Intracellular delivery of antisense peptide nucleic acid by fluorescent mesoporous silica nanoparticles

Bioconjugate Chemistry

Volumn 25, Issue 8, 2014, Pages 1412-1420

  Ma, Xing ^a,b   Devi, Gitali ^a   Qu, Qiuyu ^a   Toh, Desiree Faye Kaixin ^a   Chen, Gang ^a   Zhao, Yanli ^a,b  

^a Nanyang Technological University   (Singapore)

^b NANYANG TECHNOLOGICAL UNIVERSITY   (Singapore)

Author keywords

[No Author keywords available]

Indexed keywords

COVALENT BONDS; CYTOLOGY; DISEASES; FLUORESCENCE; LANTHANUM COMPOUNDS; NUCLEIC ACIDS; SILICA NANOPARTICLES; SULFUR COMPOUNDS;

ANTISENSE PEPTIDES; B-CELL LYMPHOMA; CANCER CELLS; CELL PERMEABILITY; DISULPHIDE BONDS; IN-VITRO; INTRACELLULAR DELIVERY; MESOPOROUS SILICA NANOPARTICLES; PEPTIDE NUCLEIC ACID; PROTEIN EXPRESSIONS;

PEPTIDES;

CARBOXYLIC ACID; CYANINE DYE 5; DRUG CARRIER; FLUORESCENT DYE; FLUORESCENT MESOPOROUS SILICA NANOPARTICLE; NANOPARTICLE; PEPTIDE NUCLEIC ACID; PROTEIN BCL 2; UNCLASSIFIED DRUG; ANTISENSE OLIGONUCLEOTIDE; SILICON DIOXIDE;

AMIDATION; ARTICLE; CANCER CELL; CELL MEMBRANE PERMEABILITY; CHEMICAL STRUCTURE; CONFOCAL LASER MICROSCOPY; CONJUGATE; CONTROLLED STUDY; CYTOTOXICITY ASSAY; DISULFIDE BOND; DNA SEQUENCE; DRUG DELIVERY SYSTEM; FEMALE; FIELD EMISSION SCANNING ELECTRON MICROSCOPY; GENE SILENCING; HUMAN; HUMAN CELL; IN VITRO STUDY; INTRACELLULAR TRANSPORT; MATRIX ASSISTED LASER DESORPTION IONIZATION TIME OF FLIGHT MASS SPECTROMETRY; OXIDATION REDUCTION STATE; PROTEIN EXPRESSION; REVERSED PHASE HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; SURFACE PROPERTY; TRANSMISSION ELECTRON MICROSCOPY; WESTERN BLOTTING; ZETA POTENTIAL; CHEMISTRY; CYTOPLASM; DEFICIENCY; GENETICS; HELA CELL LINE; INTRACELLULAR SPACE; METABOLISM; NUCLEOTIDE SEQUENCE; POROSITY;

BASE SEQUENCE; CYTOPLASM; DRUG CARRIERS; FLUORESCENT DYES; GENE SILENCING; HELA CELLS; HUMANS; INTRACELLULAR SPACE; NANOPARTICLES; OLIGONUCLEOTIDES, ANTISENSE; PEPTIDE NUCLEIC ACIDS; POROSITY; PROTO-ONCOGENE PROTEINS C-BCL-2; SILICON DIOXIDE;

EID: 84906343732     PISSN: 10431802     EISSN: 15204812     Source Type: Journal    
DOI: 10.1021/bc5002714     Document Type: Article

References (28)

