Dysregulation of protein degradation pathways may mediate the liver injury and phospholipidosis associated with a cationic amphiphilic antibiotic drug

Toxicology and Applied Pharmacology

Volumn 280, Issue 1, 2014, Pages 21-29

  Mosedale, Merrie ^a   Wu, Hong ^b   Kurtz, C Lisa ^a   Schmidt, Stephen P ^b   Adkins, Karissa ^b   Harrill, Alison H ^a,c  

^a HAMNER INSTITUTES FOR HEALTH SCIENCES   (United States)

^b PFIZER INC   (United States)

^c UNIVERSITY OF ARKANSAS FOR MEDICAL SCIENCES   (United States)

Author keywords

Drug induced liver injury; Mouse diversity panel; Phospholipidosis

Indexed keywords

ALANINE AMINOTRANSFERASE; AMPHOPHILE; ASPARTATE AMINOTRANSFERASE; KETOLIDE; MESSENGER RNA; MICRORNA 122; PF 04287881; UNCLASSIFIED DRUG; ANTIBIOTIC AGENT; ANTIINFECTIVE AGENT; PHOSPHOLIPID;

AGED; ALANINE AMINOTRANSFERASE BLOOD LEVEL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ANTIGEN PRESENTATION; ARTICLE; ASPARTATE AMINOTRANSFERASE BLOOD LEVEL; CELL DEATH; CELL VACUOLE; CONTROLLED STUDY; CORRELATION ANALYSIS; DRUG TRANSPORT; FEMALE; KUPFFER CELL; LIPIDOSIS; LIVER HYPERTROPHY; LIVER NECROSIS; LIVER TOXICITY; LYSOSOME; MOUSE; NONHUMAN; NUCLEOTIDE SEQUENCE; PHOSPHOLIPID METABOLISM; PROTEIN DEGRADATION; PROTEIN EXPRESSION; TOXIC HEPATITIS; UBIQUITINATION; CELL FUNCTION; DISORDERS OF AMINO ACID AND PROTEIN METABOLISM; DRUG EXPOSURE; DRUG MECHANISM; ELECTRON MICROSCOPE; ELECTRON MICROSCOPY; GENE EXPRESSION; GENETIC ASSOCIATION; GENETIC VARIABILITY; LIVER FUNCTION TEST; LIVER INJURY; PHASE 1 CLINICAL TRIAL; RANDOMIZED CONTROLLED TRIAL; REAL TIME POLYMERASE CHAIN REACTION; TRANSCRIPTOMICS; 129 MOUSE; ANIMAL; BAGG ALBINO MOUSE; C3H MOUSE; C57BL MOUSE; CBA MOUSE; DBA MOUSE; DRUG EFFECTS; METABOLISM; PHYSIOLOGY; RANDOMIZATION; SIGNAL TRANSDUCTION; SPECIES DIFFERENCE;

ANIMALS; ANTI-BACTERIAL AGENTS; DRUG-INDUCED LIVER INJURY; FEMALE; MICE; MICE, 129 STRAIN; MICE, INBRED BALB C; MICE, INBRED C3H; MICE, INBRED C57BL; MICE, INBRED CBA; MICE, INBRED DBA; PHOSPHOLIPIDS; PROTEOLYSIS; RANDOM ALLOCATION; SIGNAL TRANSDUCTION; SPECIES SPECIFICITY;

EID: 84906484195     PISSN: 0041008X     EISSN: 10960333     Source Type: Journal    
DOI: 10.1016/j.taap.2014.06.013     Document Type: Article

References (34)

