The old but new IgM Fc receptor (FcμR)

Current Topics in Microbiology and Immunology

Volumn 382, Issue , 2014, Pages 3-28

  Kubagawa, Hiromi ^a   Kubagawa, Yoshiki ^a   Jones, Dewitt ^a   Nasti, Tahseen H ^b   Walter, Mark R ^c   Honjo, Kazuhito ^a  

^a University of Alabama at Birmingham   (United States)

^b UNIVERSITY OF ALABAMA AT BIRMINGHAM   (United States)

^c University of Alabama at Birmingham   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CELL PROTEIN; COMPLEMENTARY DNA; FAS INHIBITORY MOLECULE 3 PROTEIN; FC RECEPTOR; IMMUNOGLOBULIN M FC RECEPTOR; IMMUNOGLOBULIN RECEPTOR; MONOCLONAL ANTIBODY; SERINE; TYROSINE; UNCLASSIFIED DRUG; BINDING PROTEIN; CD3 ANTIGEN; COMPLEMENT RECEPTOR; IMMUNOGLOBULIN A; IMMUNOGLOBULIN E; IMMUNOGLOBULIN G; IMMUNOGLOBULIN G3; IMMUNOGLOBULIN M; IMMUNOGLOBULIN M ANTIBODY;

BINDING AFFINITY; BINDING SITE; CELLULAR DISTRIBUTION; CHRONIC LYMPHATIC LEUKEMIA; CYTOPLASM; DISEASE ACTIVITY; EXON; FCMR GENE; GENE; GENE FUNCTION; GENE IDENTIFICATION; HUMAN; MOLECULAR CLONING; MOLECULAR PATHOLOGY; NONHUMAN; PREDICTION; PRIORITY JOURNAL; PROTEIN BINDING; PROTEIN DEFICIENCY; PROTEIN DETERMINATION; PROTEIN EXPRESSION; PROTEIN FUNCTION; PROTEIN STRUCTURE; RESIDUE ANALYSIS; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; REVIEW; SIGNAL TRANSDUCTION; ANTIBODY RESPONSE; ANTIGEN BINDING; ARTICLE; B LYMPHOCYTE; CELLULAR IMMUNITY; CRYSTAL STRUCTURE; GENETIC ORGANIZATION; IMMUNE DYSREGULATION; IMMUNOGLOBULIN BLOOD LEVEL; KNOCKOUT MOUSE; LIGAND BINDING; PROTEIN DOMAIN; PROTEIN LOCALIZATION; PROTEIN PROTEIN INTERACTION;

MUS;

AMINO ACID SEQUENCE; ANIMALS; EXONS; HUMANS; IMMUNOGLOBULIN M; MICE; MOLECULAR SEQUENCE DATA; RECEPTORS, FC;

EID: 84906850152     PISSN: 0070217X     EISSN: 21969965     Source Type: Book Series    
DOI: 10.1007/978-3-319-07911-0_1     Document Type: Review

References (67)

