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Volumn 3, Issue 2, 2014, Pages

Tumor suppressor NDRG2 tips the balance of oncogenic TGF-b via EMT inhibition in colorectal cancer

Author keywords

colorectal cancer; EMT; methylation; NDRG2; TGF

Indexed keywords

FIBRONECTIN; N MYC DOWNSTREAM REGULATED GENE 2; NERVE CELL ADHESION MOLECULE; PROTEIN; PROTEIN C MYB; PROTEIN MIZ 1; SMAD2 PROTEIN; SMAD3 PROTEIN; TRANSCRIPTION FACTOR SNAIL; TRANSCRIPTION FACTOR SP1; TRANSCRIPTION FACTOR TWIST; TRANSFORMING GROWTH FACTOR BETA; TUMOR SUPPRESSOR PROTEIN; UNCLASSIFIED DRUG; UVOMORULIN; VIMENTIN;

EID: 84906791490     PISSN: None     EISSN: 21579024     Source Type: Journal    
DOI: 10.1038/oncsis.2013.48     Document Type: Article
Times cited : (72)

References (47)
  • 2
    • 0025312728 scopus 로고
    • A genetic model for colorectal tumorigenesis
    • Fearon ER, Vogelstein B. A genetic model for colorectal tumorigenesis. Cell 1990; 61: 759-767.
    • (1990) Cell , vol.61 , pp. 759-767
    • Fearon, E.R.1    Vogelstein, B.2
  • 3
    • 0034785348 scopus 로고    scopus 로고
    • TGF-beta signaling in tumor suppression and cancer progression
    • Derynck R, Akhurst RJ, Balmain A. TGF-beta signaling in tumor suppression and cancer progression. Nat Genet 2001; 29: 117-129.
    • (2001) Nat Genet , vol.29 , pp. 117-129
    • Derynck, R.1    Akhurst, R.J.2    Balmain, A.3
  • 4
    • 0032430075 scopus 로고    scopus 로고
    • Signal transduction by transforming growth factor-beta: A cooperative paradigm with extensive negative regulation
    • Engel ME, Datta PK, Moses HL. Signal transduction by transforming growth factor-beta: a cooperative paradigm with extensive negative regulation. J Cell Biochem Suppl 1998; 30-31: 111-122.
    • (1998) J Cell Biochem Suppl , vol.30-31 , pp. 111-122
    • Engel, M.E.1    Datta, P.K.2    Moses, H.L.3
  • 5
    • 0035196587 scopus 로고    scopus 로고
    • Transforming growth factor beta enhances epithelial cell survival via Akt-dependent regulation of FKHRL1
    • Shin I, Bakin AV, Rodeck U, Brunet A, Arteaga CL. Transforming growth factor beta enhances epithelial cell survival via Akt-dependent regulation of FKHRL1. Mol Biol Cell 2001; 12: 3328-3339.
    • (2001) Mol Biol Cell , vol.12 , pp. 3328-3339
    • Shin, I.1    Bakin, A.V.2    Rodeck, U.3    Brunet, A.4    Arteaga, C.L.5
  • 6
    • 0029073142 scopus 로고
    • Transforming growth factor beta induces the cyclin-dependent kinase inhibitor p21 through a p53-independent mechanism
    • Datto MB, Li Y, Panus JF, Howe DJ, Xiong Y, Wang XF. Transforming growth factor beta induces the cyclin-dependent kinase inhibitor p21 through a p53-independent mechanism. Proc Natl Acad Sci USA 1995; 92: 5545-5549.
    • (1995) Proc Natl Acad Sci USA , vol.92 , pp. 5545-5549
    • Datto, M.B.1    Li, Y.2    Panus, J.F.3    Howe, D.J.4    Xiong, Y.5    Wang, X.F.6
  • 7
    • 0028168242 scopus 로고
    • P15INK4B is a potential effector of TGF-beta-induced cell cycle arrest
    • Hannon GJ, Beach D. p15INK4B is a potential effector of TGF-beta-induced cell cycle arrest. Nature 1994; 371: 257-261.
