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Volumn 8, Issue 9, 2014, Pages 1043-1054

Specific changes of gut commensal microbiota and TLRs during indomethacin-induced acute intestinal inflammation in rats

Author keywords

Bacterial adherence; FISH; Gut commensal microbiota; Gut inflammation; Host bacterial interactions; Inflammatory bowel disease; TLR; Toll like receptors

Indexed keywords

DNA 16S; INDOMETACIN; TOLL LIKE RECEPTOR; TOLL LIKE RECEPTOR 2; TOLL LIKE RECEPTOR 4; MYELOPEROXIDASE;

EID: 84906792093     PISSN: 18739946     EISSN: 18764479     Source Type: Journal    
DOI: 10.1016/j.crohns.2014.02.001     Document Type: Article
Times cited : (49)

References (53)
  • 1
    • 0035793372 scopus 로고    scopus 로고
    • Molecular analysis of commensal host-microbial relationships in the intestine
    • Hooper L.V., Wong M.H., Thelin A., Hansson L., Falk P.G., Gordon J.I. Molecular analysis of commensal host-microbial relationships in the intestine. Science 2001, 291:881-884.
    • (2001) Science , vol.291 , pp. 881-884
    • Hooper, L.V.1    Wong, M.H.2    Thelin, A.3    Hansson, L.4    Falk, P.G.5    Gordon, J.I.6
  • 2
    • 77649086402 scopus 로고    scopus 로고
    • Immune adaptations that maintain homeostasis with the intestinal microbiota
    • Hooper L.V., Macpherson A.J. Immune adaptations that maintain homeostasis with the intestinal microbiota. Nat Rev Immunol 2010, 10:159-169.
    • (2010) Nat Rev Immunol , vol.10 , pp. 159-169
    • Hooper, L.V.1    Macpherson, A.J.2
  • 3
    • 84885391816 scopus 로고    scopus 로고
    • Messages from the Inside. The Dynamic Environment that Favors Intestinal Homeostasis
    • Eri R., Chieppa M. Messages from the Inside. The Dynamic Environment that Favors Intestinal Homeostasis. Front Immunol 2013, 4:323.
    • (2013) Front Immunol , vol.4 , pp. 323
    • Eri, R.1    Chieppa, M.2
  • 4
    • 34547176642 scopus 로고    scopus 로고
    • Unravelling the pathogenesis of inflammatory bowel disease
    • Xavier R.J., Podolsky D.K. Unravelling the pathogenesis of inflammatory bowel disease. Nature 2007, 448:427-434.
    • (2007) Nature , vol.448 , pp. 427-434
    • Xavier, R.J.1    Podolsky, D.K.2
  • 5
    • 0028003794 scopus 로고
    • The germfree state prevents development of gut and joint inflammatory disease in HLA-B27 transgenic rats
    • Taurog J.D., Richardson J.A., Croft J.T., Simmons W.A., Zhou M., Fernández-Sueiro J.L., et al. The germfree state prevents development of gut and joint inflammatory disease in HLA-B27 transgenic rats. J Exp Med 1994, 180:2359-2364.
    • (1994) J Exp Med , vol.180 , pp. 2359-2364
    • Taurog, J.D.1    Richardson, J.A.2    Croft, J.T.3    Simmons, W.A.4    Zhou, M.5    Fernández-Sueiro, J.L.6
  • 6
    • 84892825869 scopus 로고    scopus 로고
    • Rifaximin Alters Intestinal Bacteria and Prevents Stress-Induced Gut Inflammation and Visceral Hyperalgesia in Rats
    • Xu D., Gao J., Gillilland M., Wu X., Song I., Kao J.Y., et al. Rifaximin Alters Intestinal Bacteria and Prevents Stress-Induced Gut Inflammation and Visceral Hyperalgesia in Rats. Gastroenterology 2014, 146:484-496.
    • (2014) Gastroenterology , vol.146 , pp. 484-496
    • Xu, D.1    Gao, J.2    Gillilland, M.3    Wu, X.4    Song, I.5    Kao, J.Y.6
  • 8
    • 84876708979 scopus 로고    scopus 로고
    • The interplay between the gut immune system and microbiota in health and disease: nutraceutical intervention for restoring intestinal homeostasis
    • Magrone T., Jirillo E. The interplay between the gut immune system and microbiota in health and disease: nutraceutical intervention for restoring intestinal homeostasis. Curr Pharm Des 2013, 19:1329-1342.
