Single cell gel electrophoresis (SCGE) and Pig-a mutation assay in vivo-tools for genotoxicity testing from a regulatory perspective: A study of benzo[a]pyrene in Ogg1-/- mice

Mutation Research - Genetic Toxicology and Environmental Mutagenesis

Volumn 772, Issue , 2014, Pages 34-41

  Graupner, Anne ^a   Instanes, Christine ^a   Dertinger, Stephen D ^b   Andersen, Jill Mari ^a   Lindeman, Birgitte ^a   Rongved, Tonje Danielsen ^a   Brunborg, Gunnar ^a   Olsen, Ann Karin ^a  

^a NORWEGIAN INSTITUTE OF PUBLIC HEALTH   (Norway)

^b LITRON LABORATORIES   (United States)

Author keywords

Alkaline single cell gel electrophoresis (SCGE); Benzo a pyrene (BaP); Genotoxicity; Hazard identification; Pig a mutation assay; Risk assessment

Indexed keywords

BENZO[A]PYRENE; DNA FORMAMIDOPYRIMIDINE GLYCOSYLASE; REACTIVE OXYGEN METABOLITE; DNA GLYCOSYLTRANSFERASE; MEMBRANE PROTEIN; MUTAGENIC AGENT; OGG1 PROTEIN, MOUSE; PHOSPHATIDYLINOSITOL GLYCAN-CLASS A PROTEIN;

ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; COMET ASSAY; COMPARATIVE STUDY; CONTROLLED STUDY; DNA ADDUCT; DNA DAMAGE; ERYTHROCYTE; EXCISION REPAIR; EXPERIMENTAL PIG; GENE INACTIVATION; GENE MUTATION; GENOTOXICITY; GENOTYPE; GERM CELL; IN VIVO STUDY; MOUSE; MUTAGENICITY; MUTATION RATE; NONHUMAN; PHENOTYPE; PRACTICE GUIDELINE; PRIORITY JOURNAL; RETICULOCYTE; RISK ASSESSMENT; ANIMAL; DRUG EFFECTS; ELECTROPHORESIS; ERYTHROCYTE DISORDER; GENETICS; KNOCKOUT MOUSE; METABOLISM; MUTATION; OXIDATIVE STRESS; PATHOLOGY; PROCEDURES;

ANIMALS; BENZO(A)PYRENE; DNA DAMAGE; DNA GLYCOSYLASES; ELECTROPHORESIS; ERYTHROCYTES, ABNORMAL; MEMBRANE PROTEINS; MICE; MICE, KNOCKOUT; MUTAGENS; MUTATION; OXIDATIVE STRESS; REACTIVE OXYGEN SPECIES;

EID: 84906505457     PISSN: 13835718     EISSN: 18793592     Source Type: Journal    
DOI: 10.1016/j.mrgentox.2014.07.010     Document Type: Article

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