Cardiovascular safety of stimulants in children with attention-deficit/ hyperactivity disorder: A nationwide prospective cohort study

Journal of Child and Adolescent Psychopharmacology

Volumn 24, Issue 6, 2014, Pages 302-310

  Dalsgaard, Søren ^a,b,c,d   Kvist, Anette Primdal ^a   Leckman, James F ^e   Nielsen, Helena Skyt ^a   Simonsen, Marianne ^a  

^a AARHUS UNIVERSITY   (Denmark)

^b H LUNDBECK A S   (Denmark)

^c Hospital of Telemark   (Norway)

^d UNIVERSITY OF SOUTHERN DENMARK   (Denmark)

^e YALE UNIVERSITY   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CENTRAL STIMULANT AGENT;

ADOLESCENT; ARTICLE; ATTENTION DEFICIT DISORDER; CARDIOVASCULAR DISEASE; CARDIOVASCULAR RISK; CHILD; COR PULMONALE; DENMARK; DOSE RESPONSE; DRUG SAFETY; FEMALE; FOLLOW UP; HEART ARREST; HEART ARRHYTHMIA; HEART DISEASE; HEART DISEASE NOT OTHERWISE SPECIFIED; HEART FAILURE; HUMAN; HYPERTENSION; ISCHEMIC HEART DISEASE; LONGITUDINAL STUDY; MAJOR CLINICAL STUDY; MALE; PRESCRIPTION; PROSPECTIVE STUDY; ATTENTION DEFICIT DISORDER WITH HYPERACTIVITY; CARDIOVASCULAR DISEASES; CHEMICALLY INDUCED; COHORT ANALYSIS; PROPORTIONAL HAZARDS MODEL; RISK FACTOR; TIME;

ADOLESCENT; ATTENTION DEFICIT DISORDER WITH HYPERACTIVITY; CARDIOVASCULAR DISEASES; CENTRAL NERVOUS SYSTEM STIMULANTS; CHILD; COHORT STUDIES; DOSE-RESPONSE RELATIONSHIP, DRUG; FEMALE; FOLLOW-UP STUDIES; HUMANS; LONGITUDINAL STUDIES; MALE; PROPORTIONAL HAZARDS MODELS; PROSPECTIVE STUDIES; RISK FACTORS; TIME FACTORS;

EID: 84906551774     PISSN: 10445463     EISSN: 15578992     Source Type: Journal    
DOI: 10.1089/cap.2014.0020     Document Type: Article

References (48)

