Serotonin (5-HT) augmentation reduces provoked aggression associated with primary psychopathy traits

Journal of Personality Disorders

Volumn 28, Issue 3, 2014, Pages 449-461

  Fanning, Jennifer R ^a,b   Guillot, Casey R ^a   Marsic, Angelika ^a   McCloskey, Michael S ^c  

^a UNIVERSITY OF SOUTHERN MISSISSIPPI   (United States)

^b YALE UNIVERSITY   (United States)

^c TEMPLE UNIVERSITY   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

PAROXETINE; SEROTONIN; SEROTONIN UPTAKE INHIBITOR;

ADULT; AGGRESSION; ANTISOCIAL PERSONALITY DISORDER; ARTICLE; DRUG EFFECT; EMPATHY; FEMALE; HUMAN; MALE; PHYSIOLOGY; PSYCHOLOGICAL ASPECT; REACTION TIME; SELF REPORT; YOUNG ADULT;

ADULT; AGGRESSION; ANTISOCIAL PERSONALITY DISORDER; EMPATHY; FEMALE; HUMANS; MALE; PAROXETINE; REACTION TIME; SELF REPORT; SEROTONIN; SEROTONIN UPTAKE INHIBITORS; YOUNG ADULT;

EID: 84906927147     PISSN: 0885579X     EISSN: 19432763     Source Type: Journal    
DOI: 10.1521/pedi_2012_26_065     Document Type: Article

References (52)

