J. Obes. (Lond.) 33(11), 1243-1248 (2009). doi:10.1038/ijo.2009.161
14. L. Tao, Z. Zhang, Z. Chen, D. Zhou, W. Li, M. Kan, D. Zhang, L. He, G. Huang, Y. Liu, A common variant near the melanocortin 4 receptor is associated with low-density lipoprotein cholesterol and total cholesterol in the Chinese Han population. Mol. Biol. Rep. 39(6), 6487-6493 (2012). doi:10.1007/s11033-012- 1476-4
15. Y.S. Cho, M.J. Go, Y.J. Kim, J.Y. Heo, J.H. Oh, H.J. Ban, D. Yoon, M.H. Lee, D.J. Kim, M. Park, S.H. Cha, J.W. Kim, B.G. Han, H. Min, Y. Ahn, M.S. Park, H.R. Han, H.Y. Jang, E.Y. Cho, J.E. Lee, N.H. Cho, C. Shin, T. Park, J.W. Park, J.K. Lee, L. Cardon, G. Clarke, M.I. McCarthy, J.Y. Lee, B. Oh, H.L. Kim, A large-scale genome-wide association study of Asian populations uncovers genetic factors influencing eight quantitative traits. Nat. Genet. 41(5), 527-534 (2009). doi:10.1038/ng.357
16. J. Shi, J. Long, Y.T. Gao, W. Lu, Q. Cai, W. Wen, Y. Zheng, K. Yu, Y.B. Xiang, F.B. Hu, W. Zheng, X.O. Shu, Evaluation of genetic susceptibility loci for obesity in Chinese women. Am. J. Epidemiol. 172(3), 244-254 (2010). doi:10.1093/aje/kwq129
17. P.B. Mutombo, M. Yamasaki, T. Hamano, M. Isomura, T. Nabika, K. Shiwaku, MC4R rs17782313 gene polymorphism was associated with glycated hemoglobin independently of its effect on BMI in Japanese: the Shimane COHRE study. Endocr Res (2013) [Epub ahead of print]. doi:10.3109/07435800.2013.844163
18. G. Bronner, A.M. Sattler, A. Hinney, M. Soufi, F. Geller, H. Schafer, B. Maisch, J. Hebebrand, J.R. Schaefer, The 103I variant of the melanocortin 4 receptor is associated with low serum triglyceride levels. J. Clin. Endocrinol. Metab. 91(2), 535-538 (2006). doi:10.1210/jc.2005-0919
19. R. Nogueiras, P. Wiedmer, D. Perez-Tilve, C. Veyrat-Durebex, J.M. Keogh, G.M. Sutton, P.T. Pfluger, T.R. Castaneda, S. Neschen, S.M. Hofmann, P.N. Howles, D.A. Morgan, S.C. Benoit, I. Szanto, B. Schrott, A. Schurmann, H.G. Joost, C. Hammond, D.Y. Hui, S.C. Woods, K. Rahmouni, A.A. Butler, I.S. Farooqi, S. O'Rahilly, F. Rohner-Jeanrenaud, M.H. Tschop, The central melanocortin system directly controls peripheral lipid metabolism. J. Clin. Invest. 117(11), 3475-3488 (2007). doi:10.1172/JCI31743
20. S.I. Kring, C. Holst, S. Toubro, A. Astrup, T. Hansen, O. Pedersen, T.I. Sorensen, Common variants near MC4R in relation to body fat, body fat distribution, metabolic traits and energy expenditure. Int. J. Obes. (Lond.) 34(1), 182-189 (2010). doi:10.1038/ijo.2009.215
21. N. Hamajima, The Japan Multi-Institutional Collaborative Cohort Study (J-MICC Study) to detect gene-environment interactions for cancer. Asian Pac. J. Cancer Prev. 8(2), 317-323 (2007)