1. Adachi T, Harumiya S, Takematsu H, Kozutsumi Y, Wabl M, Fujimoto M, Tedder TF (2012) CD22 serves as a receptor for soluble IgM. Eur J Immunol 42:241-247
2. Akula S, Mohammadamin S, Hellman L (2014) Fc receptors for immunoglobulins and their appearance during vertebrate evolution. PLoS One 9:e96903
3. Arai S, Maehara N, Iwamura Y, Honda S, Nakashima K, Kai T, Ogishi M, Morita K, Kurokawa J, Mori M, Motoi Y, Miyake K, Matsuhashi N, Yamamura K, Ohara O, Shibuya A, Wakeland EK, Li QZ, Miyazaki T (2013) Obesity-associated autoantibody production requires AIM to retain the immunoglobulin M immune complex on follicular dendritic cells. Cell Rep 3:1187-1198
4. Baker N, Ehrenstein MR (2002) Cutting edge: selection of B lymphocyte subsets is regulated by natural IgM. J Immunol 169:6686-6690
5. Baumgarth N, Tung JW, Herzenberg LA (2005) Inherent specificities in natural antibodies: a key to immune defense against pathogen invasion. Springer Semin Immunopathol 26:347-362
6. Brenner D, Brustle A, Lin GH, Lang PA, Duncan GS, Knobbe-Thomsen CB, St PM, Reardon C, Tusche MW, Snow B, Hamilton SR, Pfefferle A, Gilani SO, Ohashi PS, Lang KS, Mak TW (2014) Toso controls encephalitogenic immune responses by dendritic cells and regulatory T cells. Proc. Natl. Acad. Sci. U. S. A 111:1060-1065
7. Brodeur PH, Wortis HH (1980) Regulation of thymus-independent responses: unresponsiveness to a second challenge of TNP-Ficoll is mediated by hapten-specific antibodies. J Immunol 125:1499-1505
8. Burns GF, Cawley JC, Barker CR (1979) Characterization of the receptor for IgM present on human B lymphocytes. Immunology 36:569-577
9. Buzzi M, Lu L, Lombardi AJ, Posner MR, Brautigan DL, Fast LD, Frackelton AR (1992) Differentiation-induced changes in protein-tyrosine phosphatase activity and commensurate expression of CD45 in human leukemia cell lines. Cancer Res 52:4027-4035
10. Castillo-Davis CI, Mekhedov SL, Hartl DL, Koonin EV, Kondrashov FA (2002) Selection for short introns in highly expressed genes. Nat Genet 31:415-418
11. Choi SC, Wang H, Tian L, Murakami Y, Shin DM, Borrego F, Morse HC III, Coligan JE (2013) Mouse IgM Fc receptor, FCMR, promotes B cell development and modulates antigen-driven immune responses. J. Immunol. 190:987-996
12. Daéron M (1997) Fc receptor biology. Annu Rev Immunol 15:203-234
13. Davis RS, Wang YH, Kubagawa H, Cooper MD (2001) Identification of a family of Fc receptor homologs with preferential B cell expression. Proc Natl Acad Sci USA 98:9772-9777
14. Duhren-von MM, Ubelhart R, Schneider D, Wossning T, Bach MP, Buchner M, Hofmann D, Surova E, Follo M, Kohler F, Wardemann H, Zirlik K, Veelken H, Jumaa H (2012) Chronic lymphocytic leukaemia is driven by antigen-independent cell-autonomous signalling. Nature 489:309-312
15. Ehrenstein MR, Notley CA (2010) The importance of natural IgM: scavenger, protector and regulator. Nat Rev Immunol 10:778-786
16. Ehrenstein MR, O'Keefe TL, Davies SL, Neuberger MS (1998) Targeted gene disruption reveals a role for natural secretory IgM in the maturation of the primary immune response. Proc Natl Acad Sci USA 95:10089-10093
