-
1
-
-
20044390015
-
A potent small molecule inhibits polyglutamine aggregation in Huntington’s disease neurons and suppresses neurodegeneration in vivo
-
Zhang X, Smith DL, Meriin AB, Engemann S, Russel DE, Roark M, Washington SL, Maxwell MM, Marsh JL, Thompson LM, Wanker EE, Young AB, Housman DE, Bates GP, Sherman MY, Kazantsev AG. A potent small molecule inhibits polyglutamine aggregation in Huntington’s disease neurons and suppresses neurodegeneration in vivo. Proc Natl Acad Sci U S A. 2005;102:892-7.
-
(2005)
Proc Natl Acad Sci U S A.
, vol.102
, pp. 892-897
-
-
Zhang, X.1
Smith, D.L.2
Meriin, A.B.3
Engemann, S.4
Russel, D.E.5
Roark, M.6
Washington, S.L.7
Maxwell, M.M.8
Marsh, J.L.9
Thompson, L.M.10
Wanker, E.E.11
Young, A.B.12
Housman, D.E.13
Bates, G.P.14
Sherman, M.Y.15
Kazantsev, A.G.16
-
2
-
-
36749022180
-
A small-molecule therapeutic lead for Huntington’s disease: Preclinical pharmacology and efficacy of C2-8 in the R6/2 transgenic mouse
-
Chopra V, Fox JH, Lieberman G, Dorsey K, Matson W, Waldmeier P, Housman DE, Kazantsev A, Young AB, Hersch S. A small-molecule therapeutic lead for Huntington’s disease: Preclinical pharmacology and efficacy of C2-8 in the R6/2 transgenic mouse. Proc Natl Acad Sci U S A. 2007;104:16685-9.
-
(2007)
Proc Natl Acad Sci U S A.
, vol.104
, pp. 16685-16689
-
-
Chopra, V.1
Fox, J.H.2
Lieberman, G.3
Dorsey, K.4
Matson, W.5
Waldmeier, P.6
Housman, D.E.7
Kazantsev, A.8
Young, A.B.9
Hersch, S.10
-
3
-
-
16044373842
-
Exon 1 of the HD gene with an expanded CAG repeat is sufficient to cause a progressive neurological phenotype in transgenic mice
-
Mangiarini L, Sathasivam K, Seller M, Cozens B, Harper A, Hetherington C, Lawton M, Trottier Y, Lehrach H, Davies SW, Bates GP. Exon 1 of the HD gene with an expanded CAG repeat is sufficient to cause a progressive neurological phenotype in transgenic mice. Cell. 1996;87:493-506.
-
(1996)
Cell.
, vol.87
, pp. 493-506
-
-
Mangiarini, L.1
Sathasivam, K.2
Seller, M.3
Cozens, B.4
Harper, A.5
Hetherington, C.6
Lawton, M.7
Trottier, Y.8
Lehrach, H.9
Davies, S.W.10
Bates, G.P.11
-
4
-
-
84867302438
-
A call for transparent reporting to optimize the predictive value of preclinical research
-
Landis SC, Amara SG, Asadullah K, Austin CP, Blumenstein R, Bradley EW, Crystal RG, Darnell RB, Ferrante RJ, Fillit H, Finkelstein R, Fisher M, Gendelman HE, Golub RM, Goudreau JL, Gross RA, Gubitz AK, Hesterlee SE, Howells DW, Huguenard J, Kelner K, Koroshetz W, Krainc D, Lazic SE, Levine MS, Macleod MR, McCall JM, Moxley RT, 3rd, Narasimhan K, Noble LJ, Perrin S, Porter JD, Steward O, Unger E, Utz U, Silberberg SD. A call for transparent reporting to optimize the predictive value of preclinical research. Nature. 2012;490:187-91.
-
(2012)
Nature.