    • (2013) Curr Pharm Des , vol.19 , pp. 1329-1342
    • Magrone, T.1    Jirillo, E.2
  • 9
    • 33750077286 scopus 로고    scopus 로고
    • Culture-independent analysis of indomethacin-induced alterations in the rat gastrointestinal microbiota
    • Dalby A.B., Frank D.N., St Amand A.L., Bendele A.M., Pace N.R. Culture-independent analysis of indomethacin-induced alterations in the rat gastrointestinal microbiota. Appl Environ Microbiol 2006, 72:6707-6715.
    • (2006) Appl Environ Microbiol , vol.72 , pp. 6707-6715
    • Dalby, A.B.1    Frank, D.N.2    St Amand, A.L.3    Bendele, A.M.4    Pace, N.R.5
  • 10
    • 3042643488 scopus 로고    scopus 로고
    • Intestinal motor disorders associated with cyclical bacterial overgrowth in a rat model of enteritis
    • Porras M., Martín M.T., Soler M., Vergara P. Intestinal motor disorders associated with cyclical bacterial overgrowth in a rat model of enteritis. Am J Physiol Gastrointest Liver Physiol 2004, 287:G58-G64.
    • (2004) Am J Physiol Gastrointest Liver Physiol , vol.287
    • Porras, M.1    Martín, M.T.2    Soler, M.3    Vergara, P.4
  • 11
    • 44349137461 scopus 로고    scopus 로고
    • Intestinal epithelial barrier dysfunction and dendritic cell redistribution during early stages of inflammation in the rat: role for TLR-2 and-4 blockage
    • Silva M.A., Jury J., Porras M., Vergara P., Perdue M.H. Intestinal epithelial barrier dysfunction and dendritic cell redistribution during early stages of inflammation in the rat: role for TLR-2 and-4 blockage. Inflamm Bowel Dis 2008, 14:632-644.
    • (2008) Inflamm Bowel Dis , vol.14 , pp. 632-644
    • Silva, M.A.1    Jury, J.2    Porras, M.3    Vergara, P.4    Perdue, M.H.5
  • 12
    • 79958840965 scopus 로고    scopus 로고
    • Constitutive activation of epithelial TLR4 augments inflammatory responses to mucosal injury and drives colitis-associated tumorigenesis
    • Fukata M., Shang L., Santaolalla R., Sotolongo J., Pastorini C., España C., et al. Constitutive activation of epithelial TLR4 augments inflammatory responses to mucosal injury and drives colitis-associated tumorigenesis. Inflamm Bowel Dis 2011, 17:1464-1473.
    • (2011) Inflamm Bowel Dis , vol.17 , pp. 1464-1473
    • Fukata, M.1    Shang, L.2    Santaolalla, R.3    Sotolongo, J.4    Pastorini, C.5    España, C.6
  • 13
    • 77958096095 scopus 로고    scopus 로고
    • Characterization of Housing-Related Spontaneous Variations of Gut Microbiota and Expression of Toll Like Receptors 2 and 4 in Rats
    • Terán-Ventura E., Roca M., Martin M.T., Abarca M.L., Martinez V., Vergara P. Characterization of Housing-Related Spontaneous Variations of Gut Microbiota and Expression of Toll Like Receptors 2 and 4 in Rats. Microb Ecol 2010, 60:691-702.
    • (2010) Microb Ecol , vol.60 , pp. 691-702
    • Terán-Ventura, E.1    Roca, M.2    Martin, M.T.3    Abarca, M.L.4    Martinez, V.5    Vergara, P.6
  • 14
    • 84880131833 scopus 로고    scopus 로고
    • Stress and antibiotics alter luminal and wall-adhered microbiota and enhance the local expression of visceral sensory-related systems in mice
    • Aguilera M., Vergara P., Martínez V. Stress and antibiotics alter luminal and wall-adhered microbiota and enhance the local expression of visceral sensory-related systems in mice. Neurogastroenterol Motil 2013, 25:e515-e529.
