Physical activity after breast cancer: Effect on survival and patient-reported outcomes

Current Breast Cancer Reports

Volumn 6, Issue 3, 2014, Pages 193-204

  Brenner, Darren R ^a   Neilson, Heather K ^a   Courneya, Kerry S ^b   Friedenreich, Christine M ^a,c  

^a ALBERTA HEALTH SERVICES   (Canada)

^b UNIVERSITY OF ALBERTA   (Canada)

^c UNIVERSITY OF CALGARY   (Canada)

Author keywords

Biological markers; Breast cancer; Controlled clinical trials; Health related fitness; Mortality; Patient reported outcomes; Physical activity; Quality of life; Sedentary behavior; Survivorship

Indexed keywords

AROMATASE INHIBITOR; DOXORUBICIN;

BREAST CANCER; CANCER ADJUVANT THERAPY; CANCER RECURRENCE; CANCER SURVIVAL; CARDIOTOXICITY; HUMAN; KINESIOTHERAPY; METASTASIS; PHYSICAL ACTIVITY; RESISTANCE TRAINING; REVIEW; SELF REPORT;

EID: 84906935261     PISSN: 19434588     EISSN: 19434596     Source Type: Journal    
DOI: 10.1007/s12609-014-0147-y     Document Type: Review

References (73)

