Hypolipidemic and antioxidant activity of aqueous extract of fruit of Withania coagulans (Stocks) Dunal in cholesterol-fed hyperlipidemic rabbit model

Indian Journal of Experimental Biology

Volumn 52, Issue 9, 2014, Pages 870-875

  Shukla, Kirtikar ^a   Dikshit, Piyush ^a   Shukla, Rimi ^a   Sharma, Sonal ^a   Gambhir, Jasvinder K ^a  

^a UNIVERSITY COLLEGE OF MEDICAL SCIENCES   (India)

Author keywords

Hypercholesterolemia; Lipid lowering activities; Lipid metabolism; Oxidative stress; Withania coagulans

Indexed keywords

ANTILIPEMIC AGENT; ANTIOXIDANT; CHOLESTEROL; LIPID; PLANT EXTRACT;

ANIMAL; ARTICLE; BLOOD; CHEMISTRY; DRUG EFFECT; ENZYMOLOGY; FRUIT; LIVER; MALE; METABOLISM; PATHOLOGY; RABBIT; WITHANIA;

ANIMALS; ANTIOXIDANTS; CHOLESTEROL; FRUIT; HYPOLIPIDEMIC AGENTS; LIPIDS; LIVER; MALE; PLANT EXTRACTS; RABBITS; WITHANIA;

EID: 84906923016     PISSN: 00195189     EISSN: 09751009     Source Type: Journal    
DOI: None     Document Type: Letter

References (34)