1. Aileru AA, Carpentier RG: Mechanisms of the in vitro effects of amphetamine on rat sinus node automaticity and membrane potentials of atrial fibers. J Electrocardiol 29: 123-130, 1996.
2. American Psychiatric Association: Diagnostic and Statistical Manual of Mental Disorders, 4th ed., Text Revision. Washington, DC; American Psychiatric Association, 2000.
3. Arcieri R, Germinario EAP, Bonati M, Masi G, Zuddas A, Vella S, Chiarotti F, Panei, Italian Attention-Deficit/Hyperactivity Disorder Regional Reference Centers: Cardiovascular measures in children and adolescents with attention-deficit/hyperactivity disorder who are new users of methylphenidate and atomoxetine. J Child Adolesc Psychopharmacol 22: 423-431, 2012.
4. Bahcelioglu M, Gozil R, Take G, Elmas C, Oktem H, Kadioglu D, Calguner E, Erdogan D, Sargon MF, Yazici AC, Tas M, Bardakci Y, Senol S: Dose-related immunohistochemical and ultrastructural changes after oral methylphenidate administration in cerebrum and cerebellum of the rat. World J Biol Psychiatry 10: 531-543, 2009.
5. Buchhorn R, Conzelmann A, Willaschek C, Stork D, Taurines R, Renner TJ: Heart rate variability and methylphenidate in children with ADHD. Atten Defic Hyperact Disord 4: 85-91, 2012a.
6. Buchhorn R, Muller C, Willaschek C, Norozi K: How to predict the impact of methylphenidate on cardiovascular risk in children with attention deficit disorder: Methylphenidate improves autonomic dysfunction in children with ADHD. ISRN Pharm 2012: 170935, 2012b.
7. Casis O, Espiña L, Gallego M: Effects of amphetamine on calcium and potassium currents in rat heart. J Cardiovasc Pharmacol 36: 390-395, 2000.
8. Cooper WO, Habel LA, Sox CM, Chan KA, Arbogast PG, Cheetham TC, Murray KT, Quinn VP, Stein CM, Callahan ST, Fireman BH, Fish FA, Kirshner HS, O'Duffy A, Connell FA, Ray WA: ADHD drugs and serious cardiovascular events in children and young adults. N Engl J Med 365: 1896-1904, 2011.
9. Dalsgaard S, Leckman JF, Nielsen HS, Simonsen M: Gender and injuries predict stimulant medication J Child Adolesc Psychopharmacol. 2014 [Epub ahead of print].
10. Dalsgaard S, Mortensen PB, Frydenberg M, Thomsen PH: Conduct problems, gender and adult psychiatric outcome of children with attention-deficit hyperactivity disorder. Br J Psychiatry 181: 416-421, 2002.
11. Dalsgaard S, Nielsen HS, Simonsen M: Five-fold increase in national prevalence rates of attention-deficit/hyperactivity disorder medications for children and adolescents with autism spectrum disorder, attention-deficit/ hyperactivity disorder, and other psychiatric disorders: A Danish register-based study. J Child Adolesc Psychopharmacol 23: 432-439, 2013a.
12. Dalsgaard S, Humlum MK, Nielsen HS, Simonsen M. Common Danish standards in prescribing medication for children and adolescents with ADHD. Eur Child Adolesc Psychiatry DOI: 10.1007/s00787-013-0508-5, 2013b.
13. Dresel S, Krause J, Krause KH, LaFougere C, Brinkbaumer K, Kung HF, Hahn K, Tatsch K: Attention deficit hyperactivity disorder: binding of [99mTc]TRODAT-1 to the dopamine transporter before and after methylphenidate treatment. Eur J Nucl Med 27: 1518-1524, 2000.
14. Findling RL, Short EJ, Manos MJ: Short-term cardiovascular effects of methylphenidate and Adderall. J Am Acad Child Adolesc Psychiatry 40: 525-529, 2001.
15. Fusar-Poli P, Rubia K, Rossi G, Sartori G, Balottin U: Striatal dopamine transporter alterations in ADHD: Pathophysiology or adaptation to psychostimulants? A meta-analysis. Am J Psychiatry 169: 264-272, 2012.
