Mechanisms underlying sleep-wake disturbances in alcoholism: Focus on the cholinergic pedunculopontine tegmentum

Behavioural Brain Research

Volumn 274, Issue , 2014, Pages 291-301

  Knapp, Clifford M ^a   Ciraulo, Domenic A ^a   Datta, Subimal ^a  

^a BOSTON UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

Alcohol addiction; GABA; Glutamate; Pedunculopontine tegmentum; Receptor; Sleep wakefulness

Indexed keywords

4 AMINOBUTYRIC ACID B RECEPTOR; ALCOHOL; KAINIC ACID RECEPTOR; N METHYL DEXTRO ASPARTIC ACID RECEPTOR; 4 AMINOBUTYRIC ACID A RECEPTOR; ACETYLCHOLINE;

ADULT; ALCOHOL CONSUMPTION; ALCOHOL USE DISORDER; ALCOHOL WITHDRAWAL; ALCOHOLISM; ALPHA RHYTHM; BETA RHYTHM; CHOLINERGIC NERVE CELL; CHOLINERGIC PEDUNCULOPONTINE TEGMENTUM; CIRCADIAN RHYTHM SLEEP DISORDER; DAYTIME SOMNOLENCE; DELTA RHYTHM; DISEASE ASSOCIATION; DISEASE MODEL; ELECTROENCEPHALOGRAM; GAMMA RHYTHM; HUMAN; MISCELLANEOUS NAMED GROUPS; NERVE CELL CHARACTERISTICS AND FUNCTIONS; NEUROADAPTATION; NEUROBIOLOGY; NEUROMODULATION; NEUROPATHOLOGY; NON ALCOHOLIC; NONHUMAN; NONREM SLEEP; PATHOPHYSIOLOGY; PRIORITY JOURNAL; REM SLEEP; REVIEW; SACCADIC EYE MOVEMENT; SENSITIVITY ANALYSIS; SLEEP DISORDER; SLEEP SPINDLE; SLEEP STAGE; SLEEP TIME; SLEEP WAKING CYCLE; TEGMENTUM; VENTRAL TEGMENTUM; WAKEFULNESS; ANIMAL; COMPLICATION; METABOLISM; PATHOLOGY; PEDUNCULOPONTINE TEGMENTAL NUCLEUS; SLEEP DISORDERS, CIRCADIAN RHYTHM;

ACETYLCHOLINE; ALCOHOLISM; ANIMALS; HUMANS; PEDUNCULOPONTINE TEGMENTAL NUCLEUS; RECEPTORS, GABA-A; RECEPTORS, KAINIC ACID; RECEPTORS, N-METHYL-D-ASPARTATE; SLEEP DISORDERS, CIRCADIAN RHYTHM;

EID: 84906860765     PISSN: 01664328     EISSN: 18727549     Source Type: Journal    
DOI: 10.1016/j.bbr.2014.08.029     Document Type: Review

References (214)

1. Diagnostic and statistical manual of mental disorders (DSM-5) 2013, American Psychiatric Association, American Psychiatric Publishing, Washington, DC. fifth ed.
2. National Institute on Alcohol Abuse and Alcoholism (〈www.niaaa.nih.gov〉). Alcohol facts and statistics (2014).
3. Brower K.J. Alcohol's effects on sleep in alcoholics. Alcohol Res Health 2001, 25:110-125.
4. Landolt H.P., Gillin J.C. Sleep abnormalities during abstinence in alcohol-dependent patients. Aetiology and management. CNS Drugs 2001, 15:413-425.
5. Roehrs T., Roth T. Sleep, sleepiness, and alcohol use. Alcohol Res Health 2001, 25:101-109.
6. Roehrs T., Roth T. Sleep, sleepiness, sleep disorders and alcohol use and abuse. Sleep Med Rev 2001, 5:287-297.
7. Koob G.F. A role for brain stress systems in addiction. Neuron 2008, 59:11-34.
8. Koob G.F., Volkow N.D. Neurocircuitry of addiction. Neuropsychopharmacology 2010, 35:217-238.
9. Koob G.F. Theoretical frameworks and mechanistic aspects of alcohol addiction: alcohol addiction as a reward deficit disorder. Curr Top Behav Neurosci 2011, 13:3-30.
10. Ross S., Peselow E. The neurobiology of addictive disorders. Clin Neuropharmacol 2009, 32:269-276.
11. Valenzuela C.F., Harris R.A. Alcohol: neurobiology. Substance abuse: a comprehensive textbook 1997, Williams and Wilkins, Philadelphia, USA. third ed.
12. Datta S., Maclean R.R. Neurobiological mechanisms for the regulation of mammalian sleep-wake behavior: reinterpretation of historical evidence and inclusion of contemporary cellular and molecular evidence. Neurosci Biobehav Rev 2007, 31:775-824.
13. Datta S. Cellular and chemical neuroscience of mammalian sleep. Sleep Med 2010, 11:431-440.
14. Pace-Schott E.F., Hobson J.A. The neurobiology of sleep: genetics, cellular physiology and subcortical networks. Nat Rev Neurosci 2002, 3:591-605.
15. Datta S. Sleep: learning and memory. Encyclopedia of behavioral neuroscience. 2010, 218-226. Academic Press, Oxford. G. Koob, M. Le Moal, R. Thompson (Eds.).
16. Dijk D.J.B.D., Aeschbach D., Tobler I., Borbely A.A. The effects of ethanol on human sleep EEG power spectra differ from those of benzodiazepine receptor agonists. Neuropsychopharmacology 1992, 7:225-232.
17. Gresham S.C., Webb W.B., Williams R.L. Alcohol and caffeine: effect on inferred visual dreaming. Science 1963, 140:1226-1227.