17. Engels N, Konig LM, Heemann C, Lutz J, Tsubata T, Griep S, Schrader V, Wienands J (2009) Recruitment of the cytoplasmic adaptor Grb2 to surface IgG and IgE provides antigen receptor-intrinsic costimulation to class-switched B cells. Nat Immunol 10:1018-1025
18. Ferrarini M, Hoffman T, Fu SM, Winchester R, Kunkel HG (1977) Receptors for IgM on certain human B lymphocytes. J Immunol 119:1525-1529
19. Gardiner EE, Karunakaran D, Arthur JF, Mu FT, Powell MS, Baker RI, Hogarth PM, Kahn ML, Andrews RK, Berndt MC (2008) Dual ITAM-mediated proteolytic pathways for irreversible inactivation of platelet receptors: de-ITAM-izing FcγRIIa. Blood 111:165-174
20. Hamburger AE, West AP Jr, Bjorkman PJ (2004) Crystal structure of a polymeric immunoglobulin binding fragment of the human polymeric immunoglobulin receptor. Structure 12:1925-1935
21. Hitoshi Y, Lorens J, Kitada SI, Fisher J, LaBarge M, Ring HZ, Francke U, Reed JC, Kinoshita S, Nolan GP (1998) Toso, a cell surface, specific regulator of Fas-induced apoptosis in T cells. Immunity 8:461-471
22. Honda S, Kurita N, Miyamoto A, Cho Y, Usui K, Takeshita K, Takahashi S, Yasui T, Kikutani H, Kinoshita T, Fujita T, Tahara-Hanaoka S, Shibuya K, Shibuya A (2009) Enhanced humoral immune responses against T-independent antigens in Fca/lR-deficient mice. Proc Natl Acad Sci USA 106:11230-11235
23. Honjo K, Kubagawa Y, Kubagawa H (2012a) Is Toso an antiapoptotic protein or an Fc receptor for IgM? Blood 119:1789-1790
24. Honjo K, Kubagawa Y, Jones DM, Dizon B, Zhu Z, Ohno H, Izui S, Kearney JF, Kubagawa H (2012b) Altered Ig levels and antibody responses in mice deficient for the Fc receptor for IgM (FclR). Proc Natl Acad Sci USA 109:15882-15887
25. Honjo K, Kubagawa Y, Kubagawa H (2013) Is Toso/IgM Fc receptor (FclR) expressed by innate immune cells? Proc Natl Acad Sci USA 110:E2540-E2541
26. Hoover RG, Dieckgraefe BK, Lynch RG (1981) T cells with Fc receptors for IgA: induction of T alpha cells in vivo and in vitro by purified IgA. J Immunol 127:1560-1563
27. Hosokawa T (1979) Studies on B-cell memory. II. T-cell independent antigen can induce B-cell memory. Immunology 38:291-299
28. Kikuno K, Kang DW, Tahara K, Torii I, Kubagawa HM, Ho KJ, Baudino L, Nishizaki N, Shibuya A, Kubagawa H (2007) Unusual biochemical features and follicular dendritic cell expression of human Fca/l receptor. Eur J Immunol 37:3540-3550
29. Kubagawa H, Burrows PD, Cooper MD (1997) A novel pair of immunoglobulin-like receptors expressed by B cells and myeloid cells. Proc Natl Acad Sci USA 94:5261-5266
30. Kubagawa H, Oka S, Kubagawa Y, Torii I, Takayama E, Kang DW, Gartland GL, Bertoli LF, Mori H, Takatsu H, Kitamura T, Ohno H, Wang JY (2009) Identity of the elusive IgM Fc receptor (FclR) in humans. J Exp Med 206:2779-2793
31. Lang KS, Lang PA, Meryk A, Pandyra AA, Boucher LM, Pozdeev VI, Tusche MW, Gothert JR, Haight J, Wakeham A, You-Ten AJ, McIlwain DR, Merches K, Khairnar V, Recher M, Nolan GP, Hitoshi Y, Funkner P, Navarini AA, Verschoor A, Shaabani N, Honke N, Penn LZ, Ohashi PS, Haussinger D, Lee KH, Mak TW (2013) Involvement of Toso in activation of monocytes, macrophages, and granulocytes. Proc Natl Acad Sci USA 110:2593-2598
32. Li FJ, Kubagawa Y, McCollum MK, Wilson L, Motohashi T, Bertoli LF, Barton JC, Barnes S, Davis RS, Kubagawa H (2011) Enhanced levels of both membrane-bound and soluble forms of IgM Fc receptor (FclR) in patients with chronic lymphocytic leukemia. Blood 118:4902-4909
