Functional effects of a pathogenic mutation in cereblon (CRBN) on the regulation of protein synthesis via the AMPK-mTOR cascade

Journal of Biological Chemistry

Volumn 289, Issue 34, 2014, Pages 23343-23352

  Lee, Kwang Min ^a,b   Yang, Seung Joo ^a   Choi, Ja Hyun ^a   Park, Chul Seung ^a  

^a Gwangju Institute of Science and Technology (GIST)   (South Korea)

^b UNIVERSITY OF TEXAS SOUTHWESTERN MEDICAL CENTER   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

AMINO ACIDS; CELL CULTURE; MACHINERY; MAMMALS;

COGNITIVE FUNCTIONS; ECTOPIC EXPRESSIONS; MAMMALIAN TARGET OF RAPAMYCIN (MTOR); NEGATIVE REGULATORS; PATHOGENIC MUTATION; PLAUSIBLE MECHANISMS; PROTEIN TRANSLATION; SYNAPTIC PLASTICITY;

ANTIBIOTICS;

BRAIN PROTEIN; CEREBLON PROTEIN; HYDROXYMETHYLGLUTARYL COENZYME A REDUCTASE KINASE; MAMMALIAN TARGET OF RAPAMYCIN; MESSENGER RNA; MUTANT PROTEIN; UNCLASSIFIED DRUG; ADENYLATE KINASE; CRBN PROTEIN, MOUSE; MTOR PROTEIN, MOUSE; NERVE PROTEIN; TARGET OF RAPAMYCIN KINASE;

AMINO ACID COMPOSITION; ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; BRAIN FUNCTION; CEREBLON GENE; CONTROLLED STUDY; DOWN REGULATION; EMBRYO; ENZYME ACTIVITY; ENZYME INHIBITION; FIBROBLAST; GENE; GENE EXPRESSION; GENE MUTATION; HUMAN; HUMAN CELL; LEARNING; MALE; MEMORY; MOUSE; NERVE CELL PLASTICITY; NONHUMAN; PRIORITY JOURNAL; PROTEIN DEFECT; PROTEIN EXPRESSION; PROTEIN SYNTHESIS INHIBITION; PROTEIN SYNTHESIS REGULATION; SIGNAL TRANSDUCTION; UPREGULATION; WILD TYPE; ANIMAL; BRAIN; ENZYMOLOGY; GENETICS; KNOCKOUT MOUSE; LEARNING DISORDER; MEMORY DISORDER; METABOLISM; MUTATION; PHOSPHORYLATION; PROTEIN SYNTHESIS;

ADENYLATE KINASE; ANIMALS; BRAIN; LEARNING DISORDERS; MALE; MEMORY DISORDERS; MICE; MICE, KNOCKOUT; MUTATION; NERVE TISSUE PROTEINS; PHOSPHORYLATION; PROTEIN BIOSYNTHESIS; TOR SERINE-THREONINE KINASES;

EID: 84906539719     PISSN: 00219258     EISSN: 1083351X     Source Type: Journal    
DOI: 10.1074/jbc.M113.523423     Document Type: Article

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