-
1
-
-
15844426692
-
Atm-deficient mice: a paradigm of ataxia telangiectasia
-
doi: 10.1016/S0092-8674(00)80086-0
-
Barlow, C., Hirotsune, S., Paylor, R., Liyanage, M., Eckhaus, M., Collins, F.,et al. (1996). Atm-deficient mice: a paradigm of ataxia telangiectasia. Cell 86, 159-171. doi: 10.1016/S0092-8674(00)80086-0
-
(1996)
Cell
, vol.86
, pp. 159-171
-
-
Barlow, C.1
Hirotsune, S.2
Paylor, R.3
Liyanage, M.4
Eckhaus, M.5
Collins, F.6
-
2
-
-
18244421978
-
Atm deficiency results in severe meiotic disruption as early as leptonema of prophase I
-
Barlow, C., Liyanage, M., Moens, P. B., Tarsounas, M., Nagashima, K., Brown, K.,et al. (1998). Atm deficiency results in severe meiotic disruption as early as leptonema of prophase I. Development 125, 4007-4017.
-
(1998)
Development
, vol.125
, pp. 4007-4017
-
-
Barlow, C.1
Liyanage, M.2
Moens, P.B.3
Tarsounas, M.4
Nagashima, K.5
Brown, K.6
-
3
-
-
0037967272
-
Tumorigenesis and the angiogenic switch
-
doi: 10.1038/nrc1093
-
Bergers, G., and Benjamin, L. E. (2003). Tumorigenesis and the angiogenic switch. Nat. Rev. Cancer 3, 401-410. doi: 10.1038/nrc1093
-
(2003)
Nat. Rev. Cancer
, vol.3
, pp. 401-410
-
-
Bergers, G.1
Benjamin, L.E.2
-
4
-
-
84862023155
-
ARF suppresses hepatic vascular neoplasia in a carcinogen-exposed murine model
-
doi: 10.1002/path.4024
-
Busch, S. E., Gurley, K. E., Moser, R. D., and Kemp, C. J. (2012). ARF suppresses hepatic vascular neoplasia in a carcinogen-exposed murine model. J. Pathol. 227, 298-305. doi: 10.1002/path.4024
-
(2012)
J. Pathol.
, vol.227
, pp. 298-305
-
-
Busch, S.E.1
Gurley, K.E.2
Moser, R.D.3
Kemp, C.J.4
-
5
-
-
0036787299
-
Mouse models of male infertility
-
doi: 10.1038/nrg911
-
Cooke, H. J., and Saunders, P. T. (2002). Mouse models of male infertility. Nat. Rev. Genet. 3, 790-801. doi: 10.1038/nrg911
-
(2002)
Nat. Rev. Genet.
, vol.3
, pp. 790-801
-
-
Cooke, H.J.1
Saunders, P.T.2
-
6
-
-
79960952294
-
Expression of arf tumor suppressor in spermatogonia facilitates meiotic progression in male germ cells
-
doi: 10.1371/journal.pgen.1002157
-
Churchman, M. L., Roig, I., Jasin, M., Keeney, S., and Sherr, C. J. (2011). Expression of arf tumor suppressor in spermatogonia facilitates meiotic progression in male germ cells. PLoS Genet. 7:e1002157. doi: 10.1371/journal.pgen.1002157
-
(2011)
PLoS Genet
, vol.7
-
-
Churchman, M.L.1
Roig, I.2
Jasin, M.3
Keeney, S.4
Sherr, C.J.5
-
7
-
-
84895459357
-
Therapeutic options targeting angiogenesis in nonsmall cell lung cancer
-
doi: 10.1183/09059180.00008913
-
Crinò, L., and Metro, G. (2014). Therapeutic options targeting angiogenesis in nonsmall cell lung cancer. Eur. Respir. Rev. 23, 79-91. doi: 10.1183/09059180.00008913
-
(2014)
Eur. Respir. Rev.
