메뉴 건너뛰기




Volumn 40, Issue 2, 2014, Pages 157-163

Elevated circulating PCSK-9 concentration in renal failure patients is corrected by renal replacement therapy

Author keywords

Hypercholesterolemia; PCSK 9; Renal failure

Indexed keywords

C REACTIVE PROTEIN; CREATININE; GLUCOSE; HEMOGLOBIN A1C; HIGH DENSITY LIPOPROTEIN CHOLESTEROL; HYDROXYMETHYLGLUTARYL COENZYME A REDUCTASE INHIBITOR; LOW DENSITY LIPOPROTEIN CHOLESTEROL; PROPROTEIN CONVERTASE SUBTILISIN KEXIN TYPE 9; PROTEIN; TRIACYLGLYCEROL; UNCLASSIFIED DRUG; PCSK9 PROTEIN, HUMAN; SERINE PROTEINASE;

EID: 84906577482     PISSN: 02508095     EISSN: 14219670     Source Type: Journal    
DOI: 10.1159/000365935     Document Type: Article
Times cited : (51)

References (30)
  • 1
    • 84922680162 scopus 로고    scopus 로고
    • Proprotein convertase subtilisin/kexin type 9: From the discovery to the development of new therapies for cardiovascular diseases
    • Ferri N: Proprotein convertase subtilisin/kexin type 9: from the discovery to the development of new therapies for cardiovascular diseases. Scientifica 2012; 2012: 927352.
    • (2012) Scientifica , vol.2012 , pp. 927352
    • Ferri, N.1
  • 5
    • 33645103550 scopus 로고    scopus 로고
    • Sequence variations in PCSK9, low LDL, and protection against coronary heart disease
    • Cohen JC, Boerwinkle E, Mosley TH Jr, Hobbs HH: Sequence variations in PCSK9, low LDL, and protection against coronary heart disease. N Engl J Med 2006; 354: 1264-1272.
    • (2006) N Engl J Med , vol.354 , pp. 1264-1272
    • Cohen, J.C.1    Boerwinkle, E.2    Mosley, T.H.3    Hobbs, H.H.4
  • 6
    • 2442670243 scopus 로고    scopus 로고
    • Mutations in the PCSK9 gene in Norwegian subjects with autosomal dominant hypercholesterolemia
    • Leren TP: Mutations in the PCSK9 gene in Norwegian subjects with autosomal dominant hypercholesterolemia. Clin Genet 2004; 65: 419-422.
    • (2004) Clin Genet , vol.65 , pp. 419-422
    • Leren, T.P.1
  • 10
    • 84863494422 scopus 로고    scopus 로고
    • Effect of a monoclonal antibody to PCSK9, REGN727/ SAR236553, to reduce low-density lipoprotein cholesterol in patients with heterozygous familial hypercholesterolaemia on stable statin dose with or without ezetimibe therapy: A phase 2 randomised controlled trial
    • Stein EA, Gipe D, Bergeron J, Gaudet D, Weiss R, Dufour R, Wu R, Pordy R: Effect of a monoclonal antibody to PCSK9, REGN727/ SAR236553, to reduce low-density lipoprotein cholesterol in patients with heterozygous familial hypercholesterolaemia on stable statin dose with or without ezetimibe therapy: A phase 2 randomised controlled trial. Lancet 2012; 380: 29-36.
    • (2012) Lancet , vol.380 , pp. 29-36
    • Stein, E.A.1    Gipe, D.2    Bergeron, J.3    Gaudet, D.4    Weiss, R.5    Dufour, R.6    Wu, R.7    Pordy, R.8
  • 11
    • 84862219022 scopus 로고    scopus 로고
    • Safety and efficacy of a monoclonal antibody to proprotein convertase subtilisin/kexin type 9 serine protease, SAR236553/REGN727, in patients with primary hypercholesterolemia receiving ongoing stable atorvastatin therapy
    • McKenney JM, Koren MJ, Kereiakes DJ, Hanotin C, Ferrand AC, Stein EA: Safety and efficacy of a monoclonal antibody to proprotein convertase subtilisin/kexin type 9 serine protease, SAR236553/REGN727, in patients with primary hypercholesterolemia receiving ongoing stable atorvastatin therapy. J Am Coll Cardiol 2012; 59: 2344-2353.
    • (2012) J Am Coll Cardiol , vol.59 , pp. 2344-2353
    • McKenney, J.M.1    Koren, M.J.2    Kereiakes, D.J.3    Hanotin, C.4    Ferrand, A.C.5    Stein, E.A.6
  • 15
    • 80055018021 scopus 로고    scopus 로고
    • Lack of association between plasma PCSK9 and LDLapoB100 catabolism in patients with uncontrolled type 2 diabetes
    • Verges B, Duvillard L, Brindisi MC, Gautier E, Krempf M, Costet P, Cariou B: Lack of association between plasma PCSK9 and LDLapoB100 catabolism in patients with uncontrolled type 2 diabetes. Atherosclerosis 2011; 219: 342-348.
    • (2011) Atherosclerosis , vol.219 , pp. 342-348
    • Verges, B.1    Duvillard, L.2    Brindisi, M.C.3    Gautier, E.4    Krempf, M.5    Costet, P.6    Cariou, B.7
  • 17
    • 84897112851 scopus 로고    scopus 로고
    • Plasma PCSK9 in nephrotic syndrome and in peritoneal dialysis: A cross-sectional study
