Impact of nanoparticle aggregation on protein recovery through a pentadentate chelate ligand on magnetic carriers

ACS Applied Materials and Interfaces

Volumn 6, Issue 16, 2014, Pages 13607-13616

  Fraga Garcia P ^a   Freiherr Von Roman, M ^a   Reinlein, S ^a   Wolf, M ^a   Berensmeier, S ^a  

^a TECHNICAL UNIVERSITY OF MUNICH   (Germany)

Author keywords

agglomeration; aggregation; biomolecule purification; magnetic separation; nanoparticles; pentadentate chelate ligand; protein recovery

Indexed keywords

AGGLOMERATION; AMINO ACIDS; BINDING SITES; BIOMOLECULES; CHELATION; ESCHERICHIA COLI; HIGH RESOLUTION TRANSMISSION ELECTRON MICROSCOPY; LIGANDS; LIGHT SCATTERING; LIGHT TRANSMISSION; MAGNETIC SEPARATION; MAGNETITE; MAGNETITE NANOPARTICLES; METAL IONS; METALS; NANOPARTICLES; RECOMBINANT PROTEINS; RECOVERY; SATURATION MAGNETIZATION; SPECIFIC SURFACE AREA;

AGGLOMERATION EFFECTS; CHELATE LIGANDS; CONTINUOUS DEVELOPMENT; DOWNSTREAM-PROCESSING; GREEN FLUORESCENT PROTEIN; NANOPARTICLE AGGREGATION; PROTEIN RECOVERY; SEPARATION TECHNIQUES;

NANOMAGNETICS;

EDETIC ACID; GREEN FLUORESCENT PROTEIN; LIGAND; MAGNETITE NANOPARTICLE;

ADSORPTION; BINDING SITE; CHEMISTRY; HYDRODYNAMICS; ISOLATION AND PURIFICATION; MAGNETISM; PARTICLE SIZE; TEMPERATURE; THEORETICAL MODEL; TIME; ULTRASTRUCTURE;

ADSORPTION; BINDING SITES; EDETIC ACID; GREEN FLUORESCENT PROTEINS; HYDRODYNAMICS; LIGANDS; MAGNETIC PHENOMENA; MAGNETITE NANOPARTICLES; MODELS, THEORETICAL; PARTICLE SIZE; TEMPERATURE; TIME FACTORS;

EID: 84906815102     PISSN: 19448244     EISSN: 19448252     Source Type: Journal    
DOI: 10.1021/am503082s     Document Type: Article

References (56)