16. Graham J, Banaschewski T, Buitelaar J, Coghill D, Danckaerts M, Dittmann RW, Dopfner M, Hamilton R, Hollis C, Holtmann M, Hulpke-Wette M, Lecendreux M, Rosenthal E, Rothenberger A, Santosh P, Sergeant J, Simonoff E, Sonuga-Barke E, Wong IC, Zuddas A, Steinhausen HC, Taylor E: European guidelines on managing adverse effects of medication for ADHD. Eur Child Adolesc Psychiatry 20: 17-37, 2011.
17. Graham J, Coghill D: Adverse effects of pharmacotherapies for attention-deficit hyperactivity disorder: epidemiology, prevention and management. CNS Drugs 22: 213-237, 2008.
18. Habel LA, Cooper WO, Sox CM, Chan KA, Fireman BH, Arbogast PG, Cheetham TC, Quinn VP, Dublin S, Boudreau DM, Andrade SE, Pawloski PA, Raebel MA, Smith DH, Achacoso N, Uratsu C, Go AS, Sidney S, Nguyen-Huynh MN, Ray WA, Selby JV: ADHD medications and risk of serious cardiovascular events in young and middle-aged adults. JAMA. 306: 2673-2683, 2011.
19. Hamilton RM, Rosenthal E, Hulpke-Wette M, Graham JG, Sergeant J: Cardiovascular considerations of attention deficit hyperactivity disorder medications: A report of the European Network on Hyperactivity Disorders work group, European Attention Deficit Hyperactivity Disorder Guidelines Group on attention deficit hyperactivity disorder drug safety meeting. Cardiol Young 22: 63-70, 2012.
20. Henderson TA, Fischer VW: Effects of methylphenidate (Ritalin) on mammalian myocardial ultrastructure. Am J Cardiovasc Pathol 5: 68-78, 1995.
21. Holick CN, Turnbull BR, Jones ME, Chaudhry S, Bangs ME, Seeger JD: Atomoxetine and cerebrovascular outcomes in adults. J Clin Psychopharmacol 29: 453-460, 2009.
22. Huang YS, Tsai MH: Long-term outcomes with medications for attention-deficit hyperactivity disorder: Current status of knowledge. CNS Drugs 25: 539-554, 2011.
23. Imeraj L, Antrop I, Roeyers H, Deschepper E, Bal S, Deboutte D: Diurnal variations in arousal: a naturalistic heart rate study in children with ADHD. Eur Child Adolesc Psychiatry 20: 381-392, 2011.
24. Jiao X, Velez S, Ringstad J, Eyma V, Miller D, Bleiberg M: Myocardial infarction associated with adderall XR and alcohol use in a young man. J Am Board Fam Med 22: 197-201, 2009.
25. Kauppila E, Vanninen E, Kuusela T, Kaurijoki S, Karhunen L, Pietilainen KH, Rissanen A, Kaprio J, Tiihonen J, Kuikka J: Cardiac repolarization and striatal dopamine transporter function are interrelated. Nucl Med Commun 30: 713-717, 2009.
26. Krause KH, Dresel SH, Krause J, Kung HF, Tatsch K: Increased striatal dopamine transporter in adult patients with attention deficit hyperactivity disorder: Effects of methylphenidate as measured by single photon emission computed tomography. Neurosci Lett 285: 107-110, 2000.
27. Kraut AA, Langner I, Lindemann C, Banaschewski T, Petermann U, Petermann F, Mikolajczyk RT, Garbe E: Comorbidities in ADHD children treated with methylphenidate: a database study. BMC Psychiatry 13: 11, 2013.
28. Lang HC, Scheffler RM, Hu TW: The discrepancy in attention deficit hyperactivity disorder (ADHD) medications diffusion: 1994-2003: A global pharmaceutical data analysis. Health Policy 97: 71-78, 2010.
29. Linnet KM, Dalsgaard S, Obel C, Wisborg K, Henriksen TB, Rodriguez A, Kotimaa A, Moilanen I, Thomsen PH, Olsen J, Jarvelin MR: Maternal lifestyle factors in pregnancy risk of attention deficit hyperactivity disorder and associated behaviors: Review of the current evidence. Am J Psychiatry 160: 1028-1040, 2003.
30. Linnet KM, Wisborg K, Secher NJ, Hove Thomsen P, Obel C, Dalsgaard S, Henriksen TB: Coffee consumption during pregnancy and the risk of hyperkinetic disorder and ADHD: A prospective cohort study. Acta Paediatr 98: 173-179, 2009.