    • (1994) Nature , vol.371 , pp. 257-261
    • Hannon, G.J.1    Beach, D.2
  • 8
    • 0025329363 scopus 로고
    • Transforming growth factor beta 1 suppression of c-myc gene transcription: Role in inhibition of keratinocyte proliferation
    • Pietenpol JA, Holt JT, Stein RW, Moses HL. Transforming growth factor beta 1 suppression of c-myc gene transcription: role in inhibition of keratinocyte proliferation. Proc Natl Acad Sci USA 1990; 87: 3758-3762.
    • (1990) Proc Natl Acad Sci USA , vol.87 , pp. 3758-3762
    • Pietenpol, J.A.1    Holt, J.T.2    Stein, R.W.3    Moses, H.L.4
  • 9
    • 15744372725 scopus 로고    scopus 로고
    • Role of transforming growth factor Beta in human cancer
    • Elliott RL, Blobe GC. Role of transforming growth factor Beta in human cancer. J Clin Oncol 2005; 23: 2078-2093.
    • (2005) J Clin Oncol , vol.23 , pp. 2078-2093
    • Elliott, R.L.1    Blobe, G.C.2
  • 10
    • 0034644472 scopus 로고    scopus 로고
    • TGFbeta signaling in growth control, cancer, and heritable disorders
    • Massague J, Blain SW, Lo RS. TGFbeta signaling in growth control, cancer, and heritable disorders. Cell 2000; 103: 295-309.
    • (2000) Cell , vol.103 , pp. 295-309
    • Massague, J.1    Blain, S.W.2    Lo, R.S.3
  • 11
    • 0034612789 scopus 로고    scopus 로고
    • Role of transforming growth factor-beta signaling in cancer
    • de Caestecker MP, Piek E, Roberts AB. Role of transforming growth factor-beta signaling in cancer. J Natl Cancer Inst 2000; 92: 1388-1402.
    • (2000) J Natl Cancer Inst , vol.92 , pp. 1388-1402
    • De Caestecker, M.P.1    Piek, E.2    Roberts, A.B.3
  • 13
    • 16044369574 scopus 로고    scopus 로고
    • MADR2 maps to 18q21 and encodes a TGFbeta-regulated MAD-related protein that is functionally mutated in colorectal carcinoma
    • Eppert K, Scherer SW, Ozcelik H, Pirone R, Hoodless P, Kim H et al. MADR2 maps to 18q21 and encodes a TGFbeta-regulated MAD-related protein that is functionally mutated in colorectal carcinoma. Cell 1996; 86: 543-552.
    • (1996) Cell , vol.86 , pp. 543-552
    • Eppert, K.1    Scherer, S.W.2    Ozcelik, H.3    Pirone, R.4    Hoodless, P.5    Kim, H.6
  • 14
    • 0028785603 scopus 로고
    • Microsatellite instability and mutations of the transforming growth factor beta type II receptor gene in colorectal cancer
    • Parsons R, Myeroff LL, Liu B, Willson JK, Markowitz SD, Kinzler KW et al. Microsatellite instability and mutations of the transforming growth factor beta type II receptor gene in colorectal cancer. Cancer Res 1995; 55: 5548-5550.
    • (1995) Cancer Res , vol.55 , pp. 5548-5550
    • Parsons, R.1    Myeroff, L.L.2    Liu, B.3    Willson, J.K.4    Markowitz, S.D.5    Kinzler, K.W.6
  • 15
    • 0033587016 scopus 로고    scopus 로고
    • DPC4/SMAD4 mediated tumor suppression of colon carcinoma cells is associated with reduced urokinase expression
    • Schwarte-Waldhoff I, Klein S, Blass-Kampmann S, Hintelmann A, Eilert C, Dreschers S et al. DPC4/SMAD4 mediated tumor suppression of colon carcinoma cells is associated with reduced urokinase expression. Oncogene 1999; 18: 3152-3158.
    • (1999) Oncogene , vol.18 , pp. 3152-3158
    • Schwarte-Waldhoff, I.1    Klein, S.2    Blass-Kampmann, S.3    Hintelmann, A.4    Eilert, C.5    Dreschers, S.6
  • 16
    • 0033585086 scopus 로고    scopus 로고
    • Smad4/DPC4 silencing and hyperactive Ras jointly disrupt transforming growth factor-beta antiproliferative responses in colon cancer cells
    • Calonge MJ, Massague J. Smad4/DPC4 silencing and hyperactive Ras jointly disrupt transforming growth factor-beta antiproliferative responses in colon cancer cells. J Biol Chem 1999; 274: 33637-33643.