, vol.23
, pp. 79-91
-
-
Crinò, L.1
Metro, G.2
-
10
-
-
84856159566
-
Targeted therapies for renal cell carcinoma: review of adverse event management strategies
-
doi: 10.1093/jnci/djr511
-
Eisen, T., Sternberg, C. N., Robert, C., Mulders, P., Pyle, L., Zbinden, S.,et al. (2012). Targeted therapies for renal cell carcinoma: review of adverse event management strategies. J. Natl. Cancer Inst. 104, 93-113. doi: 10.1093/jnci/djr511
-
(2012)
J. Natl. Cancer Inst.
, vol.104
, pp. 93-113
-
-
Eisen, T.1
Sternberg, C.N.2
Robert, C.3
Mulders, P.4
Pyle, L.5
Zbinden, S.6
-
11
-
-
0029848286
-
Pleiotropic defects in ataxia-telangiectasia protein-deficient mice
-
doi: 10.1073/pnas.93.23.13084
-
Elson, A., Wang, Y., Daugherty, C. J., Morton, C. C., Zhou, F., Campos-Torres, J.,et al. (1996). Pleiotropic defects in ataxia-telangiectasia protein-deficient mice. Proc. Natl. Acad. Sci. U.S.A. 93, 13084-13089. doi: 10.1073/pnas.93.23.13084
-
(1996)
Proc. Natl. Acad. Sci. U.S.A.
, vol.93
, pp. 13084-13089
-
-
Elson, A.1
Wang, Y.2
Daugherty, C.J.3
Morton, C.C.4
Zhou, F.5
Campos-Torres, J.6
-
12
-
-
0035958932
-
The p14ARF tumor suppressor protein facilitates nucleolar sequestration of hypoxia-inducible factor-1alpha (HIF-1alpha) and inhibits HIF-1-mediated transcription
-
doi: 10.1074/jbc.M102847200
-
Fatyol, K., and Szalay, A. A. (2001). The p14ARF tumor suppressor protein facilitates nucleolar sequestration of hypoxia-inducible factor-1alpha (HIF-1alpha) and inhibits HIF-1-mediated transcription. J. Biol. Chem. 276, 28421-28429. doi: 10.1074/jbc.M102847200
-
(2001)
J. Biol. Chem.
, vol.276
, pp. 28421-28429
-
-
Fatyol, K.1
Szalay, A.A.2
-
13
-
-
2442621619
-
Discovery and development of bevacizumab, an anti-VEGF antibody for treating cancer
-
doi: 10.1038/nrd1381
-
Ferrara, N., Hillan, K. J., Gerber, H. P., and Novotny, W. (2004). Discovery and development of bevacizumab, an anti-VEGF antibody for treating cancer. Nat. Rev. Drug Discov. 3, 391-400. doi: 10.1038/nrd1381
-
(2004)
Nat. Rev. Drug Discov.
, vol.3
, pp. 391-400
-
-
Ferrara, N.1
Hillan, K.J.2
Gerber, H.P.3
Novotny, W.4
-
14
-
-
69549101925
-
Expression of the Arf tumor suppressor gene is controlled by Tgfbeta2 during development
-
doi: 10.1242/dev.033548
-
Freeman-Anderson, N. E., Zheng, Y., McCalla-Martin, A. C., Treanor, L. M., Zhao, Y. D., Garfin, P. M.,et al. (2009). Expression of the Arf tumor suppressor gene is controlled by Tgfbeta2 during development. Development 136, 2081-2089. doi: 10.1242/dev.033548
-
(2009)
Development
, vol.136
, pp. 2081-2089
-
-
Freeman-Anderson, N.E.1
Zheng, Y.2
McCalla-Martin, A.C.3
Treanor, L.M.4
Zhao, Y.D.5
Garfin, P.M.6
-
15
-
-
70350238489
-
Improved ATM kinase inhibitor KU-60019 radiosensitizes glioma cells, compromises insulin, AKT and ERK prosurvival signaling, and inhibits migration and invasion
-
doi: 10.1158/1535-7163.MCT-09-0519
-
Golding, S. E., Rosenberg, E., Valerie, N., Hussaini, I., Frigerio, M., Cockcroft, X. F.,et al. (2009). Improved ATM kinase inhibitor KU-60019 radiosensitizes glioma cells, compromises insulin, AKT and ERK prosurvival signaling, and inhibits migration and invasion. Mol. Cancer Ther. 8, 2894-902. doi: 10.1158/1535-7163.MCT-09-0519
-
(2009)
Mol. Cancer Ther.
