Effects of an exercise and hypocaloric healthy eating program on biomarkers associated with long-term prognosis after early-stage breast cancer: A randomized controlled trial

Cancer Causes and Control

Volumn 24, Issue 1, 2013, Pages 181-191

  Scott, E ^a   Daley, A J ^b   Doll, H ^c   Woodroofe, N ^d   Coleman, R E ^e   Mutrie, N ^f   Crank, H ^d   Powers, H J ^e   Saxton, J M ^g  

^a UNIVERSITY OF SHEFFIELD   (United Kingdom)

^b UNIVERSITY OF BIRMINGHAM   (United Kingdom)

^c UNIVERSITY OF EAST ANGLIA   (United Kingdom)

^d SHEFFIELD HALLAM UNIVERSITY   (United Kingdom)

^e UNIVERSITY OF SHEFFIELD   (United Kingdom)

^f UNIVERSITY OF EDINBURGH   (United Kingdom)

^g UNIVERSITY OF EAST ANGLIA   (United Kingdom)

Author keywords

Breast cancer; Health outcomes; Lifestyle intervention

Indexed keywords

BIOLOGICAL MARKER; LEPTIN; SATURATED FATTY ACID;

ADULT; AEROBIC EXERCISE; AGED; ARTICLE; BLOOD ANALYSIS; BODY MASS; BREAST CANCER; CALORIC INTAKE; CANCER PROGNOSIS; CANCER STAGING; CARDIOPULMONARY FUNCTION; CARDIOVASCULAR RISK; CLINICAL EFFECTIVENESS; CONTROLLED STUDY; CONVALESCENCE; DIASTOLIC BLOOD PRESSURE; DISEASE ASSOCIATION; EARLY CANCER; FAT INTAKE; FEMALE; FITNESS; HEALTH PROGRAM; HUMAN; LIFESTYLE MODIFICATION; LOW CALORY DIET; MACRONUTRIENT; MAJOR CLINICAL STUDY; NUTRIENT MANAGEMENT; NUTRITIONAL ASSESSMENT; OBESITY; PERSONALIZED MEDICINE; PRIORITY JOURNAL; QUALITY OF LIFE; RANDOMIZED CONTROLLED TRIAL; RECURRENT CANCER; RISK ASSESSMENT; THERAPY EFFECT; TREATMENT DURATION; TREATMENT OUTCOME; WAIST CIRCUMFERENCE; WAIST HIP RATIO; WEIGHT REDUCTION; WOMEN'S HEALTH;

ADULT; AGED; BREAST NEOPLASMS; CALORIC RESTRICTION; CARCINOMA; EXERCISE; EXERCISE THERAPY; FEEDING BEHAVIOR; FEMALE; HEALTH; HUMANS; MIDDLE AGED; NEOPLASM STAGING; OVERWEIGHT; PROGNOSIS; SURVIVORS; TUMOR MARKERS, BIOLOGICAL; WEIGHT REDUCTION PROGRAMS;

EID: 84871808132     PISSN: 09575243     EISSN: 15737225     Source Type: Journal    
DOI: 10.1007/s10552-012-0104-x     Document Type: Article

References (55)