33. MartinezVG,Moestrup SK, Holmskov U, Mollenhauer J, LozanoF(2011) The conserved scavenger receptor cysteine-rich superfamily in therapy and diagnosis. Pharmacol Rev 63:967-1000
34. Maruoka T, Nagata T, Kasahara M (2004) Identification of the rat IgA Fc receptor encoded in the leukocyte receptor complex. Immunogenetics 55:712-716
35. Maurer MA, Rakocevic G, Leung CS, Quast I, Lukacišin M, Goebels N, Münz C, Wardemann H, Dalakas M, Lünemann JD (2012) Rituximab induces sustained reduction of pathogenic B cells in patients with peripheral nervous system autoimmunity. J Clin Invest 122:1393-1402
36. McEwan WA, Tam JC, Watkinson RE, Bidgood SR, Mallery DL, James LC (2013) Intracellular antibody-bound pathogens stimulate immune signaling via the Fc receptor TRIM21. Nat Immunol 14:327-336
37. Miyazaki T, Kurokawa J, Arai S (2011) AIMing at metabolic syndrome. Towards the development of novel therapies for metabolic diseases via apoptosis inhibitor of macrophage (AIM). Circ J 75:2522-2531
38. Monteiro RC, Van De Winkel JG (2003) IgA Fc receptors. Annu Rev Immunol 21:177-204
39. Moretta L, Webb SR, Grossi CE, Lydyard PM, Cooper MD (1977) Functional analysis of two human T-cell subpopulations: help and suppression of B-cell responses by T cells bearing receptors for IgM (Tl) or IgG (Tc). J Exp Med 146:184-200
40. Murakami Y, Narayanan S, Su S, Childs R, Krzewski K, Borrego F, Weck J, Coligan JE (2012) Toso, a functional IgM receptor, is regulated by IL-2 in T and NK cells. J Immunol 189:587-597
41. Nakamura T, Kubagawa H, Ohno T, Cooper MD (1993) Characterization of an IgM Fc-binding receptor on human T cells. J Immunol 151:6933-6941
42. Nguyen XH, Lang PA, Lang KS, Adam D, Fattakhova G, Foger N, Kamal MA, Prilla P, Mathieu S, Wagner C, Mak T, Chan AC, Lee KH (2011) Toso regulates the balance between apoptotic and nonapoptotic death receptor signaling by facilitating RIP1 ubiquitination. Blood 118:598-608
43. Nimmerjahn F, Bruhns P, Horiuchi K, Ravetch JV (2005) FcγRIV: a novel FcR with distinct IgG subclass specificity. Immunity 23:41-51
44. Obukhanych TV, Nussenzweig MC (2006) T-independent type II immune responses generate memory B cells. J Exp Med 203:305-310
45. Ohno T, Kubagawa H, Sanders SK, Cooper MD (1990) Biochemical nature of an Fcl receptor on human B-lineage cells. J Exp Med 172:1165-1175
46. Ouchida R, Mori H, Hase K, Takatsu H, Kurosaki T, Tokuhisa T, Ohno H, Wang JY (2012) Critical role of the IgM Fc receptor in IgM homeostasis, B-cell survival, and humoral immune responses. Proc Natl Acad Sci USA 109:E2699-E2706
47. Pichler WJ, Knapp W (1977) Receptors for IgM-coated erythrocytes on chronic lymphatic leukemia cells. J Immunol 118:1010-1015
48. Platsoucas CD, Kempin S, Karanas A, Clarkson B, Good RA, Gupta S (1980) Receptors for immunoglobulin isotype on T and B lymphocytes from untreated patients with chronic lymphocytic leukaemia. Clin Exp Immunol 40:256-263
49. Poe JC, Tedder TF (2012) CD22 and Siglec-G in B cell function and tolerance. Trends Immunol 33:413-420