1. Porath, J.; Carlsson, J.; Olsson, I.; Belfrage, G. Metal Chelate Affinity Chromatography, A New Approach to Protein Fractionation Nature 1975, 258, 598-599
2. Chaga, G. S. Twenty-Five Years of Immobilized Metal Ion Affinity Chromatography: Past, Present and Future J. Biochem. Biophys. Methods 2001, 49, 313-334
3. Gaberc-Porekar, V.; Menart, V. Potential for Using Histidine Tags in Purification of Proteins at Large Scale Chem. Eng. Technol. 2005, 28, 1306-1314
4. Loennerdal, B.; Keen, C. L. Metal Chelate Affinity Chromatography of Proteins J. Appl. Biochem. 1982, 4, 203-208
5. Porath, J. Immobilized Metal Ion Affinity Chromatography Protein Expression Purif. 1992, 3, 263-281
6. Zhu, J.; Sun, G. Facile Fabrication of Hydrophilic Nanofibrous Membranes with an Immobilized Metal-Chelate Affinity Complex for Selective Protein Separation ACS Appl. Mater. Interfaces 2014, 6, 925-932
7. Hochuli, E.; Bannwarth, W.; Doebeli, H.; Gentz, R.; Stueber, D. Genetic Approach to Facilitate Purification of Recombinant Proteins with a Novel Metal Chelate Adsorbent Bio/Technology 1988, 6, 1321-1325
8. Nakamura, I.; Makino, A.; Ohmae, M.; Kimura, S. Immobilization of His-Tagged Endoglucanase on Gold via Various Ni-NTA Self-Assembled Monolayers and Its Hydrolytic Activity Macromol. Biosci. 2010, 10, 1265-1272
9. Yip, T. T.; Nakagawa, Y.; Porath, J. Evaluation of the Interaction of Peptides with Copper(II), Nickel(II), and Zinc(II) by High-Performance Immobilized Metal Ion Affinity Chromatography Anal. Biochem. 1989, 183, 159-171
10. Young, C. L.; Britton, Z. T.; Robinson, A. S. Recombinant Protein Expression and Purification: A Comprehensive Review of Affinity Tags and Microbial Applications Biotechnol. J. 2012, 7, 620-634
11. McCurley, M. F.; Seitz, W. R. The Nature of Immobilized Tris(carboxymethyl)ethylenediamine Talanta 1989, 36, 341-346
12. Haner, M.; Henzl, M. T.; Raissouni, B.; Birnbaum, E. R. Synthesis of a New Chelating Gel: Removal of Calcium Ions from Parvalbumin Anal. Biochem. 1984, 138, 229-234
13. Patchornik, G. Purification of His-Tagged Proteins with [Desthiobiotin-BSA-EDTA] Conjugates Exhibiting Resistance to EDTA Bioconjugate Chem. 2008, 19, 673-679
14. Andersson, L. C.; Arefalk, A.; Lind, O.; Noren, B. Method for Preparation of a Biomolecule Adsorbent for the Purification of Proteins by IMAC (WO2009008802A1).
15. Andersson, L. C.; Belew, M.; Gebru, T.; Glad, G.; Lindgren, H.; Norrman, N. A Method of Preparing an Immobilized Metal Ion Chromatography Adsorbent and Methods of Purifying Proteins, Peptides or Polynucleotides (WO2007139470A1).
16. Algotsson, M.; Andersson, L. C.; Brekkan, E.; Hedemyr, L.; Maloisel, J.-L.; Palmgren, R. Novel Chelator and Use Thereof (WO2011152782A1).
17. Franzreb, M.; Siemann-Herzberg, M.; Hobley, T. J.; Thomas, O. R. T. Protein Purification using Magnetic Adsorbent Particles Appl. Microbiol. Biotechnol. 2006, 70, 505-516
18. Gupta, A. K.; Gupta, M. Synthesis and Surface Engineering of Iron Oxide Nanoparticles for Biomedical Applications Biomaterials 2005, 26, 3995-4021
19. Laurent, S.; Forge, D.; Port, M.; Roch, A.; Robic, C.; Vander Elst, L.; Muller, R. N. Magnetic Iron Oxide Nanoparticles: Synthesis, Stabilization, Vectorization, Physicochemical Characterizations, and Biological Applications Chem. Rev. 2008, 108, 2064-2110
20. 4 Nanoparticles with Various Sizes and Magnetic Properties by Controlled Hydrolysis J. Colloid Interface Sci. 2007, 314, 274-280
21. Jolivet, J.-P; Chanéac, C.; Tronc, E. Iron Oxide Chemistry. From Molecular Clusters to Extended Solid Networks Chem. Commun. 2004, 481-487