18. MacLean A.W., Cairns J. Dose-response effects of ethanol on the sleep of young men. J Stud Alcohol 1982, 43:434-444.
19. Roehrs T., Papineau K., Rosenthal L., Roth T. Ethanol as a hypnotic in insomniacs: self administration and effects on sleep and mood. Neuropsychopharmacology 1999, 20:279-286.
20. Rundell O.H., Lester B.K., Griffiths W.J., Williams H.L. Alcohol and sleep in young adults. Psychopharmacologia 1972, 26:201-218.
21. Stone B.M. Sleep and low doses of alcohol. Electroencephalogr Clin Neurophysiol 1980, 48:706-709.
22. Williams D.L., MacLean A.W., Cairns J. Dose-response effects of ethanol on the sleep of young women. J Stud Alcohol 1983, 44:515-523.
23. Yules R.B., Freedman D.X., Chandler K.A. The effect of ethyl alcohol on man's electroencephalographic sleep cycle. Electroencephalogr Clin Neurophysiol 1966, 20:109-111.
24. Landolt H.P., Roth C., Dijk D.J., Borbely A.A. Late-afternoon ethanol intake affects nocturnal sleep and the sleep EEG in middle-aged men. J Clin Psychopharmacol 1996, 16:428-436.
25. Ghosh T.K., Copeland R.L., Alex P.K., Pradhan S.N. Behavioral effects of ethanol inhalation in rats. Pharmacol Biochem Behav 1991, 38:699-704.
26. Ghosh T.K., Copeland R.L., Pradhan S.N. Effects of ethanol inhalation on EEG in rats. Pharmacol Biochem Behav 1991, 38:293-297.
27. Hattan D.G., Eacho P.I. Relationship of ethanol blood level to REM and non-REM sleep time and distribution in the rat. Life Sci 1978, 22:839-846.
28. Hill S.Y., Reyes R.B. Effects of chronic and acute ethanol administration on sleep in laboratory rats. J Stud Alcohol 1978, 39:47-55.
29. Kubota T., De A., Brown R.A., Simasko S.M., Krueger J.M. Diurnal effects of acute and chronic administration of ethanol on sleep in rats. Alcohol Clin Exp Res 2002, 26:1153-1161.
30. Mendelson W.B., Hill S.Y. Effects of the acute administration of ethanol on the sleep of the rat: a dose-response study. Pharmacol Biochem Behav 1978, 8:723-726.
31. Gross M.M., Goodenough D.R., Hastey J., Lewis E. Experimental study of sleep in chronic alcoholics before, during, and after four days of heavy drinking with a nondrinking comparison. Ann N Y Acad Sci 1973, 215:254-265.
32. Gross M.M., Hastey J.M. The relation between baseline slow wave sleep and the slow wave sleep response to alcohol in alcoholics. Adv Exp Med Biol 1975, 59:467-475.
33. Wagman A.M., Allen R.P. Effects of alcohol ingestion and abstinence on slow wave sleep of alcoholics. Adv Exp Med Biol 1975, 59:453-466.
34. Prinz P.N., Roehrs T.A., Vitaliano P.P., Linnoila M., Weitzman E.D. Effect of alcohol on sleep and nighttime plasma growth hormone and cortisol concentrations. J Clin Endocrinol Metab 1980, 51:759-764.
35. Mello N.K., Mendelson J.H. Behavioral studies of sleep patterns in alcoholics during intoxication and withdrawal. J Pharmacol Exp Ther 1970, 175:94-112.
36. Mukherjee S., Kazerooni M., Simasko S.M. Dose-response study of chronic alcohol induced changes in sleep patterns in rats. Brain Res 2008, 1208:120-127.
37. Mukherjee S., Simasko S.M. Chronic alcohol treatment in rats alters sleep by fragmenting periods of vigilance cycling in the light period with extended wakenings. Behav Brain Res 2009, 198:113-124.
38. Sharma R., Engemann S.C., Sahota P., Thakkar M.M. Effects of ethanol on extracellular levels of adenosine in the basal forebrain: an in vivo microdialysis study in freely behaving rats. Alcohol Clin Exp Res 2010, 34:813-818.
39. Adamson J., Burdick J.A. Sleep of dry alcoholics. Arch Gen Psychiatry 1973, 28:146-149.
40. Brower K.J., Aldrich M.S., Hall J.M. Polysomnographic and subjective sleep predictors of alcoholic relapse. Alcohol Clin Exp Res 1998, 22:1864-1871.
41. Brower K.J., Aldrich M.S., Robinson E.A., Zucker R.A., Greden J.F. Insomnia, self-medication, and relapse to alcoholism. Am J Psychiatry 2001, 158:399-404.
42. De Soto C.B., O'Donnell W.E., Allred L.J., Lopes C.E. Symptomatology in alcoholics at various stages of abstinence. Alcohol Clin Exp Res 1985, 9:505-512.
43. Drummond S.P., Gillin J.C., Smith T.L., DeModena A. The sleep of abstinent pure primary alcoholic patients: natural course and relationship to relapse. Alcohol Clin Exp Res 1998, 22:1796-1802.
44. Foster J.H., Marshall E.J., Peters T.J. Application of a quality of life measure, the life situation survey (LSS), to alcohol-dependent subjects in relapse and remission. Alcohol Clin Exp Res 2000, 24:1687-1692.
45. Gross M.M. Sleep disturbances in alcoholism. Alcoholism: interdisciplinary approaches to an enduring problem 1976, 257-309. Addison-Wesley Publishing Co., Munich, Germany.
46. Imatoh N., Nakazawa Y., Ohshima H., Ishibashi M., Yokoyama T. Circadian rhythm of REM sleep of chronic alcoholics during alcohol withdrawal. Drug Alcohol Depend 1986, 18:77-85.
47. Ishibashi M., Nakazawa Y., Yokoyama T., Koga Y., Miyahara Y., Hayashida N., et al. Cerebral atrophy and slow wave sleep of abstinent chronic alcoholics. Drug Alcohol Depend 1987, 19:325-332.