    • (2013) Neurogastroenterol Motil , vol.25
    • Aguilera, M.1    Vergara, P.2    Martínez, V.3
  • 15
    • 84878769570 scopus 로고    scopus 로고
    • Environment-related adaptive changes of gut commensal microbiota do not alter colonic toll-like receptors but modulate the local expression of sensory-related systems in rats
    • Aguilera M., Vergara P., Martínez V. Environment-related adaptive changes of gut commensal microbiota do not alter colonic toll-like receptors but modulate the local expression of sensory-related systems in rats. Microb Ecol 2013, 66:232-243.
    • (2013) Microb Ecol , vol.66 , pp. 232-243
    • Aguilera, M.1    Vergara, P.2    Martínez, V.3
  • 16
    • 0025294528 scopus 로고
    • Combination of 16S rRNA-targeted oligonucleotide probes with flow cytometry for analyzing mixed microbial populations
    • Amann R.I., Binder B.J., Olson R.J., Chisholm S.W., Devereux R., Stahl D.A. Combination of 16S rRNA-targeted oligonucleotide probes with flow cytometry for analyzing mixed microbial populations. Appl Environ Microbiol 1990, 56:919-1925.
    • (1990) Appl Environ Microbiol , vol.56 , pp. 919-1925
    • Amann, R.I.1    Binder, B.J.2    Olson, R.J.3    Chisholm, S.W.4    Devereux, R.5    Stahl, D.A.6
  • 17
    • 0036854372 scopus 로고    scopus 로고
    • Analysis of 16S libraries of mouse gastrointestinal microflora reveals a large new group of mouse intestinal bacteria
    • Salzman N.H., de Jong H., Paterson Y., Harmsen H.J., Welling G.W., Bos N.A. Analysis of 16S libraries of mouse gastrointestinal microflora reveals a large new group of mouse intestinal bacteria. Microbiology 2002, 148:3651-3660.
    • (2002) Microbiology , vol.148 , pp. 3651-3660
    • Salzman, N.H.1    de Jong, H.2    Paterson, Y.3    Harmsen, H.J.4    Welling, G.W.5    Bos, N.A.6
  • 19
    • 27744574905 scopus 로고    scopus 로고
    • Quantification of bacteria in human feces using 16S rRNA-hybridization, DNA-staining and flow cytometry
    • Vaahtovuo J., Korkeamaki M., Munukka E., Viljanen M.K., Toivanen P. Quantification of bacteria in human feces using 16S rRNA-hybridization, DNA-staining and flow cytometry. J Microbiol Methods 2005, 63:276-286.
    • (2005) J Microbiol Methods , vol.63 , pp. 276-286
    • Vaahtovuo, J.1    Korkeamaki, M.2    Munukka, E.3    Viljanen, M.K.4    Toivanen, P.5
  • 20
    • 18444366772 scopus 로고    scopus 로고
    • Influence of dietary zinc oxide and copper sulfate on the gastrointestinal ecosystem in newly weaned piglets
    • Hojberg O., Canibe N., Poulsen H.D., Hedemann M.S., Jensen B.B. Influence of dietary zinc oxide and copper sulfate on the gastrointestinal ecosystem in newly weaned piglets. Appl Environ Microbiol 2005, 71:2267-2277.
    • (2005) Appl Environ Microbiol , vol.71 , pp. 2267-2277
    • Hojberg, O.1    Canibe, N.2    Poulsen, H.D.3    Hedemann, M.S.4    Jensen, B.B.5
  • 21
    • 0035040382 scopus 로고    scopus 로고
    • Terminal restriction fragment patterns: a tool for comparing microbial communities and assessing community dynamics
    • Kitts C.L. Terminal restriction fragment patterns: a tool for comparing microbial communities and assessing community dynamics. Curr Issues Intest Microbiol 2001, 2:17-25.
    • (2001) Curr Issues Intest Microbiol , vol.2 , pp. 17-25
    • Kitts, C.L.1
  • 23
    • 34250889906 scopus 로고    scopus 로고
    • Molecular methods in microbial ecology
    • Caister Academic Press, University of Otago, Dunedin, New Zealand, G.W. Tannock (Ed.)
