Dlx5 and Mef2 regulate a novel Runx2 enhancer for osteoblast-specific expression

Journal of Bone and Mineral Research

Volumn 29, Issue 9, 2014, Pages 1960-1969

  Kawane, Tetsuya ^a   Komori, Hisato ^a   Liu, Wenguang ^a,b   Moriishi, Takeshi ^a   Miyazaki, Toshihiro ^a   Mori, Masako ^a   Matsuo, Yuki ^a   Takada, Yoshio ^c   Izumi, Shinichi ^a   Jiang, Qing ^a   Nishimura, Riko ^d   Kawai, Yosuke ^a   Komori, Toshihisa ^a  

^a NAGASAKI UNIVERSITY GRADUATE SCHOOL OF BIOMEDICAL SCIENCES   (Japan)

^b NORTHEAST NORMAL UNIVERSITY   (China)

^c ASAHI KASEI PHARMA CORPORATION   (Japan)

^d OSAKA UNIVERSITY   (Japan)

Author keywords

DLX5; ENHANCER; MEF2; OSTEOBLAST; RUNX2

Indexed keywords

ENHANCEOSOME; GREEN FLUORESCENT PROTEIN; HISTONE H3; MYOCYTE ENHANCER FACTOR 2; TRANSCRIPTION FACTOR DLX5; TRANSCRIPTION FACTOR RUNX2; BETA CATENIN; CTNNB1 PROTEIN, HUMAN; DLX5 PROTEIN, MOUSE; HEPATOCYTE NUCLEAR FACTOR 1ALPHA; HISTONE; HNF1A PROTEIN, MOUSE; HOMEODOMAIN PROTEIN; OSTERIX PROTEIN, MOUSE; SMAD1 PROTEIN; TRANSCRIPTION FACTOR; TRANSCRIPTION FACTOR SOX;

ANIMAL EXPERIMENT; ARTICLE; BINDING SITE; CHICKEN; CONTROLLED STUDY; EMBRYO; ENHANCER REGION; GENE EXPRESSION; GENE LOCUS; HORSE; HUMAN; HUMAN CELL; MOUSE; NONHUMAN; OPOSSUM; OSTEOBLAST; PROMOTER REGION; PROTEIN EXPRESSION; PROTEIN PROTEIN INTERACTION; REPRODUCTION; ANIMAL; ANTIBODY SPECIFICITY; BACTERIAL ARTIFICIAL CHROMOSOME; BASE PAIRING; CELL LINE; CHROMATIN IMMUNOPRECIPITATION; GEL MOBILITY SHIFT ASSAY; GENE EXPRESSION REGULATION; GENETICS; METABOLISM; PROTEIN PROCESSING; REPORTER GENE; TRANSGENIC MOUSE;

ANIMALS; BASE PAIRING; BETA CATENIN; CELL LINE; CHROMATIN IMMUNOPRECIPITATION; CHROMOSOMES, ARTIFICIAL, BACTERIAL; CORE BINDING FACTOR ALPHA 1 SUBUNIT; ELECTROPHORETIC MOBILITY SHIFT ASSAY; ENHANCER ELEMENTS, GENETIC; GENE EXPRESSION REGULATION; GENES, REPORTER; GENETIC LOCI; GREEN FLUORESCENT PROTEINS; HEPATOCYTE NUCLEAR FACTOR 1-ALPHA; HISTONES; HOMEODOMAIN PROTEINS; MEF2 TRANSCRIPTION FACTORS; MICE; MICE, TRANSGENIC; ORGAN SPECIFICITY; OSTEOBLASTS; PROMOTER REGIONS, GENETIC; PROTEIN PROCESSING, POST-TRANSLATIONAL; SMAD1 PROTEIN; SOX TRANSCRIPTION FACTORS; TRANSCRIPTION FACTORS;

EID: 84906351601     PISSN: 08840431     EISSN: 15234681     Source Type: Journal    
DOI: 10.1002/jbmr.2240     Document Type: Article

References (18)