1. •• Jones LW, Alfano CM. Exercise-oncology research: past, present, and future. Acta Oncol. 2013;52(2):195-215. Provides context for our paper, describing the evolution of exercise-oncology research and ongoing studies. Our systematic search for ongoing clinical trials covers studies registered with ClinicalTrials.gov since August 1, 2012 when Jones and Alfano performed a similar review.
2. Villarini A, Pasanisi P, Traina A, et al. Lifestyle and breast cancer recurrences: the DIANA-5 trial. Tumori. 2012;98(1):1-18.
3. •• Courneya KS, Vallance JK, Culos-Reed SN, et al. The Alberta moving beyond breast cancer (AMBER) cohort study: a prospective study of physical activity and health-related fitness in breast cancer survivors. BMC Cancer. 2012;12:525. Our own study, ongoing in Canada, that will relate accelerometer-based and self-reported measures of physical activity and sedentary behavior prospectively to breast cancer outcomes. This large study of 1,500 breast cancer patients will be the first prospective cohort study designed specifically to examine the effects of physical activity and health-related fitness in breast cancer survivorship, from the time of diagnosis to the end of life.
4. Carayol M, Romieu G, Bleuse J-P, et al. Adapted physical activity and diet (APAD) during adjuvant breast cancer therapy: Design and implementation of a prospective randomized controlled trial. Contemp Clin Trials. 2013;36(2):531-43.
5. •• Courneya KS, Segal RJ, McKenzie DC et al. Effects of Exercise during Adjuvant Chemotherapy on Breast Cancer Outcomes. Med Sci Sports Exerc. 2014. This exploratory analysis is the first randomized trial involving breast cancer patients to relate an exercise intervention during adjuvant chemotherapy to survival and recurrence outcomes.
6. Courneya KS, Segal RJ, Mackey JR, et al. Effects of aerobic and resistance exercise in breast cancer patients receiving adjuvant chemotherapy: a multicenter randomized controlled trial. J Clin Oncol. 2007;25(28):4396-404.
7. Jones LW, Fels DR, West M, et al. Modulation of circulating angiogenic factors and tumor biology by aerobic training in breast cancer patients receiving neoadjuvant chemotherapy. Cancer Prev Res (Phila). 2013;6(9):925-37.
8. Rao R, Cruz V, Peng Y, et al. Bootcamp during neoadjuvant chemotherapy for breast cancer: a randomized pilot trial. Breast Cancer (Auckl). 2012;6:39-46.
9. Speck RM, Courneya KS, Masse LC, et al. An update of controlled physical activity trials in cancer survivors: a systematic review and meta-analysis. J Cancer Surviv. 2010;4(2):87-100.
10. Potthoff K, Schmidt ME, Wiskemann J, et al. Randomized controlled trial to evaluate the effects of progressive resistance training compared to progressive muscle relaxation in breast cancer patients undergoing adjuvant radiotherapy: the BEST study. BMC Cancer. 2013;13:162.
11. Schmidt ME, Wiskemann J, Krakowski-Roosen H, et al. Progressive resistance versus relaxation training for breast cancer patients during adjuvant chemotherapy: design and rationale of a randomized controlled trial (BEATE study). Contemp Clin Trials. 2013;34(1):117-25.
12. Ballard-Barbash R, Friedenreich CM, Courneya KS, et al. Physical activity, biomarkers, and disease outcomes in cancer survivors: a systematic review. J Natl Cancer Inst. 2012;104(11):815-40.
13. •• Fontein DBY, de Glas NA, Duijm M, et al. Age and the effect of physical activity on breast cancer survival: a systematic review. Cancer Treat Rev. 2013;39(8):958-65. This review article summarizes the methods, study populations, and results of 17 observational studies that examined the relation between self-reported physical activity and survival and/or recurrence among breast cancer survivors. We identified four additional studies that have been published since the November 9, 2012 search done by Fontein et al.
14. Schmidt ME, Chang-Claude J, Vrieling A, et al. Association of prediagnosis physical activity with recurrence and mortality among women with breast cancer. Int J Cancer. 2013;133(6):1431-40.
15. Tao MH, Hainaut P, Marian C, et al. Association of prediagnostic physical activity with survival following breast cancer diagnosis: influence of TP53 mutation status. Cancer Causes Control. 2013;24(12):2177-86.
16. Urbscheit N, Brown K. The association between physical activity and breast cancer recurrence and survival. Curr Nutr Rep. 2013;3(1):16-21.
17. McLaughlin VH, Trentham-Dietz A, Hampton JM, et al. Lifestyle factors and the risk of a second breast cancer after Ductal carcinoma in situ. Cancer Epidemiol Biomarkers Prev. 2014;23(3):450-60.
18. Keegan TH, Milne RL, Andrulis IL, et al. Past recreational physical activity, body size, and all-cause mortality following breast cancer diagnosis: results from the breast cancer family registry. Breast Cancer Res Treat. 2010;123(2):531-42.
19. Abrahamson PE, Gammon MD, Lund MJ, et al. Recreational physical activity and survival among young women with breast cancer. Cancer. 2006;107(8):1777-85.
20. Bertram LA, Stefanick ML, Saquib N, et al. Physical activity, additional breast cancer events, and mortality among early-stage breast cancer survivors: findings from the WHEL Study. Cancer Causes Control. 2011;22(3):427-35.
21. Borugian MJ, Sheps SB, Kim-Sing C, et al. Insulin, macronutrient intake, and physical activity: are potential indicators of insulin resistance associated with mortality from breast cancer? Cancer Epidemiol Biomarkers Prev. 2004;13(7):1163-72.