    • (1999) J Biol Chem , vol.274 , pp. 33637-33643
    • Calonge, M.J.1    Massague, J.2
  • 17
    • 0037491744 scopus 로고    scopus 로고
    • N-Myc downstream-regulated gene 2 (NDRG2) inhibits glioblastoma cell proliferation
    • Deng Y, Yao L, Chau L, Ng SS, Peng Y, Liu X et al. N-Myc downstream-regulated gene 2 (NDRG2) inhibits glioblastoma cell proliferation. Int J Cancer 2003; 106: 342-347.
    • (2003) Int J Cancer , vol.106 , pp. 342-347
    • Deng, Y.1    Yao, L.2    Chau, L.3    Ng, S.S.4    Peng, Y.5    Liu, X.6
  • 18
    • 0142200334 scopus 로고    scopus 로고
    • Expression and regulation of NDRG2 (N-myc downstream regulated gene 2) during the differentiation of dendritic cells
    • Choi SC, Kim KD, Kim JT, Kim JW, Yoon DY, Choe YK et al. Expression and regulation of NDRG2 (N-myc downstream regulated gene 2) during the differentiation of dendritic cells. FEBS Lett 2003; 553: 413-418.
    • (2003) FEBS Lett , vol.553 , pp. 413-418
    • Choi, S.C.1    Kim, K.D.2    Kim, J.T.3    Kim, J.W.4    Yoon, D.Y.5    Choe, Y.K.6
  • 19
    • 23944445044 scopus 로고    scopus 로고
    • Ndrg2 promotes neurite outgrowth of NGF-differentiated PC12 cells
    • Takahashi K, Yamada M, Ohata H, Honda K. Ndrg2 promotes neurite outgrowth of NGF-differentiated PC12 cells. Neurosci Lett 2005; 388: 157-162.
    • (2005) Neurosci Lett , vol.388 , pp. 157-162
    • Takahashi, K.1    Yamada, M.2    Ohata, H.3    Honda, K.4
  • 20
    • 33845986380 scopus 로고    scopus 로고
    • The repression of human differentiation-related gene NDRG2 expression by Myc via Miz-1-dependent interaction with the NDRG2 core promoter
    • Zhang J, Li F, Liu X, Shen L, Liu J, Su J et al. The repression of human differentiation-related gene NDRG2 expression by Myc via Miz-1-dependent interaction with the NDRG2 core promoter. J Biol Chem 2006; 281: 39159-39168.
    • (2006) J Biol Chem , vol.281 , pp. 39159-39168
    • Zhang, J.1    Li, F.2    Liu, X.3    Shen, L.4    Liu, J.5    Su, J.6
  • 22
    • 78751541963 scopus 로고    scopus 로고
    • Prediction of colorectal cancer relapse and prognosis by tissue mRNA levels of NDRG2
    • Chu D, Zhang Z, Li Y, Wu L, Zhang J, Wang W. Prediction of colorectal cancer relapse and prognosis by tissue mRNA levels of NDRG2. Mol Cancer Ther 2011; 10: 47-56.
    • (2011) Mol Cancer Ther , vol.10 , pp. 47-56
    • Chu, D.1    Zhang, Z.2    Li, Y.3    Wu, L.4    Zhang, J.5    Wang, W.6
  • 23
    • 29244469466 scopus 로고    scopus 로고
    • The epigenetic progenitor origin of human cancer
    • Feinberg AP, Ohlsson R, Henikoff S. The epigenetic progenitor origin of human cancer. Nat Rev Genet 2006; 7: 21-33.
    • (2006) Nat Rev Genet , vol.7 , pp. 21-33
    • Feinberg, A.P.1    Ohlsson, R.2    Henikoff, S.3
  • 24
    • 33846008439 scopus 로고    scopus 로고
    • Colorectal cancer: A model for epigenetic tumorigenesis
    • Wong JJ, Hawkins NJ, Ward RL. Colorectal cancer: a model for epigenetic tumorigenesis. Gut 2007; 56: 140-148.