22. Guo, J.; Yang, W.; Wang, C. Magnetic Colloidal Supraparticles: Design, Fabrication and Biomedical Applications Adv. Mater. 2013, 1-19
23. Liu, Z.; Li, M.; Pu, F.; Ren, J.; Yang, X.; Qu, X. Hierarchical Magnetic Core-Shell Nanoarchitectures: Non-Linker Reagent Synthetic Route and Applications in a Biomolecule Separation System J. Mater. Chem. 2012, 22, 2935-2942
24. Liu, X.; Guan, Y.; Liu, H.; Ma, Z.; Yang, Y.; Wu, X. Preparation and Characterization of Magnetic Polymer Nanospheres with High Protein Binding Capacity J. Magn. Magn. Mater. 2005, 293, 111-118
25. Ma, Z. Y.; Guan, Y. P.; Liu, X. Q.; Liu, H. Z. Synthesis of Magnetic Chelator for High-Capacity Immobilized Metal Affinity Adsorption of Protein by Cerium Initiated Graft Polymerization Langmuir 2005, 21, 6987-6994
26. Odabasi, M.; Uzun, L.; Denizli, A. Porous Magnetic Chelator Support for Albumin Adsorption by Immobilized Metal Affinity Separation J. Appl. Polym. Sci. 2004, 93, 2501-2510
27. Li, Y.-C.; Lin, Y.-S.; Tsai, P.-J.; Chen, C.-T.; Chen, W.-Y.; Chen, Y.-C. Nitrilotriacetic Acid-Coated Magnetic Nanoparticles as Affinity Probes for Enrichment of Histidine-Tagged Proteins and Phosphorylated Peptides Anal. Chem. 2007, 79, 7519-7525
28. 2+/NTA- Derivatized Branch Polyglycerol Magnetic Nanoparticles for Protein Adsorption J. Nanopart. Res. 2010, 12, 2467-2472
29. Bauer, J.; Holschuh, K. Industrial Production, Surface Modification, and Application of Magnetic Particles. In Upscaling of Bio-Nano-Processes; Nirschl, H.; Keller, K., Eds.; Springer: Berlin, Heidelberg, 2014.
30. Massart, R. Preparation of Aqueous Magnetic Liquids in Alkaline and Acidic Media IEEE Trans. Magn. 1981, 17, 1247-1248
31. Sugimoto, T.; Matijevic, E. Formation of Uniform Spherical Magnetite Particles by Crystallization from Ferrous Hydroxide Gels J. Colloid Interface Sci. 1980, 74, 227-243
32. Stöber, W.; Fink, A.; Bohn, E. Controlled Growth of Monodisperse Silica Spheres in the Micron Size Range J. Colloid Interface Sci. 1968, 26, 62-69
33. Saal, K. Surface Silanization and Its Application in Biomolecule Coupling. Ph.D. Thesis, Tartu University, 2006.
34. Rozenberg, B. A. Kinetics, Thermodynamics and Mechanism of Reactions of Epoxy Oligomers with Amines. In Epoxy Resins and Composites II; Dusek, K., Eds.; Springer: Berlin, Heidelberg, 1986; Vol. 75, pp 113-165.
35. Takeshita, T.; Shimoara, T.-A.; Maeda, S. Synthesis of EDTA-Monoalkylamide Chelates and Evaluation of the Surface-Active Properties J. Am. Oil Chem. Soc. 1982, 59, 104-107
36. Zheng, J.; Ma, C.; Sun, Y.; Pan, M.; Li, L.; Hu, X.; Yang, W. Maltodextrin-Modified Magnetic Microspheres for Selective Enrichment of Maltose Binding Proteins ACS Appl. Mater. Interfaces 2014, 6, 3568-3574
37. Santoyo Salazar, J.; Perez, L.; De Abril, O.; Truong Phuoc, L.; Ihiawakrim, D.; Vazquez, M.; Greneche, J.-M.; Begin-Colin, S.; Pourroy, G. Magnetic Iron Oxide Nanoparticles in 10-40 nm Range: Composition in Terms of Magnetite/Maghemite Ratio and Effect on the Magnetic Properties Chem. Mater. 2011, 23, 1379-1386
38. Lu, A.-H.; Salabas, E. L.; Schüth, F. Magnetic Nanoparticles: Synthesis, Protection, Functionalization, and Application Angew. Chem., Int. Ed. 2007, 46, 1222-1244
39. OBrien, S. M.; Sloane, R. P.; Thomas, O. R.; Dunnill, P. Characterisation of Non-Porous Magnetic Chelator Supports and their Use to Recover Polyhistidine-Tailed T4 Lysozyme from a Crude E. Coli Extract J. Biotechnol. 1997, 54, 53-67