22. Chen X, Lu W, Zheng W, et al. Exercise after diagnosis of breast cancer in association with survival. Cancer Prev Res. 2011;4(9):1409-18.
23. Cleveland RJ, Eng SM, Stevens J, et al. Influence of prediagnostic recreational physical activity on survival from breast cancer. Eur J Cancer Prev. 2012;21(1):46-54.
24. Dal Maso L, Zucchetto A, Talamini R, et al. Effect of obesity and other lifestyle factors on mortality in women with breast cancer. Int J Cancer. 2008;123(9):2188-94.
25. Emaus A, Veierod MB, Tretli S, et al. Metabolic profile, physical activity, and mortality in breast cancer patients. Breast Cancer Res Treat. 2010;121(3):651-60.
26. Enger SM, Bernstein L. Exercise activity, body size and premenopausal breast cancer survival. Br J Cancer. 2004;90(11):2138-41.
27. Friedenreich CM, Gregory J, Kopciuk KA, et al. Prospective cohort study of lifetime physical activity and breast cancer survival. Int J Cancer. 2009;124(8):1954-62.
28. Hellmann SS, Thygesen LC, Tolstrup JS, Gronbaek M. Modifiable risk factors and survival in women diagnosed with primary breast cancer: results from a prospective cohort study. Eur J Cancer Prev. 2010;19(5):366-73.
29. Holick CN, Newcomb PA, Trentham-Dietz A, et al. Physical activity and survival after diagnosis of invasive breast cancer. Cancer Epidemiol Biomark Prev. 2008;17(2):379-86.
30. Holmes MD, Chen WY, Feskanich D, et al. Physical activity and survival after breast cancer diagnosis. JAMA. 2005;293(20):2479-86.
31. Irwin ML, McTiernan A, Manson JE, et al. Physical activity and survival in postmenopausal women with breast cancer: results from the women's health initiative. Cancer Prev Res. 2011;4(4):522-9.
32. Irwin ML, Smith AW, McTiernan A, et al. Influence of pre- and postdiagnosis physical activity on mortality in breast cancer survivors: the health, eating, activity, and lifestyle study. J Clin Oncol. 2008;26(24):3958-64.
33. Rohan TE, Fu W, Hiller JE. Physical activity and survival from breast cancer. Eur J Cancer Prev. 1995;4(5):419-24.
34. Sternfeld B, Weltzien E, Quesenberry Jr CP, et al. Physical activity and risk of recurrence and mortality in breast cancer survivors: findings from the LACE study. Cancer Epidemiol Biomarkers Prev. 2009;18(1):87-95.
35. West-Wright CN, Henderson KD, Sullivan-Halley J, et al. Long-term and recent recreational physical activity and survival after breast cancer: the California Teachers Study. Cancer Epidemiol Biomarkers Prev. 2009;18(11):2851-9.
36. Ibrahim EM, Al-Homaidh A. Physical activity and survival after breast cancer diagnosis: meta-analysis of published studies. Med Oncol. 2011;28(3):753-65.
37. Beasley JM, Kwan ML, Chen WY, et al. Meeting the physical activity guidelines and survival after breast cancer: findings from the after breast cancer pooling project. Breast Cancer Res Treat. 2012;131(2):637-43.
38. Ballard-Barbash R, Hunsberger S, Alciati MH, et al. Physical activity, weight control, and breast cancer risk and survival: clinical trial rationale and design considerations. J Natl Cancer Inst. 2009;101(9):630-43.
39. Guinan E, Hussey J, Broderick JM, et al. The effect of aerobic exercise on metabolic and inflammatory markers in breast cancer survivors - a pilot study. Support Care Cancer. 2013;21(7):1983-92.
40. Rogers LQ, Fogleman A, Trammell R, et al. Effects of a physical activity behavior change intervention on inflammation and related health outcomes in breast cancer survivors: pilot randomized trial. Integr Cancer Ther. 2013;12(4):323-35.
41. Betof AS, Dewhirst MW, Jones LW. Effects and potential mechanisms of exercise training on cancer progression: a translational perspective. Brain Behav Immun. 2013;30:S75-87.
42. Löf M, Bergström K, Weiderpass E. Physical activity and biomarkers in breast cancer survivors: a systematic review. Maturitas. 2012;73(2):134-42.
43. • Fong DY, Ho JW, Hui BP, et al. Physical activity for cancer survivors: meta-analysis of randomised controlled trials. BMJ. 2012;344:e70. Summarizes results from 34 randomized exercise trials conducted on cancer patients who completed their cancer treatment; 65 % of trials involved breast cancer patients. Reports on biomarkers for breast cancer, health-related fitness, and patient-reported outcomes.
44. Scott E, Daley AJ, Doll H, et al. Effects of an exercise and hypocaloric healthy eating program on biomarkers associated with long-term prognosis after early-stage breast cancer: a randomized controlled trial. Cancer Causes Control. 2012;24(1):181-91.
45. •• Schmitz K. Physical activity and breast cancer survivorship. Recent Results Cancer Res. 2011;186:189-215. Provides a historical basis for our review, providing an overview of physical activity effects during breast cancer survivorship. All randomized trials of exercise in breast cancer survivors are identified (21 during treatment; 36 after treatment) and characterized in summary tables.
46. • Courneya KS, McKenzie DC, Mackey JR, et al. Effects of exercise dose and type during breast cancer chemotherapy: multicenter randomized trial. J Natl Cancer Inst. 2013;105(23):1821-32. Presents the results of a trial comparing, low aerobic, high aerobic, and resistance training versus usual care. First results to suggest that higher doses obtain signficant improvements in patient reported outcomes.
