Synthesis of novel 1,2,4-triazoles, triazolothiadiazines and triazolothiadiazoles as potential anticancer agents

European Journal of Medicinal Chemistry

Volumn 86, Issue , 2014, Pages 75-80

  Kamel, Mona M ^a   Megally Abdo, Nadia Y ^b  

^a CAIRO UNIVERSITY   (Egypt)

^b Alexandria University   (Egypt)

Author keywords

Anticancer activity; Isonicotinic acid hydrazide; Mercaptotriazoles; Triazolothiadiazines; Triazolothiadiazoles

Indexed keywords

1 (4 BROMOPHENYL) 3 [3 MERCAPTO 5 (PYRIDIN 4 YL) 4H 1,2,4 TRIAZOL 4 YL]THIOUREA; 1 (4 CHLOROPHENYL) 3 [3 MERCAPTO 5 (PYRIDIN 4 YL) 4H 1,2,4 TRIAZOL 4 YL]THIOUREA; 1 [3 MERCAPTO 5 (PYRIDIN 4 YL) 4H 1,2,4 TRIAZOL 4 YL] 3 (4 METHOXYPHENYL)THIOUREA; 1 [3 MERCAPTO 5 (PYRIDIN 4 YL) 4H 1,2,4 TRIAZOL 4 YL] 3 (PTOLYL)THIOUREA; 1,2,4 TRIAZOLE DERIVATIVE; 6 (2 CHLOROPHENYL) 3 (PYRIDIN 4 YL)[1,2,4]TRIAZOLO[3,4-B][1,3,4]THIADIAZOLE; 6 (2,4 DICHLOROPHENYL) 3 (PYRIDIN 4 YL)[1,2,4]TRIAZOLO[3,4B][1,3,4]THIADIAZOLE; 6 (4 BROMOPHENYL) 3 (PYRIDIN 4 YL) 7H [1,2,4]TRIAZOLO[3,4B][1,3,4]THIADIAZINE; 6 (4 CHLOROPHENYL) 3 (PYRIDIN 4 YL)[1,2,4]TRIAZOLO[3,4 B][1,3,4]THIADIAZOLE; 6 PHENYL 3 (PYRIDIN 4 YL) 7H [1,2,4]TRIAZOLO[3,4 B][1,3,4]THIADIAZINE; 6 PHENYL 3 (PYRIDIN 4 YL) [1,2,4]TRIAZOLO[3,4 B][1,3,4]THIADIAZOLE; ANTINEOPLASTIC AGENT; HYDRAZIDE DERIVATIVE; N(3 MERCAPTO 5 (PYRIDIN 4 YL) 4H 1,2,4 TRIAZOL 4 YL) 4 NITROBENZAMIDE; N(3 MERCAPTO 5 (PYRIDIN 4 YL) 4H 1,2,4 TRIAZOL 4 YL)ACETAMIDE; N(4 CHLOROPHENYL) 3 (PYRIDIN 4 YL)[1,2,4]TRIAZOLO[3,4 B][1,3,4]THIADIAZOL 6 AMINE; N(4 METHOXYPHENYL) 3 (PYRIDIN 4 YL)[1,2,4]TRIAZOLO[3,4 B][1,3,4]THIADIAZOL 6 AMINE; N(4 METHYLPHENYL) 3 (PYRIDIN 4 YL)[1,2,4]TRIAZOLO[3,4 B][1,3,4]THIADIAZOL 6 AMINE; N(P BROMOPHENYL) 3 (PYRIDIN 4 YL)[1,2,4]TRIAZOLO[3,4 B][1,3,4]THIADIAZOL 6 AMINE; THIADIAZINE DERIVATIVE; THIADIAZOLE DERIVATIVE; UNCLASSIFIED DRUG; 1 (3 MERCAPTO 5 (PYRIDIN 4 YL) 4H 1,2,4 TRIAZOL 4 YL) 3 (4 METHOXYPHENYL)THIOUREA; 1 [3 MERCAPTO 5 (PYRIDIN 4 YL) 4H 1,2,4 TRIAZOL 4 YL] 3 (P TOLYL)THIOUREA; 3,6 DISUBSTITUTED [1,2,4]TRIAZOLO[3,4 B]THIADIAZINE; 3,6 DISUBSTITUTED [1,2,4]TRIAZOLO[3,4 B][1,3,4]THIADIAZOLE; 4 AMINO 5 PYRIDIN 4 YL 4H [1,2,4]TRIAZOLE 3 THIOL; 6 (2 CHLOROPHENYL) 3 (PYRIDIN 4 YL) [1,2,4]TRIAZOLO[3,4 B][1,3,4]THIDIAZOLE; 6 (2,4 DICHLOROPHENYL) 3 (PYRIDIN 4 YL) [1,2,4]TRIAZOLO[3,4 B][1,3,4]THIDIAZOLE; 6 (4 BROMOPHENYL) 3 (PYRIDIN 4 YL) 7H [1,2,4]TRIAZOLO[3,4 B][1,3,4]THIADIAZINE; 6 (4 CHLOROPHENYL) 3 (PYRIDIN 4 YL) [1,2,4]TRIAZOLO[3,4 B][1,3,4]THIDIAZOLE; 6 METHYL 3 (PYRIDIN 4 YL)[1,2,4]TRIAZOLO[3,4 B][1,3,4]THIADIAZOLE; CHS 828; CYTOTOXIC AGENT; N (4 CHLOROPHENYL) 3 (PYRIDIN 4 YL) [1,2,4]TRIAZOLO[3,4 B][1,3,4]THIADIAZOLE 6 AMINE; N (4 METHOXYPHENYL) 3 (PYRIDIN 4 YL) [1,2,4]TRIAZOLO[3,4 B][1,3,4]THIADIAZOLE 6 AMINE; N (4 METHYLPHENYL) 3 (PYRIDIN 4 YL) [1,2,4]TRIAZOLO[3,4 B][1,3,4]THIADIAZOLE 6 AMINE; N (P BROMOPHENYL) 3 (PYRIDIN 4 YL) [1,2,4]TRIAZOLO[3,4 B][1,3,4]THIADIAZOLE 6 AMINE; N SUBSTITUTED 3 MERCAPTO [1,2,4]TRIAZOLE; N [3 MERCAPTO 5 (PYRIDIN 4 YL) 4H 1,2,4 TRIAZOL 4 YL] 4 NITROBENZAMIDE; N [3 MERCAPTO 5 (PYRIDIN 4 YL) 4H 1,2,4 TRIAZOL 4 YL]ACETAMIDE; TRIAZOLE DERIVATIVE;