1. Aiken, L. S., & West, S. G. (1991). Multiple regression: Testing and interpreting interactions. Thousand Oaks, CA: Sage Publications.
2. American Psychlatrie Association. (2000). Diagnostic and statistical manual oj mental disorders (4th ed., text rev.). Washington, DC: Author.
3. Anderson, C. A., & Bushman, B. J. (1997). External validity of “trivial" experiments: The case of laboratory aggression. Review of General Psychology, J, 19-41.
4. Baron, R. A., & Richardson, D. R. (1994). Human aggression (2nd ed.). New York: Plenum Press.
5. Berman M. E., McCloskey, M. S., Fanning, J. R., Schumacher, J. A., & Coccaro, E. F. (2009). Serotonin augmentation reduces response to attack in aggressive individuals. Psychological Science, 20. 714-720.
6. Berman, M. E., Tracy, J. I., & Coccaro, E. F. (1997). The serotonin hypothesis of aggression revisited. Clinical Psychology Review, 17, 651-665.
7. Bettencourt, B. A., Talley, A., Benjamin, A. J., & Valentine, J. (2006). Personality and aggressive behavior under provoking and neutral conditions: A meta-ana-lytic review. Psychological Bulletin, 132, 751-777.
8. Blair, J. R. (2003). Neurobiological basis of psychopathy. British Journal of Psychiatry, 182, 5-7.
9. Bushman, B. J., & Baumeister R. F. (1998). Threatened egotism, narcissism, selfesteem, and direct and displaced aggression: Does self-love or self-hate lead to violence? Journal of Personality and Social Psychology, 75, 219-229.
10. Cale, E. M., & Lilienfeld, S. O. (2006). Psychopathy factors and risk for aggressive behavior: A test of the "threatened egotism” hypothesis. Law and Human Behavior, 30, 51-74.
11. Carpenter, L. L., Anderson, G. M., Siniscal-chi, J. M., Chappell P. B., & Price, L. H. (2003). Acute changes in cerebrospinal fluid 5-H1AA following oral paroxetine challenge in healthy humans. Neuropsychopharmacology, 28, 339-347.
12. Cima, M., & Raine, A. (2009). Distinct characteristics of psychopathy relate to different subtypes of aggression. Personality and Individual Differences, 47. 835-840.
13. Cleare, A. J., & Bond, A. J. (1995). The effect of tryptophan depletion and enhancement on subjective and behavioural aggression in normal male subjects. Psychopharmacology, 118, 72-81.
14. Coccaro, E. F. (1989). Central serotonin and impulsive aggression. British Journal of Psychiatry, 155, 52-62.
15. Cohen, J. (1992). Statistical power analysis. Current Directions in Psychological Science, 1, 98-101.
16. Cohen, J., Cohen, P., West, S. G., & Aiken, L. S. (2003). Applied multiple regression/correlation analysis for the behavioral sciences (3rd ed.). Mahwah, NJ: Lawrence Erlbaum.
17. Coid, J., Yang M., Ullrich, S., Roberts, A., Moran, P., Bebbington, P., et al. (2009). Psychopathy among prisoners in England and Wales. International Journal of Law and Psychiatry, 32, 134-141.
18. Cooke, D. J, & Michle, C. (2001). Refining the construct of psychopathy: Towards a hierarchical model. Psychological Assessment, 13, 171-188.
19. Crockett, M. J., Clark, L., Hauser, M. D., & Robbins, T. W. (2010). Serotonin selectively Influences moral Judgment and behavior through effects on harm avoidance. Proceedings of the National Academy of Science of the United States of America, 170, 17433-17438.
20. Dolan, M. C., & Anderson, I. M. (2003). The relationship between serotonergic function and the Psychopathy Checklist: Screening Version. Journal of Psychopharmacology, 17,216-222.
21. First, M. B., Gibbon, M., Spltzer, R. L., & Williams, J. B. W. (1998). Computer-assisted SCID -clinician version (CAS-CV) [Computer software]. North Tonawanda, NY: Multi-Health Systems, American Psychiatric Association Press.
22. Giancola, P. R. (2004). Difflcult temperament, acute alcohol intoxication, and aggressive behavior. Drug and Alcohol Dependence, 74, 135-145.
23. Giancola, P. R., & Chermack, S. T. (1998). Construct validity of laboratory aggression paradigms: A response to Te-deschi and Quigley (1996). Aggression and Violent Behavior, 3, 237-253.
24. Hare R. D. (1991). The Hare psychopathy checklist-revised. Toronto, ON: Multi-Health Systems.
25. Hare, R. D., & Neumann, C. S. (2006). The PCL-R assessment of psychopathy: Development, structural properties, and new nireetions. In C. J. Patrick (Ed.), Handbook of the psychopathy. (pp. 58-88). New York: Guilford Press.
26. Hare, R. D., & Neumann, C. S, (2008). Psychopathy as a clinical and empirical construct. Annual Review of Clinical Psychology, 4, 217-246.
27. Jaccard, J., Wan, C. K., & Turrisi, R. (1990). The detection and interpretation of interaction effects between continuous variables in multiple regression. Multivariate Behavioral Research. 25, 467-478.
28. Jolliffe, D., & Farrington, D. P. (2004). Empathy and offending: A systematic review and meta-analysis. Aggression and Violent Behavior, 9. 441-476.