48. Williams H.L., Rundell O.H. Altered sleep physiology in chronic alcoholics: reversal with abstinence. Alcohol Clin Exp Res 1981, 5:318-325.
49. Aubin H.J., Monfort J.C., Benoit O., Goldenberg F., Roullet-Volmi M.C., Barrucand D. Alcohol, sleep and biological rhythms. Neurophysiol Clin 1993, 23:61-70.
50. Brower K.J., Hall J.M. Effects of age and alcoholism on sleep: a controlled study. J Stud Alcohol 2001, 62:335-343.
51. Gann H., Feige B., Hohagen F., van Calker D., Geiss D., Dieter R. Sleep and the cholinergic rapid eye movement sleep induction test in patients with primary alcohol dependence. Biol Psychiatry 2001, 50:383-390.
52. Gillin J.C., Smith T.L., Irwin M., Kripke D.F., Schuckit M. EEG sleep studies in pure primary alcoholism during subacute withdrawal: relationships to normal controls, age, and other clinical variables. Biol Psychiatry 1990, 27:477-488.
53. Gillin J.C., Smith T.L., Irwin M., Butters N., Demodena A., Schuckit M. Increased pressure for rapid eye movement sleep at time of hospital admission predicts relapse in nondepressed patients with primary alcoholism at 3-month follow-up. Arch Gen Psychiatry 1994, 51:189-197.
54. Snyder S., Karacan I. Sleep patterns of sober chronic alcoholics. Neuropsychobiology 1985, 13:97-100.
55. Zarcone V. Alcoholism and sleep. Adv Biosci 1978, 21:29-38.
56. Gann H., Feige B., Fasihi S., van Calker D., Voderholzer U., Riemann D. Periodic limb movements during sleep in alcohol dependent patients. Eur Arch Psychiatry Clin Neurosci 2002, 252:124-129.
57. Landolt H.P., Borbely A.A. Alcohol and sleep disorders. Ther Umsch 2000, 57:241-245.
58. Brower K.J. Insomnia, alcoholism and relapse. Sleep Med Rev 2003, 7:523-539.
59. Clark C.P., Gillin J.C., Golshan S., Demodena A., Smith T.L., Danowski S., et al. Increased REM sleep density at admission predicts relapse by three months in primary alcoholics with a lifetime diagnosis of secondary depression. Biol Psychiatry 1998, 43:601-607.
60. Mackenzie A., Funderburk F.R., Allen R.P. Sleep, anxiety, and depression in abstinent and drinking alcoholics. Subst Use Misuse 1999, 34:347-361.
61. Ehlers C.L., Slawecki C.J. Effects of chronic ethanol exposure on sleep in rats. Alcohol 2000, 20:173-179.
62. Gitlow S.E., Bentkover S.H., Dziedzic S.W., Khazan N. Persistence of abnormal REM sleep response to ethanol as a result of previous ethanol ingestion. Psychopharmacologia 1973, 33:135-140.
63. Mendelson W.B., Majchrowicz E., Mirmirani N., Dawson S., Gillin J.C., Wyatt R.J. Sleep during chronic ethanol administration and withdrawal in rats. J Stud Alcohol 1978, 39:1213-1223.
64. Rouhani S., Dall'Ava-Santucci J., Bajenaru O., Emmanouilidis E., Tran G., Manicom R., et al. Effects of muscimol or homotaurine on sleep-wake states in alcohol-dependent rats during withdrawal. Pharmacol Biochem Behav 1998, 59:955-960.
65. Veatch L.M. Disruptions in sleep time and sleep architecture in a mouse model of repeated ethanol withdrawal. Alcohol Clin Exp Res 2006, 30:1214-1222.
66. Davis P.A., Gibbs F.A., Davis H., Jetter W.W., Trowbridge L.S. The effects of alcohol upon the electroencephalogram (brain waves). Q J Study Alcohol 1941, 1:626-637.
67. Engel G.L., Rosenbaum M. Delerium III. Electroencephalographic changes associated with acute alcoholic intoxication. Arch Neurol Psychiatry 1945, 53:44-50.
68. Holmberg G., Martens S. Electroencephalographic changes in man correlated with blood alcohol concentration and some other conditions following standardized ingestion of alcohol. Q J Stud Alcohol 1955, 16:411-424.
69. Lehtinen I., Lang A.H., Jantii V., Pakkanen A., Keskinen E., Nyrke T., et al. Ethanol-induced disturbance in human arousal mechanism. Psychopharmacology 1981, 73:223-229.
70. Lukas S.E., Mendelson J.H., Benedikt R.A., Jones B. EEG alpha activity increases during transient episodes of ethanol-induced euphoria. Pharmacol Biochem Behav 1986, 25:889-895.
71. Michel C.H., Batting K. Separate and combined psychophysiological effects of cigarette smoking and alcohol consumption. Psychopharmacology 1989, 97:65-73.
72. Cohen H.L., Porjesz B., Begleiter H. Ethanol-induced alterations in electroencephalographic activity in adult males. Neuropsychopharmacology 1993, 8:365-370.
73. Ehlers C.L., Wall T.L., Schuckit M.A. EEG spectral characteristics following ethanol administration in young men. EEG Clin Neurophysiol 1989, 73:179-187.
74. Newman H.W. The effects of alcohol on the electroencephalogram. Stanford Med Bull 1959, 17:55-60.
75. Little H.J. The contribution of electrophysiology to knowledge of the acute and chronic effects of ethanol. Pharmacol Ther 1999, 84:333-353.
76. Murphree H.B., Schultz R.E., Jusko A.G. Effects of high congener intake by human subjects on the EEG. Q J Stud Alcohol 1970, 5(Suppl):50-61.
77. Lehtinen I., Lang A.H., Keskinen E. Acute effects of small doses of alcohol on the NSD parameters (normalized slope descriptors) of human EEG. Psychopharmacology 1978, 60:87-92.