1. Reiner Z & Tedeschi-Reiner E, Atherosclerosis - a paradox of Eastern European countries, Atherosclerosis, 7 (2006) Suppl: 461. doi: 10.1016/S1567-5688(06)81854-4.
2. Shukla R, Gupta S, Gambhir J K, Prabhu K M & Murthy P S, Antioxidant effect of aqueous extract of Ficus bengalensis in hypercholesterolaemic rabbits, J Ethnopharmacol, 92 (2004) 47.
3. Atta-ur-Rahman, Dur-e-Shahwar, Naz A & Choudhary M I, Withanolides from Withania coagulans, Phytochemistry, 63 (2003) 387.
4. Hemlatha S, Wahi A K, Singh P N & Chansouria J P N, Hypolipidemic activity of aqueous extract of Withania coagulans Dunal in albino rats, Phytother Res, 20 (2006) 614.
5. Shukla K, Dikshit P, Shukla R & Gambhir J K, The aqueous extract of Withania coagulans fruit partially reverses nicotinamide / streptozotocin induced diabetes mellitus in rats, J Med Food, 15 (2012) 718.
6. Shukla K, Dikshit P, Tyagi M K, Shukla R & Gambhir J K, Ameliorative effect of Withania coagulans on dyslipidemia and oxidative stress in nicotinamide -streptozotocin induced diabetes mellitus, Food Chem Toxicol, 50 (2012) 3595.
7. Dornas W C, Oliveira T T, Augusto L E & Nagem T J, Experimental atherosclerosis in rabbits, Arq Bras Cardiol, 95 (2010) 272.
8. Singleton V L & Rossi J A, Colorimetry of total phenolics with phosphomolybdic- phosphotungstic acid reagents, Am J Enol Vitic,16 (1965) 144.
9. Chang C, Yang M, Wen H & Chern J, Estimation of total flavonoid content in propolis by two complimentary colorimetric methods, J Food Drug Anal, 10 (2002) 178.
10. Parasuraman S, Raveendran R & Kesavan R, Blood sample collection in small laboratory animals, J Pharmacol Pharmacother, 1(2010) 87.
11. Friedewald W T, Levy R I & Fredrickson D S, Estimation of concentration of low density lipoprotein cholesterol in plasma, without use of the preparative ultracentrifuge, Clin Chem, 18 (1972) 499.
12. Rao A V & Ramakrishnan S, Indirect assessment of hydroxymethylglutaryl-CoA reductase activity in liver tissue, Clin Chem, 21 (1975) 1523.
13. Nakanishi S & Numa S, Purification of rat liver acetyl coenzyme A carboxylase and immunochemical studies on its synthesis and degradation, Eur J Biochem, 16 (1970) 161.
14. Beutler E, Duron D & Kelly B M, Improved method for the determination of blood glutathione, J Lab Clin Med, 61 (1963) 882.
15. Ellman G L, Tissue sulfhydryl groups, Arch Biochem Biophys, 82 (1959) 70.
16. Satoh K, Serum lipid peroxide in cerebrospinal disorder determined by new colorimetric methods, Clin Chim Acta, 90 (1978) 37.
17. Wills E D, Mechanisms of lipid peroxide formation in animal tissues, J Biochem, 99 (1966) 667.
18. Nandi A & Chatterjee I B, Assay of superoxide dismutase activity in animal tissue, J Biosci, 13 (1988) 305.
19. Folch J, Lees M & Sloane G, A simple method for the isolation and purification of total lipids from animal tissues, J Biol Chem, 226 (1957) 497.
20. Drabkin D L & Austin J H, Spectrophotometric studies. II. Preparations from washed blood cells; nitric oxide hemoglobin and sulfhemoglobin, J Biol Chem, 112 (1935) 51.
21. Lowry O H, Rosebrough N J, Farr A L & Randall R J, Protein measurement with the Folin phenol reagent, J Biol Chem, 193 (1951) 265.
22. Burt A D, Mutton A & Day C P, Diagnosis and interpretation of steatosis and steatohepatitis, Semin Diagnostic Path, 15 (1998) 246.
23. Angulo P & Lindor K D, Non-alcoholic fatty liver disease, J Gastroenterol Hepatol, (2002) S186.
24. Suanarunsawat T, Ayutthaya W D, Songsak T, Thirawarapan S & Poungshompoo S, Lipid lowering and antioxidative activities of aqueous extract of Ocimum sanctum L. leaves in rats fed with a high-cholesterol diet, Oxid Med Cell Longev, (2011) (Serial on the Internet) doi: 10.1155/2011/962025
25. Yang X, Yang L & Zheng H, Hypolipidemic and antioxidant effects of mulberry (Morus alba L.) fruit in hyperlipidemia rats, Food Chem Toxicol, 48 (2010) 2374.
26. Mathur D, Agrawal R C & Shrivastava V, Phytochemical screening and determination of antioxidant potential of fruits extracts of Withania coagulans, Rec Res Sci Tech, 3 (2011) 26.
27. Chen C W & Cheng H, A rice bran oil diet increases LDL-receptor and HMG-CoA reductase mRNA expressions and insulin sensitivity in rats with streptozotocin/nicotinamide-induced type 2 diabetes, J Nutr, 136 (2006) 1472.
28. DeBose-Boyd R A, Feedback regulation of cholesterol synthesis: sterol accelerated ubiquitination and degradation of HMG CoA Reductase, Cell Res, 18 (2008) 609.
29. Meydani M & Hasan S T, Dietary polyphenols and obesity, Nutrients, 2 (2010) 737.
30. Suanarunsawat T, Ayutthaya W D, Songsak T, Thirawarapan S & Poungshompoo S, Lipid-lowering and antioxidative activities of aqueous extracts of Ocimum sanctum L leaves in rats fed with a high-cholesterol diet, Oxid Med Cell Longev, (2011): 962025. doi: 10.1155/2011/962025.
31. Van Acker S A, Berg van den D J & Tromp M N, Structural aspects of antioxidant activity of flavonoids, Free Radic Biol Med, 20 (1996) 331.
32. Fki I, Bouaziz M, Sahnoun Z & Sayadi S, Hypocholesterolemic effect of phenolic-rich extracts of Chemlali olive cultivar in rats fed a cholesterol rich diet, Bioorg Med Chem, 13 (2005) 5362.
33. Orrenius S & Moldeus P, The multiple roles of glutathione in drug metabolism, Trends J Pharm Sci, 5 (1984) 432.
34. Brawn K & Fridovich I, Superoxide radical and superoxide dismutase: threat and defence, Acta Physiol Scand, 492 (1980) 9.