Jumbled NETs promote vasculitis

Arthritis and Rheumatism

Volumn 64, Issue 11, 2012, Pages 3498-3501

  Radic, Marko ^a   Kaplan, Mariana J ^b  

^a UNIVERSITY OF TENNESSEE HEALTH SCIENCE CENTER   (United States)

^b UNIVERSITY OF MICHIGAN MEDICAL SCHOOL   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

AUTOANTIGEN; CHLORPROMAZINE; HYDRALAZINE; MYELOPEROXIDASE; NEUTROPHIL CYTOPLASMIC ANTIBODY; PENICILLAMINE; PROCAINAMIDE; PROPYLTHIOURACIL; SALAZOSULFAPYRIDINE;

AGRANULOCYTOSIS; ANTIBODY PRODUCTION; ANTIGEN PRESENTATION; AUTOIMMUNE DISEASE; AUTOIMMUNITY; CELL DEATH; CHEMICAL MODIFICATION; CLINICAL FEATURE; CRESCENTIC GLOMERULONEPHRITIS; CUTANEOUS VASCULITIS; DRUG INDUCED AUTOIMMUNITY; DRUG INDUCED DISEASE; DRUG TARGETING; FELTY SYNDROME; GENETIC PREDISPOSITION; GRAVES DISEASE; HUMAN; HYPERTENSION; HYPERTHYROIDISM; IMMUNOLOGICAL TOLERANCE; IMMUNOREACTIVITY; NEUTROPHIL EXTRACELLULAR TRAP; NEUTROPHIL GRANULE; NONHUMAN; PLASMACYTOID DENDRITIC CELL; POLYANGITIS; PRIORITY JOURNAL; PSORIASIS; REVIEW; SYSTEMIC LUPUS ERYTHEMATOSUS; VASCULITIS;

ANIMALS; ANTI-NEUTROPHIL CYTOPLASMIC ANTIBODY-ASSOCIATED VASCULITIS; HUMANS; NEUTROPHILS; PEROXIDASE; PROPYLTHIOURACIL;

EID: 84868129324     PISSN: 00043591     EISSN: 15290131     Source Type: Journal    
DOI: 10.1002/art.34615     Document Type: Review

References (28)