78. Ehlers C.L., Schuckit M.A. EEG response to ethanol in sons of alcoholics. Psychopharmacol Bull 1988, 24:434-437.
79. Ehlers C.L., Schuckit M.A. EEG fast frequency activity in the sons of alcoholics. Biol Psychiatry 1990, 27:631-641.
80. Lukas S.E., Mendelson J.H., Woods B.T., Mello N.K., Teoh S.K. Topographic distribution of EEG alpha activity during ethanol-induced intoxication in women. J Stud Alcohol 1989, 50:176-185.
81. Ehlers C.L., Schuckit M.A. Evaluation of EEG alpha activity in sons of alcoholics. Neuropsychopharmacology 1991, 4:199-205.
82. Bauer L.O., Hesselbrock V.M. EEG and subjective correlates of the risk for alcoholism. J Stud Alcohol 1993, 54:577-589.
83. Courtney K.E., Polich J. Binge drinking effects on EEG in young adult humans. Int J Environ Res Public Health 2010, 7:2325-2336.
84. Morzorati S., Lamishaw B., Lumeng L., Li T.K., Bemis K., Clemens J. Effect of low dose ethanol on the EEG of ethanol preferring and non-preferring rats. Brain Res Bull 1988, 21:101-104.
85. Robeldo P., Lumeng L., Li T.K., Ehlers C.L. Effects of MK801 and diazepam on the EEG of P and NP rats. Alcohol Clin Exp Res 1994, 18:363-368.
86. Slawecki C.J., Bentancourt M., Li T.K., Ehlers C.L. Neurophysiological findings and drinking levels in high-alcohol-drinking (HAD) and low-alcohol-drinking (LAD) rats. Alcohol Clin Exp Res 2000, 24:1492-1499.
87. Bauer L.O. Electroencephalographic and autonomic predictors of relapse in alcohol-dependent patients. Alcohol Clin Exp Res. 1994, 18:755-760.
88. Costa L., Bauer L. Quantitative electroencephalographic differences associated with alcohol, cocaine, heroin and dual-substance dependence. Drug Alcohol Depend 1997, 46:87-93.
89. Winterer G.A., Kloppel B., Heinz A., Ziller M., Dufeu P., Schmidt L.G., et al. Quantitative E.E.G. (QEEG) predicts relapse in patients with chronic alcoholism and points to a frontally pronounced cerebral disturbance. Psychiatry Res 1998, 78:101-113.
90. Finn P.R., Justus A. Reduced EEG alpha power in the male and female offspring of alcoholics. Alcohol Clin Exp Res 1999, 23:256-262.
91. Rangaswamy M., Porjesz B., Chorlian D.B., Wang K., Jones K., Bauer L.O., et al. Beta power in the EEG of alcoholics. Biol Psychiatry 2002, 52:831-842.
92. Porjesz B., Begleiter H. Alcoholism and human electrophysiology. Alcohol Res Health 2003, 27:153-160.
93. Coutin-Churchman P., Moreno R., Anez Y., Vergara F. Clinical correlates of quantitative EEG alterations in alcoholic patients. Clin Neurophysiol 2006, 117:740-751.
94. Propping P., Kruger J., Mark N. Genetic disposition to alcoholism: An EEG study in alcoholics and their relatives. Hum Genet 1981, 59:51-59.
95. Bauer L.O. Predicting relapse to alcohol and drug abuse via quantitative electroencephalography. Neuropsychopharmacology 2001, 25:332-340.
96. Coutin-Churchman P., Anez Y., Uzcategui M., Alvarez L., Vergara F., Mendez L., et al. Quantitative spectral analysis of EEG in psychiatry revisited: drawing signs out of numbers in a clinical setting. Clin Neurophysiol 2003, 114:2294-2306.
97. Rangaswamy M., Porjesz B., Chorlian D.B., Choi K., Jones K.A., Wang K., et al. Theta power in the EEG of alcoholics. Alcohol Clin Exp Res 2003, 27:607-615.
98. Saleut-Zyhlarz G.M., Arnold O., Anderer P., Oberndorfer S., Walter H., Lesch O.M., et al. Differences in brain function between relapsing and abstaining alcohol-dependent patients, evaluated by EEG mapping. Alcohol Alcohol 2004, 39:233-240.
99. Jaaskelainen I.P., Hirvonen J., Saher M., Pekkonen E., Sillanaukee P., Naatanen R., et al. Dose-dependent suppression by ethanol of transient auditory 40-Hz response. Psychopharmacology 2000, 148:132-135.
100. Campbell A.E., Sumner P., Singh K.D., Muthukumaraswamy S.D. Acute effects of alcohol on stimulus-induced gamma oscillations in human primary visual and motor cortices. Neuropsychopharmacology 2014, (PMID: 24622470). 10.1038/npp.2014.58.
101. Padmanabhapillai A., Tang Y., Ranganathan M., Rangaswamy M., Jones K.A., Chorlian D.B., et al. Evoked gamma band response in male adolescent subjects at high risk for alcoholism during a visual oddball task. Int J Psychophysiol 2006, 62:262-271.
102. De Bruin E.A., Biji S., Stam C.J., Bocker K.B.E., Kenemans J.L., Verbaten M.N. Abnormal EEG synchronization in heavily drinking students. Clin Neurophysiol 2004, 115:2048-2055.
103. Coullaut-Valera R., Arbaiza I., Bajo R., Arrue R., Lopez M.E., Coullaut-Valera J., et al. Drug polyconsumption is associated with increased synchronization of brain electrical-activity at rest and in a counting task. Int J Neural Syst 2014, 24:1450005. 10.1142/S0129065714500051.
104. Sharma R., Engemann S., Sahota P., Thakkar M.M. Role of adenosine and wake-promoting basal forebrain in insomnia and associated sleep disruptions caused by ethanol dependence. J Neurochem 2010, 115:782-794.
