Synthesis and evaluation of coumarin derivatives as potential dual-action HIV-1 protease and reverse transcriptase inhibitors

Bioorganic and Medicinal Chemistry

Volumn 21, Issue 7, 2013, Pages 1964-1971

  Olomola, Temitope O ^a   Klein, Rosalyn ^a   Mautsa, Nicodemus ^a   Sayed, Yasien ^b   Kaye, Perry T ^a  

^a RHODES UNIVERSITY   (South Africa)

^b UNIVERSITY OF THE WITWATERSRAND   (South Africa)

Author keywords

Azidothymidine (AZT); Baylis Hillman reaction; Coumarins; Dual action HIV 1 PR RT inhibitors

Indexed keywords

6 BROMOCOUMARIN; 6 CHLOROCOUMARIN; 8 ETHOXYCOUMARIN; 8 METHOXYCOUMARIN; AMINE; CHLORIDE; COPPER; COUMARIN DERIVATIVE; HUMAN IMMUNODEFICIENCY VIRUS PROTEINASE; HUMAN IMMUNODEFICIENCY VIRUS PROTEINASE INHIBITOR; RNA DIRECTED DNA POLYMERASE; RNA DIRECTED DNA POLYMERASE INHIBITOR; TRIAZOLE DERIVATIVE; UNCLASSIFIED DRUG; ZIDOVUDINE;

ALKYNYLATION; ANALYTIC METHOD; ARTICLE; BENZYLATION; CATALYST; CLICK CHEMISTRY; COMPUTER MODEL; CYCLOADDITION; DRUG CONJUGATION; DRUG SCREENING; DRUG STRUCTURE; DRUG SYNTHESIS; ENZYME INHIBITION; NUCLEAR MAGNETIC RESONANCE; SATURATION TRANSFER DIFFERENCE; STRUCTURE ANALYSIS;

COUMARINS; HIV INFECTIONS; HIV PROTEASE; HIV PROTEASE INHIBITORS; HIV REVERSE TRANSCRIPTASE; HIV-1; HUMANS; MODELS, MOLECULAR; REVERSE TRANSCRIPTASE INHIBITORS; ZIDOVUDINE;

HUMAN IMMUNODEFICIENCY VIRUS 1;

EID: 84875217138     PISSN: 09680896     EISSN: 14643391     Source Type: Journal    
DOI: 10.1016/j.bmc.2013.01.025     Document Type: Article

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