Enhancement of 5-fluorouracil-induced cytotoxicity by leucovorin in 5-fluorouracil-resistant gastric cancer cells with upregulated expression of thymidylate synthase

Gastric Cancer

Volumn 17, Issue 1, 2014, Pages 188-195

  Nakamura, Ayako ^a,b   Nakajima, Go ^a   Okuyama, Ryuji ^a   Kuramochi, Hidekazu ^a   Kondoh, Yurin ^a   Kanemura, Toshinori ^a   Takechi, Teiji ^b   Yamamoto, Masakazu ^a   Hayashi, Kazuhiko ^a  

^a TOKYO WOMEN'S MEDICAL UNIVERSITY   (Japan)

^b TAIHO PHARMACEUTICAL CO LTD   (Japan)

Author keywords

5 Fluorouracil; Acquired resistance; Gastric cancer; Leucovorin; Thymidylate synthase

Indexed keywords

DIHYDROPYRIMIDINE DEHYDROGENASE; FLUOROURACIL; FOLINIC ACID; MESSENGER RNA; OROTATE PHOSPHORIBOSYLTRANSFERASE; THYMIDINE PHOSPHORYLASE; THYMIDYLATE SYNTHASE;

ARTICLE; CANCER CELL; CANCER RESISTANCE; CELL STRAIN; CELL STRAIN KATOIII; CELL STRAIN MKN45; CELL STRAIN MKN74; CELL STRAIN NCI N87; CONCENTRATION RESPONSE; CONTROLLED STUDY; DIHYDROPYRIMIDINE DEHYDROGENASE GENE; DRUG CYTOTOXICITY; DRUG METABOLISM; DRUG POTENTIATION; GENE EXPRESSION; GENE EXPRESSION REGULATION; HUMAN; HUMAN CELL; OROTATE PHOSPHORIBOSYLTRANSFERASE GENE; PRIORITY JOURNAL; PROTEIN EXPRESSION; STOMACH CANCER; THYMIDINE PHOSPHORYLASE GENE; THYMIDYLATE SYNTHASE GENE; UPREGULATION;

CELL LINE, TUMOR; DRUG RESISTANCE, NEOPLASM; FLUOROURACIL; GENE EXPRESSION REGULATION, NEOPLASTIC; HUMANS; LEUCOVORIN; STOMACH NEOPLASMS; THYMIDYLATE SYNTHASE; UP-REGULATION;

EID: 84891628249     PISSN: 14363291     EISSN: 14363305     Source Type: Journal    
DOI: 10.1007/s10120-013-0249-7     Document Type: Article

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