The immunophenotypes of blast cells in B-cell precursor acute lymphoblastic leukemia: How different are they from their normal counterparts?

Cytometry Part B - Clinical Cytometry

Volumn 86, Issue 5, 2014, Pages 329-339

  Sȩdek, Ł ^a   Bulsa, J ^a   Sonsala, A ^a   Twardoch, M ^a   Wieczorek, M ^b   Malinowska, I ^c   Derwich, K ^d   Niedzwiecki M ^e   Sobol Milejska, G ^a   Kowalczyk, J R ^f   Mazur, B ^a   Szczepanski T ^a  

^a MEDICAL UNIVERSITY OF SILESIA   (Poland)

^b Pediatric and Oncological Hospital in Chorzów   (Poland)

^c MEDICAL UNIVERSITY OF WARSAW   (Poland)

^d POZNAN UNIVERSITY OF MEDICAL SCIENCES   (Poland)

^e MEDICAL UNIVERSITY OF GDANSK   (Poland)

^f MEDICAL UNIVERSITY OF LUBLIN   (Poland)

Author keywords

acute leukemia; acute lymphoblastic leukemia; cytometry; flow cytometry; hematogone; hematology; immunophenotype; immunophenotyping; leukemia; lymphocyte

Indexed keywords

CD20 ANTIGEN; CD22 ANTIGEN; CD34 ANTIGEN; CD38 ANTIGEN; CD45 ANTIGEN; COMMON ACUTE LYMPHOBLASTIC LEUKEMIA ANTIGEN; DNA NUCLEOTIDYLEXOTRANSFERASE; FLUOROCHROME; MONOCLONAL ANTIBODY; CD19 ANTIGEN; MEMBRANE METALLOENDOPEPTIDASE;

ACUTE LYMPHOBLASTIC LEUKEMIA; ADOLESCENT; ANTIGEN EXPRESSION; ARTICLE; BLAST CELL; CELL POPULATION; CHILD; COMPARATIVE STUDY; CONTROLLED STUDY; FLOW CYTOMETRY; FLUORESCENCE; GENE OVEREXPRESSION; HUMAN; HUMAN CELL; IMMUNOPHENOTYPING; INFANT; MAJOR CLINICAL STUDY; NEWBORN; PRE B LYMPHOCYTE; PRIORITY JOURNAL; QUANTITATIVE ANALYSIS; BIOSYNTHESIS; FEMALE; MALE; PATHOLOGY; PRESCHOOL CHILD; PROCEDURES;

ADOLESCENT; ANTIGENS, CD19; CHILD; CHILD, PRESCHOOL; FEMALE; FLOW CYTOMETRY; HUMANS; IMMUNOPHENOTYPING; INFANT; MALE; NEPRILYSIN; PRECURSOR B-CELL LYMPHOBLASTIC LEUKEMIA-LYMPHOMA; PRECURSOR CELLS, B-LYMPHOID;

EID: 84906334214     PISSN: 15524949     EISSN: 15524957     Source Type: Journal    
DOI: 10.1002/cyto.b.21176     Document Type: Article

References (34)