105. Thakkar M.M., Engemann S.C., Sharma R., Sahota P. Role of wake-promoting basal forebrain and adenosinergic mechanisms in sleep-promoting effects of ethanol. Alcohol Clin Exp Res 2010, 34:997-1005.
106. Thakkar M.M., Engemann S.C., Sharma R., Mohan R.R., Sahota P. Sleep-wakefulness in alcohol preferring and non-preferring rats following binge alcohol administration. Neuroscience 2010, 170:22-27.
107. Majchrowicz E. Induction of physical dependence upon ethanol and the associated behavioral changes in rats. Psychopharmacologia 1975, 43:245-254.
108. Braconi S., Sidhpura N., Aujla H., Martin-Fardon R., Weiss F., Ciccocioppo R. Revisiting intragastric ethanol intubation as a dependence induction method for studies of ethanol reward and motivation in rats. Alcohol Clin Exp Res 2010, 34:538-544.
109. Majchrowicz E., Hunt W.A. Temporal relationship of the induction of tolerance and physical dependence after continuous intoxication with maximum tolerable doses of ethanol in rats. Psychopharmacology 1976, 50:107-112.
110. Meert T.F., Huysmans H. Repeated characterization of alcohol withdrawal reactions in rats chronically exposed to an alcohol liquid diet. Prog Neuropsychopharmacol Biol Psychiatry 1994, 18:947-960.
111. Macey D.J., Schulteis G., Heinrichs S.C., Koob G.F. Time-dependent quantifiable withdrawal from ethanol in the rat: effect of method of dependence induction. Alcohol 1996, 13:163-170.
112. Chung C.S., Wang J., Wehman M., Rhoads D.E. Severity of alcohol withdrawal symptoms depends on developmental stage of Long-Evans rats. Pharmacol Biochem Behav 2008, 89:137-144.
113. Serrano A., Rivera P., Pavon F.J., Decara J., Suarez J., Rodriguez de Fonseca F., et al. Differential effects of single versus repeated alcohol withdrawal on the expression of endocannabinoid system-related genes in the rat amygdala. Alcohol Clin Exp Res 2012, 36:984-994.
114. Gilpin N.W., Smith A.D., Cole M., Weiss F., Koob G.F., Richardson H.N. Operant behavior and alcohol levels in blood and brain of alcohol-dependent rats. Alcohol Clin Exp Res 2009, 33:2113-2123.
115. Ruwe W.D., Bauce L., Flemons W.W., Veale W.L., Pittman Q.J. Alcohol dependence and withdrawal in the rat. An effective means of induction and assessment. J Pharmacol Methods 1986, 15:225-234.
116. Veatch L.M. Disruptions in sleep time and sleep architecture in a mouse model of repeated ethanol withdrawal. Alcohol Clin Exp Res 2006, 30:1214-1222.
117. Wiggins W.F., Graef J.D., Huitt T.W., Godwin D.W. Ethosuximide reduces ethanol withdrawal-mediated disruptions in sleep-related EEG patterns. Alcohol Clin Exp Res 2013, 37:372-382.
118. Fidler T.L., Oberlin B.G., Struthers A.M., Cunningham C.L. Schedule of passive ethanol exposure affects subsequent intragastric ethanol self-infusion. Alcohol Clin Exp Res 2009, 33:1909-1923.
119. Simms J.A., Steensland P., Medina B., Abernathy K.E., Chandler L.J., Wise R., et al. Intermittent access to 20% ethanol induces high ethanol consumption in Long-Evans and Wistar rats. Alcohol Clin Exp Res 2008, 32:1816-1823.
120. Kampov-Polevoy A.B., Matthews D.B., Gause L., Morrow A.L., Overstreet D.H. P rats develop physical dependence on alcohol via voluntary drinking: changes in seizure thresholds, anxiety, and patterns of alcohol drinking. Alcohol Clin Exp Res 2000, 24:278-284.
121. McCarley R.W. Neurobiology of REM and NREM sleep. Sleep Med 2007, 8:302-330.
122. Davis K.M., Wu J.Y. Role of glutamatergic and GABAergic systems in alcoholism. J Biomed Sci 2001, 8:7-19.
123. Gilpin N.W., Koob G.F. Neurobiology of alcohol dependence: focus on motivational mechanisms. Alcohol Res Health 2008, 31:185-195.
124. Harris R.A. Ethanol actions on multiple ion channels: which are important. Alcohol Clin Exp Res 1999, 23:1563-1570.
125. Harris R.A., Mihic S.J. Alcohol and inhibitory receptors: unexpected specificity from a nonspecific drug. Proc Natl Acad Sci U S A 2004, 101:2-3.
126. Proctor W.R., Diao L., Freund R.K., Browning M.D., Wu P.H. Synaptic GABAergic and glutamatergic mechanisms underlying alcohol sensitivity in mouse hippocampal neurons. J Physiol 2006, 575:145-159.
127. Tsai G. Glutamatergic neurotransmission in alcoholism. J Biomed Sci 1998, 5:309-320.
128. Biggio G., Concas A., Follesa P., Sanna E., Serra M. Stress, ethanol, and neuroactive steroids. Pharmacol Ther 2007, 116:140-171.
129. Kelm M.K., Criswell H.E., Breese G.R. Ethanol-enhanced GABA release: a focus on G protein-coupled receptors. Brain Res Rev 2011, 65:113-123.
130. Datta S., Patterson E.H., Spoley E.E. Excitation of the pedunculopontine tegmental NMDA receptors induces wakefulness and cortical activation in the rat. J Neurosci Res 2001, 66:109-116.
131. Datta S., Spoley E.E., Patterson E.H. Microinjection of glutamate into the pedunculopontine tegmentum induces REM sleep and wakefulness in the rat. Am J Physiol Regul Integr Comp Physiol 2001, 280:R752-R759.
132. Datta S. Evidence that REM sleep is controlled by the activation of brain stem pedunculopontine tegmental kainate receptor. J Neurophysiol 2002, 87:1790-1798.