    • Jin K, Park BS, Kim YW, Vaziri ND: Plasma PCSK9 in nephrotic syndrome and in peritoneal dialysis: A cross-sectional study. Am J Kidney Dis 2014; 63: 584-589.
    • (2014) Am J Kidney Dis , vol.63 , pp. 584-589
    • Jin, K.1    Park, B.S.2    Kim, Y.W.3    Vaziri, N.D.4
  • 18
    • 84863884462 scopus 로고    scopus 로고
    • Dyslipidemia, statins, and CKD patients' outcomes-review of the evidence in the postsharp era
    • Heymann EP, Kassimatis TI, Goldsmith DJ: Dyslipidemia, statins, and CKD patients' outcomes-review of the evidence in the postsharp era. J Nephrol 2012; 25: 460-472.
    • (2012) J Nephrol , vol.25 , pp. 460-472
    • Heymann, E.P.1    Kassimatis, T.I.2    Goldsmith, D.J.3
  • 20
    • 0021717457 scopus 로고
    • Liver transplantation to provide low-density-lipoprotein receptors and lower plasma cholesterol in a child with homozygous familial hypercholesterolemia
    • Bilheimer DW, Goldstein JL, Grundy SM, Starzl TE, Brown MS: Liver transplantation to provide low-density-lipoprotein receptors and lower plasma cholesterol in a child with homozygous familial hypercholesterolemia. N Engl J Med 1984; 311: 1658-1664.
    • (1984) N Engl J Med , vol.311 , pp. 1658-1664
    • Bilheimer, D.W.1    Goldstein, J.L.2    Grundy, S.M.3    Starzl, T.E.4    Brown, M.S.5
  • 23
    • 80052921322 scopus 로고    scopus 로고
    • Oxidative stress and inflammation: Implications in uremia and hemodialysis
    • Libetta C, Sepe V, Esposito P, Galli F, Dal Canton A: Oxidative stress and inflammation: implications in uremia and hemodialysis. Clin Biochem 2011; 44: 1189-1198.
    • (2011) Clin Biochem , vol.44 , pp. 1189-1198
    • Libetta, C.1    Sepe, V.2    Esposito, P.3    Galli, F.4    Dal Canton, A.5
  • 24
    • 38949109659 scopus 로고    scopus 로고
    • Atorvastatin increases human serum levels of proprotein convertase subtilisin/kexin type 9
    • Careskey HE, Davis RA, Alborn WE, Troutt JS, Cao G, Konrad RJ: Atorvastatin increases human serum levels of proprotein convertase subtilisin/kexin type 9. J Lipid Res 2008; 49: 394-398.
    • (2008) J Lipid Res , vol.49 , pp. 394-398
    • Careskey, H.E.1    Davis, R.A.2    Alborn, W.E.3    Troutt, J.S.4    Cao, G.5    Konrad, R.J.6
  • 26
    • 84893848116 scopus 로고    scopus 로고
    • Having excess levels of PCSK9 is not sufficient to induce complex formation between PCSK9 and the LDL receptor
    • Wooten CJ, Adcock AF, Agina-Obu DI, Lopez D: Having excess levels of PCSK9 is not sufficient to induce complex formation between PCSK9 and the LDL receptor. Arch Biochem Biophys 2014; 545: 124-132.
    • (2014) Arch Biochem Biophys , vol.545 , pp. 124-132
    • Wooten, C.J.1    Adcock, A.F.2    Agina-Obu, D.I.3    Lopez, D.4
  • 27
    • 0018743864 scopus 로고
    • Metabolic studies in familial hypercholesterolemia: Evidence for a gene-dosage effect in vivo
    • Bilheimer DW, Stone NJ, Grundy SM: Metabolic studies in familial hypercholesterolemia: evidence for a gene-dosage effect in vivo. J Clin Invest 1979; 64: 524-533.
    • (1979) J Clin Invest , vol.64 , pp. 524-533
    • Bilheimer, D.W.1    Stone, N.J.2    Grundy, S.M.3
  • 29
    • 33750090075 scopus 로고    scopus 로고
    • The proprotein convertase (PC) PCSK9 is inactivated by furin and/or PC5/6A: Functional consequences of natural mutations and post-translational modifications
    • Benjannet S, Rhainds D, Hamelin J, Nassoury N, Seidah NG: The proprotein convertase (PC) PCSK9 is inactivated by furin and/or PC5/6A: functional consequences of natural mutations and post-translational modifications. J Biol Chem 2006; 281: 30561-30572.
    • (2006) J Biol Chem , vol.281 , pp. 30561-30572
    • Benjannet, S.1    Rhainds, D.2    Hamelin, J.3    Nassoury, N.4    Seidah, N.G.5
  • 30
    • 77956797294 scopus 로고    scopus 로고
    • High-dose atorvastatin causes a rapid sustained increase in human serum PCSK9 and disrupts its correlation with LDL cholesterol
    • Welder G, Zineh I, Pacanowski MA, Troutt JS, Cao G, Konrad RJ: High-dose atorvastatin causes a rapid sustained increase in human serum PCSK9 and disrupts its correlation with LDL cholesterol. J Lipid Res 2010; 51: 2714-2721.
    • (2010) J Lipid Res , vol.51 , pp. 2714-2721
    • Welder, G.1    Zineh, I.2    Pacanowski, M.A.3    Troutt, J.S.4    Cao, G.5    Konrad, R.J.6


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.