Single cell activity patterns of pedunculopontine tegmentum neurons across the sleep-wake cycle in the freely moving rats

Journal of Neuroscience Research

Volumn 70, Issue 4, 2002, Pages 611-621

  Datta, Subimal ^a   Siwek, Donald F ^a  

^a BOSTON UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

Cholinergic cell compartment; Cortical activation; Pedunculopontine tegmentum nucleus; REM on; Single cell activity; Sleep wake cycle; Wake REM on

Indexed keywords

GLUTAMIC ACID;

ANIMAL EXPERIMENT; ARTICLE; BODY MOVEMENT; BRAIN STEM; CHOLINERGIC NERVE CELL; CONTROLLED STUDY; CORRELATION ANALYSIS; MALE; MICROINJECTION; NERVE CELL; NEUROPHYSIOLOGY; NONHUMAN; PONS ANGLE; PRIORITY JOURNAL; RAT; REM SLEEP; SLEEP WAKING CYCLE; SLOW WAVE SLEEP; TEGMENTUM; WAKEFULNESS;

ACTION POTENTIALS; ANIMALS; CHOLINERGIC FIBERS; CIRCADIAN RHYTHM; ELECTRODES, IMPLANTED; ELECTROENCEPHALOGRAPHY; ELECTROMYOGRAPHY; ELECTROOCULOGRAPHY; INFERIOR COLLICULUS; MALE; MESENCEPHALON; NEURONS; PONS; RATS; RATS, SPRAGUE-DAWLEY; TEGMENTUM MESENCEPHALI; WAKEFULNESS;

EID: 0037110664     PISSN: 03604012     EISSN: None     Source Type: Journal    
DOI: 10.1002/jnr.10405     Document Type: Article

References (49)