    • Zoetendal E.G., Mackie R.I. Molecular methods in microbial ecology. Probiotics and prebiotics: Scientific aspects 2005, 1-24. Caister Academic Press, University of Otago, Dunedin, New Zealand. 1st ed. G.W. Tannock (Ed.).
    • (2005) Probiotics and prebiotics: Scientific aspects , pp. 1-24
    • Zoetendal, E.G.1    Mackie, R.I.2
  • 24
    • 33749518677 scopus 로고    scopus 로고
    • Localized colonic inflammation increases cytokine levels in distant small intestinal segments in the rat
    • Barada K.A., Mourad F.H., Sawah S.I., Khoury C., Safieh-Garabedian B., Nassar C.F., et al. Localized colonic inflammation increases cytokine levels in distant small intestinal segments in the rat. Life Sci 2006, 79:2032-2042.
    • (2006) Life Sci , vol.79 , pp. 2032-2042
    • Barada, K.A.1    Mourad, F.H.2    Sawah, S.I.3    Khoury, C.4    Safieh-Garabedian, B.5    Nassar, C.F.6
  • 25
    • 0029121060 scopus 로고
    • Experimental colitis alters myenteric nerve function at inflamed and noninflamed sites in the rat
    • Jacobson K., McHugh K., Collins S.M. Experimental colitis alters myenteric nerve function at inflamed and noninflamed sites in the rat. Gastroenterology 1995, 109:718-722.
    • (1995) Gastroenterology , vol.109 , pp. 718-722
    • Jacobson, K.1    McHugh, K.2    Collins, S.M.3
  • 26
    • 40949140201 scopus 로고    scopus 로고
    • Review article: gastrointestinal sensory and motor disturbances in inflammatory bowel disease-clinical relevance and pathophysiological mechanisms
    • De Schepper H.U., De Man J.G., Moreels T.G., Pelckmans P.A., De Winter B.Y. Review article: gastrointestinal sensory and motor disturbances in inflammatory bowel disease-clinical relevance and pathophysiological mechanisms. Aliment Pharmacol Ther 2008, 27:621-637.
    • (2008) Aliment Pharmacol Ther , vol.27 , pp. 621-637
    • De Schepper, H.U.1    De Man, J.G.2    Moreels, T.G.3    Pelckmans, P.A.4    De Winter, B.Y.5
  • 27
    • 38649115342 scopus 로고    scopus 로고
    • Microbial influences in inflammatory bowel diseases
    • Sartor R.B. Microbial influences in inflammatory bowel diseases. Gastroenterology 2008, 134:577-594.
    • (2008) Gastroenterology , vol.134 , pp. 577-594
    • Sartor, R.B.1
  • 29
    • 84874937803 scopus 로고    scopus 로고
    • Rebamipide inhibits indomethacin-induced small intestinal injury: possible involvement of intestinal microbiota modulation by upregulation of α-defensin 5
    • Tanigawa T., Watanabe T., Otani K., Nadatani Y., Ohkawa F., Sogawa M., et al. Rebamipide inhibits indomethacin-induced small intestinal injury: possible involvement of intestinal microbiota modulation by upregulation of α-defensin 5. Eur J Pharmacol 2013, 704:64-69.
    • (2013) Eur J Pharmacol , vol.704 , pp. 64-69
    • Tanigawa, T.1    Watanabe, T.2    Otani, K.3    Nadatani, Y.4    Ohkawa, F.5    Sogawa, M.6
  • 30
    • 84865834946 scopus 로고    scopus 로고
    • Terminal-restriction fragment length polymorphism (T-RFLP) analysis for changes in the gut microbiota profiles of indomethacin- and rebamipide-treated mice
    • Imaeda H., Fujimoto T., Takahashi K., Kasumi E., Fujiyama Y., Andoh A. Terminal-restriction fragment length polymorphism (T-RFLP) analysis for changes in the gut microbiota profiles of indomethacin- and rebamipide-treated mice. Digestion 2012, 86:250-257.