1. Rathinam C, Flavell RA,. The hematopoiesis paradigm: Clarity or ambiguity? Blood 2008; 112: 3534-3535.
2. Sevilla DW, Emmons FN, Bai X, Colovai A, Bhagat G, Alobeid B,. The pattern of cytoplasmic IgM expression in the context of the three currently recognised maturational stages of hematogones. Leuk Lymphoma 2009; 50: 642-644.
3. van Lochem EG, van der Velden VH, Wind HK, te Marvelde JG, Westerdaal NA, van Dongen JJ,. Immunophenotypic differentiation patterns of normal hematopoiesis in human bone marrow: Reference patterns for age-related changes and disease-induced shifts. Cytometry B Clin Cytom 2004; 60: 1-13.
4. Lucio P, Parreira A, van den Beemd MW, van Lochem EG, van Wering ER, Baars E, Porwit-MacDonald A, Bjorklund E, Gaipa G, Biondi A, Orfao A, Janossy G, van Dongen JJ, San Miguel JF,. Flow cytometric analysis of normal B cell differentiation: A frame of reference for the detection of minimal residual disease in precursor-B-ALL. Leukemia 1999; 13: 419-427.
5. Pieters R, Carroll WL,. Biology and treatment of acute lymphoblastic leukemia. Pediatr Clin North Am 2008; 55: 1-20.
6. Onciu M,. Acute lymphoblastic leukemia. Hematol Oncol Clin N Am 2009; 23: 655-674.
7. Szczepański T, van der Velden VH, van Dongen JJ,. Classification systems for acute and chronic leukaemias. Best Pract Res Clin Haematol 2003; 16: 561-582.
8. Ferrando AA, Neuberg DS, Staunton J, Loh ML, Huard C, Raimondi SC, Behm FG, Pui CH, Downing JR, Gilliland DG, Lander ES, Golub TR, Look AT,. Gene expression signatures define novel oncogenic pathways in T-cell acute lymphoblastic leukemia. Cancer Cell 2001; 1: 75-87.
9. Ratei R, Schabath R, Karawajew L, Zimmermann M, Möricke A, Schrappe M, Ludwig WD,. Lineage classification of childhood acute lymphoblastic leukemia according to the EGIL recommendations: Results of the ALL-BFM 2000 Trial. Klin Padiatr 2013; 225 (Suppl 1): S34-S39.
10. Orfao A, Ortuño F, de Santiago M, Lopez A, San Miguel JF,. Immunophenotyping of acute leukemias and myelodysplastic syndromes. Cytometry Part A 2004; 58A: 62-71.
11. Jaffe ES,. The 2008 WHO classification of lymphomas: Implications for clinical practice and translational research. Hematology Am Soc Hematol Educ Program 2009; 523-531.
12. Craig FE,. Flow cytometric evaluation of B-cell lymphoid neoplasms. Clin Lab Med 2007; 27: 487-512.
13. Seegmiller AC, Kroft SH, Karandikar NJ, McKenna RW,. Characterization of immunophenotypic aberrancies in 200 cases of B acute lymphoblastic leukemia. Am J Clin Pathol 2009; 132: 940-949.
14. Szczepański T, van der Velden VH, van Dongen JJ,. Flow-cytometric immunophenotyping of normal and malignant lymphocytes. Clin Chem Lab Med 2006; 44: 775-796.
15. McKenna RW, Asplund SL, Kroft SH,. Immunophenotypic analysis of hematogones (B-lymphocyte precursors) and neoplastic lymphoblasts by 4-color flow cytometry. Leuk Lymphoma 2004; 45: 277-285.
16. McKenna RW, Washington LT, Aquino DB, Picker LJ, Kroft SH,. Immunophenotypic analysis of hematogones (B-lymphocyte precursors) in 662 consecutive bone marrow specimens by 4-color flow cytometry. Blood 2001; 98: 2498-2507.
17. Babusikova O, Zeleznikova T, Mlcakova A, Kusenda J, Stevulova L,. The knowledge on the 3rd type hematogones could contribute to more precise detection of small numbers of precursor B-acute lymphoblastic leukemia. Neoplasma 2005; 52: 502-509.
18. van Lochem EG, Wiegers YM, van den Beemd R, Hahlen K, van Dongen JJ, Hooijkaas H,. Regeneration pattern of precursor-B-cells in bone marrow of acute lymphoblastic leukemia patients depends on the type of preceding chemotherapy. Leukemia 2000; 14: 688-695.
19. Sevilla DW, Colovai AI, Emmons FN, Bhagat G, Alobeid B,. Hematogones: A review and update. Leuk Lymphoma 2010; 51: 10-19.