1. Aston-Jones G, Bloom FE. 1981. Activity of norepinephrine-containing locus coeruleus neurons in behaving rats anticipates fluctuations in the sleep-waking cycle. J Neurosci 1:876-886.
2. Bourgin P, Escourrou P, Gaultier C, Adrien J. 1995. Induction of rapid eye movement sleep by carbachol infusion into the pontine reticular formation in the rat. NeuroReport 6:532-536.
3. Chu NS, Bloom FE. 1973. Norepinephnne-containing neurons: Changes in spontaneous discharge patterns during sleeping and waking. Science 179: 908-910.
4. Clements JR, Grant S. 1990. Glutamate-like immunoreactivity in neurons of the laterodorsal tegmental and pedunculopontine nuclei in the rat. Neurosci Lett 120:70-73.
5. Datta S. 1995. Neuronal activity in the peribrachial area: Relationship to behavioral state control. Neurosci Biobehav Rev 19:67-84.
6. Datta S. 1997. Cellular basis of pontine ponto-geniculo-occipital wave generation and modulation. Cell Mol Neurobiol 17:341-365.
7. Datta S. 2002. Evidence that REM sleep is controlled by the activation of brain stem pedunculo pontine tegmental kainate receptor. J Neurophysiol 87:1790-1798.
8. Datta S, Hobson JA. 1994. Neuronal activity in the caudolateral peribrachial pons: Relationship to PGO waves and rapid eye movements. J Neurophysiol 71:95-109.
9. Datta S, Hobson JA. 1995. Suppression of ponto-geniculo-occipital waves by neuro-toxic lesions of pontine caudo-lateral peribrachial cells. Neuroscience 67:703-712.
10. Datta S, Hobson JA. 2000. The rat as an experimental model for sleep neurophysiology. Behav Neurosci 114:1239-1244.
11. Datta S, Siwek DF. 1997. Excitation of the brainstem pedunculopontine tegmentum cholinergic cells induces wakefulness and REM sleep. J Neurophysiol 77:2975-2988.
12. Datta S, Patterson EH, Siwek DF. 1997. Endogenous and exogenous nitric oxide in the pedunculopontine tegmentum induces sleep. Synapse 27: 69-78.
13. Datta S, CurroDossi R, Pare D, Oakson G, Steriade M. 1991. Substantia nigra reticulata neurons during sleep-waking states: Relationship with ponto-geniculo-occipital waves. Brain Res 566:344-347.
14. Datta S, Spoley EE, Patterson EH. 2001a. Microinjection of glutamate into the pedunculopontine tegmentum induces REM sleep and wakefulness in the rat. Am J Physiol Regulatory Integrative Comp Physiol 280:R752-R759.
15. Datta S, Patterson EH, Spoley EE. 2001b. Excitation of the pedunculopontine tegmental NMDA receptors induces wakefulness and cortical activation in the rat. J Neurosci Res 66:109-116.
16. El-Mansari M, Sakai K, Jouvet M. 1989. Unitary characteristics of presumptive cholinergic tegmental neurons during the sleep-waking cycle in freely moving cats. Exp Brain Res 76:519-529.
17. El-Mansari M, Sakai K, Jouvet M. 1990. Responses of presumed cholinergic mesopontine tegmental neurons to carbachol microinjections in freely moving cats. Exp Brain Res 83:115-123.
18. Foote SL. 1973. Compansatory changes in REM sleep time of cats during ad libitum sleep and following brief REM sleep deprivation. Brain Res 54:261-276.
19. Foote SL, Bloom FE, Aston-Jones G. 1983. Nucleus locus coeruleus: New evidence of anatomical and physiological specificity. Physiol Rev 63:844-914.
20. Ford B, Holmes CJ, Mainville L, Jones BE. 1995. GABAergic neurons in the rat pontomesencephalic tegmentum: Codistribution with cholinergic and other tegmental neurons projecting to the posterior lateral thalamus. J Comp Neurol 363:177-196.
21. Garcia-Rill E. 1991. The pedunculopontine nucleus. Prog Neurobiol 36: 363-389.
22. Garcia-Rill E, Kinjo N, Atsuta Y, Ishikawa Y, Webber M, Skinner RD. 1990. Posterior midbrain-induced locomotion. Brain Res Bull 24:499-508.
23. Gnadt JW, Pegram GV. 1986. Cholinergic brainstem mechanism of REM sleep in the rat. Brain Res 384:29-41.
24. Hobson JA, McCarley RW. Wyzinski PW. 1975. Sleep cycle oscillations: Reciprocal discharge by two brainstem neuronal groups. Science 189:55-58.
25. Jones BE, Beaudet A. 1987. Distribution of acetylcholine and catecholamine neurons in the cat brain stem studied by choline acetyltransferase and tyrosine hydroxylase immunohisto-chemistry. J Comp Neurol 261: 15-32.
