메뉴 건너뛰기




Volumn 2, Issue 4, 2013, Pages 443-451

An independent study of the preclinical efficacy of C2-8 in the R6/2 transgenic mouse model of huntington’s disease

Author keywords

Aggregate; C2 8; Huntingtin; Huntington s disease; Preclinical; R6 2

Indexed keywords

ANILIDE; HUNTINGTIN; N (4 BROMOPHENYL) 3 (4 BROMOPHENYLAMINOSULFONYL)BENZAMIDE; N-(4-BROMOPHENYL) 3-(4-BROMOPHENYLAMINOSULFONYL)BENZAMIDE; NEUROPROTECTIVE AGENT; SULFONAMIDE;

EID: 84906922788     PISSN: 18796397     EISSN: 18796400     Source Type: Journal    
DOI: 10.3233/JHD-130074     Document Type: Article
Times cited : (10)

References (13)
  • 7
    • 80755126040 scopus 로고    scopus 로고
    • Administration of substances to laboratory animals: Routes of administration and factors to consider
    • Turner PV, Brabb T, PekowC, Vasbinder MA. Administration of substances to laboratory animals: Routes of administration and factors to consider. J Am Assoc Lab Anim Sci. 201;50:600-13.
    • J Am Assoc Lab Anim Sci. , vol.201 , Issue.50 , pp. 600-613
    • Turner, P.V.1    Brabb, T.2    Pekow, C.3    Vasbinder, M.A.4
  • 8
    • 60849106352 scopus 로고    scopus 로고
    • Bacterial artificial chromosome transgenic mice expressing a truncated mutant parkin exhibit age-dependent hypokinetic motor deficits, dopaminergic neuron degeneration, and accumulation of proteinase K-resistant alpha-synuclein
    • Lu XH, Fleming SM, Meurers B, Ackerson LC, Mortazavi F, Lo V, Hernandez D, Sulzer D, Jackson GR, Maidment NT, ChesseletMF, YangXW. Bacterial artificial chromosome transgenic mice expressing a truncated mutant parkin exhibit age-dependent hypokinetic motor deficits, dopaminergic neuron degeneration, and accumulation of proteinase K-resistant alpha-synuclein. J Neurosci. 2009;29:1962-76.
    • (2009) J Neurosci. , vol.29 , pp. 1962-1976
    • Lu, X.H.1    Fleming, S.M.2    Meurers, B.3    Ackerson, L.C.4    Mortazavi, F.5    Lo, V.6    Hernandez, D.7    Sulzer, D.8    Jackson, G.R.9    Maidment, N.T.10    Chesselet, M.F.11    Yang, X.W.12
  • 10
    • 0032475931 scopus 로고    scopus 로고
    • Huntingtin acts in the nucleus to induce apoptosis but death does not correlate with the formation of intranuclear inclusions
    • Saudou F, Finkbeiner S, Devys D, GreenbergME. Huntingtin acts in the nucleus to induce apoptosis but death does not correlate with the formation of intranuclear inclusions. Cell. 1998;95:55-66.
    • (1998) Cell. , vol.95 , pp. 55-66
    • Saudou, F.1    Finkbeiner, S.2    Devys, D.3    Greenberg, M.E.4
  • 11
    • 7244236320 scopus 로고    scopus 로고
    • Inclusion body formation reduces levels of mutant huntingtin and the risk of neuronal death
    • Arrasate M, Mitra S, Schweitzer ES, Segal MR, Finkbeiner S. Inclusion body formation reduces levels of mutant huntingtin and the risk of neuronal death. Nature. 2004;431:805-10.
    • (2004) Nature. , vol.431 , pp. 805-810
    • Arrasate, M.1    Mitra, S.2    Schweitzer, E.S.3    Segal, M.R.4    Finkbeiner, S.5
  • 12
    • 49349110821 scopus 로고    scopus 로고
    • Huntington’s disease: Revisiting the aggregation hypothesis in polyglutamine neurodegenerative diseases
    • Truant R, Atwal RS, Desmond C, Munsie L, Tran T. "Huntington’s disease: Revisiting the aggregation hypothesis in polyglutamine neurodegenerative diseases". Febs J. 2008;275:4252-62.
    • (2008) Febs J. , vol.275 , pp. 4252-4262
    • Truant, R.1    Atwal, R.S.2    Desmond, C.3    Munsie, L.4    Tran, T.5


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.