Epigenetics and suicidal behavior research pathways

American Journal of Preventive Medicine

Volumn 47, Issue 3 SUPPL. 2, 2014, Pages

  Turecki, Gustavo ^a  

^a DOUGLAS MENTAL HEALTH UNIVERSITY INSTITUTE   (Canada)

Author keywords

[No Author keywords available]

Indexed keywords

4 AMINOBUTYRIC ACID; BRAIN DERIVED NEUROTROPHIC FACTOR; ENVIRONMENTAL CHEMICAL; NEUROTROPHIN;

ARTICLE; BEHAVIOR CHANGE; DEPRESSIVE PSYCHOSIS; DISEASE ASSOCIATION; DISEASE PREDISPOSITION; DNA METHYLATION; EARLY LIFE STRESS; ENVIRONMENTAL FACTOR; EPIGENETICS; GENE EXPRESSION; GENE FUNCTION; GENETIC ASSOCIATION; GENETIC REGULATION; GENETIC RISK; HEREDITY; HUMAN; MENTAL DISEASE; MUTATION; NONHUMAN; PRIMARY MEDICAL CARE; PSYCHOLOGICAL ASPECT; PSYCHOSOCIAL ENVIRONMENT; REGULATORY MECHANISM; RISK ASSESSMENT; RISK FACTOR; SOCIAL ASPECT; SUICIDAL BEHAVIOR; SUICIDE ATTEMPT; ANIMAL; GENETIC EPIGENESIS; RESEARCH; SUICIDAL IDEATION; SUICIDE; TRENDS;

ANIMALS; EPIGENESIS, GENETIC; HUMANS; RESEARCH; RISK FACTORS; SUICIDAL IDEATION; SUICIDE;

EID: 84906320681     PISSN: 07493797     EISSN: 18732607     Source Type: Journal    
DOI: 10.1016/j.amepre.2014.06.011     Document Type: Article

References (84)