    • (2012) Digestion , vol.86 , pp. 250-257
    • Imaeda, H.1    Fujimoto, T.2    Takahashi, K.3    Kasumi, E.4    Fujiyama, Y.5    Andoh, A.6
  • 31
    • 69749099183 scopus 로고    scopus 로고
    • Probiotic Lactobacillus casei strain Shirota prevents indomethacin-induced small intestinal injury: involvement of lactic acid
    • Watanabe T., Nishio H., Tanigawa T., et al. Probiotic Lactobacillus casei strain Shirota prevents indomethacin-induced small intestinal injury: involvement of lactic acid. Am J Physiol 2009, 297:G506-G513.
    • (2009) Am J Physiol , vol.297
    • Watanabe, T.1    Nishio, H.2    Tanigawa, T.3
  • 32
    • 0017690751 scopus 로고
    • Resistance of germfree rats to indomethacin-induced intestinal lesions
    • Robert A., Asano T. Resistance of germfree rats to indomethacin-induced intestinal lesions. Prostaglandins 1977, 14:333-341.
    • (1977) Prostaglandins , vol.14 , pp. 333-341
    • Robert, A.1    Asano, T.2
  • 33
    • 0021967179 scopus 로고
    • Indometacin-induced gastrointestinal lesions in relation to tissue concentration, food intake and bacterial invasion in the rat
    • Weissenborn U., Maedge S., Buettner D., Sewing K.F. Indometacin-induced gastrointestinal lesions in relation to tissue concentration, food intake and bacterial invasion in the rat. Pharmacology 1985, 30:32-39.
    • (1985) Pharmacology , vol.30 , pp. 32-39
    • Weissenborn, U.1    Maedge, S.2    Buettner, D.3    Sewing, K.F.4
  • 34
    • 0020678175 scopus 로고
    • Role of bacteria in gastric ulceration produced by indomethacin in the rat: cytoprotective action of antibiotics
    • Satoh H., Guth P.H., Grossman M.I. Role of bacteria in gastric ulceration produced by indomethacin in the rat: cytoprotective action of antibiotics. Gastroenterology 1983, 84:483-489.
    • (1983) Gastroenterology , vol.84 , pp. 483-489
    • Satoh, H.1    Guth, P.H.2    Grossman, M.I.3
  • 35
    • 0024331287 scopus 로고
    • Neomycin prevents indomethacin-induced gastric peristalsis and mucosal injury in the rat
    • Mersereau W.A., Hinchey E.J. Neomycin prevents indomethacin-induced gastric peristalsis and mucosal injury in the rat. Can J Physiol Pharmacol 1989, 67:1029-1032.
    • (1989) Can J Physiol Pharmacol , vol.67 , pp. 1029-1032
    • Mersereau, W.A.1    Hinchey, E.J.2
  • 36
    • 0029787769 scopus 로고    scopus 로고
    • Role of intestinal bacteria in ileal ulcer formation in rats treated with a nonsteroidal antiinflammatory drug
    • Uejima M., Kinouchi T., Kataoka K., Hiraoka I., Ohnishi Y. Role of intestinal bacteria in ileal ulcer formation in rats treated with a nonsteroidal antiinflammatory drug. Microbiol Immunol 1996, 40:553-560.
    • (1996) Microbiol Immunol , vol.40 , pp. 553-560
    • Uejima, M.1    Kinouchi, T.2    Kataoka, K.3    Hiraoka, I.4    Ohnishi, Y.5
  • 38
    • 84871530893 scopus 로고    scopus 로고
    • Reduced diversity and imbalance of fecal microbiota in patients with ulcerative colitis
    • Nemoto H., Kataoka K., Ishikawa H., Ikata K., Arimochi H., Iwasaki T., et al. Reduced diversity and imbalance of fecal microbiota in patients with ulcerative colitis. Dig Dis Sci 2012, 57:2955-2964.
    • (2012) Dig Dis Sci , vol.57 , pp. 2955-2964
    • Nemoto, H.1    Kataoka, K.2    Ishikawa, H.3    Ikata, K.4    Arimochi, H.5    Iwasaki, T.6
  • 40
    • 33845428754 scopus 로고    scopus 로고
    • Gram-negative bacteria aggravate murine small intestinal Th1-type immunopathology following oral infection with Toxoplasma gondii
    • Heimesaat M.M., Bereswill S., Fischer A., Fuchs D., Struck D., Niebergall J., et al. Gram-negative bacteria aggravate murine small intestinal Th1-type immunopathology following oral infection with Toxoplasma gondii. Immunology 2006, 177:8785-8795.