    • (2007) Gut , vol.56 , pp. 140-148
    • Wong, J.J.1    Hawkins, N.J.2    Ward, R.L.3
  • 25
    • 34848918829 scopus 로고    scopus 로고
    • Comparing the DNA hypermethylome with gene mutations in human colorectal cancer
    • Schuebel KE, Chen W, Cope L, Glockner SC, Suzuki H, Yi JM et al. Comparing the DNA hypermethylome with gene mutations in human colorectal cancer. PLoS Genet 2007; 3: 1709-1723.
    • (2007) PLoS Genet , vol.3 , pp. 1709-1723
    • Schuebel, K.E.1    Chen, W.2    Cope, L.3    Glockner, S.C.4    Suzuki, H.5    Yi, J.M.6
  • 26
    • 33846192840 scopus 로고    scopus 로고
    • The CpG island methylator phenotype and chromosomal instability are inversely correlated in sporadic colorectal cancer
    • Goel A, Nagasaka T, Arnold CN, Inoue T, Hamilton C, Niedzwiecki D et al. The CpG island methylator phenotype and chromosomal instability are inversely correlated in sporadic colorectal cancer. Gastroenterology 2007; 132: 127-138.
    • (2007) Gastroenterology , vol.132 , pp. 127-138
    • Goel, A.1    Nagasaka, T.2    Arnold, C.N.3    Inoue, T.4    Hamilton, C.5    Niedzwiecki, D.6
  • 27
    • 40549090918 scopus 로고    scopus 로고
    • Integrated analysis of chromosomal, microsatellite and epigenetic instability in colorectal cancer identifies specific associations between promoter methylation of pivotal tumour suppressor and DNA repair genes and specific chromosomal alterations
    • Derks S, Postma C, Carvalho B, van den Bosch SM, Moerkerk PT, Herman JG et al. Integrated analysis of chromosomal, microsatellite and epigenetic instability in colorectal cancer identifies specific associations between promoter methylation of pivotal tumour suppressor and DNA repair genes and specific chromosomal alterations. Carcinogenesis 2008; 29: 434-439.
    • (2008) Carcinogenesis , vol.29 , pp. 434-439
    • Derks, S.1    Postma, C.2    Carvalho, B.3    Van Den Bosch, S.M.4    Moerkerk, P.T.5    Herman, J.G.6
  • 28
    • 0036789184 scopus 로고    scopus 로고
    • Colorectal adenoma to carcinoma progression follows multiple pathways of chromosomal instability
    • Hermsen M, Postma C, Baak J, Weiss M, Rapallo A, Sciutto A et al. Colorectal adenoma to carcinoma progression follows multiple pathways of chromosomal instability. Gastroenterology 2002; 123: 1109-1119.
    • (2002) Gastroenterology , vol.123 , pp. 1109-1119
    • Hermsen, M.1    Postma, C.2    Baak, J.3    Weiss, M.4    Rapallo, A.5    Sciutto, A.6
  • 29
    • 3142691130 scopus 로고    scopus 로고
    • Array comparative genomic hybridization analysis of colorectal cancer cell lines and primary carcinomas
    • Douglas EJ, Fiegler H, Rowan A, Halford S, Bicknell DC, Bodmer W et al. Array comparative genomic hybridization analysis of colorectal cancer cell lines and primary carcinomas. Cancer Res 2004; 64: 4817-4825.
    • (2004) Cancer Res , vol.64 , pp. 4817-4825
    • Douglas, E.J.1    Fiegler, H.2    Rowan, A.3    Halford, S.4    Bicknell, D.C.5    Bodmer, W.6
  • 30
    • 36348970735 scopus 로고    scopus 로고
    • Common and distinct genomic events in sporadic colorectal cancer and diverse cancer types
    • Martin ES, Tonon G, Sinha R, Xiao Y, Feng B, Kimmelman AC et al. Common and distinct genomic events in sporadic colorectal cancer and diverse cancer types. Cancer Res 2007; 67: 10736-10743.