, vol.8
, pp. 2894-2902
-
-
Golding, S.E.1
Rosenberg, E.2
Valerie, N.3
Hussaini, I.4
Frigerio, M.5
Cockcroft, X.F.6
-
16
-
-
77951888636
-
p19ARF deficiency reduces macrophage and vascular smooth muscle cell apoptosis and aggravates atherosclerosis
-
doi: 10.1016/j.jacc.2010.01.026
-
González-Navarro, H., Abu Nabah, Y. N., Vinué, A., Andrés-Manzano, M. J., Collado, M., Serrano, M.,et al. (2010). p19ARF deficiency reduces macrophage and vascular smooth muscle cell apoptosis and aggravates atherosclerosis. J. Am. Coll. Cardiol. 55, 2258-2268. doi: 10.1016/j.jacc.2010.01.026
-
(2010)
J. Am. Coll. Cardiol.
, vol.55
, pp. 2258-2268
-
-
González-Navarro, H.1
Abu Nabah, Y.N.2
Vinué, A.3
Andrés-Manzano, M.J.4
Collado, M.5
Serrano, M.6
-
17
-
-
65549141147
-
Transient expression of the Arf tumor suppressor during male germ cell and eye development in Arf-Cre reporter mice
-
doi: 10.1073/pnas.0902310106
-
Gromley, A., Churchman, M. L., Zindy, F., and Sherr, C. J. (2009). Transient expression of the Arf tumor suppressor during male germ cell and eye development in Arf-Cre reporter mice. Proc. Natl. Acad. Sci. U.S.A. 106, 6285-6290. doi: 10.1073/pnas.0902310106
-
(2009)
Proc. Natl. Acad. Sci. U.S.A.
, vol.106
, pp. 6285-6290
-
-
Gromley, A.1
Churchman, M.L.2
Zindy, F.3
Sherr, C.J.4
-
18
-
-
77954688615
-
DNA double strand break repair, chromosome synapsis and transcriptional silencing in meiosis
-
doi: 10.4161/epi.5.4.11518
-
Inagaki, A., Schoenmakers, S., and Baarends, W. M. (2010). DNA double strand break repair, chromosome synapsis and transcriptional silencing in meiosis. Epigenetics 5, 255-266. doi: 10.4161/epi.5.4.11518
-
(2010)
Epigenetics
, vol.5
, pp. 255-266
-
-
Inagaki, A.1
Schoenmakers, S.2
Baarends, W.M.3
-
19
-
-
0033135110
-
Tumor spectrum in ARF-deficient mice
-
Kamijo, T., Bodner, S., van de Kamp, E., Randle, D. H., and Sherr, C. J. (1999). Tumor spectrum in ARF-deficient mice. Cancer Res. 59, 2217-2222.
-
(1999)
Cancer Res.
, vol.59
, pp. 2217-2222
-
-
Kamijo, T.1
Bodner, S.2
van de Kamp, E.3
Randle, D.H.4
Sherr, C.J.5
-
20
-
-
77953168825
-
ARF suppresses tumor angiogenesis through translational control of VEGFA mRNA
-
doi: 10.1158/0008-5472.CAN-10-0368
-
Kawagishi, H., Nakamura, H., Maruyama, M., Mizutani, S., Sugimoto, K., Takagi, M.,et al. (2010). ARF suppresses tumor angiogenesis through translational control of VEGFA mRNA. Cancer Res. 70, 4749-4758. doi: 10.1158/0008-5472.CAN-10-0368
-
(2010)
Cancer Res.
, vol.70
, pp. 4749-4758
-
-
Kawagishi, H.1
Nakamura, H.2
Maruyama, M.3
Mizutani, S.4
Sugimoto, K.5
Takagi, M.6
-
21
-
-
84864682751
-
The dark side of the oxidative force in angiogenesis
-
doi: 10.1038/nm.2881
-
Kerr, B. A., and Byzova, T. V. (2012). The dark side of the oxidative force in angiogenesis. Nat. Med. 18, 1184-1185. doi: 10.1038/nm.2881
-
(2012)
Nat. Med.