1. Adams, J. M. and Cory, S. (1998) The Bcl-2 protein family: arbiters of cell survival Science 281, 1322-1326
2. Youle, R. J. and Strasser, A. (2008) The BCL-2 protein family: opposing activities that mediate cell death Nat. Rev. Mol. Cell Biol. 9, 47-59
3. Chen, A. M., Zhang, M., Wei, D. G., Stueber, D., Taratula, O., Minko, T., and He, H. X. (2009) Co-delivery of doxorubicin and Bcl-2 siRNA by mesoporous silica nanoparticles enhances the efficacy of chemotherapy in multidrug-resistant cancer cells Small 5, 2673-2677
4. Saad, M., Garbuzenko, O. B., and Minko, T. (2008) Co-delivery of siRNA and an anticancer drug for treatment of multidrug-resistant cancer Nanomedicine 3, 761-776
5. Wang, Y., Gao, S., Ye, W.-H., Yoon, H. S., and Yang, Y.-Y. (2006) Co-delivery of drugs and DNA from cationic core-shell nanoparticles self-assembled from a biodegradable copolymer Nat. Mater. 5, 791-796
6. Egholm, M., Buchardt, O., Christensen, L., Behrens, C., Freier, S. M., Driver, D. A., Berg, R. H., Kim, S. K., Norden, B., and Nielsen, P. E. (1993) PNA hybridizes to complementary oligonucleotides obeying the Watson-Crick hydrogen-bonding rules Nature 365, 566-568
7. Nielsen, P. E., Egholm, M., Berg, R., and Buchardt, O. (1991) Sequence-selective recognition of DNA by strand displacement with a thymine-substituted polyamide Science 254, 1497-1500
8. Sethi, D., Chen, C.-P., Jing, R.-Y., Thakur, M. L., and Wickstrom, E. (2012) Fluorescent peptide-PNA chimeras for imaging monoamine oxidase a mRNA in neuronal cells Bioconjugate Chem. 23, 158-163
9. Good, L. and Nielsen, P. E. (1998) Antisense inhibition of gene expression in bacteria by PNA targeted to mRNA Nat. Biotechnol. 16, 355-358
10. Shiraishi, T. and Nielsen, P. E. (2011) Improved cellular uptake of antisense peptide nucleic acids by conjugation to a cell-penetrating peptide and a lipid domain, in Bioconjugation Protocols (Mark, S. S., Ed.) pp 209-221, Humana Press, Totowa, NJ.
11. Gallazzi, F., Wang, Y., Jia, F., Shenoy, N., Landon, L. A., Hannink, M., Lever, S. Z., and Lewis, M. R. (2003) Synthesis of radiometal-labeled and fluorescent cell-permeating peptide-PNA conjugates for targeting the Bcl-2 proto-oncogene Bioconjugate Chem. 14, 1083-1095
12. Koppelhus, U. and Nielsen, P. E. (2003) Cellular delivery of peptide nucleic acid (PNA) Adv. Drug Delivery Rev. 55, 267-280
13. Duy, J., Connell, L., Eck, W., Collins, S., and Smith, R. (2010) Preparation of surfactant-stabilized gold nanoparticle-peptide nucleic acid conjugates J. Nanopart. Res. 12, 2363-2369
14. Saleh, A. F., Arzumanov, A., Abes, R., Owen, D., Lebleu, B., and Gait, M. J. (2010) Synthesis and splice-redirecting activity of branched, arginine-rich peptide dendrimer conjugates of peptide nucleic acid oligonucleotides Bioconjugate Chem. 21, 1902-1911
15. Slowing, I. I., Vivero-Escoto, J. L., Wu, C. W., and Lin, V. S. Y. (2008) Mesoporous silica nanoparticles as controlled release drug delivery and gene transfection carriers Adv. Drug Delivery Rev. 60, 1278-1288
16. Ashley, C. E., Carnes, E. C., Epler, K. E., Padilla, D. P., Phillips, G. K., Castillo, R. E., Wilkinson, D. C., Wilkinson, B. S., Burgard, C. A., Kalinich, R. M., Townson, J. L., Chackerian, B., Willman, C. L., Peabody, D. S., Wharton, W., and Brinker, C. J. (2012) Delivery of small interfering RNA by peptide-targeted mesoporous silica nanoparticle-supported lipid bilayers ACS Nano 6, 2174-2188
17. Zhang, Q., Liu, F., Nguyen, K. T., Ma, X., Wang, X. J., Xing, B. G., and Zhao, Y. L. (2012) Multifunctional mesoporous silica nanoparticles for cancer-targeted and controlled drug delivery Adv. Funct. Mater. 22, 5144-5156
18. Cheng, R., Feng, F., Meng, F., Deng, C., Feijen, J., and Zhong, Z. (2011) Glutathione-responsive nano-vehicles as a promising platform for targeted intracellular drug and gene delivery J. Controlled Release 152, 2-12
19. Luo, Z., Cai, K. Y., Hu, Y., Li, J. H., Ding, X. W., Zhang, B. L., Xu, D. W., Yang, W. H., and Liu, P. (2012) Redox-responsive molecular nanoreservoirs for controlled intracellular anticancer drug delivery based on magnetic nanoparticles Adv. Mater. 24, 431-435
20. Webb, A., Cunningham, D., Cotter, F., Clarke, P. A., Di Stefano, F., Ross, P., Corbo, M., and Dziewanowska, Z. (1997) Bcl-2 antisense therapy in patients with non-Hodgkin lymphoma Lancet 349, 1137-1141
21. Ma, X., Nguyen, K. T., Borah, P., Ang, C. Y., and Zhao, Y. (2012) Functional silica nanoparticles for redox-triggered drug/ssDNA co-delivery Adv. Healthcare Mater. 1, 690-697
22. Stöber, W., Fink, A., and Bohn, E. (1968) Controlled growth of monodisperse silica spheres in the micron size range J. Colloid Interface Sci. 26, 62-69
23. Rostovtsev, V. V., Green, L. G., Fokin, V. V., and Sharpless, K. B. (2002) A stepwise Huisgen cycloaddition process: copper(I)-catalyzed regioselective "ligation" of azides and terminal alkynes Angew. Chem., Int. Ed. 41, 2596-2599
24. Lewis, M. R., Jia, F., Gallazzi, F., Wang, Y., Zhang, J., Shenoy, N., Lever, S. Z., and Hannink, M. (2002) Radiometal-labeled peptide-PNA conjugates for targeting Bcl-2 expression: preparation, characterization, and in vitro mRNA binding Bioconjugate Chem. 13, 1176-1180
25. Voehringer, D. W., McConkey, D. J., McDonnell, T. J., Brisbay, S., and Meyn, R. E. (1998) Bcl-2 expression causes redistribution of glutathione to the nucleus Proc. Natl. Acad. Sci. U.S.A. 95, 2956-2960
26. Koppelhus, U., Shiraishi, T., Zachar, V., Pankratova, S., and Nielsen, P. E. (2008) Improved cellular activity of antisense peptide nucleic acids by conjugation to a cationic peptide-lipid (CatLip) domain Bioconjugate Chem. 19, 1526-1534
27. Devi, G., Yuan, Z., Lu, Y., Zhao, Y., and Chen, G. (2014) Incorporation of thio-pseudoisocytosine into triplex-forming peptide nucleic acids for enhanced recognition of RNA duplexes Nucleic Acids Res. 42, 4008-4018
28. Ebright, Y. W., Chen, Y., Kim, Y., and Ebright, R. H. (1996) S -[2-(4-Azidosalicylamido)ethylthio]-2-thiopyridine: radioiodinatable, cleavable, photoactivatible cross-linking agent Bioconjugate Chem. 7, 380-384