    • (2007) Cancer Res , vol.67 , pp. 10736-10743
    • Martin, E.S.1    Tonon, G.2    Sinha, R.3    Xiao, Y.4    Feng, B.5    Kimmelman, A.C.6
  • 32
    • 58149239730 scopus 로고    scopus 로고
    • Phospho-control of TGF-beta superfamily signaling
    • Wrighton KH, Lin X, Feng XH. Phospho-control of TGF-beta superfamily signaling. Cell Res 2009; 19: 8-20.
    • (2009) Cell Res , vol.19 , pp. 8-20
    • Wrighton, K.H.1    Lin, X.2    Feng, X.H.3
  • 33
    • 0035011486 scopus 로고    scopus 로고
    • Integrating Myc and TGF-beta signalling in cell-cycle control
    • Amati B. Integrating Myc and TGF-beta signalling in cell-cycle control. Nat Cell Biol 2001; 3: E112-E113.
    • (2001) Nat Cell Biol , vol.3 , pp. E112-E113
    • Amati, B.1
  • 36
    • 0028898203 scopus 로고
    • Potential role of WAF1/Cip1/p21 as a mediator of TGF-beta cytoinhibitory effect
    • Li CY, Suardet L, Little JB. Potential role of WAF1/Cip1/p21 as a mediator of TGF-beta cytoinhibitory effect. J Biol Chem 1995; 270: 4971-4974.
    • (1995) J Biol Chem , vol.270 , pp. 4971-4974
    • Li, C.Y.1    Suardet, L.2    Little, J.B.3
  • 37
    • 77949845438 scopus 로고    scopus 로고
    • Epithelial to mesenchymal transition is impaired in colon cancer cells with microsatellite instability
    • Pino MS, Kikuchi H, Zeng M, Herraiz MT, Sperduti I, Berger D et al. Epithelial to mesenchymal transition is impaired in colon cancer cells with microsatellite instability. Gastroenterology 2010; 138: 1406-1417.
    • (2010) Gastroenterology , vol.138 , pp. 1406-1417
    • Pino, M.S.1    Kikuchi, H.2    Zeng, M.3    Herraiz, M.T.4    Sperduti, I.5    Berger, D.6
  • 38
    • 0034596993 scopus 로고    scopus 로고
    • Smad2 Smad3 and Smad4 cooperate with Sp1 to induce p15(Ink4B) transcription in response to TGF-beta
    • Feng XH, Lin X, Derynck R. Smad2, Smad3 and Smad4 cooperate with Sp1 to induce p15(Ink4B) transcription in response to TGF-beta. EMBO J 2000; 19: 5178-5193.
    • (2000) EMBO J , vol.19 , pp. 5178-5193
    • Feng, X.H.1    Lin, X.2    Derynck, R.3
  • 39
    • 0034662959 scopus 로고    scopus 로고
    • A role for transcriptional repression of p21CIP1 by c-Myc in overcoming transforming growth factor beta-induced cell-cycle arrest
    • Claassen GF, Hann SR. A role for transcriptional repression of p21CIP1 by c-Myc in overcoming transforming growth factor beta-induced cell-cycle arrest. Proc Natl Acad Sci USA 2000; 97: 9498-9503.
    • (2000) Proc Natl Acad Sci USA , vol.97 , pp. 9498-9503
    • Claassen, G.F.1    Hann, S.R.2
  • 40
    • 63049123066 scopus 로고    scopus 로고
    • Transitions between epithelial and mesenchymal states: Acquisition of malignant and stem cell traits
    • Polyak K, Weinberg RA. Transitions between epithelial and mesenchymal states: acquisition of malignant and stem cell traits. Nat Rev Cancer 2009; 9: 265-273.
    • (2009) Nat Rev Cancer , vol.9 , pp. 265-273
    • Polyak, K.1    Weinberg, R.A.2
  • 41
    • 0033811676 scopus 로고    scopus 로고
    • Reduced E-cadherin expression and enlargement of cancer nuclei strongly correlate with hematogenic metastasis in colorectal adenocarcinoma
    • Ikeguchi M, Taniguchi T, Makino M, Kaibara N. Reduced E-cadherin expression and enlargement of cancer nuclei strongly correlate with hematogenic metastasis in colorectal adenocarcinoma. Scand J Gastroenterol 2000; 35: 839-846.