1. G. Turecki Suicide I.P. Stolerman, Encyclopedia of psychopharmacology 2010 Springer-Verlag Berlin Heidelberg
2. C. Ernst, N. Mechawar, and G. Turecki Suicide neurobiology Prog Neurobiol 89 4 2009 315 333
3. G. Turecki, C. Ernst, F. Jollant, B. Labonte, and N. Mechawar The neurodevelopmental origins of suicidal behavior Trends Neurosci 35 1 2012 14 23
4. A. Petronis Epigenetics as a unifying principle in the aetiology of complex traits and diseases Nature 465 7299 2010 721 727
5. B. Labonte, and G. Turecki The epigenetics of suicide: explaining the biological effects of early life environmental adversity Arch Suicide Res 14 4 2010 291 310
6. C. Nagy, and G. Turecki Sensitive periods in epigenetics: bringing us closer to complex behavioral phenotypes Epigenomics 4 4 2012 445 457
7. M.J. Meaney, and M. Szyf Maternal care as a model for experience-dependent chromatin plasticity? Trends Neurosci 28 9 2005 456 463
8. D. Liu, J. Diorio, and B. Tannenbaum et al. Maternal care, hippocampal glucocorticoid receptors, and hypothalamic-pituitary-adrenal responses to stress Science 277 5332 1997 1659 1662
9. D. Francis, J. Diorio, D. Liu, and M.J. Meaney Nongenomic transmission across generations of maternal behavior and stress responses in the rat Science 286 5442 1999 1155 1158
10. I.C. Weaver, N. Cervoni, and F.A. Champagne et al. Epigenetic programming by maternal behavior Nat Neurosci 7 8 2004 847 854
11. M. Suderman, P.O. McGowan, and A. Sasaki et al. Conserved epigenetic sensitivity to early life experience in the rat and human hippocampus Proc Natl Acad Sci U S A 109 S2 2012 17266 17272
12. C. Heim, T. Mletzko, D. Purselle, D.L. Musselman, and C.B. Nemeroff The dexamethasone/corticotropin-releasing factor test in men with major depression: role of childhood trauma Biol Psychiatry 63 4 2008 398 405
13. C. Heim, D.J. Newport, and S. Heit et al. Pituitary-adrenal and autonomic responses to stress in women after sexual and physical abuse in childhood JAMA 284 5 2000 592 597
14. L.L. Carpenter, A.R. Tyrka, and C.J. McDougle et al. Cerebrospinal fluid corticotropin-releasing factor and perceived early-life stress in depressed patients and healthy control subjects Neuropsychopharmacology 29 4 2004 777 784
15. C. Heim, L.J. Young, D.J. Newport, T. Mletzko, A.H. Miller, and C.B. Nemeroff Lower CSF oxytocin concentrations in women with a history of childhood abuse Mol Psychiatry 14 10 2009 954 958
16. W. Coryell, and M. Schlesser The dexamethasone suppression test and suicide prediction Am J Psychiatry 158 5 2001 748 753
17. L. Fardet, I. Petersen, and I. Nazareth Suicidal behavior and severe neuropsychiatric disorders following glucocorticoid therapy in primary care Am J Psychiatry 169 5 2012 491 497
18. B. Labonte, V. Yerko, and J. Gross et al. Differential glucocorticoid receptor exon 1(b), 1(c), and 1(h) expression and methylation in suicide completers with a history of childhood abuse Biol Psychiatry 72 1 2012 41 48
19. P. McGowan, A. Sasaki, and A. D'Alessio et al. Epigenetic regulation of the glucocorticoid receptor in human brain associates with childhood abuse Nat Neurosci 12 3 2009 342 348
20. K.M. Radtke, M. Ruf, and H.M. Gunter et al. Transgenerational impact of intimate partner violence on methylation in the promoter of the glucocorticoid receptor Transl Psychiatry 1 2011 e21
21. A.R. Tyrka, L.H. Price, C. Marsit, O.C. Walters, and L.L. Carpenter Childhood adversity and epigenetic modulation of the leukocyte glucocorticoid receptor: preliminary findings in healthy adults PLoS One 7 1 2012 e30148
22. N. Perroud, A. Paoloni-Giacobino, and P. Prada et al. Increased methylation of glucocorticoid receptor gene (NR3C1) in adults with a history of childhood maltreatment: a link with the severity and type of trauma Transl Psychiatry 1 2011 e59
23. S.R. Alt, J.D. Turner, and M.D. Klok et al. Differential expression of glucocorticoid receptor transcripts in major depressive disorder is not epigenetically programmed Psychoneuroendocrinology 35 4 2010 544 556
