Aluminum-induced amyloidogenesis and impairment in the clearance of amyloid peptides from the central nervous system (cns) in Alzheimer's disease (AD)

Frontiers in Neurology

Volumn 5 AUG, Issue , 2014, Pages

  Zhao, Yuhai ^a,b   Hill, James M ^a,b   Bhattacharjee, Surjyadipta ^a   Percy, Maire E ^c,d   Pogue, Aileen I D ^e   Lukiw, Walter J ^a,b,e  

^a LOUISIANA STATE UNIVERSITY HEALTH SCIENCES CENTER   (United States)

^b LOUISIANA STATE UNIVERSITY SCHOOL OF MEDICINE   (United States)

^c UNIVERSITY OF TORONTO   (Canada)

^d Neurogenetics Laboratory   (Canada)

^e Alchem Biotech   (Canada)

Author keywords

[No Author keywords available]

Indexed keywords

ALUMINUM; AMYLOID BETA PROTEIN[1-42]; AMYLOID PRECURSOR PROTEIN;

ALZHEIMER DISEASE; ARTICLE; CELL INTERACTION; DISEASE COURSE; DOWN REGULATION; EPIGENETICS; HUMAN; IMMUNE RESPONSE; INNATE IMMUNITY; MICROGLIA; PATHOGENESIS; PHAGOCYTOSIS; PROTEIN AGGREGATION; PROTEIN EXPRESSION; PROTEIN STRUCTURE; SENILE PLAQUE;

EID: 84906501183     PISSN: None     EISSN: 16642295     Source Type: Journal    
DOI: 10.3389/fneur.2014.00167     Document Type: Article

References (21)

1. Zhang YW, Thompson R, Zhang H, Xu H. APP processing in Alzheimer's disease, Molecular Brain (2011) 4:3-12.
2. Alexandrov PN, Pogue A, Bhattacharjee S, Lukiw WJ. Retinal amyloid peptides and complement factor H in transgenic models of Alzheimer's disease. Neuroreport (2011) 22:623-7. doi: 10.1097/WNR.0b013e3283497334.
3. Lukiw WJ. Amyloid beta (Aβ) peptide modulators and other current treatment strategies for Alzheimer's disease (AD). Expert Opin Emerg Drugs. (2012) Mar 23.
4. Exley C. The aluminium-amyloid cascade hypothesis and Alzheimer's disease. Subcell Biochem (2005) 38:225-34.
5. Bolognin S, Zatta P, Lorenzetto E, Valenti MT, Buffelli M. β-amyloid-aluminum complex alters cytoskeletal stability and increases ROS production in cortical neurons. Neurochem Int. (2013) 62:566-74. doi: 10.1016/j.neuint.2013.02.008.
6. Armstrong RA (2008) Spatial correlations between beta-amyloid (Aβ) deposits and blood vessels in familial Alzheimer's disease. Folia Neuropathol. 46:241-248.
7. Fu R, Shen Q, Xu P, Luo JJ, Tang Y. Phagocytosis of microglia in the central nervous system diseases. Mol Neurobiol. (2014) 49:1422-34. doi: 10.1007/s12035-013-8620-6.
8. Jones BM, Bhattacharjee S, Dua P, Hill JM, Zhao Y, Lukiw WJ. Regulating amyloidogenesis through the natural triggering receptor expressed in myeloid/microglial cells 2 (TREM2). Front Cell Neurosci (2014) 8:94. doi: 10.3389/fncel.2014.00094.
9. Zhao Y, Bhattacharjee S, Jones BM, Dua P, Alexandrov PN, Hill JM, Lukiw WJ. Regulation of TREM2 expression by an NF-κB-sensitive miRNA-34a. Neuroreport (2013) 24:318-23. doi: 10.1097/WNR.0b013e32835fb6b0.
10. Zhao Y, Lukiw WJ. TREM2 signaling, miRNA-34a and the extinction of phagocytosis. Front Cell Neurosci (2013) 7:131.doi:10.3389/fncel.2013.00131
11. Alexandrov PN, Zhao Y, Jones BM, Bhattacharjee S, Lukiw WJ. Expression of the phagocytosis-essential protein TREM2 is down-regulated by an aluminum-induced miRNA-34a in a murine microglial cell line. J Inorg Biochem. (2013) 128:267-9. doi: 10.1016/j.jinorgbio.2013.05.010.
12. Bhattacharjee S, Zhao Y, Lukiw WJ. Deficits in the miRNA-34a-regulated endogenous TREM2 phagocytosis sensor-receptor in Alzheimer's disease (AD); an update. Front Aging Neurosci. (2014) 6:116. doi: 10.3389/fnagi.2014.00116.
13. Gopal K, Srivastava SB, Shukla S, Bersillon JL. Contaminants in drinking water and its mitigation using suitable adsorbents: an overview. J Environ Biol. (2004) 25:469-75.
14. Spires-Jones TL, de Calignon A, Meyer-Luehmann M, Bacskai BJ, Hyman BT. Monitoring protein aggregation and toxicity in Alzheimer's disease mouse models using in vivo imaging. Methods (2011) 53:201-7. doi:10.1016/j.ymeth.2010.12.009.
15. Campbell A, Becaria A, Lahiri DK, Sharman K, Bondy SC. Chronic exposure to aluminum in drinking water increases inflammatory parameters selectively in the brain. J Neurosci Res (2004) 75:565-72.
16. Bondy SC. Prolonged exposure to low levels of aluminum leads to changes associated with brain aging and neurodegeneration. Toxicology (2014) 315:1-7. doi: 10.1016/j.tox.2013.10.008.
17. Drago D, Bolognin S, Zatta P. Role of metal ions in the abeta oligomerization in Alzheimer's disease and in other neurological disorders. Curr Alzheimer Res. (2008) 5:500-7.
18. Shcherbatykh I, Carpenter DO. The role of metals in the etiology of Alzheimer's disease. J Alzheimers Dis. (2007) 11:191-205.
19. Koenigsknecht-Talboo J, Meyer-Luehmann M, Parsadanian M, Garcia-Alloza M, Finn MB, Hyman BT, Bacskai BJ, Holtzman DM. Rapid microglial response around amyloid pathology after systemic anti-Aβ antibody administration in PDAPP mice. J Neurosci. (2008) 28:14156-64. doi: 10.1523/JNEUROSCI.4147-08.2008.
20. Praticò D, Uryu K, Sung S, Tang S, Trojanowski JQ, Lee VM. Aluminum modulates brain amyloidosis through oxidative stress in APP transgenic mice. FASEB J. (2002) 16:1138-40.
21. Bhattacharjee S, Zhao Y, Hill JM, Percy ME, Lukiw WJ. Aluminum and its potential contribution to Alzheimer's disease (AD). Front Aging Neurosci. (2014) 6:62. doi: 10.3389/fnagi.2014.00062.