, vol.18
, pp. 1184-1185
-
-
Kerr, B.A.1
Byzova, T.V.2
-
22
-
-
84899066730
-
MKK7 and ARF: new players in the DNA damage response scenery
-
doi: 10.4161/cc.28654
-
Kotsinas, A., Papanagnou, P., Galanos, P., Schramek, D., Townsend, P., Penninger, J. M.,et al. (2014). MKK7 and ARF: new players in the DNA damage response scenery. Cell Cycle 13, 1227-1236. doi: 10.4161/cc.28654
-
(2014)
Cell Cycle
, vol.13
, pp. 1227-1236
-
-
Kotsinas, A.1
Papanagnou, P.2
Galanos, P.3
Schramek, D.4
Townsend, P.5
Penninger, J.M.6
-
23
-
-
84862562750
-
The tumor suppressor gene ARF as a sensor of oxidative stress
-
doi: 10.2174/156652412800792633
-
Liontos, M., Pateras, I. S., Evangelou, K., and Gorgoulis, V. G. (2012). The tumor suppressor gene ARF as a sensor of oxidative stress. Curr. Mol. Med. 12, 704-715. doi: 10.2174/156652412800792633
-
(2012)
Curr. Mol. Med.
, vol.12
, pp. 704-715
-
-
Liontos, M.1
Pateras, I.S.2
Evangelou, K.3
Gorgoulis, V.G.4
-
24
-
-
0037309326
-
Tumor suppression by Ink4a-Arf: progress and puzzles
-
doi: 10.1016/S0959-437X(02)00013-8
-
Lowe, S. W., and Sherr, C. J. (2003). Tumor suppression by Ink4a-Arf: progress and puzzles. Curr. Opin. Genet. Dev. 13, 77-83. doi: 10.1016/S0959-437X(02)00013-8
-
(2003)
Curr. Opin. Genet. Dev.
, vol.13
, pp. 77-83
-
-
Lowe, S.W.1
Sherr, C.J.2
-
25
-
-
0037133685
-
The Arf tumor suppressor gene promotes hyaloid vascular regression during mouse eye development
-
doi: 10.1073/pnas.052484199
-
McKeller, R. N., Fowler, J. L., Cunningham, J. J., Warner, N., Smeyne, R. J., Zindy, F.,et al. (2002). The Arf tumor suppressor gene promotes hyaloid vascular regression during mouse eye development. Proc. Natl. Acad. Sci. U.S.A. 99, 3848-3853. doi: 10.1073/pnas.052484199
-
(2002)
Proc. Natl. Acad. Sci. U.S.A.
, vol.99
, pp. 3848-3853
-
-
McKeller, R.N.1
Fowler, J.L.2
Cunningham, J.J.3
Warner, N.4
Smeyne, R.J.5
Zindy, F.6
-
26
-
-
0032504784
-
p19ARF links the tumour suppressor p53 to Ras
-
doi: 10.1038/25870
-
Palmero, I., Pantoja, C., and Serrano, M. (1999). p19ARF links the tumour suppressor p53 to Ras. Nature 395, 125-126. doi: 10.1038/25870
-
(1999)
Nature
, vol.395
, pp. 125-126
-
-
Palmero, I.1
Pantoja, C.2
Serrano, M.3
-
27
-
-
0029587551
-
Alternative reading frames of the INK4a tumor suppressor gene encode two unrelated proteins capable of inducing cell cycle arrest
-
doi: 10.1016/0092-8674(95)90214-7
-
Quelle, D. E., Zindy, F., Ashmun, R. A., and Sherr, C. J. (1995). Alternative reading frames of the INK4a tumor suppressor gene encode two unrelated proteins capable of inducing cell cycle arrest. Cell 83, 993-100. doi: 10.1016/0092-8674(95)90214-7
-
(1995)
Cell
, vol.83
, pp. 993-1000
-
-
Quelle, D.E.1
Zindy, F.2
Ashmun, R.A.3
Sherr, C.J.4
-
28
-
-
77951937790
-
Bevacizumab toxicities and their management in ovarian cancer
-
doi: 10.1016/j.ygyno.2010.02.021
-
Randall, L. M., and Monk, B. J. (2010). Bevacizumab toxicities and their management in ovarian cancer. Gynecol. Oncol. 117, 497-504. doi: 10.1016/j.ygyno.2010.02.021
-
(2010)
Gynecol. Oncol.
