How do we measure pathology in PAH (lung and RV) and what does it tell us about the disease

Drug Discovery Today

Volumn 19, Issue 8, 2014, Pages 1257-1263

  Tuder, Rubin M ^a  

^a UNIVERSITY OF COLORADO SCHOOL OF MEDICINE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ADAPTIVE IMMUNITY; ADVENTITIA; ARTERIAL WALL THICKNESS; CARDIOPULMONARY HEMODYNAMICS; CELL PROLIFERATION; ENDOTHELIUM CELL; HEART RIGHT VENTRICLE; HEART VENTRICLE REMODELING; HUMAN; LUNG ARTERY PRESSURE; LUNG HEMODYNAMICS; MACROPHAGE; MONOCYTE; NEOINTIMA; NONHUMAN; PULMONARY HYPERTENSION; PULMONARY VASCULAR DISEASE; PULMONARY VASCULAR REMODELING; REVIEW; VASOCONSTRICTION; ANIMAL; HEART RIGHT VENTRICLE FUNCTION; HEART VENTRICLE; LUNG; PATHOLOGY;

ANIMALS; HEART VENTRICLES; HUMANS; HYPERTENSION, PULMONARY; LUNG; VENTRICULAR DYSFUNCTION, RIGHT;

EID: 84906315554     PISSN: 13596446     EISSN: 18785832     Source Type: Journal    
DOI: 10.1016/j.drudis.2014.05.022     Document Type: Review

References (44)