50. Pricop L, Rabinowich H, Morel PA, Sulica A, Whiteside TL, Herberman RB (1993) Characterization of the Fcl receptor on human natural killer cells. Interaction with its physiologic ligand, human normal IgM, specificity of binding, and functional effects. J Immunol 151:3018-3029
51. Ramchandren S, Lewis RA (2009) Monoclonal gammopathy and neuropathy. Curr Opin Neurol 22:480-485
52. Randow F, MacMicking JD, James LC (2013) Cellular self-defense: how cell-autonomous immunity protects against pathogens. Science 340:701-706
53. Ravetch JV, Kinet JP (1991) Fc receptors. Annu Rev Immunol 9:457-492
54. Reljic R (2006) In search of the elusive mouse macrophage Fca receptor. Immunol Lett 107:80-81
55. Rudders RA, Andersen J, Howard JP, Fried R (1980) The binding of IgM to B lymphocytes. I. Studies of the binding of aggregated IgM to normal and leukemic human B lymphocytes. Clin Immunol Immunopathol 15:673-686
56. Sanders SK, Kubagawa H, Suzuki T, Butler JL, Cooper MD (1987) IgM binding protein expressed by activated B cells. J Immunol 139:188-193
57. Sato S, Steeber DA, Tedder TF (1995) The CD19 signal transduction molecule is a response regulator of B-lymphocyte differentiation. Proc Natl Acad Sci USA 92:11558-11562
58. Shibuya A, Sakamoto N, Shimizu Y, Shibuya K, Osawa M, Hiroyama T, Eyre HJ, Sutherland GR, Endo Y, Fujita T, Miyabayashi T, Sakano S, Tsuji T, Nakayama E, Phillips JH, Lanier LL, Nakauchi H (2000) Fca/l receptor mediates endocytosis of IgM-coated microbes. Nat Immunol 1:441-446
59. Shima H, Takatsu H, Fukuda S, Ohmae M, Hase K, Kubagawa H, Wang JY, Ohno H (2010) Identification of TOSO/FAIM3 as an Fc receptor for IgM. Int Immunol 22:149-156
60. Shimada S, Kawaguchi-Miyashita M, Kushiro A, Sato T, Nanno M, Sako T, Matsuoka Y, Sudo K, Tagawa Y, Iwakura Y, Ohwaki M (1999) Generation of polymeric immunoglobulin receptor-deficient mouse with marked reduction of secretory IgA. J Immunol 163:5367-5373
61. Tissot JD, Sanchez JC, Vuadens F, Scherl A, Schifferli JA, Hochstrasser DF, Schneider P, Duchosal MA (2002) IgM are associated to Sp alpha (CD5 antigen-like). Electrophoresis 23:1203-1206
62. Tsitsikov EN, Gutierrez-Ramos JC, Geha RS (1997) Impaired CD19 expression and signaling, enhanced antibody response to type II T independent antigen and reduction of B-1 cells in CD81-deficient mice. Proc Natl Acad Sci USA 94:10844-10849
63. Ucker DS, Yamamoto KR (1984) Early events in the stimulation of mammary tumor virus RNA synthesis by glucocorticoids. Novel assays of transcription rates. J Biol Chem 259:7416-7420
64. Vire B, David A, Wiestner A (2011) TOSO, the Fcl receptor, is highly expressed on chronic lymphocytic leukemia B cells, internalizes upon IgM binding, shuttles to the lysosome, and is downregulated in response to TLR activation. J Immunol 187:4040-4050
65. Vivier E, Raulet DH, Moretta A, Caligiuri MA, Zitvogel L, Lanier LL, Yokoyama WM, Ugolini S (2011) Innate or adaptive immunity? the example of natural killer cells. Science 331:44-49
66. von Bülow GU, van Deursen JM, Bram RJ (2001) Regulation of the T-independent humoral response by TACI. Immunity 14:573-582
67. Yan M, Wang H, Chan B, Roose-Girma M, Erickson S, Baker T, Tumas D, Grewal IS, Dixit VM (2001) Activation and accumulation of B cells in TACI-deficient mice. Nat Immunol 2:638-643