, vol.117
, pp. 497-504
-
-
Randall, L.M.1
Monk, B.J.2
-
29
-
-
34547437224
-
Therapeutic targets in the ARF tumor suppressor pathway
-
doi: 10.2174/092986707781058869
-
Saporita, A. J., Maggi, L. B. Jr., Apicelli, A. J., and Weber, J. D. (2007). Therapeutic targets in the ARF tumor suppressor pathway. Curr. Med. Chem. 14, 1815-1827. doi: 10.2174/092986707781058869
-
(2007)
Curr. Med. Chem.
, vol.14
, pp. 1815-1827
-
-
Saporita, A.J.1
Maggi Jr., L.B.2
Apicelli, A.J.3
Weber, J.D.4
-
30
-
-
33747819484
-
Divorcing ARF and p53: an unsettled case
-
doi: 10.1038/nrc1954
-
Sherr, C. J. (2006). Divorcing ARF and p53: an unsettled case. Nat. Rev. Cancer 6, 663-73. doi: 10.1038/nrc1954
-
(2006)
Nat. Rev. Cancer
, vol.6
, pp. 663-673
-
-
Sherr, C.J.1
-
31
-
-
23844516784
-
Arf-dependent regulation of Pdgf signaling in perivascular cells in the developing mouse eye
-
doi: 10.1038/sj.emboj.7600751
-
Silva, R. L., Thornton, J. D., Martin, A. C., Rehg, J. E., Bertwistle, D., Zindy, F.,et al. (2005). Arf-dependent regulation of Pdgf signaling in perivascular cells in the developing mouse eye. EMBO J. 24, 2803-2814. doi: 10.1038/sj.emboj.7600751
-
(2005)
EMBO J.
, vol.24
, pp. 2803-2814
-
-
Silva, R.L.1
Thornton, J.D.2
Martin, A.C.3
Rehg, J.E.4
Bertwistle, D.5
Zindy, F.6
-
32
-
-
0037291204
-
Nucleolar Arf tumor suppressor inhibits ribosomal RNA processing
-
doi: 10.1016/S1097-2765(03)00057-1
-
Sugimoto, M., Kuo, M. L., Roussel, M. F., and Sherr, C. J. (2003). Nucleolar Arf tumor suppressor inhibits ribosomal RNA processing. Mol. Cell. 11, 415-424. doi: 10.1016/S1097-2765(03)00057-1
-
(2003)
Mol. Cell.
, vol.11
, pp. 415-424
-
-
Sugimoto, M.1
Kuo, M.L.2
Roussel, M.F.3
Sherr, C.J.4
-
33
-
-
19644384513
-
Sumoylation induced by the Arf tumor suppressor: a p53-independent function
-
doi: 10.1073/pnas.0502978102
-
Tago, K., Chiocca, S., and Sherr, C. J. (2005). Sumoylation induced by the Arf tumor suppressor: a p53-independent function. Proc. Natl. Acad. Sci. U.S.A. 102, 7689-7694. doi: 10.1073/pnas.0502978102
-
(2005)
Proc. Natl. Acad. Sci. U.S.A.
, vol.102
, pp. 7689-7694
-
-
Tago, K.1
Chiocca, S.2
Sherr, C.J.3
-
34
-
-
38649099103
-
Stem cell defects in ATM-deficient undifferentiated spermatogonia through DNA damage-induced cell-cycle arrest
-
doi: 10.1016/j.stem.2007.10.023
-
Takubo, K., Ohmura, M., Azuma, M., Nagamatsu, G., Yamada, W., Arai, F.,et al. (2008). Stem cell defects in ATM-deficient undifferentiated spermatogonia through DNA damage-induced cell-cycle arrest. Cell Stem Cell 2, 170-182. doi: 10.1016/j.stem.2007.10.023
-
(2008)
Cell Stem Cell
, vol.2
, pp. 170-182
-
-
Takubo, K.1
Ohmura, M.2
Azuma, M.3
Nagamatsu, G.4
Yamada, W.5
Arai, F.6
-
36
-
-
84872149730
-
Macrophages, inflammation, and tumor suppressors: ARF, a new player in the game
-
doi: 10.1155/2012/568783
-
Través, P. G., Luque, A., and Hortelano, S. (2012). Macrophages, inflammation, and tumor suppressors: ARF, a new player in the game. Mediators Inflamm. 2012, 568783. doi: 10.1155/2012/568783
-
(2012)
Mediators Inflamm.