, vol.490
, pp. 187-191
-
-
Landis, S.C.1
Amara, S.G.2
Asadullah, K.3
Austin, C.P.4
Blumenstein, R.5
Bradley, E.W.6
Crystal, R.G.7
Darnell, R.B.8
Ferrante, R.J.9
Fillit, H.10
Finkelstein, R.11
Fisher, M.12
Gendelman, H.E.13
Golub, R.M.14
Goudreau, J.L.15
Gross, R.A.16
Gubitz, A.K.17
Hesterlee, S.E.18
Howells, D.W.19
Huguenard, J.20
Kelner, K.21
Koroshetz, W.22
Krainc, D.23
Lazic, S.E.24
Levine, M.S.25
Macleod, M.R.26
McCall, J.M.27
Moxley 3rd, R.T.28
Narasimhan, K.29
Noble, L.J.30
Perrin, S.31
Porter, J.D.32
Steward, O.33
Unger, E.34
Utz, U.35
Silberberg, S.D.36
more..
-
5
-
-
46749157501
-
Full-length human mutant huntingtin with a stable polyglutamine repeat can elicit progressive and selective neuropathogenesis in BACHD mice
-
Gray M, Shirasaki DI, Cepeda C, André VM, Wilburn B, Lu XH, Tao J, Yamazaki I, Li SH, Sun YE, Li XJ, Levine MS, Yang XW. Full-length human mutant huntingtin with a stable polyglutamine repeat can elicit progressive and selective neuropathogenesis in BACHD mice. J Neurosci. 2008;28:6182-95.
-
(2008)
J Neurosci.
, vol.28
, pp. 6182-6195
-
-
Gray, M.1
Shirasaki, D.I.2
Cepeda, C.3
André, V.M.4
Wilburn, B.5
Lu, X.H.6
Tao, J.7
Yamazaki, I.8
Li, S.H.9
Sun, Y.E.10
Li, X.J.11
Levine, M.S.12
Yang, X.W.13
-
6
-
-
68249155312
-
Systematic behavioral evaluation of Huntington’s disease transgenic and knock-in mouse models
-
Menalled L, El-Khodor BF, Patry M, Suárez-Fariñas M, Orenstein SJ, Zahasky B, Leahy C, Wheeler V, Yang XW, MacDonald M, Morton AJ, Bates G, Leeds J, Park L, Howland D, Signer E, Tobin A, Brunner D. Systematic behavioral evaluation of Huntington’s disease transgenic and knock-in mouse models. Neurobiol Dis. 2009;35:319-36.
-
(2009)
Neurobiol Dis.
, vol.35
, pp. 319-336
-
-
Menalled, L.1
El-Khodor, B.F.2
Patry, M.3
Suárez-Fariñas, M.4
Orenstein, S.J.5
Zahasky, B.6
Leahy, C.7
Wheeler, V.8
Yang, X.W.9
MacDonald, M.10
Morton, A.J.11
Bates, G.12
Leeds, J.13
Park, L.14
Howland, D.15
Signer, E.16
Tobin, A.17
Brunner, D.18
-
7
-
-
80755126040
-
Administration of substances to laboratory animals: Routes of administration and factors to consider
-
Turner PV, Brabb T, PekowC, Vasbinder MA. Administration of substances to laboratory animals: Routes of administration and factors to consider. J Am Assoc Lab Anim Sci. 201;50:600-13.
-
J Am Assoc Lab Anim Sci.
, vol.201
, Issue.50
, pp. 600-613
-
-
Turner, P.V.1
Brabb, T.2
Pekow, C.3
Vasbinder, M.A.4
-
8
-
-
60849106352
-
Bacterial artificial chromosome transgenic mice expressing a truncated mutant parkin exhibit age-dependent hypokinetic motor deficits, dopaminergic neuron degeneration, and accumulation of proteinase K-resistant alpha-synuclein
-
Lu XH, Fleming SM, Meurers B, Ackerson LC, Mortazavi F, Lo V, Hernandez D, Sulzer D, Jackson GR, Maidment NT, ChesseletMF, YangXW. Bacterial artificial chromosome transgenic mice expressing a truncated mutant parkin exhibit age-dependent hypokinetic motor deficits, dopaminergic neuron degeneration, and accumulation of proteinase K-resistant alpha-synuclein. J Neurosci. 2009;29:1962-76.