1. Perry HM Jr, Schroeder HA,. Syndrome simulating collagen disease caused by hydralazine (Apresoline). J Am Med Assoc 1954; 154: 670-3.
2. Deng C, Lu Q, Zhang Z, Rao T, Attwood J, Yung R, et al. Hydralazine may induce autoimmunity by inhibiting extracellular signal-regulated kinase pathway signaling. Arthritis Rheum 2003; 48: 746-56.
3. Nakazawa D, Tomaru U, Suzuki A, Masuda S, Hasegawa R, Kobayashi T, et al. Abnormal conformation and impaired degradation of propylthiouracil-induced neutrophil extracellular traps: implications of disordered neutrophil extracellular traps in a rat model of myeloperoxidase antineutrophil cytoplasmic antibody- associated vasculitis. Arthritis Rheum 2012; 64: 3779-87.
4. Taurog A, Dorris ML,. Myeloperoxidase-catalyzed iodination and coupling. Arch Biochem Biophys 1992; 296: 239-46.
5. Nishikawa T, Nagayama Y, Seto P, Rapoport B,. Human thyroid peroxidase-myeloperoxidase chimeric molecules: tools for the study of antigen recognition by thyroid peroxidase autoantibodies. Endocrinology 1993; 133: 2496-501.
6. Lee E, Miki Y, Katsura H, Kariya K,. Mechanism of inactivation of myeloperoxidase by propylthiouracil. Biochem Pharmacol 1990; 39: 1467-71.
7. Amrhein JA, Kenny FM, Ross D,. Granulocytopenia, lupus-like syndrome, and other complications of propylthiouracil therapy. J Pediatr 1970; 76: 54-63.
8. Dolman KM, Gans RO, Vervaat TJ, Zevenbergen G, Maingay D, Nikkels RE, et al. Vasculitis and antineutrophil cytoplasmic autoantibodies associated with propylthiouracil therapy. Lancet 1993; 342: 651-2.
9. Sera N, Ashizawa K, Ando T, Abe Y, Ide A, Usa T, et al. Treatment with propylthiouracil is associated with appearance of antineutrophil cytoplasmic antibodies in some patients with Graves' disease. Thyroid 2000; 10: 595-9.
10. Csernok E, Lamprecht P, Gross WL,. Clinical and immunological features of drug-induced and infection-induced proteinase 3-antineutrophil cytoplasmic antibodies and myeloperoxidase-antineutrophil cytoplasmic antibodies and vasculitis. Curr Opin Rheumatol 2010; 22: 43-8.
11. Xiao H, Heeringa P, Hu P, Liu Z, Zhao M, Aratani Y, et al. Antineutrophil cytoplasmic autoantibodies specific for myeloperoxidase cause glomerulonephritis and vasculitis in mice. J Clin Invest 2002; 110: 955-63.
12. Xiao H, Heeringa P, Liu Z, Huugen D, Hu P, Maeda N, et al. The role of neutrophils in the induction of glomerulonephritis by anti-myeloperoxidase antibodies. Am J Pathol 2005; 167: 39-45.
13. Falk RJ, Terrell RS, Charles LA, Jennette JC,. Anti-neutrophil cytoplasmic autoantibodies induce neutrophils to degranulate and produce oxygen radicals in vitro. Proc Natl Acad Sci U S A 1990; 87: 4115-9.
14. Little MA, Smyth L, Salama AD, Mukherjee S, Smith J, Haskard D, et al. Experimental autoimmune vasculitis: an animal model of anti-neutrophil cytoplasmic autoantibody-associated systemic vasculitis. Am J Pathol 2009; 174: 1212-20.
15. Casciola-Rosen LA, Anhalt G, Rosen A,. Autoantigens targeted in systemic lupus erythematosus are clustered in two populations of surface structures on apoptotic keratinocytes. J Exp Med 1994; 179: 1317-30.
16. Radic M, Marion T, Monestier M,. Nucleosomes are exposed at the cell surface in apoptosis. J Immunol 2004; 172: 6692-700.
17. Fuchs TA, Abed U, Goosmann C, Hurwitz R, Schulze I, Wahn V, et al. Novel cell death program leads to neutrophil extracellular traps. J Cell Biol 2007; 176: 231-41.
18. Brinkmann V, Reichard U, Goosmann C, Fauler B, Uhlemann Y, Weiss DS, et al. Neutrophil extracellular traps kill bacteria. Science 2004; 303: 1532-5.
19. Kirchner T, Moller S, Klinger M, Solbach W, Laskay T, Behnen M,. The impact of various reactive oxygen species on the formation of neutrophil extracellular traps. Mediators Inflamm 2012; 2012: 849136.
20. Kessenbrock K, Krumbholz M, Schonermarck U, Back W, Gross WL, Werb Z, et al. Netting neutrophils in autoimmune small-vessel vasculitis. Nat Med 2009; 15: 623-5.
21. Li P, Li M, Lindberg MR, Kennett MJ, Xiong N, Wang Y,. PAD4 is essential for antibacterial innate immunity mediated by neutrophil extracellular traps. J Exp Med 2010; 207: 1853-62.
22. Neeli I, Khan SN, Radic M,. Histone deimination as a response to inflammatory stimuli in neutrophils. J Immunol 2008; 180: 1895-902.
23. Dwivedi N, Upadhyay J, Neeli I, Khan S, Pattanaik D, Myers L, et al. Felty's syndrome autoantibodies bind to deiminated histones and neutrophil extracellular chromatin traps. Arthritis Rheum 2012; 64: 982-92.
24. Lande R, Ganguly D, Facchinetti V, Frasca L, Conrad C, Gregorio J, et al. Neutrophils activate plasmacytoid dendritic cells by releasing self-DNA-peptide complexes in systemic lupus erythematosus. Sci Transl Med 2011; 3: 73ra19.
25. Hakkim A, Furnrohr BG, Amann K, Laube B, Abed UA, Brinkmann V, et al. Impairment of neutrophil extracellular trap degradation is associated with lupus nephritis. Proc Natl Acad Sci U S A 2010; 107: 9813-8.
26. Villanueva E, Yalavarthi S, Berthier CC, Hodgin JB, Khandpur R, Lin AM, et al. Netting neutrophils induce endothelial damage, infiltrate tissues, and expose immunostimulatory molecules in systemic lupus erythematosus. J Immunol 2011; 187: 538-52.
27. Lin AM, Rubin CJ, Khandpur R, Wang JY, Riblett M, Yalavarthi S, et al. Mast cells and neutrophils release IL-17 through extracellular trap formation in psoriasis. J Immunol 2011; 187: 490-500.
28. Tillack K, Breiden P, Martin R, Sospedra M,. T lymphocyte priming by neutrophil extracellular traps links innate and adaptive immune responses. J Immunol 2012; 188: 3150-9.