133. Datta S., Spoley E.E., Mavanji V.K., Patterson E.H. A novel role of pedunculopontine tegmental kainate receptors: a mechanism of rapid eye movement sleep generation in the rat. Neuroscience 2002, 114:157-164.
134. Datta S., Mavanji V., Patterson E.H., Ulloor J. Regulation of rapid eye movement sleep in the freely moving rat: local microinjection of serotonin, norepinephrine, and adenosine into the brainstem. Sleep 2003, 26:513-520.
135. Datta S. Activation of pedunculopontine tegmental PKA prevents GABAB receptor activation-mediated rapid eye movement sleep suppression in the freely moving rat. J Neurophysiol 2007, 97:3841-3850.
136. Datta S., Siwek D.F., Stack E.C. Identification of cholinergic and non-cholinergic neurons in the pons expressing phosphorylated cyclic adenosine monophosphate response element-binding protein as a function of rapid eye movement sleep. Neuroscience 2009, 163:397-414.
137. Datta S., Desarnaud F. Protein kinase A in the pedunculopontine tegmental nucleus of rat contributes to regulation of rapid eye movement sleep. J Neurosci 2010, 30:12263-12273.
138. Ulloor J., Mavanji V., Saha S., Siwek D.F., Datta S. Spontaneous REM sleep is modulated by the activation of the pedunculopontine tegmental GABAB receptors in the freely moving rat. J Neurophysiol 2004, 91:1822-1831.
139. George O., Koob G.F. Craving, context and the cortex. Nat Neurosci 2011, 14:409-410.
140. Nam H.W., McIver S.R., Hinton D.J., Thakkar M.M., Sari Y., Parkinson F.E., et al. Adenosine and glutamate signaling in neuron-glial interactions: implications in alcoholism and sleep disorders. Alcohol Clin Exp Res 2012, 36:1117-1125.
141. Berke J.D., Hyman S.E. Addiction, dopamine, and the molecular mechanisms of memory. Neuron 2000, 25:515-532.
142. George O., Koob G.F. Individual differences in prefrontal cortex function and the transition from drug use to drug dependence. Neurosci Biobehav Rev 2010, 35:232-247.
143. Gonzales R.A., Job M.O., Doyon W.M. The role of mesolimbic dopamine in the development and maintenance of ethanol reinforcement. Pharmacol Ther 2004, 103:121-146.
144. Grace A.A. The tonic/phasic model of dopamine system regulation and its implications for understanding alcohol and psychostimulant craving. Addiction 2000, 95(Suppl 2):S119-S128.
145. Grant K.A. The role of 5-HT3 receptors in drug dependence. Drug Alcohol Depend 1995, 38:155-171.
146. Myers R.D., Veale W.L. Alcohol preference in the rat: reduction following depletion of brain serotonin. Science 1968, 160:1469-1471.
147. Siggins G.R., Roberto M., Nie Z. The tipsy terminal: presynaptic effects of ethanol. Pharmacol Ther 2005, 107:80-98.
148. Smith R.J., Aston-Jones G. Noradrenergic transmission in the extended amygdala: role in increased drug-seeking and relapse during protracted drug abstinence. Brain Struct Funct 2008, 213:43-61.
149. Thorsell A., Neuropeptide Y. (NPY) in alcohol intake and dependence. Peptides 2007, 28:480-483.
150. Weiner J.L., Valenzuela C.F. Ethanol modulation of GABAergic transmission: the view from the slice. Pharmacol Ther 2006, 111:533-554.
151. Weiss F., Porrino L.J. Behavioral neurobiology of alcohol addiction: recent advances and challenges. J Neurosci 2002, 22:3332-3337.
152. Woodward J.J. Ethanol and NMDA receptor signaling. Crit Rev Neurobiol 2000, 14:69-89.
153. Kumar S., Porcu P., Werner D.F., Matthews D.B., Diaz-Granados J.L., Helfand R.S., et al. The role of GABA(A) receptors in the acute and chronic effects of ethanol: a decade of progress. Psychopharmacology (Berl) 2009, 205:529-564.
154. Liang J., Suryanarayanan A., Abriam A., Snyder B., Olsen R.W., Spigelman I. Mechanisms of reversible GABAA receptor plasticity after ethanol intoxication. J Neurosci 2007, 27:12367-12377.
155. Lack A.K., Christian D.T., Diaz M.R., McCool B.A. Chronic ethanol and withdrawal effects on kainate receptor-mediated excitatory neurotransmission in the rat basolateral amygdala. Alcohol 2009, 43:25-33.
156. Peris J., Eppler B., Hu M., Walker D.W., Hunter B.E., Mason K., et al. Effects of chronic ethanol exposure on GABA receptors and GABAB receptor modulation of 3H-GABA release in the hippocampus. Alcohol Clin Exp Res 1997, 21:1047-1052.
157. Boyd K.N., Kumar S., O'Buckley T.K., Morrow A.L. Chronic ethanol exposure produces tolerance to elevations in neuroactive steroids: mechanisms and reversal by exogenous ACTH. J Neurochem 2010, 115:142-152.
158. Holmes A., Spanagel R., Krystal J.H. Glutamatergic targets for new alcohol medications. Psychopharmacology (Berl) 2013, 229:539-554.
159. Datta S., Siwek D.F. Single cell activity patterns of pedunculopontine tegmentum neurons across the sleep-wake cycle in the freely moving rats. J Neurosci Res 2002, 70:611-621.
160. Datta S., Siwek D.F. Excitation of the brain stem pedunculopontine tegmentum cholinergic cells induces wakefulness and REM sleep. J Neurophysiol 1997, 77:2975-2988.
161. Gann H., Feige B., Hohagen F., van Calker D., Geiss D., Dieter R. Sleep and the cholinergic rapid eye movement sleep induction test in patients with primary alcohol dependence. Biol Psychiatry 2001, 50:383-390.