1. Mosher CE, Sloane R, Morey MC, Snyder DC, Cohen HJ, Miller PE, Demark-Wahnefried W (2009) Associations between lifestyle factors and quality of life among older long-term breast, prostate, and colorectal cancer survivors. Cancer 115:4001-4009
2. Voskuil DW, van Nes JG, Junggeburt JM, van de Velde CJ, van Leeuwen FE, de Haes JC (2010) Maintenance of physical activity and body weight in relation to subsequent quality of life in postmenopausal breast cancer patients. Ann Oncol 21:2094-2101
3. Rock CL, Demark-Wahnefried W (2002) Nutrition and survival after the diagnosis of breast cancer: a review of the evidence. J Clin Oncol 20:3302-3316 (Pubitemid 34831528)
4. Nichols HB, Trentham-Dietz A, Egan KM, Titus-Ernstoff L, Holmes MD, Bersch AJ, Holick CN, Hampton JM, Stampfer MJ, Willett WC, Newcomb PA (2009) Body mass index before and after breast cancer diagnosis: associations with all-cause, breast cancer, and cardiovascular disease mortality. Cancer Epidemiol Biomarkers Prev 18:1403-1409
5. Kroenke CH, Chen WY, Rosner B, Holmes MD (2005) Weight, weight gain, and survival after breast cancer diagnosis. J Clin Oncol 23:1370-1378
6. McTiernan A, Rajan KB, Tworoger SS, Irwin M, Bernstein L, Baumgartner R, Gilliland F, Stanczyk FZ, Yasui Y, Ballard-Barbash R (2003) Adiposity and sex hormones in postmenopausal breast cancer survivors. J Clin Oncol 21:1961-1966 (Pubitemid 46606384)
7. Campbell KL, McTiernan A (2007) Exercise and biomarkers for cancer prevention studies. J Nutr 137:161S-169S (Pubitemid 46070104)
8. Festa A, D'Agostino R Jr, Williams K, Karter AJ, Mayer-Davis EJ, Tracy RP, Haffner SM (2001) The relation of body fat mass and distribution to markers of chronic inflammation. Int J Obes Relat Metab Disord 25:1407-1415 (Pubitemid 32977855)
9. Despres JP, Lemieux I (2006) Abdominal obesity and metabolic syndrome. Nature 444:881-887 (Pubitemid 46024995)
10. Balkwill F, Coussens LM (2004) Cancer: an inflammatory link. Nature 431:405-406 (Pubitemid 39329565)
11. Kelesidis I, Kelesidis T, Mantzoros CS (2006) Adiponectin and cancer: a systematic review. Br J Cancer 94:1221-1225
12. Patnaik JL, Byers T, Diguiseppi C, Dabelea D, Denberg TD (2011) Cardiovascular disease competes with breast cancer as the leading cause of death for older females diagnosed with breast cancer: a retrospective cohort study. Breast Cancer Res 13:R64
13. Djuric Z, DiLaura NM, Jenkins I, Darga L, Jen CK, Mood D, Bradley E, Hryniuk WM (2002) Combining weight-loss counseling with the weight watchers plan for obese breast cancer survivors. Obes Res 10:657-665 (Pubitemid 135688265)
14. Jen KL, Djuric Z, DiLaura NM, Buison A, Redd JN, Maranci V, Hryniuk WM (2004) Improvement of metabolism among obese breast cancer survivors in differing weight loss regimens. Obes Res 12:306-312 (Pubitemid 41132554)
15. Chlebowski RT, Blackburn GL, Thomson CA, Nixon DW, Shapiro A, Hoy MK, Goodman MT, Giuliano AE, Karanja N, McAndrew P, Hudis C, Butler J, Merkel D, Kristal A, Caan B, Michaelson R, Vinciguerra V, Del PS, Winkler M, Hall R, Simon M, Winters BL, Elashoff RM (2006) Dietary fat reduction and breast cancer outcome: interim efficacy results from the Women's Intervention Nutrition Study. J Natl Cancer Inst 98:1767-1776 (Pubitemid 46017928)
16. Donnelly JE, Blair SN, Jakicic JM, Manore MM, Rankin JW, Smith BK (2009) American College of Sports Medicine Position Stand. Appropriate physical activity intervention strategies for weight loss and prevention of weight regain for adults. Med Sci Sports Exerc 41:459-471
17. Shaw K, Gennat H, O'Rourke P, Del MC (2006) Exercise for overweight or obesity. Cochrane Database Systematic Review 18(4):CD003817
18. Wu T, Gao X, Chen M, van Dam RM (2009) Long-term effectiveness of diet-plus-exercise interventions vs. diet-only interventions for weight loss: a meta-analysis. Obes Rev 10:313-323
19. Demark-Wahnefried W, Case LD, Blackwell K, Marcom PK, Kraus W, Aziz N, Snyder DC, Giguere JK, Shaw E (2008) Results of a diet/exercise feasibility trial to prevent adverse body composition change in breast cancer patients on adjuvant chemotherapy. Clin Breast Cancer 8:70-79 (Pubitemid 351346232)
20. Holmes MD, Chen WY, Feskanich D, Kroenke CH, Colditz GA (2005) Physical activity and survival after breast cancer diagnosis. JAMA 293:2479-2486 (Pubitemid 40705729)