1. Abboud G., Kaplowitz N. Drug-induced liver injury. Drug Saf. 2007, 30(4):277-294.
2. Ágoston M., Örsi F., Fehér E., Hagymási K., Orosz Z., Blázovics A., Fehér J., Vereckei A. Silymarin and vitamin E reduce amiodarone-induced lysosomal phospholipidosis in rats. Toxicology 2003, 190(3):231-241.
3. Alberts R., Terpstra P., Li Y., Breitling R., Nap J.P., Jansen R.C. Sequence polymorphisms cause many false cis eQTLs. PLoS ONE 2007, 2(7):e622.
4. Antoine D.J., Dear J.W., Starkey Lewis P., Platt V., Coyle J., Masson M., Thanacoody R.H., Gray A.J., Webb D.J., Moggs J.G., et al. Mechanistic biomarkers provide early and sensitive detection of acetaminophen-induced acute liver injury at first presentation to hospital. Hepatology 2013, 58(2):777-787.
5. Baronas E.T., Lee J.-W., Alden C., Hsieh F.Y. Biomarkers to monitor drug-induced phospholipidosis. Toxicol. Appl. Pharmacol. 2007, 218(1):72-78.
6. Bogue M.A., Grubb S.C. The mouse phenome project. Genetica 2004, 122(1):71-74.
7. Ciechanover A. The ubiquitin-proteasome pathway: on protein death and cell life. EMBO J. 1998, 17(24):7151-7160.
8. Cook C., Stetler C., Petrucelli L. Disruption of protein quality control in Parkinson's disease. Cold Spring Harb. Perspect. Med. 2012, 2(5).
9. Court M.H., Peter I., Hazarika S., Vasiadi M., Greenblatt D.J., Lee W. Candidate gene polymorphisms in patients with acetaminophen-induced acute liver failure. Drug Metab. Dispos. 2013, 42(1):28-32.
10. Dykstra M.J. Manual of Applied Techniques for Biological Electron Microscopy 1993, Plenum Press, New York. 1st edn.
11. Flick K., Kaiser P. Protein degradation and the stress response. Semin. Cell Dev. Biol. 2012, 23(5):515-522.
12. Gestwicki J.E., Garza D. Chapter 10-protein quality control in neurodegenerative disease. Progress in Molecular Biology and Translational Science 2012, 327-353. Academic Press. B.T. David (Ed.).
13. Halliwell W.H. Cationic amphiphilic drug-induced phospholipidosis. Toxicol. Pathol. 1997, 25(1):53-60.
14. Harrill A.H., Ross P.K., Gatti D.M., Threadgill D.W., Rusyn I. Population-based discovery of toxicogenomics biomarkers for hepatotoxicity using a laboratory strain diversity panel. Toxicol. Sci. 2009, 110(1):235-243.
15. Harrill A.H., Watkins P.B., Su S., Ross P.K., Harbourt D.E., Stylianou I.M., Boorman G.A., Russo M.W., Sackler R.S., Harris S.C., et al. Mouse population-guided resequencing reveals that variants in CD44 contribute to acetaminophen-induced liver injury in humans. Genome Res. 2009, 19(9):1507-1515.
16. Harrill A.H., DeSmet K.D., Wolf K.K., Bridges A.S., Eaddy J.S., Kurtz C.L., Hall J.E., Paine M.F., Tidwell R.R., Watkins P.B. A mouse diversity panel approach reveals the potential for clinical kidney injury due to DB289 not predicted by classical rodent models. Toxicol. Sci. 2012, 130(2):416-426.
17. Hussaini S.H., Farrington E.A. Idiosyncratic drug-induced liver injury: an overview. Expert Opin. Drug Saf. 2007, 6(6):673-684.
18. Kon K., Kim J.S., Uchiyama A., Jaeschke H., Lemasters J.J. Lysosomal iron mobilization and induction of the mitochondrial permeability transition in acetaminophen-induced toxicity to mouse hepatocytes. Toxicol. Sci. 2010, 117(1):101-108.
19. Korolchuk V.I., Menzies F.M., Rubinsztein D.C. A novel link between autophagy and the ubiquitin-proteasome system. Autophagy 2009, 5(6):862-863.
20. Kroh E.M., Parkin R.K., Mitchell P.S., Tewari M. Analysis of circulating microRNA biomarkers in plasma and serum using quantitative reverse transcription-PCR (qRT-PCR). Methods 2010, 50(4):298-301.
21. Lanfear D.E., McLeod H.L. Pharmacogenetics: using DNA to optimize drug therapy. Am. Fam. Physician 2007, 76(8):1179-1182.
22. Laterza O.F., Lim L., Garrett-Engele P.W., Vlasakova K., Muniappa N., Tanaka W.K., Johnson J.M., Sina J.F., Fare T.L., Sistare F.D., et al. Plasma MicroRNAs as sensitive and specific biomarkers of tissue injury. Clin. Chem. 2009, 55(11):1977-1983.
23. Li W., Tse F.L. Dried blood spot sampling in combination with LC-MS/MS for quantitative analysis of small molecules. Biomed. Chromatogr. 2010, 24(1):49-65.
24. Liu H.H., Lu P., Guo Y., Farrell E., Zhang X., Zheng M., Bosano B., Zhang Z., Allard J., Liao G., et al. An integrative genomic analysis identifies Bhmt2 as a diet-dependent genetic factor protecting against acetaminophen-induced liver toxicity. Genome Res. 2010, 20(1):28-35.
25. Matsumori N., Morooka A., Murata M. Detailed description of the conformation and location of membrane-bound erythromycin a using isotropic bicelles. J. Med. Chem. 2006, 49(12):3501-3508.
26. McClurg P., Janes J., Wu C., Delano D.L., Walker J.R., Batalov S., Takahashi J.S., Shimomura K., Kohsaka A., Bass J., et al. Genomewide association analysis in diverse inbred mice: power and population structure. Genetics 2007, 176(1):675-683.
27. Nandi D., Tahiliani P., Kumar A., Chandu D. The ubiquitin-proteasome system. J. Biosci. 2006, 31(1):137-155.
28. Robles M., Toscano E., Cotta J., Lucena M.I., Andrade R.J. Antibiotic-induced liver toxicity: mechanisms, clinical features and causality assessment. Curr. Drug Saf. 2010, 5(3):212-222.
29. Sawada H., Takami K., Asahi S. A toxicogenomic approach to drug-induced phospholipidosis: analysis of its induction mechanism and establishment of a novel in vitro screening system. Toxicol. Sci. 2005, 83(2):282-292.
30. Shang F., Taylor A. Ubiquitin-proteasome pathway and cellular responses to oxidative stress. Free Radic. Biol. Med. 2011, 51(1):5-16.
31. Shayman J.A., Abe A. Drug induced phospholipidosis: an acquired lysosomal storage disorder. Biochim. Biophys. Acta 2013, 1831(3):602-611.
32. Starkey Lewis P.J., Dear J., Platt V., Simpson K.J., Craig D.G.N., Antoine D.J., French N.S., Dhaun N., Webb D.J., Costello E.M., et al. Circulating microRNAs as potential markers of human drug-induced liver injury. Hepatology 2011, 54(5):1767-1776.
33. Thierry-Mieg D., Thierry-Mieg J. AceView: a comprehensive cDNA-supported gene and transcripts annotation. Genome Biol. 2006, 7(Suppl. 1S12):11-14.
34. Uchiyama A., Kim J.S., Kon K., Jaeschke H., Ikejima K., Watanabe S., Lemasters J.J. Translocation of iron from lysosomes into mitochondria is a key event during oxidative stress-induced hepatocellular injury. Hepatology 2008, 48(5):1644-1654.