162. Gillette M.U., Abbott S.M. Biological Timekeeping Sleep Med Clin 2009, 4:99-110.
163. Herzog E.D. Neurons and networks in daily rhythms. Nat Rev Neurosci. 2007, 8:790-802.
164. Hut R.A., Van der Zee E.A. The cholinergic system, circadian rhythmicity, and time memory. Behav Brain Res 2011, 221:466-480.
165. Mendoza J., Challet E. Brain clocks: from the suprachiasmatic nuclei to a cerebral network. Neuroscientist 2009, 15:477-488.
166. Moore R.Y. Organization and function of a central nervous system circadian oscillator: the suprachiasmatic hypothalamic nucleus. Fed Proc 1983, 42:2783-2789.
167. Stephan F.K., Zucker I. Circadian rhythms in drinking behavior and locomotor activity of rats are eliminated by hypothalamic lesions. Proc Natl Acad Sci U S A 1972, 69:1583-1586.
168. Van Cauter E. Diurnal and ultradian rhythms in human endocrine function: a minireview. Horm Res 1990, 34:45-53.
169. Bina K.G., Rusak B., Semba K. Localization of cholinergic neurons in the forebrain and brainstem that project to the suprachiasmatic nucleus of the hypothalamus in rat. J Comp Neurol 1993, 335:295-307.
170. Liu C., Ding J.M., Faiman L.E., Gillette M.U. Coupling of muscarinic cholinergic receptors and cGMP in nocturnal regulation of the suprachiasmatic circadian clock. J Neurosci 1997, 17:659-666.
171. Jones B.E. Arousal systems. Front Biosci 2003, 8:s438-s451.
172. Jones B.E. Activity, modulation and role of basal forebrain cholinergic neurons innervating the cerebral cortex. Prog Brain Res 2004, 145:157-169.
173. Anderson S.M., Pierce R.C. Cocaine-induced alterations in dopamine receptor signaling: implications for reinforcement and reinstatement. Pharmacol Ther 2005, 106:389-403.
174. Hashimoto J.G., Forquer M.R., Tanchuck M.A., Finn D.A., Wiren K.M. Importance of genetic background for risk of relapse shown in altered prefrontal cortex gene expression during abstinence following chronic alcohol intoxication. Neuroscience 2011, 173:57-75.
175. Kalivas P.W., Volkow N., Seamans J. Unmanageable motivation in addiction: a pathology in prefrontal-accumbens glutamate transmission. Neuron 2005, 45:647-650.
176. McFarland K., Lapish C.C., Kalivas P.W. Prefrontal glutamate release into the core of the nucleus accumbens mediates cocaine-induced reinstatement of drug-seeking behavior. J Neurosci 2003, 23:3531-3537.
177. Park W.K., Bari A.A., Jey A.R., Anderson S.M., Spealman R.D., Rowlett J.K., et al. Cocaine administered into the medial prefrontal cortex reinstates cocaine-seeking behavior by increasing AMPA receptor-mediated glutamate transmission in the nucleus accumbens. J Neurosci 2002, 22:2916-2925.
178. Schmidt H.D., Anderson S.M., Famous K.R., Kumaresan V., Pierce R.C. Anatomy and pharmacology of cocaine priming-induced reinstatement of drug seeking. Eur J Pharmacol 2005, 526:65-76.
179. Schmidt H.D., Famous K.R., Pierce R.C. The limbic circuitry underlying cocaine seeking encompasses the PPTg/LDT. Eur J Neurosci 2009, 30:1358-1369.
180. Mark G.P., Shabani S., Dobbs L.K., Hansen S.T. Cholinergic modulation of mesolimbic dopamine function and reward. Physiol Behav 2011, 104:76-81.
181. Semba K., Fibiger H.C. Afferent connections of the laterodorsal and the pedunculopontine tegmental nuclei in the rat: a retro- and antero-grade transport and immunohistochemical study. J Comp Neurol 1992, 323:387-410.
182. Sesack S.R., Deutch A.Y., Roth R.H., Bunney B.S. Topographical organization of the efferent projections of the medial prefrontal cortex in the rat: an anterograde tract-tracing study with Phaseolus vulgaris leucoagglutinin. J Comp Neurol 1989, 290:213-242.
183. Floresco S.B., West A.R., Ash B., Moore H., Grace A.A. Afferent modulation of dopamine neuron firing differentially regulates tonic and phasic dopamine transmission. Nat Neurosci 2003, 6:968-973.
184. Kelland M.D., Freeman A.S., Rubin J., Chiodo L.A. Ascending afferent regulation of rat midbrain dopamine neurons. Brain Res Bull 1993, 31:539-546.
185. Lodge D.J., Grace A.A. The laterodorsal tegmentum is essential for burst firing of ventral tegmental area dopamine neurons. Proc Natl Acad Sci U S A 2006, 103:5167-5172.
186. Lodge D.J., Grace A.A. The hippocampus modulates dopamine neuron responsivity by regulating the intensity of phasic neuron activation. Neuropsychopharmacology 2006, 31:1356-1361.
187. Charara A., Smith Y., Parent A. Glutamatergic inputs from the pedunculopontine nucleus to midbrain dopaminergic neurons in primates: Phaseolus vulgaris-leucoagglutinin anterograde labeling combined with postembedding glutamate and GABA immunohistochemistry. J Comp Neurol 1996, 364:254-266.
188. Cornwall J., Cooper J.D., Phillipson O.T. Afferent and efferent connections of the laterodorsal tegmental nucleus in the rat. Brain Res Bull 1990, 25:271-284.
189. Futami T., Takakusaki K., Kitai S.T. Glutamatergic and cholinergic inputs from the pedunculopontine tegmental nucleus to dopamine neurons in the substantia nigra pars compacta. Neurosci Res 1995, 21:331-342.