    • (2006) Immunology , vol.177 , pp. 8785-8795
    • Heimesaat, M.M.1    Bereswill, S.2    Fischer, A.3    Fuchs, D.4    Struck, D.5    Niebergall, J.6
  • 41
    • 38649129512 scopus 로고    scopus 로고
    • Shift towards pro-inflammatory intestinal bacteria aggravates acute murine colitis via Toll-like receptors 2 and 4
    • Heimesaat M.M., Fischer A., Siegmund B., Kupz A., Niebergall J., Fuchs D., et al. Shift towards pro-inflammatory intestinal bacteria aggravates acute murine colitis via Toll-like receptors 2 and 4. PLoS One 2007, 2:e662.
    • (2007) PLoS One , vol.2
    • Heimesaat, M.M.1    Fischer, A.2    Siegmund, B.3    Kupz, A.4    Niebergall, J.5    Fuchs, D.6
  • 42
    • 0031773073 scopus 로고    scopus 로고
    • Correlation of cecal microflora of HLA-B27 transgenic rats with inflammatory bowel disease
    • Onderdonk A.B., Richardson J.A., Hammer R.E., Taurog J.D. Correlation of cecal microflora of HLA-B27 transgenic rats with inflammatory bowel disease. Infect Immun 1998, 66:6022-6023.
    • (1998) Infect Immun , vol.66 , pp. 6022-6023
    • Onderdonk, A.B.1    Richardson, J.A.2    Hammer, R.E.3    Taurog, J.D.4
  • 43
    • 0035082973 scopus 로고    scopus 로고
    • Different subsets of enteric bacteria induce and perpetuate experimental colitis in rats and mice
    • Rath H.C., Schultz M., Freitag R., Dieleman L.A., Li F., Linde H.J., et al. Different subsets of enteric bacteria induce and perpetuate experimental colitis in rats and mice. Infect Immun 2001, 69:2277-2285.
    • (2001) Infect Immun , vol.69 , pp. 2277-2285
    • Rath, H.C.1    Schultz, M.2    Freitag, R.3    Dieleman, L.A.4    Li, F.5    Linde, H.J.6
  • 44
    • 0025181580 scopus 로고
    • A novel method in the induction of reliable experimental acute and chronic ulcerative colitis in mice
    • Okayasu I., Hatakeyama S., Yamada M., Ohkusa T., Inagaki Y., Nakaya R. A novel method in the induction of reliable experimental acute and chronic ulcerative colitis in mice. Gastroenterology 1990, 98:694-702.
    • (1990) Gastroenterology , vol.98 , pp. 694-702
    • Okayasu, I.1    Hatakeyama, S.2    Yamada, M.3    Ohkusa, T.4    Inagaki, Y.5    Nakaya, R.6
  • 45
    • 79958056338 scopus 로고    scopus 로고
    • The host selects mucosal and luminal associations of coevolved gut microorganisms: a novel concept
    • Van den Abbeele P., Van de Wiele T., Verstraete W., Possemiers S. The host selects mucosal and luminal associations of coevolved gut microorganisms: a novel concept. FEMS Microbiol Rev 2011, 35:681-704.
    • (2011) FEMS Microbiol Rev , vol.35 , pp. 681-704
    • Van den Abbeele, P.1    Van de Wiele, T.2    Verstraete, W.3    Possemiers, S.4
  • 46
    • 79551686484 scopus 로고    scopus 로고
    • Microbiota-immune system interaction: an uneasy alliance
    • Salzman N.H. Microbiota-immune system interaction: an uneasy alliance. Curr Opin Microbiol 2011, 14:99-105.
    • (2011) Curr Opin Microbiol , vol.14 , pp. 99-105
    • Salzman, N.H.1
  • 47
    • 5444262511 scopus 로고    scopus 로고
    • Toll-like receptor control of the adaptive immune responses
    • Iwasaki A., Medzhitov R. Toll-like receptor control of the adaptive immune responses. Nat Immunol 2004, 5:987-995.
