α-Fluorophosphonates reveal how a phosphomutase conserves transition state conformation over hexose recognition in its two-step reaction

Proceedings of the National Academy of Sciences of the United States of America

Volumn 111, Issue 34, 2014, Pages 12384-12389

  Jin, Yi ^a   Bhattasali, Debabrata ^b   Pellegrini, Erika ^a,c,d   Forget, Stephanie M ^b   Baxter, Nicola J ^a   Cliff, Matthew J ^a,e   Bowler, Matthew W ^c,d,f   Jakeman, David L ^b   Blackburn, G Michael ^a   Waltho, Jonathan P ^a,e  

^a UNIVERSITY OF SHEFFIELD   (United Kingdom)

^b DALHOUSIE UNIVERSITY   (Canada)

^c EUROPEAN SYNCHROTRON RADIATION FACILITY   (France)

^d EUROPEAN MOLECULAR BIOLOGY LABORATORY   (France)

^e UNIVERSITY OF MANCHESTER   (United Kingdom)

^f UNIV GRENOBLE ALPES   (France)

Author keywords

Phosphonate analogs; Phosphoryl transfer mechanism; Water mediated substrate recognition; X ray crystallography

Indexed keywords

BETA DEXTRO GLUCOSE 1,6 BISPHOSPHATE; FLUOROPHOSPHONIC ACID DERIVATIVE; GLUCOSE 1,6 BISPHOSPHATE; GLUCOSE 6 PHOSPHATE DEHYDROGENASE; HEXOSE; HYDROXYL GROUP; MUTASE; UNCLASSIFIED DRUG; BACTERIAL PROTEIN; FLUORINE; GLUCOSE 1 PHOSPHATE; GLUCOSE 6 PHOSPHATE; GLUCOSE PHOSPHATE; MAGNESIUM; PHOSPHOGLUCOMUTASE; PHOSPHONIC ACID DERIVATIVE; RECOMBINANT PROTEIN;

ARTICLE; BINDING AFFINITY; CONFORMATIONAL TRANSITION; CONTROLLED STUDY; DEOXYGENATION; FLUORINE NUCLEAR MAGNETIC RESONANCE; HYDROGEN BOND; HYDROGENOLYSIS; ISOMERIZATION; MOLECULAR RECOGNITION; PRIORITY JOURNAL; PROTEIN CONFORMATION; STEREOCHEMISTRY; CATALYSIS; CHEMICAL STRUCTURE; CHEMISTRY; ENZYMOLOGY; ISOMERISM; KINETICS; LACTOCOCCUS LACTIS; METABOLISM; NUCLEAR MAGNETIC RESONANCE; STATIC ELECTRICITY; THERMODYNAMICS; X RAY CRYSTALLOGRAPHY;

BACTERIAL PROTEINS; CATALYSIS; CRYSTALLOGRAPHY, X-RAY; FLUORINE; GLUCOSE-6-PHOSPHATE; GLUCOSEPHOSPHATES; HEXOSES; ISOMERISM; KINETICS; LACTOCOCCUS LACTIS; MAGNESIUM; MODELS, MOLECULAR; MOLECULAR STRUCTURE; NUCLEAR MAGNETIC RESONANCE, BIOMOLECULAR; ORGANOPHOSPHONATES; PHOSPHOGLUCOMUTASE; PROTEIN CONFORMATION; RECOMBINANT PROTEINS; STATIC ELECTRICITY; THERMODYNAMICS;

EID: 84906691698     PISSN: 00278424     EISSN: 10916490     Source Type: Journal    
DOI: 10.1073/pnas.1402850111     Document Type: Article

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