40. Jiang, W.; Prescott, M.; Devenish, R. J.; Spiccia, L.; Hearn, M. T. W. Separation of Hexahistidine Fusion Proteins with Immobilized Metal Ion Affinity Chromatographic (IMAC) Sorbents Derived from M(N+)-tacn and Its Derivatives Biotechnol. Bioeng. 2009, 103, 747-756
41. Graham, B.; Spiccia, L.; Hearn, M. T. W. Comparison of the Binding Behavior of Several Histidine-Containing Proteins with Immobilized Copper(II) Complexes of 1,4,7-triazacyclononane and 1,4-bis(1,4,7-triazacyclononan-1-yl) butane J. Chromatogr., B: Anal. Technol. Biomed. Life Sci. 2011, 879, 844-852
42. Chiang, C.-L.; Chen, C.-Y.; Chang, L.-W. Purification of Recombinant Enhanced Green Fluorescent Protein Expressed in Escherichia Coli with New Immobilized Metal Ion Affinity Magnetic Absorbents J. Chromatogr., B: Anal. Technol. Biomed. Life Sci. 2008, 864, 116-122
43. Casey, J. L.; Keep, P. A.; Chester, K. A.; Robson, L.; Hawkins, R. E.; Begent, R. H. J. Purification of Bacterially Expressed Single Chain Fv Antibodies for Clinical Applications Using Metal Chelate Chromatography J. Immunol. Methods 1995, 179, 105-116
44. 2+ Decorated Porous Magnetic Silica Spheres Synthesized by Hydrothermal-Assisted Modified-Stöber Method for His-Tagged Proteins Separation J. Colloid Interface Sci. 2012, 365, 156-162
45. Xu, C.; Xu, K.; Gu, H.; Zhong, X.; Guo, Z.; Zheng, R.; Zhang, X.; Xu, B. Nitrilotriacetic Acid-Modified Magnetic Nanoparticles as a General Agent to Bind Histidine-Tagged Proteins J. Am. Chem. Soc. 2004, 126, 3392-3393
46. Koksharov, Y. A. Magnetism of Nanoparticles: Effects of Size, Shape and Interactions. In Magnetic Nanoparticles; Gubin, S. P., Eds.; Wiley-VCH: Weinheim, 2009; pp 223-227.
47. Nichols, G.; Byard, S.; Bloxham, M. J.; Botterill, J.; Dawson, N. J.; Dennis, A.; Diart, V.; North, N. C.; Sherwood, J. D. A Review of the Terms Agglomerate and Aggregate with a Recommendation for Nomenclature Used in Powder and Particle Characterization J. Pharm. Sci. 2002, 91, 2103-2109
48. Masthoff, I.-C.; David, F.; Wittmann, C.; Garnweitner, G. Functionalization of Magnetic Nanoparticles with High-Binding Capacity for Affinity Separation of Therapeutic Proteins J. Nanopart. Res. 2014, 16, 2164
49. Ward, W. W. Biochemical and Physical Properties of Green Fluorescent Protein. In Green Fluorescent Protein; Chalfie, M.; Kain, S. R., Eds.; John Wiley & Sons, Inc.: Hoboken, NJ, USA, 2005; pp 39-65.
50. Frankamp, B. L.; Boal, A. K.; Tuominen, M. T.; Rotello, V. M. Direct Control of the Magnetic Interaction between Iron Oxide Nanoparticles through Dendrimer-Mediated Self-Assembly J. Am. Chem. Soc. 2005, 127, 9731-9735
51. Voggu, R.; Kumar, N.; Rao, C. N. R. Dependence of the Properties of Magnetic Nanoparticles on the Interparticle Separation J. Phys. Chem. C 2008, 112, 17775-17777
52. Yang, H. T.; Hasegawa, D.; Takahashi, M.; Ogawa, T. Achieving a Noninteracting Magnetic Nanoparticle System through Direct Control of Interparticle Spacing Appl. Phys. Lett. 2009, 94, 13103
53. Ormö, M.; Cubitt, A. B.; Kallio, K.; Gross, L. A.; Tsien, R. Y.; Remington, S. J. Crystal Structure of the Aequorea Victoria Green Fluorescent Protein Science 1996, 273, 1392-1395
54. 4 Hollow Microspheres/Graphene Oxide Composite for Cr(VI) Removal Dalton Trans. 2013, 42, 14710
55. 4 Nanoparticles for Targeted Delivery and Controlled Release of Cisplatin J. Am. Chem. Soc. 2009, 131, 10637-10644
56. Podsiadlo, P.; Kwon, S. G.; Koo, B.; Lee, B.; Prakapenka, V. B.; Dera, P.; Zhuravlev, K. K.; Krylova, G.; Shevchenko, E. V. How "Hollow" Are Hollow Nanoparticles? J. Am. Chem. Soc. 2013, 135, 2435-2438