, vol.2012
, pp. 568783
-
-
Través, P.G.1
Luque, A.2
Hortelano, S.3
-
37
-
-
27544431579
-
Involvement of E2F transcription factor family in cancer
-
doi: 10.1016/j.ejca.2005.08.005
-
Tsantoulis, P. K., and Gorgoulis, V. G. (2005). Involvement of E2F transcription factor family in cancer. Eur. J. Cancer 41, 2403-2414. doi: 10.1016/j.ejca.2005.08.005
-
(2005)
Eur. J. Cancer
, vol.41
, pp. 2403-2414
-
-
Tsantoulis, P.K.1
Gorgoulis, V.G.2
-
38
-
-
77957916146
-
Arffacilitates the angiogenic switch and tumor initiation in a multi-stage cancer model via p53-dependent and independent mechanisms
-
doi: 10.1371/journal.pone.0012454
-
Arffacilitates the angiogenic switch and tumor initiation in a multi-stage cancer model via p53-dependent and independent mechanisms. PLoS ONE 5:e12454. doi: 10.1371/journal.pone.0012454
-
(2010)
PLoS ONE
, vol.5
-
-
Ulanet, D.B.1
Hanahan, D.2
-
39
-
-
84881481725
-
Functional interplay between the DNA-damage-response kinase ATM and ARF tumour suppressor protein in human cancer
-
doi: 10.1038/ncb2795
-
Velimezi, G., Liontos, M., Vougas, K., Roumeliotis, T., Bartkova, J., Sideridou, M.,et al. (2013). Functional interplay between the DNA-damage-response kinase ATM and ARF tumour suppressor protein in human cancer. Nat. Cell Biol. 15, 967-977. doi: 10.1038/ncb2795
-
(2013)
Nat. Cell Biol.
, vol.15
, pp. 967-977
-
-
Velimezi, G.1
Liontos, M.2
Vougas, K.3
Roumeliotis, T.4
Bartkova, J.5
Sideridou, M.6
-
41
-
-
0029844048
-
Targeted disruption of ATM leads to growth retardation, chromosomal fragmentation during meiosis, immune defects, and thymic lymphoma
-
doi: 10.1101/gad.10.19.2411
-
Xu, Y., Ashley, T., Brainerd, E. E., Bronson, R. T., Meyn, M. S., and Baltimore, D. (1996). Targeted disruption of ATM leads to growth retardation, chromosomal fragmentation during meiosis, immune defects, and thymic lymphoma. Genes Dev. 10, 2411-2422. doi: 10.1101/gad.10.19.2411
-
(1996)
Genes Dev.
, vol.10
, pp. 2411-2422
-
-
Xu, Y.1
Ashley, T.2
Brainerd, E.E.3
Bronson, R.T.4
Meyn, M.S.5
Baltimore, D.6
-
42
-
-
2342566462
-
p19ARF determines the balance between normal cell proliferation rate and apoptosis during mammary gland development
-
doi: 10.1091/mbc.E03-11-0785
-
Yi, Y., Shepard, A., Kittrell, F., Mulac-Jericevic, B., Medina, D., and Said, T. K. (2004). p19ARF determines the balance between normal cell proliferation rate and apoptosis during mammary gland development. Mol. Biol. Cell 15, 2302-2311. doi: 10.1091/mbc.E03-11-0785
-
(2004)
Mol. Biol. Cell
, vol.15
, pp. 2302-2311
-
-
Yi, Y.1
Shepard, A.2
Kittrell, F.3
Mulac-Jericevic, B.4
Medina, D.5
Said, T.K.6
-
43
-
-
0032145569
-
Myc signaling via the ARF tumor suppressor regulates p53-dependent apoptosis and immortalization
-
doi: 10.1101/gad.12.15.2424
-
Zindy, F., Eischen, C. M., Randle, D. H., Kamijo, T., Cleveland, J. L., Sherr, C. J.,et al. (1998). Myc signaling via the ARF tumor suppressor regulates p53-dependent apoptosis and immortalization. Genes Dev. 12, 2424-2433. doi: 10.1101/gad.12.15.2424
-
(1998)
Genes Dev.
, vol.12
, pp. 2424-2433
-
-
Zindy, F.1
Eischen, C.M.2
Randle, D.H.3
Kamijo, T.4
Cleveland, J.L.5
Sherr, C.J.6
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