21. Holick CN, Newcomb PA, Trentham-Dietz A, Titus-Ernstoff L, Bersch AJ, Stampfer MJ, Baron JA, Egan KM, Willett WC (2008) Physical activity and survival after diagnosis of invasive breast cancer. Cancer Epidemiol Biomarkers Prev 17:379-386 (Pubitemid 351272790)
22. Irwin ML (2009) Physical activity interventions for cancer survivors. Br J Sports Med 43:32-38
23. Pierce JP, Stefanick ML, Flatt SW, Natarajan L, Sternfeld B, Madlensky L, Al-Delaimy WK, Thomson CA, Kealey S, Hajek R, Parker BA, Newman VA, Caan B, Rock CL (2007) Greater survival after breast cancer in physically active women with high vegetable-fruit intake regardless of obesity. J Clin Oncol 25:2345-2351 (Pubitemid 46999205)
24. McNeely ML, Campbell KL, Rowe BH, Klassen TP, Mackey JR, Courneya KS (2006) Effects of exercise on breast cancer patients and survivors: a systematic review and meta-analysis. CMAJ 175:34-41 (Pubitemid 44065189)
25. Schmitz KH, Courneya KS, Matthews C, Demark-Wahnefried W, Galvão DA, Pinto BM, Irwin ML, Wolin KY, Segal RJ, Lucia A, Schneider CM, von Gruenigen VE, Schwartz AL (2010) American College of Sports Medicine roundtable on exercise guidelines for cancer survivors. Med Sci Sports Exerc 42:1409-1426
26. Utter AC, Nieman DC, Shannonhouse EM, Butterworth DE, Nieman CN (1998) Influence of diet and/or exercise on body composition and cardiorespiratory fitness in obese women. Int J Sports Nutr 8:213-222
27. Kaukua J, Pekkarinen T, Mustajoki P (2003) Health-related quality of life in obese outpatients losing weight with very-low-energy diet and behavioural modification: a 2 year follow-up study. Int J Obes Relat Metab Disord 27:1233-1241 (Pubitemid 37281672)
28. Wadden TA, Steen SN, Wingate BJ, Foster GD (1996) Psychosocial consequences of weight reduction: how much weight loss is enough? Am J Clin Nutr 63:461S-465S (Pubitemid 26075833)
29. Ebbeling CB, Ward A, Puleo EM, Widrick J, Rippe JM (1991) Development of a single-stage submaximal treadmill walking test. Med Sci Sports Exerc 23:966-973
30. Cella DF, Tulsky DS, Gray G, Serafin B, Linn E, Bonomi A, Silberman M, Yellen SB, Wincour P, Brannon J (1993) The functional assessment of cancer therapy scale: development and validation of the general measure. J Clin Oncol 11:570-579 (Pubitemid 23071057)
31. Matthews DR, Hosker JP, Rudenski AS, Naylor BA, Treacher DF, Turner RC (1985) Homeostasis model assessment: insulin resistance and beta-cell function from fasting plasma glucose and insulin concentrations in man. Diabetologia 28:412-419 (Pubitemid 15018832)
32. Demark-Wahnefried W, Clipp EC, Lipkus IM, Lobach D, Snyder DC, Sloane R, Peterson B, Macri JM, Rock CL, McBride CM, Kraus WE (2007) Main outcomes of the FRESH START trial: a sequentially tailored, diet and exercise mailed print intervention among breast and prostate cancer survivors. J Clin Oncol 25:2709-2718 (Pubitemid 47123178)
33. Demark-Wahnefried W, Kenyon AJ, Eberle P, Skye A, Kraus WE (2002) Preventing sarcopenic obesity among breast cancer patients who receive adjuvant chemotherapy: results of a feasibility study. Clin Exerc Physiol 4:44-49
34. McTiernan A, Ulrich C, Kumai C, Bean D, Schwartz R, Mahloch J, Hastings R, Gralow J, Potter JD (1998) Anthropometric and hormone effects of an eight-week exercise-diet intervention in breast cancer patients: results of a pilot study. Cancer Epidemiol Biomarkers Prev 7:477-481 (Pubitemid 28354110)
35. Morey MC, Snyder DC, Sloane R, Cohen HJ, Peterson B, Hartman TJ, Miller P, Mitchell DC, Demark-Wahnefried W (2009) Effects of home-based diet and exercise on functional outcomes among older, overweight long-term cancer survivors: RENEW: a randomized controlled trial. JAMA 301:1883-1891
36. Goodwin P, Esplen MJ, Butler K, Winocur J, Pritchard K, Brazel S, Gao J, Miller A (1998) Multidisciplinary weight management in locoregional breast cancer: results of a phase II study. Breast Cancer Res Treat 48:53-64 (Pubitemid 28073533)
37. Powell LA, Nieman DC, Melby C, Cureton K, Schmidt D, Howley ET, Hill JO, Mault JR, Alexander H, Stewart DJ (2001) Assessment of body composition change in a community-based weight management program. J Am Coll Nutr 20:26-31 (Pubitemid 32244962)