190. Hallanger A.E., Wainer B.H. Ascending projections from the pedunculopontine tegmental nucleus and the adjacent mesopontine tegmentum in the rat. J Comp Neurol 1988, 274:483-515.
191. Oakman S.A., Faris P.L., Kerr P.E., Cozzari C., Hartman B.K. Distribution of pontomesencephalic cholinergic neurons projecting to substantia nigra differs significantly from those projecting to ventral tegmental area. J Neurosci 1995, 15:5859-5869.
192. Oakman S.A., Faris P.L., Cozzari C., Hartman B.K. Characterization of the extent of pontomesencephalic cholinergic neurons' projections to the thalamus: comparison with projections to midbrain dopaminergic groups. Neuroscience 1999, 94:529-547.
193. Omelchenko N., Sesack S.R. Laterodorsal tegmental projections to identified cell populations in the rat ventral tegmental area. J Comp Neurol 2005, 483:217-235.
194. Steininger T.L., Rye D.B., Wainer B.H. Afferent projections to the cholinergic pedunculopontine tegmental nucleus and adjacent midbrain extrapyramidal area in the albino rat. I. Retrograde tracing studies. J Comp Neurol 1992, 321:515-543.
195. Woolf N.J., Butcher L.L. Cholinergic systems in the rat brain: IV. Descending projections of the pontomesencephalic tegmentum. Brain Res Bull 1989, 23:519-540.
196. Forster G.L., Blaha C.D. Pedunculopontine tegmental stimulation evokes striatal dopamine efflux by activation of acetylcholine and glutamate receptors in the midbrain and pons of the rat. Eur J Neurosci 2003, 17:751-762.
197. Klink R., de Kerchove d'Exaerde A., Zoli M., Changeux J.P. Molecular and physiological diversity of nicotinic acetylcholine receptors in the midbrain dopaminergic nuclei. J Neurosci 2001, 21:1452-1463.
198. Steidl S., Miller A.D., Blaha C.D., Yeomans J.S. M(5) muscarinic receptors mediate striatal dopamine activation by ventral tegmental morphine and pedunculopontine stimulation in mice. PLoS One 2011, 6:e27538.
199. Kamens H.M., Andersen J., Picciotto M.R. The nicotinic acetylcholine receptor partial agonist varenicline increases the ataxic and sedative-hypnotic effects of acute ethanol administration in C57BL/6J mice. Alcohol Clin Exp Res 2010, 34:2053-2060.
200. Kamens H.M., Andersen J., Picciotto M.R. Modulation of ethanol consumption by genetic and pharmacological manipulation of nicotinic acetylcholine receptors in mice. Psychopharmacology (Berl) 2010, 208:613-626.
201. McKee S.A., Harrison E.L., O'Malley S.S., Krishnan-Sarin S., Shi J., Tetrault J.M., et al. Varenicline reduces alcohol self-administration in heavy-drinking smokers. Biol Psychiatry 2009, 66:185-190.
202. Litten R.Z., Ryan M.L., Fertig J.B., Falk D.E., Johnson B., Dunn K.E., et al. A double-blind, placebo-controlled trial assessing the efficacy of varenicline tartrate for alcohol dependence. J Addict Med 2013, 7:277-286.
203. Kranzler H.R., Anton R.F. Implications of recent neuropsychopharmacologic research for understanding the etiology and development of alcoholism. J Consult Clin Psychol 1994, 62:1116-1126.
204. Pierucci-Lagha A., Feinn R., Modesto-Lowe V., Swift R., Nellissery M., Covault J., et al. Effects of rapid tryptophan depletion on mood and urge to drink in patients with co-morbid major depression and alcohol dependence. Psychopharmacology (Berl) 2004, 171:340-348.
205. Virkkunen M., Linnoila M. Serotonin in early onset, male alcoholics with violent behaviour. Ann Med 1990, 22:327-331.
206. Weiss F., Parsons L.H., Schulteis G., Hyytia P., Lorang M.T., Bloom F.E., et al. Ethanol self-administration restores withdrawal-associated deficiencies in accumbal dopamine and 5-hydroxytryptamine release in dependent rats. J Neurosci 1996, 16:3474-3485.
207. Ting A.K.R., Dockstader C., Heinmiller A., Grieder T., van der Kooy D. GABA(A) receptors mediate the opposing roles of dopamine and the tegmental pedunculopontine nucleus in the motivational effects of ethanol. Eur J Neurosci 2009, 29:1235-1244.
208. Fiorillo C.D.N.W., Schultz W. The temporal precision of reward prediction in dopamine neurons. Nat Neurosci 2008, 11:966-973.
209. Totah N.K., Kim Y., Moghaddam B. Distinct prestimulus and poststimulus activation of VTA neurons correlates with stimulus detection. J Neurophysiol 2013, 110:75-85.
210. Lammel S., Lim B.K., Ran C., Huang K.W., Betley M.J., Tye K.M., et al. Input-specific control of reward and aversion in the ventral tegmental area. Nature 2012, 491:212-217.
211. Garcia-Rill E., Simon C., Smith K., Kezunovic N., Hyde J. The pedunculopontine tegmental nucleus: from basic neuroscience to neurosurgical applications. J Neural Transm 2011, 118:1397-1407.
212. Garcia-Rill E., Kezunovic N., D'Onofrio S., Luster B., Hyde J., Bisagno V., et al. Gamma band activity in the RAS-intracellular mechanisms. Exp Brain Res 2014, 232:1509-1522.
213. Simon C., Kezunovic N., Ye M., Hyde J., Hayar A., Williams D.K., Garcia-Rill E. Gamma band unit and population responses in the pedunculopontine nucleus. J Neurophysiology 2010, 104:463-474.
214. Kezunovic N., Urbano F.J., Simon C., Hyde J., Smith K., Garcia-Rill E. Mechanism behind gamma band activity in the pedunculopontine nucleus (PPN). Eur J Neurosci 2011, 34:404-415.