1. Komori T,. Runx2, a multifunctional transcription factor in skeletal development. J Cell Biochem. 2002; 87 (1): 1-8.
2. Fujiwara M, Tagashira S, Harada H, et al. Isolation and characterization of the distal promoter region of mouse Cbfa1. Biochim Biophys Acta. 1999 Sep 3; 1446 (3): 265-72.
3. Park MH, Shin HI, Choi JY, et al. Differential expression patterns of Runx2 isoforms in cranial suture morphogenesis. J Bone Miner Res. 2001 May; 16 (5): 885-92.
4. Zambotti A, Makhluf H, Shen J, Ducy P,. Characterization of an osteoblast-specific enhancer element in the CBFA1 gene. J Biol Chem. 2002 Nov 1; 277 (44): 41497-506.
5. Lee MH, Kim YJ, Yoon WJ, et al. Dlx5 specifically regulates Runx2 type II expression by binding to homeodomain-response elements in the Runx2 distal promoter. J Biol Chem. 2005 Oct 21; 280 (42): 35579-87.
6. Hassan MQ, Tare R, Lee SH, et al. HOXA10 controls osteoblastogenesis by directly activating bone regulatory and phenotypic genes. Mol Cell Biol. 2007 May; 27 (9): 3337-52.
7. Zhang Y, Hassan MQ, Xie RL, et al. Co-stimulation of the bone-related Runx2 P1 promoter in mesenchymal cells by SP1 and ETS transcription factors at polymorphic purine-rich DNA sequences (Y-repeats). J Biol Chem. 2009 Jan 30; 284 (5): 3125-35.
8. Gaur T, Lengner CJ, Hovhannisyan H, et al. Canonical WNT signaling promotes osteogenesis by directly stimulating Runx2 gene expression. J Biol Chem. 2005 Sep 30; 280 (39): 33132-40.
9. Lengner CJ, Drissi H, Choi JY, et al. Activation of the bone-related Runx2/Cbfa1 promoter in mesenchymal condensations and developing chondrocytes of the axial skeleton. Mech Dev. 2002 Jun; 114 (1-2): 167-70.
10. Maeno T, Moriishi T, Yoshida CA, et al. Early onset of Runx2 expression caused craniosynostosis, ectopic bone formation, and limb defects. Bone. 2011 Oct; 49 (4): 673-82.
11. Ueta C, Iwamoto M, Kanatani N, et al. Skeletal malformations caused by overexpression of Cbfa1 or its dominant negative form in chondrocytes. J Cell Biol. 2001 Apr 2; 153 (1): 87-100.
12. Kamekura S, Kawasaki Y, Hoshi K, et al. Contribution of runt-related transcription factor 2 to the pathogenesis of osteoarthritis in mice after induction of knee joint instability. Arthritis Rheum. 2006 Aug; 54 (8): 2462-70.
13. Yoshida CA, Komori H, Maruyama Z, et al. SP7 inhibits osteoblast differentiation at a late stage in mice. PLoS One. 2012; 7 (3): e32364.
14. Muramatsu S, Wakabayashi M, Ohno T, et al. Functional gene screening system identified TRPV4 as a regulator of chondrogenic differentiation. J Biol Chem. 2007 Nov 2; 282 (44): 32158-67.
15. Yoshida CA, Yamamoto H, Fujita T, et al. Runx2 and Runx3 are essential for chondrocyte maturation, and Runx2 regulates limb growth through induction of Indian hedgehog. Genes Dev. 2004 Apr 15; 18 (8): 952-63.
16. Satokata I, Ma L, Ohshima H, et al. Msx2 deficiency in mice causes pleiotropic defects in bone growth and ectodermal organ formation. Nat Genet. 2000 Apr; 24 (4): 391-5.
17. Robledo RF, Rajan L, Li X, Lufkin T,. The Dlx5 and Dlx6 homeobox genes are essential for craniofacial, axial, and appendicular skeletal development. Genes Dev. 2002 May 1; 16 (9): 1089-101.
18. Ong CT, Corces VG,. Enhancers: emerging roles in cell fate specification. EMBO Rep. 2012 May; 13 (5): 423-30.