38. Pakiz B, Flatt SW, Bardwell WA, Rock CL, Mills PJ (2011) Effects of a weight loss intervention on body mass, fitness, and inflammatory biomarkers in overweight or obese breast cancer survivors. Int J Behav Med 18:333-341
39. Vance V, Mourtzakis M, McCargar L, Hanning R (2011) Weight gain in breast cancer survivors: prevalence, pattern and health consequences. Obes Rev 12:282-294
40. Harvie M (2010) The importance of controlling body weight after a diagnosis of breast cancer: the role of diet and exercise in breast cancer patient management. In: Saxton JM, Daley AJ (eds) Exercise and cancer survivorship: impact on health outcomes and quality of life. Springer, New York, pp 73-96
41. Irwin ML (2010) The biological mechanisms by which physical activity might have an impact on outcome/prognosis after a breast cancer diagnosis. In: Saxton JM, Daley AJ (eds) Exercise and cancer survivorship: impact on health outcomes and quality of life. Springer, New York, pp 97-112
42. Goodwin PJ, Ennis M, Pritchard KI, Trudeau ME, Koo J, Taylor SK, Hood N (2012) Insulin- and obesity-related variables in early-stage breast cancer: correlations and time course of prognostic associations. J Clin Oncol 30:164-171
43. Martini G, Valenti R, Giovani S, Campagna S, Franci B, Nuti R (2001) Leptin and body composition in healthy postmenopausal women. Panminerva Med 43:149-154 (Pubitemid 33642139)
44. Gami AS, Witt BJ, Howard DE, Erwin PJ, Gami LA, Somers VK, Montori VM (2007) Metabolic syndrome and risk of incident cardiovascular events and death: a systematic review and meta-analysis of longitudinal studies. J Am Coll Cardiol 49:403-414 (Pubitemid 46135879)
45. Rosato V, Bosetti C, Talamini R, Levi F, Montella M, Giacosa A, Negri E, La Vecchia C (2011) Metabolic syndrome and the risk of breast cancer in postmenopausal women. Ann Oncol 22:2687-2692
46. Bjorge T, Lukanova A, Jonsson H, Tretli S, Ulmer H, Manjer J, Stocks T, Selmer R, Nagel G, Almquist M, Concin H, Hallmans G, Haggstrom C, Stattin P, Engeland A (2010) Metabolic syndrome and breast cancer in the me-can (metabolic syndrome and cancer) project. Cancer Epidemiol Biomarkers Prev 19:1737-1745
47. Pierce BL, Ballard-Barbash R, Bernstein L, Baumgartner RN, Neuhouser ML, Wener MH, Baumgartner KB, Gilliland FD, Sorensen BE, McTiernan A, Ulrich CM (2009) Elevated biomarkers of inflammation are associated with reduced survival among breast cancer patients. J Clin Oncol 27:3437-3444
48. Thomson CA, Thompson PA, Wright-Bea J, Nardi E, Frey GR, Stopeck A (2009) Metabolic syndrome and elevated C-reactive protein in breast cancer survivors on adjuvant hormone therapy. J Womens Health (Larchmt) 18:2041-2047
49. Havel PJ, Kasim-Karakas S, Mueller W, Johnson PR, Gingerich RL, Stern JS (1996) Relationship of plasma leptin to plasma insulin and adiposity in normal weight and overweight women: effects of dietary fat content and sustained weight loss. J Clin Endocrinol Metab 81:4406-4413 (Pubitemid 26412052)
50. Christensen JO, Svendsen OL, Hassager C, Christiansen C (1998) Leptin in overweight postmenopausal women: no relationship with metabolic syndrome X or effect of exercise in addition to diet. Int J Obes Relat Metab Disord 22:195-199 (Pubitemid 28112017)
51. Bellizzi KM, Rowland JH, Jeffery DD, McNeel T (2005) Health behaviors of cancer survivors: examining opportunities for cancer control intervention. J Clin Oncol 23:8884-8893 (Pubitemid 46217465)
52. Eton DT, Cella D, Yost KJ, Yount SE, Peterman AH, Neuberg DS, Sledge GW, Wood WC (2004) A combination of distribution- and anchor-based approaches determined minimally important differences (MIDs) for four endpoints in a breast cancer scale. J Clin Epidemiol 57:898-910 (Pubitemid 39422527)
53. Bardwell WA, Major JM, Rock CL, Newman VA, Thomson CA, Chilton JA, Dimsdale JE, Pierce JP (2004) Health-related quality of life in women previously treated for early-stage breast cancer. Psychooncology 13:595-604 (Pubitemid 39248386)
54. Darga LL, Magnan M, Mood D, Hryniuk WM, DiLaura NM, Djuric Z (2007) Quality of life as a predictor of weight loss in obese, early-stage breast cancer survivors. Oncol Nurs Forum 34:86-92
55. Daley AJ, Crank H, Saxton JM, Mutrie N, Coleman R, Roalfe A (2007) Randomized trial of exercise therapy in women treated for breast cancer. J Clin Oncol 25:1713-1721 (Pubitemid 46797952)