20. Kalina T, Flores-Montero J, van der Velden VH, Martin-Ayuso M, Böttcher S, Ritgen M, Almeida J, Lhermitte L, Asnafi V, Mendonca A, de Tute R, Cullen M, Sedek Ł, Vidriales MB, Perez JJ, te Marvelde JG, Mejstřikova E, Hrusak O, Szczepański T, van Dongen JJ, Orfao A,. EuroFlow standardization of flow cytometer instrument settings and immunophenotyping protocols. Leukemia 2012; 26: 1986-2010.
21. Pedreira CE, Costa ES, Lecrevisse Q, van Dongen JJ, Orfao A, on behalf of the EuroFlow Consortium,. Overview of clinical flow cytometry data analysis: Recent advances and future challenges. Trends Biotechnol 2013; 31: 415-427.
22. van Dongen JJ, Lhermitte L, Böttcher S, Almeida J, van der Velden VH, Flores-Montero J, Rawstron A, Asnafi V, Lecrevisse Q, Lucio P, Mejstřikova E, Szczepański T, Kalina T, de Tute R, Brüggemann M, Sedek Ł, Cullen M, Langereak AW, Mendonca A, Macintyre E, Martin-Ayuso M, Hrusak O, Vidriales MB, Orfao A,. EuroFlow antibody panels for standardized n-dimensional flow cytometric immunophenotyping of normal, reactive and malignant leukocytes. Leukemia 2012; 26: 1908-1975.
23. Babusikova O, Zeleznikova T, Kirschnerova G, Kankuri E,. Hematogones in acute leukemia during and after therapy. Leuk Lymphoma 2008; 49: 1935-1944.
24. Kalff A, Juneja S,. B-acute leukemic lymphoblasts versus hematogones: The wolf in sheep's clothing. Leuk Lymphoma 2009; 50: 523-524.
25. Pia̧tosa B, Birbach M, Siewiera K, Ussowicz M, Kałwak K, Drabko K, Rekawek A, Tkaczyk K, Kurowski PN,. Significant changes in the composition of the precursor B-cell compartment in children less than 2 years old. Cytometry Part B 2013; 84B: 179-186.
26. Wood BL,. Myeloid malignancies: myelodysplastic syndromes, myeloproliferative disorders, and acute myeloid leukemia. Clin Lab Med 2007; 27: 551-575.
27. Babusikova O, Zeleznikova T,. Normal maturation sequence of immunoglobulin light and heavy chains in hematogone stages 1, 2 and 3 in acute leukemia after treatment. Neoplasma 2008; 55: 501-506.
28. Qadir M, Barcos M, Stewart CC, Sait SN, Ford LA, Baer MR,. Routine immunophenotyping in acute leukemia: Role in lineage assignment and reassignment. Cytometry B Clin Cytom 2006; 70: 329-334.
29. Nakamura A, Tsurusawa M, Kato A, Taga T, Hatae Y, Miyake M, Mimaya J, Onodera N, Watanabe A, Watanabe T, Kanegane H, Matsuhita T, Iwai A, Hyakuna N, Gushi K, Kawakami T, Sekine I, Izichi O, Asami K, Kikuta A, Tanaka A, Fujimoto T,. Prognostic impact of CD45 antigen expression in high-risk, childhood B-cell precursor acute lymphoblastic leukemia. Leuk Lymphoma 2001; 42: 393-398.
30. Ratei R, Sperling C, Karawajew L, Schott G, Schrappe M, Harbott J, Riehm H, Ludwig WD,. Immunophenotype and clinical characteristics of CD45-negative and CD45-positive childhood acute lymphoblastic leukemia. Ann Hematol 1998; 77: 107-114.
31. Tong H, Zhang J, Lu C, Liu Z, Zheng Y,. Immunophenotypic, cytogenetic and clinical features of 113 acute lymphoblastic leukaemia patients in China. Ann Acad Med Singapore 2010; 39: 49-53.
32. Cáp J, Babusíková O, Kaiserová E, Jamárik M,. Expression of CD10, CD19 and CD34 markers in bone marrow samples of children with precursor B-cell acute lymphoblastic leukemia in clinical and hematological remission. Neoplasma 1998; 55: 501-506.
33. Lucio P, Gaipa G, van Lochem EG, van Wering ER, Porwit-MacDonald A, Faria T, Bjorklund E, Biondi A, van den Beemd MW, Baars E, Vidriales B, Parreira A, van Dongen JJ, San Miguel JF, Orfao A,. BIOMED-I concerted action report: flow cytometric immunophenotyping of precursor B-ALL with standardized triple-stainings. BIOMED-1 Concerted Action Investigation of Minimal Residual Disease in Acute Leukemia: International Standardization and Clinical Evaluation. Leukemia 2001; 15: 1185-1192.
34. Hurford MT, Altman AJ, DiGiuseppe JA, Sherburne BJ, Rezuke WN,. Unique pattern of nuclear TdT immunofluorescence distinguishes normal precursor B cells (hematogones) from lymphoblasts of precursor B-lymphoblastic leukemia. Am J Clin Pathol 2008; 129: 700-705.