22. K. Wakai, N. Hamajima, R. Okada, M. Naito, E. Morita, A. Hishida, S. Kawai, K. Nishio, G. Yin, Y. Asai, K. Matsuo, S. Hosono, H. Ito, M. Watanabe, T. Kawase, T. Suzuki, K. Tajima, K. Tanaka, Y. Higaki, M. Hara, T. Imaizumi, N. Taguchi, K. Nakamura, H. Nanri, T. Sakamoto, M. Horita, K. Shinchi, Y. Kita, T.C. Turin, N. Rumana, K. Matsui, K. Miura, H. Ueshima, N. Takashima, Y. Nakamura, S. Suzuki, R. Ando, A. Hosono, N. Imaeda, K. Shibata, C. Goto, N. Hattori, M. Fukatsu, T. Yamada, S. Tokudome, T. Takezaki, H. Niimura, K. Hirasada, A. Nakamura, M. Tatebo, S. Ogawa, N. Tsunematsu, S. Chiba, H. Mikami, S. Kono, K. Ohnaka, R. Takayanagi, Y. Watanabe, E. Ozaki, M. Shigeta, N. Kuriyama, A. Yoshikawa, D. Matsui, I. Watanabe, K. Inoue, K. Ozasa, S. Mitani, K. Arisawa, H. Uemura, M. Hiyoshi, H. Takami, M. Yamaguchi, M. Nakamoto, H. Takeda, M. Kubo, H. Tanaka, Profile of participants and genotype distributions of 108 polymorphisms in a cross-sectional study of associations of genotypes with lifestyle and clinical factors: a project in the Japan Multi-Institutional Collaborative Cohort (J-MICC) Study. J. Epidemiol. 21(3), 223-235 (2011)
23. S. Tokudome, C. Goto, N. Imaeda, Y. Tokudome, M. Ikeda, S. Maki, Development of a data-based short food frequency questionnaire for assessing nutrient intake by middle-aged Japanese. Asian Pac. J. Cancer Prev. 5(1), 40-43 (2004)
24. Y. Tokudome, C. Goto, N. Imaeda, T. Hasegawa, R. Kato, K. Hirose, K. Tajima, S. Tokudome, Relative validity of a short food frequency questionnaire for assessing nutrient intake versus three-day weighed diet records in middle-aged Japanese. J. Epidemiol. 15(4), 135-145 (2005)
25. N. Imaeda, C. Goto, Y. Tokudome, K. Hirose, K. Tajima, S. Tokudome, Reproducibility of a short food frequency questionnaire for Japanese general population. J. Epidemiol. 17(3), 100-107 (2007)
26. E.T. Liem, J.M. Vonk, P.J. Sauer, G. van der Steege, E. Oosterom, R.P. Stolk, H. Snieder, Influence of common variants near INSIG2, in FTO, and near MC4R genes on overweight and the metabolic profile in adolescence: the TRAILS (TRacking Adolescents' Individual Lives Survey) Study. Am. J. Clin. Nutr. 91(2), 321-328 (2010). doi:10.3945/ajcn.2009.28186
27. T.M. Teslovich, K. Musunuru, A.V. Smith, A.C. Edmondson, I.M. Stylianou, M. Koseki, J.P. Pirruccello, S. Ripatti, D.I. Chasman, C.J. Willer, C.T. Johansen, S.W. Fouchier, A. Isaacs, G.M. Peloso, M. Barbalic, S.L. Ricketts, J.C. Bis, Y.S. Aulchenko, G. Thorleifsson, M.F. Feitosa, J. Chambers, M. Orho-Melander, O. Melander, T. Johnson, X. Li, X. Guo, M. Li, Y. Shin Cho, M. Jin Go, Y. Jin Kim, J.Y. Lee, T. Park, K. Kim, X. Sim, R. Twee-Hee Ong, D.C. Croteau-Chonka, L.A. Lange, J.D. Smith, K. Song, J. Hua