Indomethacin inhibits activation of endothelial nitric oxide synthase in the rat kidney: Possible role of this effect in the pathogenesis of indomethacin-induced renal damage

Chemico-Biological Interactions

Volumn 221, Issue , 2014, Pages 77-87

  Nagappan, Arumugam Suriyam ^a   Varghese, Joe ^a   Pranesh, Gautham Tumkur ^a,b   Jeyaseelan, Visalakshi ^a   Jacob, Molly ^a  

^a CHRISTIAN MEDICAL COLLEGE   (India)

^b Clinigene International Limited   (India)

Author keywords

Heme oxygenase 1; Indomethacin; Kidney; Nitric oxide synthase type III; NSAID; Oxidative stress

Indexed keywords

ENDOTHELIAL NITRIC OXIDE SYNTHASE; HEME; HEME OXYGENASE; HEME OXYGENASE 1; INDOMETACIN; INDUCIBLE NITRIC OXIDE SYNTHASE; MESSENGER RNA; MITOGEN ACTIVATED PROTEIN KINASE P38; NITRIC OXIDE; NITRITE; PROTOPORPHYRIN TIN; PROTOPORPHYRIN ZINC; TRANSCRIPTION FACTOR NRF2; NITRIC OXIDE SYNTHASE; PROSTAGLANDIN SYNTHASE INHIBITOR;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CONTROLLED STUDY; DRUG INDUCED DISEASE; ENOS GENE; ENZYME ACTIVITY; ENZYME INACTIVATION; GLOMERULAR DYSFUNCTION; HO 1 GENE; INOS GENE; INTRACELLULAR SIGNALING; KIDNEY INJURY; KIDNEY PERFUSION; KIDNEY TUBULE DAMAGE; MALE; NONHUMAN; OXIDATIVE STRESS; PATHOGENESIS; PROTEIN INDUCTION; RAT; SINGLE DRUG DOSE; ANIMAL; ANTAGONISTS AND INHIBITORS; CHEMICALLY INDUCED; DRUG EFFECTS; ENDOTHELIUM CELL; ENZYMOLOGY; KIDNEY; KIDNEY DISEASE; METABOLISM; ORAL DRUG ADMINISTRATION; PATHOLOGY; PATHOPHYSIOLOGY; POLYACRYLAMIDE GEL ELECTROPHORESIS; STATISTICAL MODEL; WESTERN BLOTTING; WISTAR RAT;

ADMINISTRATION, ORAL; ANIMALS; BLOTTING, WESTERN; CYCLOOXYGENASE INHIBITORS; ELECTROPHORESIS, POLYACRYLAMIDE GEL; ENDOTHELIAL CELLS; HEME OXYGENASE-1; INDOMETHACIN; KIDNEY; KIDNEY DISEASES; LINEAR MODELS; MALE; NITRIC OXIDE SYNTHASE; RATS; RATS, WISTAR;

EID: 84906703463     PISSN: 00092797     EISSN: 18727786     Source Type: Journal    
DOI: 10.1016/j.cbi.2014.07.014     Document Type: Article

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