47. Ewertz M, Jensen AB. Late effects of breast cancer treatment and potentials for rehabilitation. Acta Oncol. 2011;50(2):187-93.
48. Smith LA, Cornelius VR, Plummer CJ, et al. Cardiotoxicity of anthracycline agents for the treatment of cancer: systematic review and meta-analysis of randomised controlled trials. BMC Cancer. 2010;10:337.
49. Khouri MG, Douglas PS, Mackey JR, et al. Cancer therapy-induced cardiac toxicity in early breast cancer: addressing the unresolved issues. Circulation. 2012;126(23):2749-63.
50. Sturgeon KM, Ky B, Libonati JR, Schmitz KH. The effects of exercise on cardiovascular outcomes before, during, and after treatment for breast cancer. Breast Cancer Res Treat. 2014;143(2):219-26.
51. Patnaik JL, Byers T, Diguiseppi C, et al. The influence of comorbidities on overall survival among older women diagnosed with breast cancer. J Natl Cancer Inst. 2011;103(14):1101-11.
52. Patnaik JL, Byers T, DiGuiseppi C, et al. Cardiovascular disease competes with breast cancer as the leading cause of death for older females diagnosed with breast cancer: a retrospective cohort study. Breast Cancer Res. 2011;13(3):R64.
53. Scott JM, Khakoo A, Mackey JR, et al. Modulation of anthracycline-induced cardiotoxicity by aerobic exercise in breast cancer: current evidence and underlying mechanisms. Circulation. 2011;124(5):642-50.
54. Jones L, V D, M H et al., editors. Effects of aerobic training to improve cardiovascular function and prevent cardiac remodeling after cytotoxic therapy in early breast cancer. 102nd Annual Meeting of the American Association for Cancer Research 2011 April 2-6. Orlando, Florida. Philadelphia (PA): AACR. 2011;Abstract no. 502.
55. Knobf MT, Coviello J. Lifestyle interventions for cardiovascular risk reduction in women with breast cancer. Curr Cardiol Rev. 2011;7(4):250-7.
56. Janelsins MC, Mustian KM, Peppone LJ et al. Interventions to alleviate symptoms related to breast cancer treatments and areas of needed research. J Cancer Sci Ther. 2011;Suppl 2:S2-001.
57. Buffart LM, Ros WJG, Chinapaw MJM, et al. Mediators of physical exercise for improvement in cancer survivors' quality of life. Psychooncology. 2014;23(3):330-8.
58. Rizzoli R, Body JJ, Censi A, et al. Guidance for the prevention of bone loss and fractures in postmenopausal women treated with aromatase inhibitors for breast cancer: an ESCEO position paper. Osteoporos Int. 2012;23(11):2567-76.
59. Saarto T, Sievanen H, Kellokumpu-Lehtinen P, et al. Effect of supervised and home exercise training on bone mineral density among breast cancer patients. A 12-month randomised controlled trial. Osteoporos Int. 2012;23(5):1601-12.
60. Irwin M, Cartmel B, Ercolano E, et al. editors. Aromatase inhibitors, arthralgias, and exercise in breast cancer survivors. ASCO Annual Meeting, 2012: J Clin Oncol 2012; 30 (supplement): Abstract Number TPS669.
61. Irwin ML, Cartmel B, Gross C, et al., editors. Randomized trial of exercise vs. usual care on aromatase inhibitor-associated arthralgias in women with breast cancer: The hormones and physical exercise (HOPE) study San Antonio Breast Cancer Symposium, 2013 December 10-14; :S3-03.
62. Courneya KS, Friedenreich CM. Relationship between exercise pattern across the cancer experience and current quality of life in colorectal cancer survivors. J Altern Complement Med. 1997;3(3):215-26.
63. • Lynch BM, Dunstan DW, Vallance JK, Owen N. Don't take cancer sitting down. Cancer. 2013;119(11):1928-35. A compelling commentary advocating further research into the emerging effect of sedentary behavior in cancer survivorship. Emphasises a need for further research in breast cancer survivors.
64. George SM, Alfano CM, Wilder Smith A, et al. Sedentary behavior, health-related quality of life, and fatigue among breast cancer survivors. J Phys Act Health. 2013;10(3):350-8.
65. George SM, Smith AW, Alfano CM, et al. The association between television watching time and all-cause mortality after breast cancer. J Cancer Surviv. 2013;7(2):247-52.
66. George SM, Alfano CM, Groves J, et al. Objectively measured sedentary time is related to quality of life among cancer survivors. PLoS ONE. 2014;9(2):e87937.
67. Lynch BM, Dunstan DW, Healy GN, et al. Objectively measured physical activity and sedentary time of breast cancer survivors, and associations with adiposity: findings from NHANES (2003-2006). Cancer Causes Control. 2010;21(2):283-8.
68. Rogers LQ, Markwell SJ, Courneya KS, et al. Physical activity type and intensity among rural breast cancer survivors: patterns and associations with fatigue and depressive symptoms. J Cancer Surviv. 2010;5(1):54-61.
69. Schmitz KH, Courneya KS, Matthews C, et al. American College of Sports Medicine roundtable on exercise guidelines for cancer survivors. Med Sci Sports Exerc. 2010;42(7):1409-26.
70. Rock CL, Doyle C, Demark-Wahnefried W, et al. Nutrition and physical activity guidelines for cancer survivors. CA Cancer J Clin. 2012;62(4):242-74.
71. Carmichael AR. Physical activity as an adjuvant treatment for breast cancer; is it time for guidelines? Eur J Surg Oncol. 2014;40(2):137-9.
72. Schmitz KH. Exercise for secondary prevention of breast cancer: moving from evidence to changing clinical practice. Cancer Prev Res. 2011;4(4):476-80.
73. Muraca L, Leung D, Clark A, et al. Breast cancer survivors: taking charge of lifestyle choices after treatment. Eur J Oncol Nurs. 2011;15(3):250-3.