26. Kayama Y, Ohta M, Jodo E. 1992. Firing of possibly cholinergic neurons in the rat laterodorsal tegmental nucleus during sleep and wakefulness. Brain Res 569:210-220.
27. Kosaka T, Tauchi M, Dahl JL. 1988. Cholinergic neurons containing GABA-like and/or glutamic acid decarboxylase-like immunoreactivities in various brain regions of the rat. Exp Brain Res 70:605-617.
28. Koyama Y, Sakai K. 2000. Modulation of presumed cholinergic mesopontine tegmental neurons by acetylcholine and monoamines applied iontophoretically in unanesthetized cats. Neuroscience 96:723-733.
29. Lee R-S, Steffensen SC, Henriksen SJ. 2001. Discharge profiles of ventral tegmental area GABA neurons during movement, anesthesia, and sleepwake cycle. J Neurosci 21:1757-1766.
30. Marks GA, Birabil CG. 1998. Enhancement of rapid eye movement sleep in the rat by cholinergic and adenosinergic agonists infused into the pontine reticular formation. Neuroscience 86:29-37.
31. Marks GA, Birabil CG. 2000. Infusion of adenylyl cyclase inhibitor SQ22,536 into the medial pontine reticular formation of rats enhances rapid eye movement sleep. Neuroscience 98:311-315.
32. McGinyy DJ, Harper RM. 1976. Dorsal raphe neurons: Depression of firing during sleep in cats. Brain Res 101:569-575.
33. McGinty DJ, Siegel JM. 1992. Brain neuronal unit discharge in freely moving animals: Methods and application in the study of sleep mechanisms. In: Epstein AN, Morrison AR, editors. Progress in Psychobiology, Physiology and Psychology, 15th Ed. San Diego: Academic Press, Inc. p 85-139.
34. Mesulam M-M., Mufson EJ, Wainer BH, Levey AI. 1983. Central cholinergic pathways in the rat: An overview based on an alternative nomenclature (Ch1-Ch6). Neuroscience 10:1185-1201.
35. Paxinos G, Watson C. 1986. The Rat Brain in Stereotaxic Coordinates. San Diego: Academic Press.
36. Rye DB, Saper CB, Lee HJ, Wainer BH. 1987. Pedunculopontine tegmental nucleus of the rat: Cytoarchitecture, cytochemistry, and some extrapyramidal connections of the mesopontine tegmentum. J Comp Neurol 259:483-528.
37. Saito H, Sakai K, Jouvet M. 1977. Discharge patterns of the nucleus parabrachialis lateralis neurons of the cat during sleep and waking. Brain Res 134:59-72.
38. Sakai K, El-Mansari M, Jouvet M. 1990. Inhibition by carbachol microinjections of presumptive cholinergic PGO-on neurons in freely moving cats. Brain Res 527:213-223.
39. Sanford LD, Tejani-Butt SM, Ross RJ, Morrison AR. 1996. Elicited PGO waves in rats: Lack of 5-HT1A inhibition in putative pontine generator region. Pharmac Biochem Behav 53:323-327.
40. Sanford LD, Hunt WK, Ross RJ, Pack AI, Morrison AR. 1998. Central administration of a 5-HT2 receptor agonist and antagonist: Lack of effect on rapid eye movement sleep and PGO waves. Sleep Res Online 2:80-86.
41. Siegel JM. 1979. Behavioral functions of the reticular formation. Brain Res Rev 1:69-105.
42. Siegel JM, McGinty DJ. 1977. Pontine reticular formation neurons: Relationship to discharge to motor activity. Science 196:678-680.
43. Steriade M, McCarley RW. 1990. Brainstem Control of Wakefulness and Sleep. New York: Plenum.
44. Steriade M, Datta S, Pare D, Oakson G, Currodossi R. 1990a. Neuronal activities in brain-stem cholinergic nuclei related to tonic activation processes in thalamocortical systems. J Neurosci 10:2541-2559.
45. Steriade M, Pare D, Datta S, Oakson G, Currodosi R. 1990b. Different cellular types in mesopontine cholinergic nuclei related to pontogeniculo-occipital waves. J Neurosci 10:2560-2579.
46. Stem WC, Forbes WB, Morgane PJ. 1974. Absence of ponto-geniculooccipital (PGO) spikes in rats. Physiol Behav 12:293-295.
47. Torterolo P, Yamuy J, Sampogna S, Morales FR, Chase MH. 2001. GABAergic neurons of the laterodorsal and Pedunculopontine tegmental nuclei of the cat express c-fos during carbachol-induced active sleep. Brain Res 892:309-319.
48. Vincent SR, Satoh K, Armstrong DM, Fibiger HC. 1983. NADPH-diaphorase: A selective histochemical marker for the cholinergic neurons of the pontine reticular formation. Neurosci Lett 43:31-36.
49. Vincent SR, Satoh K, Armstrong DM, Panula P, Vale W, Fibiger HC. 1986. Neuropeptides and NADPH-diaphorase activity in the ascending cholinergic reticular system of the rat. Neurosci 17:167-182.