    • (2000) Scand J Gastroenterol , vol.35 , pp. 839-846
    • Ikeguchi, M.1    Taniguchi, T.2    Makino, M.3    Kaibara, N.4
  • 42
    • 84867303575 scopus 로고    scopus 로고
    • NDRG2 correlated with favorable recurrence-free survival inhibits metastasis of mouse breast cancer cells via attenuation of active TGF-b production
    • Oh SS, Kim D, Kim DH, Chang HH, Sohn KC, Kim KH et al. NDRG2 correlated with favorable recurrence-free survival inhibits metastasis of mouse breast cancer cells via attenuation of active TGF-b production. Carcinogenesis 2012; 33: 1882-1888.
    • (2012) Carcinogenesis , vol.33 , pp. 1882-1888
    • Oh, S.S.1    Kim, D.2    Kim, D.H.3    Chang, H.H.4    Sohn, K.C.5    Kim, K.H.6
  • 43
    • 49249103692 scopus 로고    scopus 로고
    • Functional and clinical evidence for NDRG2 as a candidate suppressor of liver cancer metastasis
    • Lee DC, Kang YK, Kim WH, Jang YJ, Kim DJ, Park IY et al. Functional and clinical evidence for NDRG2 as a candidate suppressor of liver cancer metastasis. Cancer Res 2008; 68: 4210-4220.
    • (2008) Cancer Res , vol.68 , pp. 4210-4220
    • Lee, D.C.1    Kang, Y.K.2    Kim, W.H.3    Jang, Y.J.4    Kim, D.J.5    Park, I.Y.6
  • 44
    • 84882613636 scopus 로고    scopus 로고
    • NDRG2 positively regulates E-cadherin expression and prolongs overall survival in colon cancer patients
    • Kim YJ, Kang HB, Yim HS, Kim JH, Kim JW. NDRG2 positively regulates E-cadherin expression and prolongs overall survival in colon cancer patients. Oncol Rep 2013; 30: 1890-1898.
    • (2013) Oncol Rep , vol.30 , pp. 1890-1898
    • Kim, Y.J.1    Kang, H.B.2    Yim, H.S.3    Kim, J.H.4    Kim, J.W.5
  • 45
    • 79954534290 scopus 로고    scopus 로고
    • Epithelial-mesenchymal transition and senescence: Two cancer-related processes are crossing paths
    • Smit MA, Peeper DS. Epithelial-mesenchymal transition and senescence: two cancer-related processes are crossing paths. Aging (Albany, NY) 2010; 2: 735-741.
    • (2010) Aging (Albany, NY) , vol.2 , pp. 735-741
    • Smit, M.A.1    Peeper, D.S.2
  • 46
    • 73149086829 scopus 로고    scopus 로고
    • P21CIP1 attenuates Ras-and c-Myc-dependent breast tumor epithelial mesenchymal transition and cancer stem cell-like gene expression in vivo
    • Liu M, Casimiro MC, Wang C, Shirley LA, Jiao X, Katiyar S et al. p21CIP1 attenuates Ras-and c-Myc-dependent breast tumor epithelial mesenchymal transition and cancer stem cell-like gene expression in vivo. Proc Natl Acad Sci USA 2009; 106: 19035-19039.
    • (2009) Proc Natl Acad Sci USA , vol.106 , pp. 19035-19039
    • Liu, M.1    Casimiro, M.C.2    Wang, C.3    Shirley, L.A.4    Jiao, X.5    Katiyar, S.6
  • 47
    • 0026546877 scopus 로고
    • A genomic sequencing protocol that yields a positive display of 5-methylcytosine residues in individual DNA strands
    • Frommer M, McDonald LE, Millar DS, Collis CM, Watt F, Grigg GW et al. A genomic sequencing protocol that yields a positive display of 5-methylcytosine residues in individual DNA strands. Proc Natl Acad Sci USA 1992; 89: 1827-1831.
    • (1992) Proc Natl Acad Sci USA , vol.89 , pp. 1827-1831
    • Frommer, M.1    McDonald, L.E.2    Millar, D.S.3    Collis, C.M.4    Watt, F.5    Grigg, G.W.6


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