29. Judd, C. M., Kenny, D. A., & McClelland, G. H., (2001). Estimating and testing mediation and moderation in wtthin-subject designs. Psychological Methods. 6, 115-134.
30. Kojima, H., Terao, T., Iwakavva, M., Soya, A., Inoue, N., Shlraishi, Y., et al. (2003). Paroxetine as a 5-HT neuroendocrine probe. Psychopharmacology. 167, 97-102.
31. Levenson, M. R., Kiehl, K. A., & Fitzpatrick, C. M. (1995). Assessing psychopathic attributes in a noninstitutionalized population. Journal of Personality and Social Psychology, 68. 151-158.
32. Lidberg, L., Modln, I, Oreland, L., Tuck, J. R., & Gillner, A. (1985). Platelet monoamine oxidase activity and psychopathy. Psychiatry Research, 16, 339-343.
33. Marcus, D. K., John, S. L., & Edens, J. F. (2004). A taxometric analysis of psychopathic personality. Journal of Abnormal Psychology, 113, 626-635.
34. McCloskey, M. S., Berman, M. E., Echevarria, D. E., & Coccaro, E. F. (2009). Effects of acute alcohol intoxication and paroxetine on aggression in men. Alcohol: Clinical and Experimental Research, 33, 1-10.
35. Mehrabian, A. (1997). Relations among personality scales of aggression, violence and empathy: Validational evidence bearing on the Risk of Eruptive Violence Scale. Aggressive Behavior, 23, 433-445.
36. Miczek, K. A., Fish, E. W, de Bold, J. F, & de Almeida, R. M. M. (2002). Social and neural determinants of aggressive behavior: Pharmacotherapeutlc targets at serotonin, dopamine and -ami-nobutyric acid systems. Psychopharmacology. 163. 434-458.
37. Porter, S., Campbell, M. A., Woodworth, M., & Birt, A. R. (2001). A new psychological conceptualization of the sexual psychopath. In F. Columbus (Ed.), Advances in psychology research, (Vol. 7., pp. 21-36). Hauppauge, NY: Nova Science Publishers.
38. Porter, S., & Woodworth, M. (2006). Psychopathy and aggression. In C. J. Patrick (Ed.), Handbook of the psychopathy (pp. 481-494). New York: Guilford Press.
39. Porter, S., Woodworth, M., Earle, J., Drugge, J., & Boer, D. (2003). Characteristics of sexual homicides committed by psychopathic and non-psychopathic offenders. Law and Human Behavior, 27, 459-470.
40. Quinsey, V. L., Rice, M. E., & Harris, G. T. (1995). Actuarial prediction of sexual recidivism. Journal of Interpersonal Violence, 10. 85-105.
41. Reidy, D. E., Zeichner A., Miller, J. D., & Martinez, M. A. (2007). Psychopathy and aggression: Examining the role of psychopathy factors in predicting laboratory aggression under hostile and instrumental conditions. Journal of Research In Personality. 41, 1244-1251.
42. Reist, C., Helmeste, D., Albers, L., Chhay, H., &Tang, S. W. (1996). Serotonin indices and impulsivity in normal volunteers. Psychiatry Research, 60, 177-184.
43. Richardson, D. R., Hammock, G. S., Smith, S. M., Gardner, W., & Signo, M. (1994). Empathy as a cognitive inhibitor of interpersonal aggression. Aggressive Behavior, 20, 275-289.
44. Salekin, R. T., Rogers, R., & Sewell, K. W. (2006). A review and meta-analysis of the Psychopathy Checklist and Psychopathy Checklist-Revised: Predictive validity of dangerousness Clinical Psychology: Science and Practice, 3. 203-215.
45. Schalling, D., Asberg, M., Edman, G., & Oreland, L. (1987). Markers for vulnerability to psychopathology: Temperament traits associated with platelet MAO activity. Acta Psychiatrica Scan-dinavica, 76, 172-182.
46. Skeem, J. L., & Mulvey E. P. (2001). Psychopathy and community violence among civil psychiatric patients: Results from the MacArthur Violence Risk Assessment Study. Journal of Consulting and Clinical Psychology. 69. 358-374.
47. Soderstrom, H., Blennow K., Manheim A., & Forsman A. (2001). CSF studies in violent offenders. 1. 5-HIAA as a negative and HVA as a positive predictor of psychopathy. Journal of Neural Transmission (Vienna, Austria: 1996), 108, 869-878.
48. Soderstrom, H., Blennow, K., Sjodin, A. K., & Forsman, A. (2003). New evidence for an association between the CSF HVA:5-HLAA ratio and psychopathic traits. Journal of Neurology, Neurosur-gery & Psychiatry, 74, 918-921.
49. Taylor, S. P. (1967). Aggressive behavior and physiological arousal as a function of provocation and the tendency to inhibit aggression. Journal oj Personality, 35, 297-310.
50. Wahlund, K., & Krisliansson, M. (2009). Aggression, psychopathy, and brain imaging: Review and future recommendations. International Journal of Law and Psychiatry, 32. 266-271.
51. Williamson, S., Hare, R. D., & Wong, S. (1987). Violence: Criminal psychopaths and their victims. Canadian Journal of Behavioral Science, 19, 454-462.
52. Woodworth, M., & Porter, S. (2002). In cold blood: Characteristics of criminal homicides as a function of psychopathy. Journal of Abnormal Psychology, 111, 436-445.