Zhao, X. Yuan, J. Luan, C. Lamina, A. Ziegler, W. Zhang, R.Y. Zee, A.F. Wright, J.C. Witteman, J.F. Wilson, G. Willemsen, H.E. Wichmann, J.B. Whitfield, D.M. Waterworth, N.J. Wareham, G. Waeber, P. Vollenweider, B.F. Voight, V. Vitart, A.G. Uitterlinden, M. Uda, J. Tuomilehto, J.R. Thompson, T. Tanaka, I. Surakka, H.M. Stringham, T.D. Spector, N. Soranzo, J.H. Smit, J. Sinisalo, K. Silander, E.J. Sijbrands, A. Scuteri, J. Scott, D. Schlessinger, S. Sanna, V. Salomaa, J. Saharinen, C. Sabatti, A. Ruokonen, I. Rudan, L.M. Rose, R. Roberts, M. Rieder, B.M. Psaty, P.P. Pramstaller, I. Pichler, M. Perola, B.W. Penninx, N.L. Pedersen, C. Pattaro, A.N. Parker, G. Pare, B.A. Oostra, C.J. O'Donnell, M.S. Nieminen, D.A. Nickerson, G.W. Montgomery, T. Meitinger, R. McPherson, M.I. McCarthy, W. McArdle, D. Masson, N.G. Martin, F. Marroni, M. Mangino, P.K. Magnusson, G. Lucas, R. Luben, R.J. Loos, M.L. Lokki, G. Lettre, C. Langenberg, L.J. Launer, E.G. Lakatta, R. Laaksonen, K.O. Kyvik, F. Kronenberg, I.R. Konig, K.T. Khaw, J. Kaprio, L.M. Kaplan, A. Johansson, M.R. Jarvelin, A.C. Janssens, E. Ingelsson, W. Igl, G. Kees Hovingh, J.J. Hottenga, A. Hofman, A.A. Hicks, C. Hengstenberg, I.M. Heid, C. Hayward, A.S. Havulinna, N.D. Hastie, T.B. Harris, T. Haritunians, A.S. Hall, U. Gyllensten, C. Guiducci, L.C. Groop, E. Gonzalez, C. Gieger, N.B. Freimer, L. Ferrucci, J. Erdmann, P. Elliott, K.G. Ejebe, A. Doring, A.F. Dominiczak, S. Demissie, P. Deloukas, E.J. de Geus, U. de Faire, G. Crawford, F.S. Collins, Y.D. Chen, M.J. Caulfield, H. Campbell, N.P. Burtt, L.L. Bonnycastle, D.I. Boomsma, S.M. Boekholdt, R.N. Bergman, I. Barroso, S. Bandinelli, C.M. Ballantyne, T.L. Assimes, T. Quertermous, D. Altshuler, M. Seielstad, T.Y. Wong, E.S. Tai, A.B. Feranil, C.W. Kuzawa, L.S. Adair, H.A. Taylor, Jr., I.B. Borecki, S.B. Gabriel, J.G. Wilson, H. Holm, U. Thorsteinsdottir, V. Gudnason, R.M. Krauss, K.L. Mohlke, J.M. Ordovas, P.B. Munroe, J.S. Kooner, A.R. Tall, R.A. Hegele, J.J. Kastelein, E.E. Schadt, J.I. Rotter, E. Boerwinkle, D.P. Strachan, V. Mooser, K. Stefansson, M.P. Reilly, N.J. Samani, H. Schunkert, L.A. Cupples, M.S. Sandhu, P.M. Ridker, D.J. Rader, C.M. van Duijn, L. Peltonen, G.R. Abecasis, M. Boehnke, S. Kathiresan, Biological, clinical and population relevance of 95 loci for blood lipids. Nature 466(7307), 707-713 (2010). doi:10.1038/nature09270
28. L. Dusatkova, H. Zamrazilova, B. Sedlackova, J. Vcelak, P. Hlavaty, I. Aldhoon Hainerova, V. Korenkova, O. Bradnova, B. Bendlova, M. Kunesova, V. Hainer, Association of obesity susceptibility gene variants with metabolic syndrome and related traits in 1,443 czech adolescents. Folia Biol (Praha) 59(3), 123-133(2013).
29. C.W. Yang, C.I. Li, C.S. Liu, D.T. Bau, C.H. Lin, W.Y. Lin, T.C. Li, C.C. Lin, The joint effect of cigarette smoking and polymorphisms on LRP5, LEPR, near MC4R and SH2B1 genes on metabolic syndrome susceptibility in Taiwan. Mol. Biol. Rep. 40(1), 525-533 (2013). doi:10.1007/s11033-012-2089-7
30. L. Qi, P. Kraft, D.J. Hunter, F.B. Hu, The common obesity variant near MC4R gene is associated with higher intakes of total energy and dietary fat, weight change and diabetes risk in women. Hum. Mol. Genet. 17(22), 3502-3508 (2008). doi:10.1093/hmg/ddn242