ANTINEOPLASTIC ACTIVITY; ARTICLE; CANCER CELL LINE; COLON CANCER; CONTROLLED STUDY; DRUG CYTOTOXICITY; DRUG STRUCTURE; DRUG SYNTHESIS; FIBROBLAST; GASTRIC CANCER CELL LINE; HEPG2 CELL LINE; HUMAN; HUMAN CELL; IC 50; IN VITRO STUDY; LIVER CANCER CELL LINE; MCF 7 CELL LINE; NASOPHARYNX CARCINOMA; BREAST CANCER; CANCER CELL; CARBON NUCLEAR MAGNETIC RESONANCE; CYTOTOXICITY; LIVER CANCER; PROTON NUCLEAR MAGNETIC RESONANCE; STOMACH CANCER; THIN LAYER CHROMATOGRAPHY; CELL CULTURE; CELL PROLIFERATION; CHEMICAL STRUCTURE; CHEMISTRY; DOSE RESPONSE; DRUG EFFECTS; DRUG SCREENING; STRUCTURE ACTIVITY RELATION; SYNTHESIS;

ANTINEOPLASTIC AGENTS; CELL PROLIFERATION; CELLS, CULTURED; DOSE-RESPONSE RELATIONSHIP, DRUG; DRUG SCREENING ASSAYS, ANTITUMOR; HUMANS; MOLECULAR STRUCTURE; STRUCTURE-ACTIVITY RELATIONSHIP; TRIAZOLES;

EID: 84906482596     PISSN: 02235234     EISSN: 17683254     Source Type: Journal    
DOI: 10.1016/j.ejmech.2014.08.047     Document Type: Article

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