Cell-cycle distribution and thymidilate synthatase (TS) expression correlate with 5-FU resistance in head and neck carcinoma cells

Anticancer Research

Volumn 34, Issue 6, 2014, Pages 2907-2912

  Ijichi, Kei ^a   Adachi, Makoto ^b   Ogawa, Tetsuya ^c   Hasegawa, Yasuhisa ^d   Murakami, Shingo ^a  

^a NAGOYA CITY UNIVERSITY GRADUATE SCHOOL OF MEDICAL SCIENCES   (Japan)

^b ASAHI UNIVERSITY   (Japan)

^c AICHI MEDICAL UNIVERSITY   (Japan)

^d AICHI CANCER CENTER HOSPITAL   (Japan)

Author keywords

5 FU; Cell cycle; Head and neck carcinoma; Resistance; Thymidylate synthase

Indexed keywords

FLUOROURACIL; THYMIDYLATE SYNTHASE; ANTINEOPLASTIC ANTIMETABOLITE;

ARTICLE; CANCER RESISTANCE; CARCINOMA CELL; CELL CYCLE PROGRESSION; CELL CYCLE S PHASE; CELL ISOLATION; CORRELATIONAL STUDY; DNA REPLICATION; DRUG EXPOSURE; ENZYME INHIBITION; FLOW CYTOMETRY; HEAD AND NECK CARCINOMA; HUMAN; HUMAN CELL; PROTEIN EXPRESSION; 5-FU; CELL CYCLE; CELL PROLIFERATION; DRUG EFFECT; DRUG RESISTANCE; ENZYMOLOGY; HEAD AND NECK TUMOR; METABOLISM; PATHOLOGY; RESISTANCE; SQUAMOUS CELL CARCINOMA; TUMOR CELL CULTURE; WESTERN BLOTTING;

5-FU; CELL CYCLE; HEAD AND NECK CARCINOMA; RESISTANCE; THYMIDYLATE SYNTHASE;

ANTIMETABOLITES, ANTINEOPLASTIC; BLOTTING, WESTERN; CARCINOMA, SQUAMOUS CELL; CELL CYCLE; CELL PROLIFERATION; DRUG RESISTANCE, NEOPLASM; FLOW CYTOMETRY; FLUOROURACIL; HEAD AND NECK NEOPLASMS; HUMANS; THYMIDYLATE SYNTHASE; TUMOR CELLS, CULTURED;

EID: 84906312799     PISSN: 02507005     EISSN: 17917530     Source Type: Journal    
DOI: None     Document Type: Article

References (10)

1. Ijichi K, Adachi M, Hasegawa Y, Ogawa T, Nakamura H, Kudoh A, Yasui Y, Murakami S and Ishizaki K: Pretreatment with 5-FU enhances cisplatin cytotoxicity in head and neck squamous cell carcinoma cells. Cancer Chemother Pharmacol 62: 745-752, 2008.
2. Derenzini M, Montanaro L, Trere D, Chilla A, Tazzari PL, Dall'Olio F and Ofner D: Thymidylate synthase protein expression and activity are related to the cell proliferation rate in human cancer cell lines. Molec Pathol: MP 55: 310-314, 2002.
3. De Angelis PM, Kravik KL, Tunheim SH, Haug T and Reichelt WH: Comparison of gene expression in HCT116 treatment derivatives generated by two different 5-fluorouracil exposure protocols. Molecular Cancer 3: 11, 2004.
4. Ligabue A, Marverti G, Liebl U and Myllykallio H: Transcriptional activation and cell cycle block are the keys for 5-fluorouracil induced up-regulation of human thymidylate synthase expression. PloS one 7: e47318, 2012.
5. Kawashima R, Haisa M, Kimura M, Takaoka M, Shirakawa Y, Takeda H, Uetsuka H, Gunduz M, Nagai N, Tanaka N and Naomoto Y: Cyclin A correlates with the sensitivity of human cancer cells to cytotoxic effects of 5-FU. Int J Oncol 24: 273-278, 2004.
6. Libra M, Navolanic PM, Talamini R, Cecchin E, Sartor F, Tumolo S, Masier S, Travali S, Boiocchi M and Toffoli G: Thymidylate synthetase mRNA levels are increased in liver metastases of colorectal cancer patients resistant to fluoropyrimidine-based chemotherapy. BMC cancer 4: 11, 2004.
7. Kamoshida S, Matsuoka H, Ishikawa T, Maeda K, Shimomura R, Inada K and Tsutsumi Y: Immunohistochemical evaluation of thymidylate synthase (TS) and p16INK4a in advanced colorectal cancer: implication of TS expression in 5-FU-based adjuvant chemotherapy. Jap J Clin Oncol 34: 594-601, 2004.
8. Sakakura K, Chikamatsu K, Shino M, Sakurai T and Furuya N: Expression of thymidylate synthase and dihydropyrimidine dehydrogenase in oral squamous cell carcinoma: possible markers as predictors of clinical outcome. Acta Oto-laryngol 126: 1295-302, 2006.
9. Nakamura A, Nakajima G, Okuyama R, Kuramochi H, Kondoh Y, Kanemura T, Takechi T, Yamamoto M and Hayashi K: Enhancement of 5-fluorouracil-induced cytotoxicity by leucovorin in 5-fluorouracil-resistant gastric cancer cells with upregulated expression of thymidylate synthase. Gastric Cancer 17: 188-195, 2014.
10. Murata S, Adachi M, Kioi M, Torigoe S, Ijichi K, Hasegawa Y, Ogawa T, Bhayani MK, Lai SY, Mitsudo K and Tohnai I: Etodolac improves 5-FU sensitivity of head and neck cancer cells through inhibition of thymidylate synthase. Anticancer Res 31: 2893-8, 2011.