1. A. Zaiman et al. One hundred years of research in the pathogenesis of pulmonary hypertension Am. J. Respir. Cell Mol. Biol. 33 2005 425 431
2. E. Stacher et al. Modern age pathology of pulmonary arterial hypertension Am. J. Respir. Crit. Care Med. 186 2012 261 272
3. R.M. Tuder et al. Pathology of pulmonary hypertension Clin. Chest Med. 34 2013 639 650
4. A. Hislop, and L. Reid Intra-pulmonary arterial development during fetal life-branching pattern and structure J. Anat. 113 1972 35 48
5. R.M. Tuder et al. Prostacyclin synthase expression is decreased in lungs from patients with severe pulmonary hypertension Am. J. Respir. Crit. Care Med. 159 1999 1925 1932
6. C. Muhlfeld, and M. Ochs Quantitative microscopy of the lung: a problem-based approach. Part 2: stereological parameters and study designs in various diseases of the respiratory tract Am. J. Physiol. Lung Cell. Mol. Physiol. 305 2013 L205 L221
7. R.M. Tuder et al. Pathology of pulmonary hypertension Clin. Chest Med. 28 2007 23 42
8. R.M. Tuder, and A.L. Zaiman Pathology of pulmonary vascular disease A. Peacock, L.J. Rubin, Pulmonary Circulation 2nd edn 2004 Arnold London 25 32
9. G. Yaginuma et al. Distribution of arterial lesions and collateral pathways in the pulmonary hypertension of congenital heart disease: a computer aided reconstruction study Thorax 45 1990 586 590
10. C.D. Cool et al. Three-dimensional reconstruction of pulmonary arteries in plexiform pulmonary hypertension using cell specific markers: evidence for a dynamic and heterogeneous process of pulmonary endothelial cell growth Am. J. Pathol. 155 1999 411 419
11. L. Taraseviciene-Stewart et al. Inhibition of the VEGF receptor 2 combined with chronic hypoxia causes cell death-dependent pulmonary endothelial cell proliferation and severe pulmonary hypertension FASEB J. 15 2001 427 438
12. K. Abe et al. Formation of plexiform lesions in experimental severe pulmonary arterial hypertension Circulation 121 2010 2747 2754
13. M. Toba et al. Temporal hemodynamic and histological progression in Sugen5416/hypoxia/normoxia-exposed pulmonary arterial hypertensive rats Am. J. Physiol. Heart Circ. Physiol. 306 2014 H243 H250
14. P. Smith, and D. Heath Electron microscopy of the plexiform lesion Thorax 34 1979 177 186
15. N. Rudarakanchana et al. New insights into the pathogenesis and treatment of primary pulmonary hypertension Thorax 56 2001 888 890
16. D. Heath, and J.E. Edwards The pathology of hypertensive pulmonary vascular disease; a description of six grades of structural changes in the pulmonary arteries with special reference to congenital cardiac septal defects Circulation 18 1958 533 547
17. G.G. Pietra et al. Histopathology of primary pulmonary hypertension. A qualitative and quantitative study of pulmonary blood vessels from 58 patients in the National Heart, Lung, and Blood Institute, Primary Pulmonary Hypertension Registry Circulation 80 1989 1198 1206
18. I. Chazova et al. Pulmonary artery adventitial changes and venous involvement in primary pulmonary hypertension Am. J. Pathol. 146 1995 389 397
19. H.J. Bogaard et al. Copper dependence of angioproliferation in pulmonary arterial hypertension in rats and humans Am. J. Respir. Cell. Mol. Biol. 46 2012 582 591
20. J. Gomez-Arroyo et al. A brief overview of mouse models of pulmonary arterial hypertension: problems and prospects Am. J. Physiol. Lung Cell. Mol. Physiol. 302 2012 L977 L991
21. A.W. Caslin et al. The histopathology of 36 cases of plexogenic pulmonary arteriopathy Histopathology 16 1990 9 19
22. H. Dib et al. Targets of anti-endothelial cell antibodies in pulmonary hypertension and scleroderma Eur. Resp. J. 39 2011 1405 1414
23. F. Perros et al. Pulmonary lymphoid neogenesis in idiopathic pulmonary arterial hypertension Am. J. Respir. Crit. Care Med. 185 2012 311 321
24. R.M. Tuder et al. Exuberant endothelial cell growth and elements of inflammation are present in plexiform lesions of pulmonary hypertension Am. J. Pathol. 144 1994 275 285
25. R. Savai et al. Immune and inflammatory cell involvement in the pathology of idiopathic pulmonary arterial hypertension Am. J. Respir. Crit. Care Med. 186 2012 897 908
26. P. Dorfmuller et al. Chemokine RANTES in severe pulmonary arterial hypertension Am. J. Respir. Crit. Care Med. 165 2002 534 539
27. F. Perros et al. Platelet-derived growth factor expression and function in idiopathic pulmonary arterial hypertension Am. J. Respir. Crit. Care Med. 178 2008 81 88
28. A. Richter et al. Impaired transforming growth Factor β signaling in idiopathic pulmonary arterial hypertension Am. J. Respir. Crit. Care Med. 170 2004 1340 1348
29. W. Tian et al. Blocking macrophage leukotriene b4 prevents endothelial injury and reverses pulmonary hypertension Sci. Transl. Med. 5 2013 200ra117
30. B.B. Graham et al. Transforming growth factor-β signaling promotes pulmonary hypertension caused by Schistosoma mansoni Circulation 128 2013 1354 1364
31. S.M. Majka et al. Evidence for cell fusion is absent in vascular lesions associated with pulmonary arterial hypertension Am. J. Physiol. Lung Cell. Mol. Physiol. 295 2008 L1028 L1039
32. K. Asosingh et al. Circulating angiogenic precursors in idiopathic pulmonary arterial hypertension Am. J. Pathol. 172 2008 615 627
33. K. Asosingh et al. Pulmonary vascular disease in mice xenografted with human BM progenitors from patients with pulmonary arterial hypertension Blood 120 2012 1218 1227
34. J.R. Lavoie, and D.J. Stewart Genetically modified endothelial progenitor cells in the therapy of cardiovascular disease and pulmonary hypertension Curr. Vasc. Pharmacol. 10 2012 289 299
35. G. Hansmann et al. Mesenchymal stem cell-mediated reversal of bronchopulmonary dysplasia and associated pulmonary hypertension Pulm. Circ. 2 2012 170 181
36. N.F. Voelkel et al. Vascular endothelial growth factor in the lung Am. J. Physiol. Lung Cell. Mol. Physiol. 290 2006 L209 L221
37. D.M. Hyde et al. Design-based sampling and quantitation of the respiratory airways Toxicol. Pathol. 34 2006 286 295
38. H.J. Bogaard et al. Adrenergic receptor blockade reverses right heart remodeling and dysfunction in pulmonary hypertensive rats Am. J. Respir. Crit. Care Med. 182 2010 652 660
39. G. Sutendra et al. A metabolic remodeling in right ventricular hypertrophy is associated with decreased angiogenesis and a transition from a compensated to a decompensated state in pulmonary hypertension J. Mol. Med. 91 2013 1315 1327
40. H.J. Gundersen et al. The new stereological tools: disector, fractionator, nucleator and point sampled intercepts and their use in pathological research and diagnosis APMIS 96 1988 857 881
41. G.L. Semenza Intratumoral hypoxia, radiation resistance, and HIF-1 Cancer Cell 5 2004 405 406
42. C. Muhlfeld et al. A review of state-of-the-art stereology for better quantitative 3D morphology in cardiac research Cardiovasc. Pathol. 19 2010 65 82
43. A.P. Fishman A century of primary pulmonary hypertension L.J. Rubin, S. Rich, Primary Pulmonary Hypertension 1st edn. 1997 Macel Decker New York 1 17
44. W. Scherle A simple method for volumetry of organs in quantitative stereology Mikroskopie 26 1970 57 60