24. C.W. Tabor, and H. Tabor Polyamines Annu Rev Biochem 53 1984 749 790
25. A.E. Pegg, and R.A. Casero Jr Current status of the polyamine research field Methods Mol Biol 720 2011 3 35
26. G.M. Gilad, and V.H. Gilad Overview of the brain polyamine-stress- response: regulation, development, and modulation by lithium and role in cell survival Cell Mol Neurobiol 23 4-5 2003 637 649
27. L.M. Fiori, and G. Turecki Implication of the polyamine system in mental disorders J Psychiatry Neurosci 33 2 2008 102 110
28. M.P. Zeidan, A.D. Zomkowski, A.O. Rosa, A.L. Rodrigues, and N.H. Gabilan Evidence for imidazoline receptors involvement in the agmatine antidepressant-like effect in the forced swimming test Eur J Pharmacol 565 1-3 2007 125 131
29. F. Aricioglu, B. Kan, O. Yillar, E. Korcegez, and K. Berkman Effect of agmatine on electrically and chemically induced seizures in mice Ann N Y Acad Sci 1009 2003 141 146
30. A.D. Zomkowski, A.R. Santos, and A.L. Rodrigues Putrescine produces antidepressant-like effects in the forced swimming test and in the tail suspension test in mice Prog Neuropsychopharmacol Biol Psychiatry 30 8 2006 1419 1425
31. Y.F. Li, Z.H. Gong, J.B. Cao, H.L. Wang, Z.P. Luo, and J. Li Antidepressant-like effect of agmatine and its possible mechanism Eur J Pharmacol 469 1-3 2003 81 88
32. A. Sequeira, F.G. Gwadry, and J.M. Ffrench-Mullen et al. Implication of SSAT by gene expression and genetic variation in suicide and major depression Arch Gen Psychiatry 63 1 2006 35 48
33. L.M. Fiori, A. Bureau, and A. Labbe et al. Global gene expression profiling of the polyamine system in suicide completers Int J Neuropsychopharmacol 14 5 2011 595 605
34. T.A. Klempan, D. Rujescu, and C. Merette et al. Profiling brain expression of the spermidine/spermine N1-acetyltransferase 1 (SAT1) gene in suicide Am J Med Genet B Neuropsychiatr Genet 150B 7 2009 934 943
35. G.G. Chen, L.M. Fiori, and L. Moquin et al. Evidence of altered polyamine concentrations in cerebral cortex of suicide completers Neuropsychopharmacology 35 7 2010 1477 1484
36. M. Guipponi, S. Deutsch, and K. Kohler et al. Genetic and epigenetic analysis of SSAT gene dysregulation in suicidal behavior Am J Med Genet B Neuropsychiatr Genet 150B 6 2009 799 807
37. K-d Dahel, N Al-Saffar, and K. Flayeh Polyamine oxidase activity in sera of depressed and schizophrenic patients after ECT treatment Neurochem Res 26 4 2001 415 418
38. L.M. Fiori, J.A. Gross, and G. Turecki Effects of histone modifications on increased expression of polyamine biosynthetic genes in suicide Int J Neuropsychopharmacol 15 8 2011 1161 1166
39. L.M. Fiori, and G. Turecki Epigenetic regulation of spermidine/spermine N(1)-acetyltransferase (SAT1) in Suicide J Psychiatr Res 45 9 2011 1229 1235
40. L.M. Fiori, and G. Turecki Genetic and epigenetic influences on expression of spermine synthase and spermine oxidase in suicide completers Int J Neuropsychopharmacol 13 6 2010 725 736
41. Y. Dwivedi, H.S. Rizavi, R.R. Conley, R.C. Roberts, C.A. Tamminga, and G.N. Pandey Altered gene expression of brain-derived neurotrophic factor and receptor tyrosine kinase B in postmortem brain of suicide subjects Arch Gen Psychiatry 60 8 2003 804 815
42. G.N. Pandey, X. Ren, H.S. Rizavi, R.R. Conley, R.C. Roberts, and Y. Dwivedi Brain-derived neurotrophic factor and tyrosine kinase B receptor signalling in post-mortem brain of teenage suicide victims Int J Neuropsychopharmacol 11 8 2008 1047 1061
43. A.R. Brunoni, P.S. Boggio, and F. Fregni Can the "yin and yang" BDNF hypothesis be used to predict the effects of rTMS treatment in neuropsychiatry? Med Hypotheses 71 2 2008 279 282
44. B. Chen, D. Dowlatshahi, G.M. MacQueen, J.F. Wang, and L.T. Young Increased hippocampal BDNF immunoreactivity in subjects treated with antidepressant medication Biol Psychiatry 50 4 2001 260 265