-
(2009)
J Neurosci.
, vol.29
, pp. 1962-1976
-
-
Lu, X.H.1
Fleming, S.M.2
Meurers, B.3
Ackerson, L.C.4
Mortazavi, F.5
Lo, V.6
Hernandez, D.7
Sulzer, D.8
Jackson, G.R.9
Maidment, N.T.10
Chesselet, M.F.11
Yang, X.W.12
-
9
-
-
0032475941
-
Ataxin-1 nuclear localization and aggregation: Role in polyglutamine-induced disease in SCA1 transgenic mice
-
Klement IA, Skinner PJ, Kaytor MD, Yi H, Hersch SM, Clark HB, Zoghbi HY, Orr HT. Ataxin-1 nuclear localization and aggregation: Role in polyglutamine-induced disease in SCA1 transgenic mice. Cell. 1998;95:41-53.
-
(1998)
Cell.
, vol.95
, pp. 41-53
-
-
Klement, I.A.1
Skinner, P.J.2
Kaytor, M.D.3
Yi, H.4
Hersch, S.M.5
Clark, H.B.6
Zoghbi, H.Y.7
Orr, H.T.8
-
10
-
-
0032475931
-
Huntingtin acts in the nucleus to induce apoptosis but death does not correlate with the formation of intranuclear inclusions
-
Saudou F, Finkbeiner S, Devys D, GreenbergME. Huntingtin acts in the nucleus to induce apoptosis but death does not correlate with the formation of intranuclear inclusions. Cell. 1998;95:55-66.
-
(1998)
Cell.
, vol.95
, pp. 55-66
-
-
Saudou, F.1
Finkbeiner, S.2
Devys, D.3
Greenberg, M.E.4
-
11
-
-
7244236320
-
Inclusion body formation reduces levels of mutant huntingtin and the risk of neuronal death
-
Arrasate M, Mitra S, Schweitzer ES, Segal MR, Finkbeiner S. Inclusion body formation reduces levels of mutant huntingtin and the risk of neuronal death. Nature. 2004;431:805-10.
-
(2004)
Nature.
, vol.431
, pp. 805-810
-
-
Arrasate, M.1
Mitra, S.2
Schweitzer, E.S.3
Segal, M.R.4
Finkbeiner, S.5
-
12
-
-
49349110821
-
Huntington’s disease: Revisiting the aggregation hypothesis in polyglutamine neurodegenerative diseases
-
Truant R, Atwal RS, Desmond C, Munsie L, Tran T. "Huntington’s disease: Revisiting the aggregation hypothesis in polyglutamine neurodegenerative diseases". Febs J. 2008;275:4252-62.
-
(2008)
Febs J.
, vol.275
, pp. 4252-4262
-
-
Truant, R.1
Atwal, R.S.2
Desmond, C.3
Munsie, L.4
Tran, T.5
-
13
-
-
84871422859
-
Comprehensive behavioral and molecular characterization of a new knock-in mouse model of Huntington’s disease: Zq175
-
Menalled LB, Kudwa AE, Miller S, Fitzpatrick J, Watson-Johnson J, Keating N, Ruiz M, Mushlin R, Alosio W, McConnell K, Connor D, Murphy C, Oakeshott S, Kwan M, Beltran J, Ghavami A, Brunner D, Park LC, Ramboz S, Howland D. Comprehensive behavioral and molecular characterization of a new knock-in mouse model of Huntington’s disease: zQ175. PLoS One. 2012;7:e49838.
-
(2012)
PLoS One.
, vol.7
, pp. e49838
-
-
Menalled, L.B.1
Kudwa, A.E.2
Miller, S.3
Fitzpatrick, J.4
Watson-Johnson, J.5
Keating, N.6
Ruiz, M.7
Mushlin, R.8
Alosio, W.9
McConnell, K.10
Connor, D.11
Murphy, C.12
Oakeshott, S.13
Kwan, M.14
Beltran, J.15
Ghavami, A.16
Brunner, D.17
Park, L.C.18
Ramboz, S.19
Howland, D.20
more..
|