    • (2004) Nat Immunol , vol.5 , pp. 987-995
    • Iwasaki, A.1    Medzhitov, R.2
  • 48
    • 76349090419 scopus 로고    scopus 로고
    • Membrane TLR signaling mechanisms in the gastrointestinal tract during sepsis
    • Buchholz B.M., Bauer A.J. Membrane TLR signaling mechanisms in the gastrointestinal tract during sepsis. Neurogastroenterol Motil 2010, 22:232-245.
    • (2010) Neurogastroenterol Motil , vol.22 , pp. 232-245
    • Buchholz, B.M.1    Bauer, A.J.2
  • 49
    • 77949414935 scopus 로고    scopus 로고
    • The induction of colitis and ileitis in mice is associated with marked increases in intestinal concentrations of stimulants of TLRs 2, 4, and 5
    • Erridge C., Duncan S.H., Bereswill S., Heimesaat M.M. The induction of colitis and ileitis in mice is associated with marked increases in intestinal concentrations of stimulants of TLRs 2, 4, and 5. PLoS One 2010, 5:e9125.
    • (2010) PLoS One , vol.5
    • Erridge, C.1    Duncan, S.H.2    Bereswill, S.3    Heimesaat, M.M.4
  • 50
    • 38549158018 scopus 로고    scopus 로고
    • Non-steroidal anti-inflammatory drug-induced small intestinal damage is Toll-like receptor 4 dependent
    • Watanabe T., Higuchi K., Kobata A., Nishio H., Tanigawa T., Shiba M., et al. Non-steroidal anti-inflammatory drug-induced small intestinal damage is Toll-like receptor 4 dependent. Gut 2008, 57:181-187.
    • (2008) Gut , vol.57 , pp. 181-187
    • Watanabe, T.1    Higuchi, K.2    Kobata, A.3    Nishio, H.4    Tanigawa, T.5    Shiba, M.6
  • 51
    • 55649115944 scopus 로고    scopus 로고
    • Expression of Toll-like receptors in the intestinal mucosa of patients with inflammatory bowel disease
    • Tanaka K. Expression of Toll-like receptors in the intestinal mucosa of patients with inflammatory bowel disease. Expert Rev Gastroenterol Hepatol 2008, 2:193-196.
    • (2008) Expert Rev Gastroenterol Hepatol , vol.2 , pp. 193-196
    • Tanaka, K.1
  • 52
    • 39449127013 scopus 로고    scopus 로고
    • Expression of Toll-like receptor 2 (TLR2), TLR4, and CD14 in biopsy samples of patients with inflammatory bowel diseases: upregulated expression of TLR2 in terminal ileum of patients with ulcerative colitis
    • Frolova L., Drastich P., Rossmann P., Klimesova K., Tlaskalova-Hogenova H. Expression of Toll-like receptor 2 (TLR2), TLR4, and CD14 in biopsy samples of patients with inflammatory bowel diseases: upregulated expression of TLR2 in terminal ileum of patients with ulcerative colitis. J Histochem Cytochem 2008, 56:267-274.
    • (2008) J Histochem Cytochem , vol.56 , pp. 267-274
    • Frolova, L.1    Drastich, P.2    Rossmann, P.3    Klimesova, K.4    Tlaskalova-Hogenova, H.5
  • 53
    • 36849077704 scopus 로고    scopus 로고
    • Increased expression of Toll-like receptor (TLR) 2 and TLR4 in the colonic mucosa of children with inflammatory bowel disease
    • Szebeni B., Veres G., Dezsõfi A., Rusai K., Vannay A., Mraz M., et al. Increased expression of Toll-like receptor (TLR) 2 and TLR4 in the colonic mucosa of children with inflammatory bowel disease. Clin Exp Immunol 2008, 151:34-41.
    • (2008) Clin Exp Immunol , vol.151 , pp. 34-41
    • Szebeni, B.1    Veres, G.2    Dezsõfi, A.3    Rusai, K.4    Vannay, A.5    Mraz, M.6


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