45. S. Sen, R. Duman, and G. Sanacora Serum brain-derived neurotrophic factor, depression, and antidepressant medications: meta-analyses and implications Biol Psychiatry 64 6 2008 527 532
46. F. Matrisciano, S. Bonaccorso, and A. Ricciardi et al. Changes in BDNF serum levels in patients with major depression disorder (MDD) after 6 months treatment with sertraline, escitalopram, or venlafaxine J Psychiatr Res 43 3 2009 247 254
47. N.M. Tsankova, O. Berton, W. Renthal, A. Kumar, R.L. Neve, and E.J. Nestler Sustained hippocampal chromatin regulation in a mouse model of depression and antidepressant action Nat Neurosci 9 4 2006 519 525
48. T.L. Roth, F.D. Lubin, A.J. Funk, and J.D. Sweatt Lasting epigenetic influence of early-life adversity on the BDNF gene Biol Psychiatry 65 9 2009 760 769
49. T.L. Roth, P.R. Zoladz, J.D. Sweatt, and D.M. Diamond Epigenetic modification of hippocampal BDNF DNA in adult rats in an animal model of post-traumatic stress disorder J Psychiatr Res 45 7 2011 919 926
50. E.S. Chen, C. Ernst, and G. Turecki The epigenetic effects of antidepressant treatment on human prefrontal cortex BDNF expression Int J Neuropsychopharmacol 14 3 2011 427 429
51. J.P. Lopez, F. Mamdani, and B. Labonte et al. Epigenetic regulation of BDNF expression according to antidepressant response Mol Psychiatry 18 4 2013 398 399
52. S. Keller, M. Sarchiapone, and F. Zarrilli et al. Increased BDNF promoter methylation in the Wernicke area of suicide subjects Arch Gen Psychiatry 67 3 2010 258 267
53. R.S. Duman, and L.M. Monteggia A neurotrophic model for stress-related mood disorders Biol Psychiatry 59 12 2006 1116 1127
54. Y.K. Kim, H.P. Lee, and S.D. Won et al. Low plasma BDNF is associated with suicidal behavior in major depression Prog Neuropsychopharmacol Biol Psychiatry 31 1 2007 78 85
55. Y. Dwivedi, H.S. Rizavi, and H. Zhang et al. Neurotrophin receptor activation and expression in human postmortem brain: effect of suicide Biol Psychiatry 65 4 2009 319 328
56. C. Aston, L. Jiang, and B.P. Sokolov Transcriptional profiling reveals evidence for signaling and oligodendroglial abnormalities in the temporal cortex from patients with major depressive disorder Mol Psychiatry 10 3 2005 309 322
57. N. Nakatani, E. Hattori, and T. Ohnishi et al. Genome-wide expression analysis detects eight genes with robust alterations specific to bipolar I disorder: relevance to neuronal network perturbation Hum Mol Genet 15 12 2006 1949 1962
58. G. Mercier, A.M. Lennon, and B. Renouf et al. MAP kinase activation by fluoxetine and its relation to gene expression in cultured rat astrocytes J Mol Neurosci 24 2 2004 207 216
59. C. Ernst, V. Deleva, and X. Deng et al. Alternative splicing, methylation state, and expression profile of tropomyosin-related kinase B in the frontal cortex of suicide completers Arch Gen Psychiatry 66 1 2009 22 32
60. C. Ernst, E.S. Chen, and G. Turecki Histone methylation and decreased expression of TrkB.T1 in orbital frontal cortex of suicide completers Mol Psychiatry 14 9 2009 830 832
61. A. Guidotti, J. Auta, and J.M. Davis et al. Decrease in reelin and glutamic acid decarboxylase67 (GAD67) expression in schizophrenia and bipolar disorder: a postmortem brain study Arch Gen Psychiatry 57 11 2000 1061 1069
62. S. Heckers, D. Stone, J. Walsh, J. Shick, P. Koul, and F.M. Benes Differential hippocampal expression of glutamic acid decarboxylase 65 and 67 messenger RNA in bipolar disorder and schizophrenia Arch Gen Psychiatry 59 6 2002 521 529
63. D.W. Volk, M.C. Austin, J.N. Pierri, A.R. Sampson, and D.A. Lewis Decreased glutamic acid decarboxylase67 messenger RNA expression in a subset of prefrontal cortical gamma-aminobutyric acid neurons in subjects with schizophrenia Arch Gen Psychiatry 57 3 2000 237 245
64. M. Veldic, H.J. Caruncho, and W.S. Liu et al. DNA-methyltransferase 1 mRNA is selectively overexpressed in telencephalic GABAergic interneurons of schizophrenia brains Proc Natl Acad Sci U S A 101 1 2004 348 353