31. Martinez-Raga J, Knecht C, Szerman N, Martinez MI: Risk of serious cardiovascular problems with medications for attention-deficit hyperactivity disorder. CNS Drugs 27: 15-30, 2013.
32. Mick E, McManus DD, Goldberg RJ: Meta-analysis of increased heart rate and blood pressure associated with CNS stimulant treatment of ADHD in adults. Eur Neuropsychopharmacol 23: 534-541, 2013.
33. Olfson M, Huang C, Gerhard T, Winterstein AG, Crystal S, Allison PD, Marcus SC: Stimulants and cardiovascular events in youth with attention-deficit/hyperactivity disorder. J Am Acad Child Adolesc Psychiatry 51: 147-156, 2012.
34. Palomar AR, Larios BN, De Sanchez VC, Perez LM, Lopez Fde L, Flores G, Gomez-Villalobos Mde J: Expression and distribution of dopamine transporter in cardiac tissues of the guinea pig. Neurochem Res 36: 399-405, 2011.
35. Pedersen CB, Gøtzsche H, Møller JØ, Mortensen PB: The Danish Civil Registration System - A cohort of eight million persons. Dan Med Bull 53: 441-449, 2006.
36. Ruwald MH, Ruwald AC, Tonder N: Methylphenidate induced ST elevation acute myocardial infarction [in Danish]. Ugeskr Laeger 174: 647-648, 2012.
37. Samuels JA, Franco K, Wan F, Sorof JM: Effect of stimulants on 24-h ambulatory blood pressure in children with ADHD: A double-blind, randomized, cross-over trial. Pediatr Nephrol 21: 92-95, 2006.
38. SAS Institute Inc.: SAS (release 9.2). Cary, NC: SAS Institute Inc.; 2000.
39. Schelleman H, Bilker WB, Kimmel SE, Daniel GW, Newcomb C, Guevara JP, Cziraky MJ, Strom BL, Hennessy S: Methylphenidate and risk of serious cardiovascular events in adults. Am J Psychiatry 169: 178-185, 2012.
40. Schelleman H, Bilker WB, Strom BL, Kimmel SE, Newcomb C, Guevara JP, Daniel GW, Cziraky MJ, Hennessy S: Cardiovascular events and death in children exposed and unexposed to ADHD agents. Pediatrics 127: 1102-1110, 2011.
41. Schimpf R, Borggrefe M, Wolpert C. Clinical and molecular genetics of the short QT syndrome. Curr Opin Cardiol 23: 192-198, 2008.
42. Tsuji H, Larson MG, Venditti FJ, Jr., Manders ES, Evans JC, Feldman CL, Levy D: Impact of reduced heart rate variability on risk for cardiac events. The Framingham Heart Study. Circulation 94: 2850-2855, 1996.
43. Vetter VL, Elia J, Erickson C, Berger S, Blum N, Uzark K, Webb CL: Cardiovascular monitoring of children and adolescents with heart disease receiving medications for attention deficit/hyperactivity disorder [corrected]: A scientific statement from the American Heart Association Council on Cardiovascular Disease in the Young Congenital Cardiac Defects Committee and the Council on Cardiovascular Nursing. Circulation 117: 2407-2423, 2008.
44. Vitiello B, Elliott GR, Swanson JM, Arnold LE, Hechtman L, Abikoff H, Molina BS, Wells K, Wigal T, Jensen PS, Greenhill LL, Kaltman JR, Severe JB, Odbert C, Hur K, Gibbons R: Blood pressure and heart rate over 10 years in the multimodal treatment study of children with ADHD. Am J Psychiatry 169: 167-177, 2012.
45. Westover AN, Halm EA: Do prescription stimulants increase the risk of adverse cardiovascular events? A systematic review. BMC Cardiovasc Disord 12: 41, 2012.
46. Winterstein AG, Gerhard T, Shuster J, Johnson M, Zito JM, Saidi A: Cardiac safety of central nervous system stimulants in children and adolescents with attention-deficit/hyperactivity disorder. Pediatrics 120: e1494-e1501, 2007.
47. Winterstein AG, Gerhard T, Shuster J, Saidi A: Cardiac safety of methylphenidate versus amphetamine salts in the treatment of ADHD. Pediatrics 124: e75-80, 2009.
48. World Health Organization: The ICD-10 Classification of Mental and Behavioural Disorders: Diagnostic Criteria for Research. Geneva: World Health Organization; 1993.