65. M. Kundakovic, Y. Chen, E. Costa, and D.R. Grayson DNA methyltransferase inhibitors coordinately induce expression of the human reelin and glutamic acid decarboxylase 67 genes Mol Pharmacol 71 3 2007 644 653
66. D.R. Grayson, X. Jia, and Y. Chen et al. Reelin promoter hypermethylation in schizophrenia Proc Natl Acad Sci U S A 102 26 2005 9341
67. Tamura Y, Kunugi H, Ohashi J, Hohjoh H. Epigenetic aberration of the human REELIN gene in psychiatric disorders. Mol Psychiatry 2007;12(6):519, 93-600
68. T.Y. Zhang, I.C. Hellstrom, R.C. Bagot, X. Wen, J. Diorio, and M.J. Meaney Maternal care and DNA methylation of a glutamic acid decarboxylase 1 promoter in rat hippocampus J Neurosci 30 39 2010 13130 13137
69. M.O. Poulter, L. Du, and I.C. Weaver et al. GABAA receptor promoter hypermethylation in suicide brain: implications for the involvement of epigenetic processes Biol Psychiatry 64 8 2008 645 652
70. B. Labonte, M. Suderman, and G. Maussion et al. Genome-wide epigenetic regulation by early-life trauma Arch Gen Psychiatry 69 7 2012 722 731
71. B. Labonte, M. Suderman, and G. Maussion et al. Genome-wide methylation changes in the brains of suicide completers Am J Psychiatry 170 5 2013 511 520
72. E.J. van der Vegt, J. van der Ende, R.F. Ferdinand, F.C. Verhulst, and H. Tiemeier Early childhood adversities and trajectories of psychiatric problems in adoptees: evidence for long lasting effects J Abnorm Child Psychol 37 2 2009 239 249
73. J.G. Johnson, P. Cohen, M.S. Gould, S. Kasen, J. Brown, and J.S. Brook Childhood adversities, interpersonal difficulties, and risk for suicide attempts during late adolescence and early adulthood Arch Gen Psychiatry 59 8 2002 741 749
74. D.M. Fergusson, L.J. Woodward, and L.J. Horwood Risk factors and life processes associated with the onset of suicidal behaviour during adolescence and early adulthood Psychol Med 30 1 2000 23 39
75. B. Wanner, F. Vitaro, R.E. Tremblay, and G. Turecki Childhood trajectories of anxiousness and disruptiveness explain the association between early-life adversity and attempted suicide Psychol Med 42 11 2012 2373 2382
76. P.A. Melas, M. Rogdaki, U. Osby, M. Schalling, C. Lavebratt, and T.J. Ekstrom Epigenetic aberrations in leukocytes of patients with schizophrenia: association of global DNA methylation with antipsychotic drug treatment and disease onset FASEB J 26 6 2012 2712 2718
77. F. Borovecki, L. Lovrecic, and J. Zhou et al. Genome-wide expression profiling of human blood reveals biomarkers for Huntington's disease Proc Natl Acad Sci U S A 102 31 2005 11023 11028
78. S.J. Glatt, I.P. Everall, and W.S. Kremen et al. Comparative gene expression analysis of blood and brain provides concurrent validation of SELENBP1 up-regulation in schizophrenia Proc Natl Acad Sci U S A 102 43 2005 15533 15538
79. M.T. Tsuang, N. Nossova, and T. Yager et al. Assessing the validity of blood-based gene expression profiles for the classification of schizophrenia and bipolar disorder: a preliminary report Am J Med Genet B Neuropsychiatr Genet 133B 1 2005 1 5
80. E.L. Dempster, R. Pidsley, and L.C. Schalkwyk et al. Disease-associated epigenetic changes in monozygotic twins discordant for schizophrenia and bipolar disorder Hum Mol Genet 20 24 2011 4786 4796
81. P.F. Sullivan, C. Fan, and C.M. Perou Evaluating the comparability of gene expression in blood and brain Am J Med Genet B Neuropsychiatr Genet 141B 3 2006 261 268
82. C. Cai, P. Langfelder, and T.F. Fuller et al. Is human blood a good surrogate for brain tissue in transcriptional studies? BMC Genomics 11 2010 589
83. M.N. Davies, M. Volta, and R. Pidsley et al. Functional annotation of the human brain methylome identifies tissue-specific epigenetic variation across brain and blood Genome Biol 13 6 2012 R43
84. N. Perroud, A. Salzmann, and P. Prada et al. Response to psychotherapy in borderline personality disorder and methylation status of the BDNF gene Transl Psychiatry 3 2013 e207